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Cited by 147Dementia and Cognitive Impairment ResearchNeural and Behavioral Psychology StudiesAlzheimer's disease research and treatments

Brain perfusion correlates of the apathy inventory dimensions of Alzheimer's disease

Benoit, M., Clairet, S., Koulibaly, P. M., Darcourt, J., Robert, P. H.·2004·International Journal of Geriatric Psychiatry
DOI 10.1002/gps.1163
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Abstract

BACKGROUND: Apathy is defined as a lack of motivation in behavior, cognition and affect. This syndrome is frequent in various neuropsychiatric diseases but little is known about its pathophysiology. OBJECTIVES: The aim of this study was to investigate the metabolic correlates of the behavioral, cognitive and emotional, aspects of apathy in Alzheimer's disease (AD). METHOD: Thirty AD patients were included. Lack of initiative, lack of interest and of emotional blunting were assessed with the Apathy Inventory (IA), a tool designed to provide a separate assessment of the behavioral, cognitive and emotional, aspects of apathy. Brain perfusion was measured by (99m)Tc-labeled bicisate (ECD) single photon emission tomography. RESULTS: The Statistical Parametric Mapping software provides negative correlation between IA total score and brain perfusion in left and right superior orbito-frontal gyrus, and to a lesser extent in left middle frontal gyrus (BA10). Lack of initiative score was negatively correlated with perfusion in right anterior cingulate cortex. Lack of interest score was negatively correlated with perfusion in right middle orbitofrontal gyrus). Emotional blunting score correlated negatively with in left superior dorsolateral prefrontal cortex activity. CONCLUSION: These results underline that the cognitive, behavioral and affective components of motivation are mediated by different fronto-sub-cortical circuits and are differently lateralized. In particular, left prefrontal hypoperfusion is involved in emotional blunting, as it was often demonstrated in depressive disorders. These distinct components of apathy may be targeted by different therapeutic means, in which dopaminergic enhancement might play a major role.

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  • Apathy in Alzheimer's disease is associated with decreased perfusion in anterior cingulate cortex.

    “Similarly apathy is associated with decreased perfusion in ACC (Benoit et al., 2004; Lanctôt et al., 2007; Robert et al., 2006), decreased ACC white matter integrity by DTI (Hahn et al., 2013; Kim et al., 2011; Ota et al., 2012) and increased amyloid burden in right ACC (Mori et al., 2014).”

    From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Benoit et al., 2004

  • Reduced initiative in Alzheimer's disease is associated with volume loss in anterior cingulate cortex.

    “Two studies have endeavored to map specific subdomains of apathy (i.e., reduced initiative, emotional blunting, or lack of initiative) to neuroimaging findings in specific brain regions (Benoit et al., 2004; Stanton et al., 2013), with the only notable finding being that reduced initiative was associated with volume loss in ACC.”

    From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Benoit et al., 2004

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Authors
Benoit, M., Clairet, S., Koulibaly, P. M., Darcourt, J., & Robert, P. H.
Affiliations
  • Centre Hospitalier Universitaire de Nice (FR)
  • Centre Antoine Lacassagne (FR)
ORCID
Venue
International Journal of Geriatric Psychiatry
Publisher
Wiley
Published
2004-07-28
Volume
19
Issue
9
Pages
864-869
ISSN
  • 0885-6230 (ISSN-L)
  • 1099-1166
DOI
10.1002/gps.1163
OpenAlex
W2014861792
Cited by
147
References
41
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 6 · 2019: 2 · 2018: 6 · 2017: 6 · 2016: 7 · 2015: 12 · 2014: 8 · 2013: 11 · 2012: 8
FWCI
4.70
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • International Journal of Geriatric Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
Centre Hospitalier Universitaire de Nice
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
apathy, Alzheimer's disease, cerebral perfusion, SPECT, emotional blunting, lack of initiative, lack of interest, orbitofrontal cortex, dorsolateral prefrontal cortex, anterior cingulate cortex, motivation, dopaminergic therapy
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cerebrovascular Circulation, Cognition Disorders, Cysteine, Humans, Middle Aged, Motivation, Organotechnetium Compounds, Tomography, Emission-Computed, Single-Photon, Mood Disorders

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