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Cited by 29Autism Spectrum Disorder ResearchAdvanced Neuroimaging Techniques and ApplicationsAttention Deficit Hyperactivity Disorder

Disorder‐specific alteration in white matter structural property in adults with autism spectrum disorder relative to adults with ADHD and adult controls

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Chiang, Huey‐Ling, Chen, Yu‐Jen, Lin, Hsiang‐Yuan, Tseng, Wen‐Yih Isaac, Gau, Susan Shur‐Fen·2017·Human Brain Mapping
DOI 10.1002/hbm.23367PMC PMC6866870
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Abstract

Objective: Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are not only often comorbid but also overlapped in behavioral and cognitive abnormalities. Little is known about whether these shared phenotypes are based on common or different underlying neuropathologies. Therefore, this study aims to examine the disorder‐specific alterations in white matter (WM) structural property. Method: The three comparison groups included 23 male adults with ASD (21.4 ± 3.1 years), 32 male adults with ADHD (23.4 ± 3.3 years), and 29 age‐matched healthy male controls (22.4 ± 3.3 years). After acquisition of the diffusion spectrum imaging (DSI), whole brain tractography was reconstructed by a tract‐based automatic analysis. Generalized fractional anisotropy (GFA) values were computed to indicate tract‐specific WM property with adjusted P value < 0.05 for false discovery rate correction. Results: Post hoc analyses revealed that men with ASD exhibited significant lower GFA values than men with ADHD and male controls in six identified fiber tracts: the right arcuate fasciculus, right cingulum (hippocampal part), anterior commissure, and three callosal fibers (ventrolateral prefrontal cortex part, precentral part, superior temporal part). There was no significant difference in the GFA values of any of the fiber tracts between men with ADHD and controls. In men with ASD, the GFA values of the right arcuate fasciculus and right cingulum (hippocampal part) were negatively associated with autistic social‐deficit symptoms, and the anterior commissure GFA value was positively correlated with intelligence. Conclusions: This study highlights the disorder‐specific alteration of the microstructural property of WM tracts in male adults with ASD. Hum Brain Mapp 38:384–395, 2017. © 2016 Wiley Periodicals, Inc.

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  • In ASD compared with ADHD, ASD participants had reduced FA in six tracts, including the right parahippocampal cingulum bundle.

    “when ASD was compared with ADHD (Chiang et al., 2017), the ASD participants had reduced FA in six tracts, including the right cingulum bundle (parahippocampal).”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Chiang et al., 2017

    The Results and Table 2 report lower values in six tracts for men with ASD than for men with ADHD, including the right cingulum (hippocampal part). The measured quantity was generalized fractional anisotropy (GFA), not FA, and the comparison was limited to men. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

  • In the right parahippocampal cingulum and right arcuate fasciculus, FA values related to autistic social-deficit symptoms.

    “In the right parahippocampal cingulum and right arcuate fasciculus these FA values related to autistic social-deficit symptoms.”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Chiang et al., 2017

    The Results (Correlations with Clinical Measures in ASD) link the right arcuate fasciculus and right hippocampal cingulum to social-deficit subscale scores in men with ASD. However, the measured values were generalized fractional anisotropy (GFA), not FA; the Discussion distinguishes those metrics. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Chiang, H., Chen, Y., Lin, H., Tseng, W. I., & Gau, S. S.
Affiliations
National Taiwan University (TW)
Corresponding author
Tseng, Wen‐Yih Isaac
ORCID
Venue
Human Brain Mapping
Publisher
Wiley
Published
2016-09-15
Volume
38
Issue
1
Pages
384-395
ISSN
  • 1065-9471 (ISSN-L)
  • 1097-0193
DOI
10.1002/hbm.23367
PMC
PMC6866870
OpenAlex
W2521897484
Cited by
29
References
8
Citations by year
2025: 2 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 3
FWCI
2.33
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Human Brain Mapping (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Council (NSC 101-2314-B-002-136-MY3, MOST103-2314-B-002-021-MY3)
  • National Health Research Institute (NHRI-EX101-10008PI, NHRI-EX102-10008PI, NHRI-EX103-10008PI, NHRI-EX104-10404PI)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Keywords
autism spectrum disorder, attention deficit hyperactivity disorder, white matter microstructure, generalized fractional anisotropy, arcuate fasciculus, cingulum, anterior commissure, corpus callosum, diffusion spectrum imaging, tractography, intelligence, adult male
MeSH terms
Autism Spectrum Disorder, Adolescent, Adult, Attention Deficit Disorder with Hyperactivity, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Nerve Fibers, Myelinated, Severity of Illness Index, Statistics as Topic, Translating, Case-Control Studies, Anisotropy, Young Adult, White Matter

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