The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Mitogen-activated protein kinase-signaling regulates the ability of Müller glia to proliferate and protect retinal neurons against excitotoxicity
Open accessAbstract
The purpose of this study was to investigate whether insulin, fibroblast growth factor (FGF), and mitogen‐activated protein kinase (MAPK) pathways protect retinal neurons against excitotoxicity and regulate the proliferation of Müller glia. We found that intraocular injections of insulin or FGF2 had variable effects upon the phosphorylation of ERK1/2, p38 MAPK, and CREB, and the expression of immediate early genes, cFos and Egr1. Accumulations of pERK1/2, p38 MAPK, pCREB, cFos and Egr1 in response to insulin or FGF2 were confined to Müller glia, whereas retinal neurons did not seem to respond to growth factors. Unlike FGF2, insulin stimulated microglia‐like cells to upregulate the intermediate filament transitin and lysosomal membrane glycoprotein (LMG). With microglia‐like cells and Müller glia stimulated by insulin or FGF2 there were profound effects upon numbers of dying neurons in response to excitotoxic damage. Although FGF2 significantly reduced numbers of dying neurons, insulin significantly increased numbers of dying neurons. In addition to neuroprotective affects, FGF2 also “primed” the Müller glia to proliferate following retinal damage, whereas insulin had no effect upon glial proliferation. Further, we found that FGF receptor isoform 1 (FGFR1) and FGFR3 were prominently expressed in the retina, whereas the insulin receptor and FGFR2 are not expressed, or are expressed at very low levels. We conclude that MAPK‐signaling through FGF receptors stimulates Müller glia to become more neuroprotective and progenitor‐like, whereas insulin acting on Müller and microglia‐like cells through unidentified receptors had the opposite effect. © 2009 Wiley‐Liss, Inc.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Additionally, MG are primarily responsive to intra-ocular insulin with increased phosphorylation of ERK1/2 and p38 [ 77 ].”
From MAPK Pathways in Ocular Pathophysiology: Potential Therapeutic Drugs and Challenges (2023) · cites this paper as [77]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Müller glia are a potential source of neural regeneration in the postnatal chicken retina
Fischer, A. J., & Reh, T. A. (2001) · Nature Neuroscience · doi:10.1038/85090 · Cited by 579
Self-citationThe transcriptome of retinal Müller glial cells
Roesch, K., Jadhav, A. P., Trimarchi, J. M., Stadler, M. B., Roska, B., Sun, B. B., & Cepko, C. L. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21730 · Cited by 409
Harada, T., Harada, C., Kohsaka, S., Wada, E., Yoshida, K., Ohno, S., Mamada, H., Tanaka, K., Parada, L. F., & Wada, K. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09228.2002 · Cited by 397
Stimulation of neural regeneration in the mouse retina
Karl, M. O., Hayes, S., Nelson, B. R., Tan, K., Buckingham, B., & Reh, T. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807453105 · Cited by 368
Wnt signaling promotes regeneration in the retina of adult mammals
Osakada, F., Ooto, S., Akagi, T., Mandai, M., Akaike, A., & Takahashi, M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4193-06.2007 · Cited by 322
Expression and characterization of a functional human insulin-like growth factor I receptor.
Steele-Perkins, G., Turner, J. D., Edman, J. C., Hari, J., Pierce, S. B., Stover, C., Rutter, W. J., & Roth, R. A. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37983-3 · Cited by 314
Peterson, W. M., Wang, Q., Tzekova, R., & Wiegand, S. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04081.2000 · Cited by 267
Potential of Müller glia to become neurogenic retinal progenitor cells
Fischer, A. J., & Reh, T. A. (2003) · Glia · doi:10.1002/glia.10218 · Cited by 252
Self-citationSteininger, T. L., Gong, H., McGinty, D., & Szymusiak, R. S. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20010122)429:4 · Cited by 251
Harada, T., Harada, C., Nakayama, N., Okuyama, S., Yoshida, K., Kohsaka, S., Matsuda, H., & Wada, K. (2000) · Neuron · doi:10.1016/s0896-6273(00)81185-x · Cited by 221
Cited by
Sorted by citations
Pollen, A. A., Nowakowski, T. J., Shuga, J., Wang, X., Leyrat, A. A., Lui, J. H., Li, N., Szpankowski, L., Fowler, B., Chen, P., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.2967 · Cited by 920
Reichenbach, A., & Bringmann, A. (2013) · Glia · doi:10.1002/glia.22477 · Cited by 756
Müller glial cell reprogramming and retina regeneration
Goldman, D. J. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3723 · Cited by 652
Govetto, A., Lalane, R. A., Sarraf, D., Figueroa, M. S., & Hubschman, J. (2016) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2016.12.006 · Cited by 538
Menon, M., Mohammadi, S., Davila-Velderrain, J., Goods, B. A., Cadwell, T. D., Xing, Y., Stemmer-Rachamimov, A., Shalek, A. K., Love, J. C., Kellis, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12780-8 · Cited by 331
HB-EGF is Necessary and Sufficient for Müller Glia Dedifferentiation and Retina Regeneration
Wan, J., Ramachandran, R., & Goldman, D. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.11.020 · Cited by 262
“MAPK signaling was previously reported to be required for proliferation of MG-derived progenitors in the postnatal chick retina (Fischer et al., 2009a; Fischer et al., 2009b) and likely mediates the effects of EGF on MG proliferation in the injured mouse retina (Karl et al., 2008).”
BackgroundRamachandran, R., Zhao, X.-F., & Goldman, D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107220108 · Cited by 206
Berner, A., Brouwers, O., Pringle, R., Klaassen, I., Colhoun, L. M., McVicar, C. M., Brockbank, S., Curry, J., Miyata, T., Brownlee, M., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2393-0 · Cited by 156
Hamon, A., Roger, J. E., Yang, X.-J., & Perron, M. (2015) · Developmental Dynamics · doi:10.1002/dvdy.24375 · Cited by 139
Turning Müller Glia into Neural Progenitors in the Retina
Fischer, A. J., & Bongini, R. E. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8152-2 · Cited by 113
Self-citationNotch signaling influences neuroprotective and proliferative properties of mature Müller glia
Ghai, K., Zelinka, C., & Fischer, A. J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4919-09.2010 · Cited by 111
Self-citationEffect of inhibition of the FGFR–MAPK signaling pathway on the development of ocular toxicities
van der Noll, R., Leijen, S., Neuteboom, G. H. G., Beijnen, J. H., & Schellens, J. H. M. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.01.003 · Cited by 106
Fischer, A. J., Zelinka, C. P., Gallina, D., Scott, M. A., & Todd, L. J. (2014) · Glia · doi:10.1002/glia.22703 · Cited by 100
Self-citationThe ciliary marginal zone (CMZ) in development and regeneration of the vertebrate eye
Fischer, A. J., Bosse, J. L., & El‐Hodiri, H. M. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.08.018 · Cited by 96
Self-citationThe chick eye in vision research: An excellent model for the study of ocular disease
Wisely, C. E., Sayed, J. A., Tamez, H. M., Zelinka, C. P., Abdel‐Rahman, M. H., Fischer, A. J., & Cebulla, C. M. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.06.004 · Cited by 97
Self-citationLens and retina regeneration: new perspectives from model organisms
Barbosa-Sabanero, K., Hoffmann, A., Judge, C. J., Lightcap, N., Tsonis, P. A., & Rio‐Tsonis, K. D. (2012) · Biochemical Journal · doi:10.1042/bj20120813 · Cited by 92
Todd, L. J., Squires, N. A., Suarez, L., & Fischer, A. J. (2016) · Scientific Reports · doi:10.1038/srep35703 · Cited by 87
Self-citationA comparative analysis of Müller glia-mediated regeneration in the vertebrate retina
Gallina, D., Todd, L. J., & Fischer, A. J. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.06.019 · Cited by 88
Self-citationPalazzo, I., Todd, L. J., Hoang, T. V., Reh, T. A., Blackshaw, S., & Fischer, A. J. (2022) · Glia · doi:10.1002/glia.24181 · Cited by 82
Self-citationMüller Glia-Mediated Retinal Regeneration
Gao, H., Luodan, A., Huang, X., Chen, X., & Xu, H. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02274-w · Cited by 84
Gallina, D., Zelinka, C. P., & Fischer, A. J. (2014) · Development · doi:10.1242/dev.109835 · Cited by 77
Self-citationStanke, J. J., Moose, H. E., El‐Hodiri, H. M., & Fischer, A. J. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22335 · Cited by 74
Self-citationThe combination of IGF1 and FGF2 and the induction of excessive ocular growth and extreme myopia
Ritchey, E. R., Zelinka, C. P., Tang, J., Liu, J., & Fischer, A. J. (2012) · Experimental Eye Research · doi:10.1016/j.exer.2012.03.019 · Cited by 71
Self-citationHeterogeneity of Glia in the Retina and Optic Nerve of Birds and Mammals
Fischer, A. J., Zelinka, C. P., & Scott, M. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010774 · Cited by 69
Self-citationZelinka, C. P., Volkov, L. I., Goodman, Z. A., Todd, L. J., Palazzo, I., Bishop, W. A., & Fischer, A. J. (2016) · Development · doi:10.1242/dev.133215 · Cited by 62
Self-citationMAPK Pathways in Ocular Pathophysiology: Potential Therapeutic Drugs and Challenges
Moustardas, P., Aberdam, D., & Lagali, N. (2023) · Cells · doi:10.3390/cells12040617 · Cited by 63
“Additionally, MG are primarily responsive to intra-ocular insulin with increased phosphorylation of ERK1/2 and p38 [77].”
BackgroundReactive retinal microglia, neuronal survival, and the formation of retinal folds and detachments
Fischer, A. J., Zelinka, C. P., & Milani‐Nejad, N. (2014) · Glia · doi:10.1002/glia.22752 · Cited by 60
Self-citationFischer, A. J., Scott, M. A., Zelinka, C. P., & Sherwood, P. (2009) · Glia · doi:10.1002/glia.20950 · Cited by 62
Self-citationPalazzo, I., Deistler, K., Hoang, T. V., Blackshaw, S., & Fischer, A. J. (2020) · Development · doi:10.1242/dev.183418 · Cited by 60
Self-citationTodd, L. J., & Fischer, A. J. (2015) · Development · doi:10.1242/dev.121616 · Cited by 57
Self-citationTodd, L. J., Palazzo, I., Squires, N. A., Mendonca, N., & Fischer, A. J. (2017) · Glia · doi:10.1002/glia.23185 · Cited by 56
Self-citationCampbell, W. A., Fritsch‐Kelleher, A., Palazzo, I., Hoang, T. V., Blackshaw, S., & Fischer, A. J. (2021) · Glia · doi:10.1002/glia.23976 · Cited by 51
Self-citationTodd, L. J., Suarez, L., Quinn, C. H., & Fischer, A. J. (2017) · Stem Cells · doi:10.1002/stem.2742 · Cited by 53
Self-citationTodd, L. J., Volkov, L. I., Zelinka, C. P., Squires, N. A., & Fischer, A. J. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.10.004 · Cited by 52
Self-citationZelinka, C. P., Scott, M. A., Volkov, L. I., & Fischer, A. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044477 · Cited by 50
Self-citationMatteucci, A., Gaddini, L., Villa, M., Varano, M., Parravano, M., Monteleone, V., Cavallo, F., Leo, L., Mallozzi, C., Malchiodi‐Albedi, F., et al. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.05.011 · Cited by 45
W nt/β‐catenin‐signaling and the formation of M üller glia‐derived progenitors in the chick retina
Gallina, D., Palazzo, I., Steffenson, L. N., Todd, L. J., & Fischer, A. J. (2015) · Developmental Neurobiology · doi:10.1002/dneu.22370 · Cited by 43
Self-citationGallina, D., Zelinka, C. P., Cebulla, C. M., & Fischer, A. J. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.08.007 · Cited by 41
Self-citationChuang, J., Huang, J.-Y., Tsai, S., Sun, H. S., Yang, S., Chuang, P., Huang, B., & Ching, C. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.08.011 · Cited by 44
Retinal cell death dependent reactive proliferative gliosis in the mouse retina
Pasha, S. P. B. S., Münch, R., Schäfer, P., Oertel, P., Sykes, A. M., Zhu, Y., & Karl, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-09743-8 · Cited by 40
Purinergic signaling in the retina: From development to disease
Ventura, A. L. M., dos Santos‐Rodrigues, A., Mitchell, C. H., & Faillace, M. P. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.10.016 · Cited by 42
Focused ultrasound as a novel strategy for noninvasive gene delivery to retinal Müller glia
Touahri, Y., Dixit, R., Kofoed, R. H., Miloska, K., Park, E., Raeisossadati, R., Markham-Coultes, K., David, L. A., Rijal, H., Zhao, J., et al. (2020) · Theranostics · doi:10.7150/thno.42611 · Cited by 40
Beach, K. M., Wang, J., & Otteson, D. C. (2017) · Stem Cells International · doi:10.1155/2017/1610691 · Cited by 39
Qian, C., Dong, B. C., Wang, X., & Zhou, F. (2020) · FEBS Journal · doi:10.1111/febs.15681 · Cited by 36
Campbell, W. A., Blum, S. A., Reske, A., Hoang, T. V., Blackshaw, S., & Fischer, A. J. (2021) · Glia · doi:10.1002/glia.24056 · Cited by 33
Self-citationTNFα activates MAPK and Jak-Stat pathways to promote mouse Müller cell proliferation.
Niu, L., Fang, Y., Yao, X., Zhang, Y., Wu, J., Chen, D. F., & Sun, X. (2021) · Experimental Eye Research · doi:10.1016/j.exer.2020.108353 · Cited by 32
Campbell, W. A., Deshmukh, A. A., Blum, S. A., Todd, L. J., Mendonca, N., Weist, J. L., Zent, J. M., Hoang, T. V., Blackshaw, S., Leight, J. L., et al. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.112984 · Cited by 31
Self-citationEl‐Hodiri, H. M., Campbell, W. A., Kelly, L. E., Hawthorn, E. C., Schwartz, M., Jalligampala, A., McCall, M. A., Meyer, K., & Fischer, A. J. (2021) · The Journal of Comparative Neurology · doi:10.1002/cne.25270 · Cited by 31
Self-citationCampbell, W. A., Tangeman, A., El‐Hodiri, H. M., Hawthorn, E. C., Hathoot, M., Blum, S., Hoang, T. V., Blackshaw, S., & Fischer, A. J. (2022) · Development · doi:10.1242/dev.200127 · Cited by 28
Self-citationRebuilding the Retina: Prospects for Müller Glial-mediated Self-repair
Langhe, R., & Pearson, R. A. (2019) · Current Eye Research · doi:10.1080/02713683.2019.1669665 · Cited by 26
Mdzomba, J. B., Joly, S., Rodriguez, L., Dirani, A., Lassiaz, P., Béhar‐Cohen, F., & Pernet, V. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2302-x · Cited by 27
Reprint of: The ciliary marginal zone (CMZ) in development and regeneration of the vertebrate eye
Fischer, A. J., Bosse, J. L., & El‐Hodiri, H. M. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.04.019 · Cited by 25
Self-citationMüller cells trophism and pathology as the next therapeutic targets for retinal diseases
Arrigo, A., Cremona, O., Aragona, E., Casoni, F., Consalez, G., Dogru, R. M., Hauck, S. M., Antropoli, A., Bianco, L., Parodi, M. B., et al. (2025) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2025.101357 · Cited by 27
MIF Inhibitor ISO-1 Protects Photoreceptors and Reduces Gliosis in Experimental Retinal Detachment
Kim, B., Kusibati, R., Heisler‐Taylor, T., Mantopoulos, D., Ding, J., Abdel‐Rahman, M. H., Satoskar, A. R., Godbout, J. P., Bhattacharya, S. K., & Cebulla, C. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-14298-9 · Cited by 23
Müller glia express rhodopsin in a mouse model of inherited retinal degeneration
Goel, M., & Dhingra, N. K. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.066 · Cited by 23
El‐Hodiri, H. M., Bentley, J. R., Reske, A., Taylor, O. B., Palazzo, I., Campbell, W. A., Halloy, N. R., & Fischer, A. J. (2023) · Development · doi:10.1242/dev.202070 · Cited by 23
Self-citationLiu, Y., Wang, C., & Su, G. (2019) · Journal of Ophthalmology · doi:10.1155/2019/5743109 · Cited by 24
Elevated serum IGF-1 level enhances retinal and choroidal thickness in untreated acromegaly patients
Zhang, X., Ma, J., Wang, Y., Li, L., Gao, L., Guo, X., Xing, B., & Zhong, Y. (2018) · Endocrine · doi:10.1007/s12020-017-1511-2 · Cited by 21
Fleming, T., Balderas-Márquez, J. E., Epardo, D., Ávila-Mendoza, J., Carranza, M., Luna, M., Harvey, S., Arámburo, C., & Martínez-Moreno, C. G. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.19-27473 · Cited by 21
Hoang, T. V., Wang, J., Boyd, P., Wang, F., Santiago, C. P., Jiang, L., Lahne, M., Yoo, S., Todd, L. J., Gonzalez, C. S., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/717876 · Cited by 23
Self-citationThe Effects of Sonic Hedgehog on Retinal Müller Cells Under High-Glucose Stress
Zhao, X., Li, Y., Lin, S., Cai, Y. L., Zhang, J., Yu, X., Yang, H., Yang, L., Chen, X. N., Luo, Y., et al. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-16104 · Cited by 20
Yu, Y., Bao, Z., Wang, X., Gong, W., Chen, H., Guan, H., Le, Y., Su, S., Chen, K., & Wang, J. M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01852 · Cited by 19
Chromatin access regulates the formation of Müller glia‐derived progenitor cells in the retina
Campbell, W. A., El‐Hodiri, H. M., Torres, D., Hawthorn, E. C., Kelly, L. E., Volkov, L. I., Akanonu, D., & Fischer, A. J. (2023) · Glia · doi:10.1002/glia.24366 · Cited by 19
Self-citationCorradetti, G., Au, A. C., Borrelli, E., Xu, X., Freund, K. B., & Sarraf, D. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.19-27476 · Cited by 19
Harun‐Or‐Rashid, M., Lindqvist, N., & Hallböök, F. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-13823 · Cited by 18
Reichenbach, A., & Bringmann, A. (2015) · Colloquium Series on Neuroglia in Biology and Medicine From Physiology to Disease · doi:10.4199/c00122ed1v01y201412ngl003 · Cited by 18
Controlled microenvironments to evaluate chemotactic properties of cultured Müller glia
Peña, J. S., Dulger, N., Singh, T., Zhou, J., Majeska, R. J., Redenti, S., & Vázquez, M. (2018) · Experimental Eye Research · doi:10.1016/j.exer.2018.05.005 · Cited by 17
Jacques, F. J., Silva, T. M., da Silva, F. E., Ornelas, I. M., & Ventura, A. L. M. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.03.019 · Cited by 16
Regulating the formation of Müller glia‐derived progenitor cells in the retina
Taylor, O. B., El‐Hodiri, H. M., Palazzo, I., Todd, L. J., & Fischer, A. J. (2024) · Glia · doi:10.1002/glia.24635 · Cited by 14
Self-citationGalán, A., Jmaeff, S., Barcelona, P. F., Brahimi, F., Šarunic, M. V., & Saragovi, H. U. (2017) · Cell Death and Disease · doi:10.1038/s41419-017-0074-8 · Cited by 15
Coorey, N. J., Shen, W., Zhu, L., & Gillies, M. C. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-15695 · Cited by 14
Fard, S. S., All‐Ericsson, C., & Hallböök, F. (2013) · Cell Cycle · doi:10.4161/cc.27200 · Cited by 13
Reactive Muller Glia as Potential Retinal Progenitors
Teri, L. L., Ellen, C. W., Muñoz-Cabrera, J., & Dharmaraj, S. (2013) · InTech eBooks · doi:10.5772/55150 · Cited by 14
Müller glia activation by VEGF-antagonizing drugs: An in vitro study on rat primary retinal cultures
Gaddini, L., Varano, M., Matteucci, A., Mallozzi, C., Villa, M., Pricci, F., & Malchiodi‐Albedi, F. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.11.010 · Cited by 12
Harun‐Or‐Rashid, M., Konjusha, D., Galindo‐Romero, C., & Hallböök, F. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167778 · Cited by 12
Taylor, O. B., Patel, S. P., Hawthorn, E. C., El‐Hodiri, H. M., & Fischer, A. J. (2024) · Glia · doi:10.1002/glia.24523 · Cited by 10
Self-citationMarkitantova, Y. V., Авдонин, П. П., & Grigoryan, E. N. (2014) · Biology Bulletin · doi:10.1134/s1062359014040074 · Cited by 12
Mafi, M., Govetto, A., Mahmoudinezhad, G., Prasad, P. S., Bousquet, E., Voichanski, S., Feo, A., & Sarraf, D. (2025) · Retina · doi:10.1097/iae.0000000000004418 · Cited by 11
Induction of a proliferative response in the zebrafish retina by injection of extracellular vesicles
Didiano, D., Abner, J. J., Hinger, S. A., Flickinger, Z., Kent, M. R., Clement, M. A., Balaiya, S., Liu, Q., Dai, X., Levine, E. M., et al. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108254 · Cited by 11
Epigenetic mechanisms of Müller glial reprogramming mediating retinal regeneration
Si, T., Li, Z., Zhang, J., Su, S., Liu, Y., Chen, S., Peng, G.-H., Cao, J., & Zang, W. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1157893 · Cited by 9
bFGF and insulin lead to migration of Müller glia to photoreceptor layer in rd1 mouse retina
Goel, M., & Dhingra, N. K. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135936 · Cited by 8
Guo, Q., Huang, S.-D., Zou, T., & Yin, Z. (2023) · International Journal of Ophthalmology · doi:10.18240/ijo.2023.04.01 · Cited by 8
Cebulla, C. M., Kim, B., George, V., Heisler‐Taylor, T., Hamadmad, S., Reese, A. Y., Kothari, S. S., Kusibati, R., Wilson, H., & Abdel‐Rahman, M. H. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-25405 · Cited by 8
Harun‐Or‐Rashid, M., Diaz‐delCastillo, M., Galindo‐Romero, C., & Hallböök, F. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-16816 · Cited by 8
MAPK signaling during Müller glial cell development in retina explant cultures
Zhang, S. S.-M., Li, H., Huang, P., Lou, L. X., Fu, X.-Y., & Barnstable, C. J. (2010) · Journal of Ocular Biology, Diseases, and Informatics · doi:10.1007/s12177-011-9064-8 · Cited by 7
Retinal transcriptome of neonatal mice after optic nerve injury
Yao, S., Wang, M., Liang, J., Ng, T. K., & Cen, L. (2023) · PLoS ONE · doi:10.1371/journal.pone.0286344 · Cited by 7
Müller Glia, Vision-Guided Ocular Growth, Retinal Stem Cells, and a Little Serendipity
Fischer, A. J. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8330 · Cited by 7
Self-citationNomura-Komoike, K., Nishino, R., & Fujieda, H. (2024) · Scientific Reports · doi:10.1038/s41598-023-50485-7 · Cited by 6
Comprehensive analysis of transcription factors involved in odontoblast differentiation mechanism
Nakazato, H., Onodera, S., Aida, N., Furusawa, M., & Azuma, T. (2024) · Medical Molecular Morphology · doi:10.1007/s00795-024-00389-w · Cited by 6
ERK1/2 pathway is activated in degenerated Rpe65-deficient mice
Métrailler, S., Emery, M., Schorderet, D. F., Cottet, S., & Roduit, R. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.08.015 · Cited by 5
BAC-Dkk3-EGFPTransgenic Mouse: AnIn VivoAnalytical Tool forDkk3Expression
Muranishi, Y., & Furukawa, T. (2012) · BioMed Research International · doi:10.1155/2012/973140 · Cited by 5
Zhang, M., Deng, X., Jiang, Z., & Ge, Z. (2022) · Medicine · doi:10.1097/md.0000000000029569 · Cited by 4
Kelly, L. E., El‐Hodiri, H. M., Crider, A., & Fischer, A. J. (2024) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2024.103932 · Cited by 4
Self-citationSükösd, A. K. (2020) · International Journal of Ophthalmology · doi:10.18240/ijo.2020.06.11 · Cited by 3
Palazzo, I., Todd, L. J., Hoang, T. V., Reh, T. A., Blackshaw, S., & Fischer, A. J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.05.463152 · Cited by 3
Self-citationFormation of Müller glia-derived progenitor cells in retinas depleted of microgliaPreprint
El‐Hodiri, H. M., Bentley, J. R., Reske, A., Palazzo, I., Campbell, W. A., Halloy, N. R., & Fischer, A. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.08.544205 · Cited by 3
Self-citationAdvancements in Müller Glia Reprogramming: Pioneering Approaches for Retinal Neuron Regeneration
Zhou, Y., Qin, S., & Wu, J. (2025) · Neuroglia · doi:10.3390/neuroglia6020020 · Cited by 2
Hyperreflective Foci in the Ectopic Inner Foveal Layer of Advanced Idiopathic Epiretinal Membranes
Valsecchi, N., Mete, M., Rapezzi, G., Elifani, M., Folgaria, G., Finzi, A., Moramarco, A., & Fontana, L. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.9.14 · Cited by 2
İçöz, M., YORGUN, M. A., Taşçı, Y. Y., & TOKLU, Y. (2024) · Turkiye Klinikleri Journal of Ophthalmology · doi:10.5336/ophthal.2023-98823 · Cited by 2
Zheng, D., Wang, Y., Guan, Y., Xu, P., Xie, B., Gao, G., Yu, X., Peng, F., Xiang, M., & Zhong, X. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04700-z · Cited by 1
Metadata
- Authors
- Fischer, A. J., Scott, M. A., Ritchey, E. R., & Sherwood, P.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Fischer, Andy J.
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2009-03-20
- Volume
- 57
- Issue
- 14
- Pages
- 1538-1552
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- PMC
- PMC2775435
- OpenAlex
- W1998523437
- Cited by
- 111
- References
- 39
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 3 · 2021: 8 · 2020: 8 · 2019: 8 · 2018: 4 · 2017: 9 · 2016: 5 · 2015: 12 · 2014: 10 · 2013: 7 · 2012: 6
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Glia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Eye Institute (R01EY016043, EY016043)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Keywords
- Müller cells, retinal neurons, excitotoxicity, neuroprotection, MAPK signaling, insulin, fibroblast growth factor 2, FGF receptor 1, FGF receptor 3, ERK1/2, p38 MAPK, CREB, c-fos, EGR1, microglia-like cells, lysosomal membrane glycoprotein, glial cell proliferation, retinal damage
- MeSH terms
- Animals, Chickens, Fibroblast Growth Factors, Insulin, Intermediate Filament Proteins, Nerve Tissue Proteins, Neuroglia, Neurotoxins, Phosphorylation, Retina, Signal Transduction, Proto-Oncogene Proteins c-fos, Cell Death, Cyclic AMP Response Element-Binding Protein, Receptors, Fibroblast Growth Factor, MAP Kinase Signaling System, p38 Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase 3, Cell Proliferation, Early Growth Response Protein 1, Lysosomal Membrane Proteins, Retinal Neurons, Nestin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
