Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging
Open accessAbstract
New neurons are generated in the adult hippocampus throughout life by neural stem/progenitor cells (NSCs), and neurogenesis is a plastic process responsive to external stimuli. We show that canonical Notch signaling through RBP-J is required for hippocampal neurogenesis. Notch signaling distinguishes morphologically distinct Sox2(+) NSCs, and within these pools subpopulations can shuttle between mitotically active or quiescent. Radial and horizontal NSCs respond selectively to neurogenic stimuli. Physical exercise activates the quiescent radial population whereas epileptic seizures induce expansion of the horizontal NSC pool. Surprisingly, reduced neurogenesis correlates with a loss of active horizontal NSCs in aged mice rather than a total loss of stem cells, and the transition to a quiescent state is reversible to rejuvenate neurogenesis in the brain. The discovery of multiple NSC populations with Notch dependence but selective responses to stimuli and reversible quiescence has important implications for the mechanisms of adaptive learning and also for regenerative therapy.
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Physical exercise increases the number of new neurons by stimulating the proliferation of radial stem cells and amplifying progenitor cells, leading to an increase in the production of neuroblasts.
“In some of these cases, e.g., physical exercise, evidence suggests that the number of new neurons is increased by actions at multiple stages in the adult neurogenesis process, including by stimulating the proliferation of radial stem cells and amplifying progenitor cells, leading to an increase in the production of neuroblasts (Bednarczyk et al., 2010; Kronenberg et al., 2006; Lugert et al., 2010;”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Lugert et al., 2010
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- Authors
- Lugert, S., Basak, O., Knuckles, P., Haussler, U., Fabel, K., Götz, M., Haas, C. A., Kempermann, G., Taylor, V., & Giachino, C.
- Affiliations
- Max Planck Society (DE)
- Center for Regenerative Therapies Dresden (DE)
- Helmholtz Munich (DE)
- University of Freiburg (DE)
- Corresponding author
- Taylor, Verdon
- Venue
- Cell stem cell
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 6
- Issue
- 5
- Pages
- 445-456
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2088906043
- Cited by
- 704
- References
- 53
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 26 · 2023: 31 · 2022: 37 · 2021: 37 · 2020: 60 · 2019: 53 · 2018: 56 · 2017: 53 · 2016: 45 · 2015: 52 · 2014: 57 · 2013: 53 · 2012: 55
- FWCI
- 16.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion)
- Site cant be reached (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- National Science Council
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- hippocampal neural stem cells, adult neurogenesis, Notch signaling, RBPJ, SOX2, quiescent stem cells, physical activity, epileptic seizures, aging, stem cell rejuvenation, stem cell morphology
- MeSH terms
- Aging, Animals, Cell Differentiation, Hippocampus, Neurons, Physical Conditioning, Animal, Recombinant Fusion Proteins, Repressor Proteins, Seizures, Stem Cells, Signal Transduction, Multipotent Stem Cells, Cell Shape, Cell Proliferation, Green Fluorescent Proteins, Mice, Basic Helix-Loop-Helix Proteins, Receptors, Notch, Neurogenesis, SOXB1 Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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