Cingulum correlates of cognitive functions in patients with mild cognitive impairment and early Alzheimer's disease: a diffusion spectrum imaging study
Abstract
Diffusion spectrum imaging (DSI) of MRI can detect neural fiber tract changes. We investigated integrity of cingulum bundle (CB) in patients with mild cognitive impairment (MCI) and early Alzheimer's disease (EAD) using DSI tractography and explored its relationship with cognitive functions. We recruited 8 patients with MCI, 9 with EAD and 15 healthy controls (HC). All subjects received a battery of neuropsychological tests to access their executive, memory and language functions. We used a 3.0-tesla MRI scanner to obtain T1- and T2-weighted images for anatomy and used a pulsed gradient twice-refocused spin-echo diffusion echo-planar imaging sequence to acquire DSI. Patients with EAD performed significantly poorer than the HC on most tests in executive and memory functions. Significantly smaller general fractional anisotropy (GFA) values were found in the posterior and inferior segments of left CB and of the anterior segment of right CB of the EAD compared with those of the HC. Spearman's correlation on the patient groups showed that GFA values of the posterior segment of the left CB were significantly negatively associated with the time used to complete Color Trails Test Part II and positively correlated with performance of the logical memory and visual reproduction. GFA values of inferior segment of bilateral CB were positively associated with the performance of visual recognition. DSI tractography demonstrates significant preferential degeneration of the CB on the left sid…
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The differences among cingulum subdivisions suggest qualitative changes along the length of the tract and add support to similar tract subdivisions used in other dMRI studies.
“These differences, which suggest qualitative changes along the length of the tract, add support to similar tract subdivisions used in other dMRI studies (e.g., Concha et al., 2005; Kates et al., 2015; Lin et al., 2014; Metzler-Baddeley et al., 2017).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Lin et al., 2014
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- Authors
- Lin, Y.-C., Shih, Y.-C., Tseng, W.-Y. I., Chu, Y.-H., Wu, M.-T., Chen, T.-F., Tang, P.-F., & Chiu, M.-J.
- Affiliations
- National Taiwan University (TW)
- Corresponding author
- Tang, Pei-Fang
- Chiu, Ming-Jang
- Venue
- Brain Topography
- Published
- 2014-01-11
- Volume
- 27
- Issue
- 3
- Pages
- 393-402
- ISSN
- 0896-0267 (ISSN-L)
- 1573-6792
- OpenAlex
- W1967180832
- Cited by
- 56
- References
- 45
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 8 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 3 · 2014: 1
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Brain Topography (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- cingulum, mild cognitive impairment, early Alzheimer's disease, fractional anisotropy, white matter integrity, executive function, memory, Color Trails Test, visual recognition memory, tractography, left hemisphere asymmetry
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cognition, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Male, Memory, Middle Aged, Neuropsychological Tests, Pattern Recognition, Visual, Linear Models, Anisotropy, Diffusion Magnetic Resonance Imaging, Executive Function, Cognitive Dysfunction
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