Adult-onset deficiency in growth hormone and insulin-like growth factor-I alters oligodendrocyte turnover in the corpus callosum
Open accessAbstract
Growth hormone (GH) and insulin‐like growth factor‐I (IGF‐I) provide trophic support during development and also appear to influence cell structure, function and replacement in the adult brain. Recent studies demonstrated effects of the GH/IGF‐I axis on adult neurogenesis, but it is unclear whether the GH/IGF‐I axis influences glial turnover in the normal adult brain. In the current study, we used a selective model of adult‐onset GH and IGF‐I deficiency to evaluate the role of GH and IGF‐I in regulating glial proliferation and survival in the adult corpus callosum. GH/IGF‐I‐deficient dwarf rats of the Lewis strain were made GH/IGF‐I replete via twice daily injections of GH starting at postnatal day 28 (P28), approximately the age at which GH pulse amplitude increases in developing rodents. GH/IGF‐I deficiency was initiated in adulthood by removing animals from GH treatment. Quantitative analyses revealed that adult‐onset GH/IGF‐I deficiency decreased cell proliferation in the white matter and decreased the survival of newborn oligodendrocytes. These findings are consistent with the hypothesis that aging‐related changes in the GH/IGF‐I axis produce deficits in ongoing turnover of oligodendrocytes, which may contribute to aging‐related cognitive changes and deficits in remyelination after injury. © 2008 Wiley‐Liss, Inc.
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- Authors
- Hua, K., Forbes, M. E., Lichtenwalner, R. J., Sonntag, W. E., & Riddle, D. R.
- Affiliations
- Wake Forest University Health Sciences (US)
- University of Oklahoma Health Sciences Center (US)
- Corresponding author
- Riddle, David R.
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2008-12-29
- Volume
- 57
- Issue
- 10
- Pages
- 1062-1071
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- PMC
- PMC2696576
- OpenAlex
- W2036293292
- Semantic Scholar
- 82292c3538a3c531d59754e6b100765bacf2eae4
- Cited by
- 36
- References
- 94
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 4 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 4 · 2012: 6
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Glia (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01ag026607-06)
- National Institute on Aging (#R01AG026607, P01AG11370, P01AG011370)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- growth hormone deficiency, insulin-like growth factor I, corpus callosum, glial cell proliferation, oligodendrocyte survival, white matter, aging, remyelination, somatotropic axis
- MeSH terms
- Aging, Animals, Cell Survival, Cognition Disorders, Corpus Callosum, Disease Models, Animal, Female, Insulin-Like Growth Factor I, Male, Memory Disorders, Myelin Sheath, Nerve Fibers, Myelinated, Nerve Regeneration, Oligodendroglia, Growth Hormone, Substance Withdrawal Syndrome, Cell Proliferation, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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