Experience-Induced Neurogenesis in the Senescent Dentate Gyrus
Open accessAbstract
We demonstrate here that under physiological conditions neurogenesis continues to occur in the dentate gyrus of senescent mice and can be stimulated by living in an enriched environment. Neurogenesis was investigated by confocal microscopy of three-channel immunofluorescent staining for the proliferation marker bromodeoxyuridine (BrdU) and neuronal and glial markers. Quantification was performed with unbiased stereological counting techniques. Neurogenesis decreased with increasing age. Stimulation of adult and aged mice by switching from standard housing to an enriched environment with opportunities for social interaction, exploration, and physical activity for 68 d resulted in an increased survival of labeled cells. Phenotypic analysis revealed that, in enriched living animals, relatively more cells differentiated into neurons, resulting in a threefold net increase of BrdU-labeled neurons in 20-month-old mice (105 vs 32 cells) and a more than twofold increase in 8-month-old mice (684 vs 285 cells) compared with littermates living under standard laboratory conditions. Corresponding absolute numbers of BrdU-positive astrocytes and BrdU-positive cells that did not show colabeling for neuronal or glial markers were not influenced. The effect on the relative distribution of phenotypes can be interpreted as a survival-promoting effect that is selective for neurons. Proliferation of progenitor cells appeared unaffected by environmental stimulation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Although aging may constrain neuronal plasticity, enriched-environment effects can be observed in older organisms.
“Although aging may constrain the degree of neuronal plasticity that is possible, studies suggest that enrichedenvironment effects can be observed in older organisms (Brown et al., 2003; Jessberger & Gage, 2008; Kempermann, Kuhn, & Gage, 1998).”
From Enrichment Effects on Adult Cognitive Development: Can the Functional Capacity of Older Adults Be Preserved and Enhanced? (2008) · cites this paper as Kempermann, Kuhn, & Gage, 1998
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
Altman, J., & Das, G. D. (1965) · Journal of Comparative Neurology · doi:10.1002/cne.901240303 · Cited by 3,592 · see citing works
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
West, M. J., Coleman, P. D., Flood, D. G., & Troncoso, J. C. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92338-8 · Cited by 1,267 · cited 1× · see citing works
“The aging hippocampal formation is affected by a number of structural and functional changes, including the loss of neurons in CA regions and the hilus (West et al., 1994), reduced synaptic densities (Saito et al.”
BackgroundEffect of Neonatal Handling on Age-Related Impairments Associated with the Hippocampus
Meaney, M. J., Aitken, D. H., van Berkel, C., Bhatnagar, S., & Sapolsky, R. M. (1988) · Science · doi:10.1126/science.3340858 · Cited by 1,074 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Coggeshall RE, Lekan HA (1996) Methods for determining numbers of cells and synapses: a case for more uniform standards for review. J Comp Neurol 364:6 -15.
- Shepherd GM (1994) Neurobiology. New York: Oxford UP.
- Silver L M (1995) Mouse genetics. New York: Oxford UP.
Cited by
Sorted by citations
Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369 · see citing works
Self-citationRunning increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880 · see citing works
Self-citationNavigation-related structural change in the hippocampi of taxi drivers
Maguire, E. A., Gadian, D. G., Johnsrude, I. S., Good, C. D., Ashburner, J., Frackowiak, R. S. J., & Frith, C. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.070039597 · Cited by 3,225 · see citing works
The adaptive brain: aging and neurocognitive scaffolding
Park, D. C., & Reuter-Lorenz, P. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093656 · Cited by 2,790 · see citing works
Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601 · see citing works
Neural consequences of enviromental enrichment
van Praag, H., Kempermann, G., & Gage, F. H. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044558 · Cited by 2,468 · see citing works
Self-citationThe Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475 · see citing works
Exercise enhances learning and hippocampal neurogenesis in aged mice
van Praag, H., Shubert, T., Zhao, C., & Gage, F. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-05.2005 · Cited by 2,078 · see citing works
Self-citationMcEwen, B. S. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02950-4 · Cited by 1,827 · see citing works
Enriched environments, experience-dependent plasticity and disorders of the nervous system
Nithianantharajah, J., & Hannan, A. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1970 · Cited by 1,771 · see citing works
Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus
Cameron, H. A., & Mckay, R. D. G. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1040 · Cited by 1,585 · see citing works
Lupien, S. J., Maheu, F., Tu, M., Fiocco, A., & Schramek, T. E. (2007) · Brain and Cognition · doi:10.1016/j.bandc.2007.02.007 · Cited by 1,474 · see citing works
Hertzog, C., Kramer, A. F., Wilson, R. S., & Lindenberger, U. (2008) · Psychological Science in the Public Interest · doi:10.1111/j.1539-6053.2009.01034.x · Cited by 1,495 · see citing works
Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood
Anacker, C., & Hen, R. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.45 · Cited by 1,014 · see citing works
Adult neurogenesis: from precursors to network and physiology
Abrous, D. N., Koehl, M., & Le Moal, M. (2005) · Physiological Reviews · doi:10.1152/physrev.00055.2003 · Cited by 971 · see citing works
Kempermann, G., Gast, D., & Gage, F. H. (2002) · Annals of Neurology · doi:10.1002/ana.10262 · Cited by 889 · see citing works
Self-citationEnvironmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice
Lazarov, O., Robinson, J., Tang, Y.-P., Hairston, I. S., Korade-Mirnics, Z., Lee, V. M.-Y., Hersh, L. B., Sapolsky, R. M., Mirnics, K., & Sisodia, S. S. (2005) · Cell · doi:10.1016/j.cell.2005.01.015 · Cited by 885 · see citing works
Kee, N., Teixeira, C. M., Wang, A. H., & Frankland, P. W. (2007) · Nature Neuroscience · doi:10.1038/nn1847 · Cited by 875 · see citing works
Peripheral Infusion of IGF-I Selectively Induces Neurogenesis in the Adult Rat Hippocampus
Åberg, M. A. I., Åberg, N. D., Hedbäcker, H., Oscarsson, J., & Eriksson, P. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-08-02896.2000 · Cited by 852 · see citing works
Farmer, J., Zhao, X., van Praag, H., Wodtke, K., Gage, F. H., & Christie, B. R. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.09.029 · Cited by 836 · see citing works
Self-citationEnriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis
Brown, J., Cooper‐Kuhn, C. M., Kempermann, G., Van Praag, H., Winkler, J., Gage, F. H., & Kuhn, H. G. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02647.x · Cited by 809 · see citing works
Self-citationTraumatic stress: effects on the brain
Bremner, J. D. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/jbremner · Cited by 738 · see citing works
The role of adult hippocampal neurogenesis in brain health and disease
Toda, T., Parylak, S. L., Linker, S. B., & Gage, F. H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0036-2 · Cited by 719 · see citing works
Self-citationRestoring production of hippocampal neurons in old age
Cameron, H. A., & McKay, R. D. G. (1999) · Nature Neuroscience · doi:10.1038/13197 · Cited by 710 · see citing works
Lugert, S., Basak, O., Knuckles, P., Haussler, U., Fabel, K., Götz, M., Haas, C. A., Kempermann, G., Taylor, V., & Giachino, C. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.03.017 · Cited by 704 · see citing works
Self-citationMurine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years
Knoth, R., Singec, I., Ditter, M., Pantazis, G., Capetian, P., Meyer, R. P., Horvat, V., Volk, B., & Kempermann, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008809 · Cited by 650 · see citing works
Self-citationPham, K., Nacher, J., Hof, P. R., & McEwen, B. S. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02513.x · Cited by 657 · see citing works
Neurogenesis and Exercise: Past and Future Directions
van Praag, H. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8028-z · Cited by 645 · see citing works
Effects of adverse experiences for brain structure and function
McEwen, B. S. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00964-1 · Cited by 639 · see citing works
FoxO3 Regulates Neural Stem Cell Homeostasis
Renault, V. M., Rafalski, V. A., Morgan, A. A., Salih, D. A. M., Brett, J. O., Webb, A. E., Villeda, S. A., Thekkat, P. U., Guillerey, C., Denko, N. C., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.09.014 · Cited by 586 · see citing works
Krystal, J. H., D'Souza, D. C., Mathalon, D., Perry, E., Belger, A., & Hoffman, R. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1582-z · Cited by 530 · see citing works
Wang, H.-W., Pasternak, J. F., Kuo, H., Ristic, H., Lambert, M. P., Chromy, B., Viola, K. L., Klein, W. L., Stine, W. B., Krafft, G. A., et al. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03058-x · Cited by 527 · see citing works
Lifecourse Social Conditions and Racial and Ethnic Patterns of Cognitive Aging
Glymour, M. M., & Manly, J. J. (2008) · Neuropsychology Review · doi:10.1007/s11065-008-9064-z · Cited by 481 · see citing works
Hochgerner, H., Zeisel, A., Lönnerberg, P., & Linnarsson, S. (2018) · Nature Neuroscience · doi:10.1038/s41593-017-0056-2 · Cited by 482 · see citing works
Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus
Kronenberg, G., Bick-Sander, A., Bunk, E., Wolf, C., Ehninger, D., & Kempermann, G. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.016 · Cited by 477 · see citing works
Self-citationWhy new neurons? Possible functions for adult hippocampal neurogenesis
Kempermann, G. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00635.2002 · Cited by 469 · see citing works
Self-citationWilliams, R. J., & Spencer, J. P. E. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.010 · Cited by 448 · see citing works
Experience-driven brain plasticity: Beyond the synapse
MARKHAM, J. A., & GREENOUGH, W. T. (2004) · Neuron Glia Biology · doi:10.1017/s1740925x05000219 · Cited by 437 · see citing works
Lichtenwalner, R. J., Forbes, M. E., Bennett, S. A., Lynch, C. D., Sonntag, W. E., & Riddle, D. R. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00378-5 · Cited by 428 · see citing works
Environment and Brain Plasticity: Towards an Endogenous Pharmacotherapy
Sale, A., Berardi, N., & Maffei, L. (2014) · Physiological Reviews · doi:10.1152/physrev.00036.2012 · Cited by 402 · see citing works
Tillerson, J. L., Caudle, W. M., Reverón, M. E., & Miller, G. W. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00096-4 · Cited by 399 · see citing works
Jin, K., Sun, Y., Xie, L., Batteur, S., Mao, X. O., Smelick, C., Logvinova, A., & Greenberg, D. A. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00046.x · Cited by 396 · see citing works
Åberg, N. D., Brywe, K. G., & Isgaard, J. (2006) · The Scientific World JOURNAL · doi:10.1100/tsw.2006.22 · Cited by 387 · see citing works
Rapamycin extends murine lifespan but has limited effects on aging
Neff, F., Flores-Dominguez, D., Ryan, D. P., Horsch, M., Schröder, S., Adler, T., Afonso, L. C., Aguilar-Pimentel, J. A., Becker, L., Garrett, L., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67674 · Cited by 374 · see citing works
Stress and hippocampal plasticity: implications for the pathophysiology of affective disorders
McEwen, B. S., & Magarinos, A. M. (2001) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.266 · Cited by 349 · see citing works
Exercise effects on depression: Possible neural mechanisms
Gujral, S., Aizenstein, H., Reynolds, C. F., Butters, M. A., & Erickson, K. I. (2017) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2017.04.012 · Cited by 334 · see citing works
Why and how physical activity promotes experience-induced brain plasticity.
Kempermann, G., Fabel, K., Ehninger, D., Babu, H., Leal-Galicia, P., Garthe, A., & Wolf, S. A. (2010) · Frontiers in Neuroscience · doi:10.3389/fnins.2010.00189 · Cited by 334 · see citing works
Self-citationInsulin-like growth factor-I and neurogenesis in the adult mammalian brain
Anderson, M. F., Åberg, M. A. I., Nilsson, M., & Eriksson, P. S. (2002) · Developmental Brain Research · doi:10.1016/s0165-3806(02)00277-8 · Cited by 314 · see citing works
Nature, nurture, and development: from evangelism through science toward policy and practice
Rutter, M. (2002) · Child Development · doi:10.1111/1467-8624.00388 · Cited by 309 · see citing works
Beckervordersandforth, R., Ebert, B., Schäffner, I., Moss, J., Fiebig, C., Shin, J., Moore, D. L., Ghosh, L., Trinchero, M. F., Stockburger, C., et al. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.017 · Cited by 303 · see citing works
Karishma, K. K., & Herbert, J. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02099.x · Cited by 297 · see citing works
Wolf, S. A., Kronenberg, G., Lehmann, K., Blankenship, A., Overall, R., Staufenbiel, M., & Kempermann, G. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.004 · Cited by 288 · see citing works
Self-citationEffects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning
Catlow, B. J., Song, S., Paredes, D. A., Kirstein, C. L., & Sanchez-Ramos, J. (2013) · Experimental Brain Research · doi:10.1007/s00221-013-3579-0 · Cited by 266 · see citing works
Neuroplasticity and cognitive aging: The scaffolding theory of aging and cognition
Goh, J. O., & Park, D. C. (2009) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2009-0493 · Cited by 253 · see citing works
Long-term effects of childhood abuse on brain and neurobiology
Bremner, J. D. (2003) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/s1056-4993(02)00098-6 · Cited by 243 · see citing works
Stroke-induced neurogenesis in aged brain
Darsalia, V., Heldmann, U., Lindvall, O., & Kokaia, Z. (2005) · Stroke · doi:10.1161/01.str.0000173151.36031.be · Cited by 240 · see citing works
Neurogenic Effect of -Amyloid Peptide in the Development of Neural Stem Cells
Lopez-Toledano, M. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0974-04.2004 · Cited by 241 · see citing works
Halperin, J. M., & Healey, D. M. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.07.006 · Cited by 237 · see citing works
Kempermann, G. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.40101.x · Cited by 231 · see citing works
Self-citationCrews, L., Adame, A., Patrick, C., DeLaney, A., Pham, E., Rockenstein, E., Hansen, L., & Masliah, E. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1305-10.2010 · Cited by 222 · see citing works
Frick, K. M. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.08.015 · Cited by 205 · see citing works
Brett, J. O., Renault, V. M., Rafalski, V. A., Webb, A. E., & Brunet, A. (2011) · Aging · doi:10.18632/aging.100285 · Cited by 207 · see citing works
Effects of Microglia on Neurogenesis
Sato, K. (2015) · Glia · doi:10.1002/glia.22858 · Cited by 187 · see citing works
Bianchi, P., Ciani, E., Guidi, S., Trazzi, S., Felice, D., Grossi, G., Fernandez, M., Giuliani, A., Calza, L., & Bartesaghi, R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0534-10.2010 · Cited by 188 · see citing works
The neurobiology and neuroendocrinology of stress
McEwen, B. S. (2002) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(01)00009-0 · Cited by 184 · see citing works
Adult neurogenesis and neurodegenerative diseases: A systems biology perspective
Horgusluoglu, E., Nudelman, K., Nho, K., & Saykin, A. J. (2017) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32429 · Cited by 174 · see citing works
Zhao, M., Li, D., Shimazu, K., Zhou, Y.-X., Lu, B., & Deng, C.-X. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.10.019 · Cited by 171 · see citing works
Lupien, S. J., Evans, A., Lord, C., Miles, J., Pruessner, M., Pike, B., & Pruessner, J. C. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.09.041 · Cited by 167 · see citing works
Pham, T. M., Söderström, S., Winblad, B., & Mohammed, A. H. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00019-4 · Cited by 162 · see citing works
The FGF-2/FGFRs neurotrophic system promotes neurogenesis in the adult brain
Mudò, G., Bonomo, A., Di Liberto, V., Frinchi, M., Fuxe, K., & Belluardo, N. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0207-z · Cited by 158 · see citing works
He, N., Jin, W.-L., Lok, K.-H., Wang, Y., Yin, M., & Wang, Z.-J. (2013) · Cell Death & Disease · doi:10.1038/cddis.2013.437 · Cited by 151 · see citing works
Environmental enrichment and the sensory brain: The role of enrichment in remediating brain injury
Alwis, D. S., & Rajan, R. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00156 · Cited by 129 · see citing works
Ward, N. L., & Lamanna, J. C. (2004) · Neurological Research · doi:10.1179/016164104x3798 · Cited by 122 · see citing works
Blackmore, D. G., Golmohammadi, M. G., Large, B., Waters, M. J., & Rietze, R. L. (2009) · Stem Cells · doi:10.1002/stem.120 · Cited by 119 · see citing works
In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice.
Rodríguez-Matellán, A., Alcazar, N., Hernández, F., Serrano, M., & Ávila, J. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.09.010 · Cited by 116 · see citing works
Angiogenesis but not neurogenesis is critical for normal learning and memory acquisition.
Kerr, A. L., Steuer, E. L., Pochtarev, V., & Swain, R. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.008 · Cited by 103 · see citing works
Herold, C., Coppola, V. J., & Bingman, V. P. (2015) · Hippocampus · doi:10.1002/hipo.22463 · Cited by 84 · see citing works
Can exercise training teach us how to treat Alzheimer's disease?
Huuha, A. M., Norevik, C. S., Moreira, J. B. N., Kobro-Flatmoen, A., Scrimgeour, N., Kivipelto, M., Van Praag, H., Ziaei, M., Sando, S. B., Wisløff, U., et al. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101559 · Cited by 79 · see citing works
Schaeffer, E. L., Forlenza, O. V., & Gattaz, W. F. (2009) · Psychopharmacology · doi:10.1007/s00213-008-1351-0 · Cited by 71 · see citing works
Hua, K., Schindler, M. K., McQuail, J. A., Forbes, M. E., & Riddle, D. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052728 · Cited by 60 · see citing works
Klotho, the Key to Healthy Brain Aging?
Vo, H. T., Laszczyk, A. M., & King, G. D. (2017) · Brain Plasticity · doi:10.3233/bpl-170057 · Cited by 50 · see citing works
Enriched environment increases the myelinated nerve fibers of aged rat corpus callosum
Zhao, Y., Shi, X., Qiu, X., Lu, W., Yang, S., Li, C., Chen, L., Zhang, L., Cheng, G., & Tang, Y. (2012) · The Anatomical Record · doi:10.1002/ar.22446 · Cited by 41 · see citing works
Social regulation of adult neurogenesis in a eusocial mammal
Peragine, D. E., Simpson, J. A., Mooney, S. J., Lovern, M. B., & Holmes, M. M. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.02.044 · Cited by 37 · see citing works
Hua, K., Forbes, M. E., Lichtenwalner, R. J., Sonntag, W. E., & Riddle, D. R. (2009) · Glia · doi:10.1002/glia.20829 · Cited by 36 · see citing works
Tirone, F., Farioli-Vecchioli, S., Micheli, L., Ceccarelli, M., & Leonardi, L. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00059 · Cited by 32 · see citing works
Furukawa, T., Nikaido, Y., Shimoyama, S., Masuyama, N., Notoya, A., & Ueno, S. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.777404 · Cited by 27 · see citing works
Gendron, M., Mesquita, B., & Barrett, L. F. (2020) · Culture, Mind, and Brain · doi:10.1017/9781108695374.010 · Cited by 20 · see citing works
- Authors
- Kempermann, G., Kuhn, H. G., & Gage, F. H.
- Affiliations
- Salk Institute for Biological Studies (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1998-05-01
- Volume
- 18
- Issue
- 9
- Pages
- 3206-3212
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6792643
- OpenAlex
- W2154908600
- Cited by
- 1,150
- References
- 3
- Citations by year
- 2026: 7 · 2025: 21 · 2024: 18 · 2023: 14 · 2022: 17 · 2021: 21 · 2020: 57 · 2019: 23 · 2018: 32 · 2017: 30 · 2016: 33 · 2015: 39 · 2014: 41 · 2013: 57 · 2012: 69
- FWCI
- 10.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (acceptedVersion)
- Funders
- Hereditary Disease Foundation
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- adult neurogenesis, dentate gyrus, aging, environmental enrichment, neuronal survival, neuronal differentiation, astrocytes, progenitor cell proliferation, hippocampus, senescence
- MeSH terms
- Aging, Animals, Bromodeoxyuridine, Cell Count, Cell Division, DNA, Female, Immunohistochemistry, Mice, Inbred C57BL, Nerve Tissue, Neurons, Phenotype, Microscopy, Confocal, Maze Learning, Dentate Gyrus, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
