Abnormal cingulum bundle development in autism: a probabilistic tractography study
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There is now considerable evidence that white matter abnormalities play a role in the neurobiology of autism. Little research has been directed, however, at understanding (a) typical white matter development in autism and how this relates to neurocognitive impairments observed in the disorder. In this study we used probabilistic tractography to identify the cingulum bundle in 21 adolescents and young adults with Autism Spectrum Disorder (ASD), and 21 age- and sex-matched healthy volunteers. We investigated group differences in the relationships between age and fractional anisotropy, a putative measure of white matter integrity, within the cingulum bundle. Moreover, in a preliminary investigation, we examined the relationship between cingulum fractional anisotropy and executive functioning using the Behavior Rating Inventory of Executive Function (BRIEF). The ASD participants demonstrated significantly lower fractional anisotropy within the cingulum bundle compared to the typically developing volunteers. There was a significant group-by-age interaction such that the ASD group did not show the typical age-associated increases in fractional anisotropy observed among healthy individuals. Moreover, lower fractional anisotropy within the cingulum bundle was associated with worse BRIEF behavioral regulation index scores in the ASD group. The current findings implicate a dysregulation in cingulum bundle white matter development occurring in late adolescence and early adulthood in ASD, and suggest that greater disturbances in this trajectory are associated with executive dysfunction in ASD.
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In ASD, cingulum FA correlations were found for behavioural regulation scores.
“Such correlations were found for behavioural regulation scores (Ikuta et al., 2014)”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Ikuta et al., 2014
In ASD studies focusing on just the cingulum, reduced FA is found.
“In those ASD studies focussing on just the cingulum, reduced FA is again found (Ameis et al., 2013; Ikuta et al., 2014)”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Ikuta et al., 2014
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- Authors
- Ikuta, T., Shafritz, K. M., Bregman, J., Peters, B. D., Gruner, P., Malhotra, A. K., & Szeszko, P. R.
- Affiliations
- Northwell Health (US)
- Feinstein Institute for Medical Research (US)
- Yale University (US)
- Corresponding author
- Ikuta, Toshikazu
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 221
- Issue
- 1
- Pages
- 63-68
- ISSN
- 0925-4927 (ISSN-L)
- PMC
- PMC3918471
- OpenAlex
- W2005387911
- Cited by
- 69
- References
- 48
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 8 · 2019: 6 · 2018: 6 · 2017: 9 · 2016: 6 · 2015: 5 · 2014: 7
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (T32MH062994)
- National Center for Research Resources (M01RR018535)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, cingulum, white matter development, fractional anisotropy, white matter integrity, executive dysfunction, behavioral regulation, age-related changes, adolescents and young adults
- MeSH terms
- Adolescent, Adult, Brain, Brain Mapping, Child, Child Development Disorders, Pervasive, Female, Humans, Male, Nerve Fibers, Myelinated, Neuropsychological Tests, Psychiatric Status Rating Scales, Socioeconomic Factors, Case-Control Studies, Anisotropy, Young Adult, Diffusion Tensor Imaging, Executive Function
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