Effects of repetitive transcranial magnetic stimulation on improvement of cognition in elderly patients with cognitive impairment: A systematic review and meta-analysis
Abstract
OBJECTIVE: This systematic review and meta-analysis aimed to examine the effects of repetitive transcranial magnetic stimulation (rTMS) on cognitive function in older patients with cognitive impairment. METHODS: A literature search was performed for articles published in English using the 10 databases (MEDLINE, EMBASE, PsycINFO, INSPEC, the Cumulative Index to Nursing and Allied Health Literature Plus, AMED, Biological Sciences, ClinicalTrials.gov, the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews) from their inception to May 2016. The primary outcome was cognitive function as measured by the Mini-Mental State Examination or the Alzheimer's Disease Assessment Scale-cognitive subscale. RESULTS: Seven RCTs were included in the meta-analysis, with a sample of 107 active and 87 sham rTMS. Active rTMS was found to be more effective in improving cognition (Hedges' g = 0.48; 95% confidence interval 0.12 to 0.84). CONCLUSIONS: High-frequency rTMS showed a benefit on cognition amongst older patients with mild to moderate Alzheimer's disease. rTMS was shown to have great potential as a safe and well-tolerated alternative intervention for cognition. Copyright © 2017 John Wiley & Sons, Ltd.
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Evidence supports pro-cognitive effects of TMS in healthy individuals and in patients with neurologic and psychiatric illnesses such as mild to moderate Alzheimer's disease, mild cognitive impairment, stroke, schizophrenia, and bipolar disorder.
“Evidence supports the pro-cognitive effects of TMS in healthy individuals (Luber & Lisanby, 2014) and in patients with neurologic and psychiatric illnesses such as mild to moderate Alzheimer's disease (Cheng et al., 2018;Chou et al., 2020;Lin et al., 2019;Wang et al., 2020), mild cognitive impairment (MCI; Chou et al., 2020;Drumond Marra et al., 2015;Jiang et al., 2021), stroke (M.Liu et al., 2021”
From Neurocognitive effects of theta burst stimulation for treatment-resistant depression in adults: A systematic review and recommendations for future research (2025) · cites this paper as Cheng et al., 2018
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- Authors
- Cheng, C. P. W., Wong, C. S. M., Lee, K. K., Chan, A. P. K., Yeung, J. W. F., & Chan, W. C.
- Affiliations
- Queen Mary Hospital (CN)
- University of Hong Kong (HK)
- School of Nursing The Hong Kong Polytechnic University Hong Kong
- Venue
- International Journal of Geriatric Psychiatry
- Publisher
- Wiley
- Published
- 2017-05-11
- Volume
- 33
- Issue
- 1
- Pages
- e1-e13
- ISSN
- 0885-6230 (ISSN-L)
- 1099-1166
- OpenAlex
- W2612031406
- Cited by
- 63
- References
- 39
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 8 · 2023: 9 · 2022: 6 · 2021: 12 · 2020: 5 · 2019: 7 · 2018: 5
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- PolyU Institutional Research Archive (Hong Kong Polytechnic University) (submittedVersion)
- OSF Preprints (OSF Preprints) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Keywords
- repetitive transcranial magnetic stimulation, cognitive impairment, Alzheimer's disease, older adults, cognitive function, high-frequency rTMS, non-pharmacological treatment, sham stimulation, Mini-Mental State Examination, Alzheimer's Disease Assessment Scale
- MeSH terms
- Alzheimer Disease, Cognition, Humans, Transcranial Magnetic Stimulation, Cognitive Dysfunction
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