MAPK signaling during Müller glial cell development in retina explant cultures
Open accessAbstract
The Müller cell is the only glial cell type generated from the retinal neuroepithelium. This cell type controls normal retina homeostasis and has been suggested to play a neuroprotective role. Recent evidence suggests that mammalian Müller cells can de-differentiate and return to a progenitor or stem cell stage following injury or disease. In vivo exploration of the molecular mechanisms of Müller cell differentiation and proliferation will add essential information to manipulate Müller cell functions. Signal transduction pathways that regulate Müller cell responses and activity are a critical part of their cellular machinery. In this study, we focus on mitogen-activated protein kinase (MAPK) signaling pathway during Müller glial cell differentiation and proliferation. We found that both MAPK and STAT3 signaling pathways are present during Müller glial cell development. Ciliary neurotrophic factor (CNTF)-stimulated Müller glial cell proliferation is associated with early developmental stages. Specific inhibition of MAPK phosphorylation significantly reduced the number of Müller glial cells with or without CNTF stimulation. These results suggested that the MAPK signal transduction pathway is important in the formation of Müller glial cells during retina development.
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Activation of the MAPK signaling pathway promotes the entry of progenitors into a MG cell differentiation pathway during embryonic retinal development, but not after birth.
“Prior work strongly supports a model whereby activation of the MAPK signaling pathway promotes the entry of progenitors into a MG cell differentiation pathway during embryonic retinal development, but not after birth [ 28 ].”
From MAPK Pathways in Ocular Pathophysiology: Potential Therapeutic Drugs and Challenges (2023) · cites this paper as [28]
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MAPK Pathways in Ocular Pathophysiology: Potential Therapeutic Drugs and Challenges
Moustardas, P., Aberdam, D., & Lagali, N. (2023) · Cells · doi:10.3390/cells12040617 · Cited by 63 · see citing works
“Prior work strongly supports a model whereby activation of the MAPK signaling pathway promotes the entry of progenitors into a MG cell differentiation pathway during embryonic retinal development, but not after birth [28].”
Background
- Authors
- Zhang, S. S.-M., Li, H., Huang, P., Lou, L. X., Fu, X.-Y., & Barnstable, C. J.
- Affiliations
- Pennsylvania State University (US)
- Peking University (CN)
- National University of Singapore (SG)
- Corresponding author
- Zhang, Samuel Shao-Min
- Venue
- Journal of Ocular Biology, Diseases, and Informatics
- Published
- 2010-12
- Volume
- 3
- Issue
- 4
- Pages
- 129-133
- ISSN
- 1936-8437 (ISSN-L)
- 1936-8445
- PMC
- PMC3289159
- OpenAlex
- W2074682674
- Cited by
- 7
- References
- 42
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2021: 1 · 2014: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of ocular biology, diseases, and informatics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Pennsylvania
- Macula Vision Research Foundation
- Pennsylvania State University
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- Müller cells, MAPK signaling, retinal development, STAT3 signaling, ciliary neurotrophic factor, glial cell proliferation, glial differentiation, retinal neuroepithelium, signal transduction
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