Apathy as a feature of prodromal Alzheimer's disease: an FDG-PET ADNI study
Abstract
OBJECTIVE: The goal of this study is to evaluate brain metabolism in mild cognitive impairment (MCI) patients with and without apathy (as determined by the Neuropsychiatric Inventory Questionnaire). METHODS: Baseline data from 65 MCI participants (11 with apathy and 54 without) from the Alzheimer's Disease (AD) Neuroimaging Initiative study were analyzed. All participants underwent a comprehensive cognitive and neuropsychiatric assessment, volumetric MRI and measures of cerebral glucose metabolism applying (18)F-fluorodeoxyglucose positron emission tomography at baseline. The presence of apathy at baseline was determined by the Neuropsychiatric Inventory Questionnaire. RESULTS: There was no difference between apathy and apathy-free MCI patients regarding cognitive assessment and neuropsychiatric measures when apathy-specific items were removed. Cerebrovascular disease load and cerebral atrophy were equivalent in both groups. Compared with the apathy-free MCI patients, MCI patients with apathy had significantly decreased metabolism in the posterior cingulate cortex. CONCLUSION: The presence of apathy in MCI patients is associated with AD-specific pattern of brain metabolic defect. These results could suggest that apathy belongs to the spectrum of prodromal AD symptoms.
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Apathy in Alzheimer's disease is associated with decreased posterior cingulate cortex metabolism.
“Apathy is also associated with decreased PCC metabolism (Delrieu et al., 2015).”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Delrieu et al., 2015
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- Authors
- Delrieu, J., Desmidt, T., Camus, V., Sourdet, S., Boutoleau‐Bretonnière, C., Mullin, E., Vellas, B., Payoux, P., Lebouvier, T., & Initiative, A. D. N.
- Affiliations
- Centre Hospitalier Universitaire de Toulouse (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- CM2R CHU de Nice Nice France
- Inserm (FR)
- Corresponding author
- Delrieu, Julien
- ORCID
- Venue
- International Journal of Geriatric Psychiatry
- Publisher
- Wiley
- Published
- 2014-06-20
- Volume
- 30
- Issue
- 5
- Pages
- 470-477
- ISSN
- 0885-6230 (ISSN-L)
- 1099-1166
- OpenAlex
- W1563387106
- Cited by
- 66
- References
- 54
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 4 · 2016: 9 · 2015: 6 · 2014: 1
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Foundation for the National Institutes of Health
- National Institute of Biomedical Imaging and Bioengineering
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- apathy, prodromal Alzheimer's disease, mild cognitive impairment, brain glucose metabolism, posterior cingulate cortex, brain atrophy, cerebrovascular disease, neuropsychiatric symptoms, FDG-PET, Neuropsychiatric Inventory Questionnaire
- MeSH terms
- Aged, Alzheimer Disease, Atrophy, Brain, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Disease Progression, Fluorodeoxyglucose F18, Positron-Emission Tomography, Apathy, Neuroimaging, Cognitive Dysfunction
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