Comparison of EQ-5D and SF-6D utilities in mental health patients
Open accessAbstract
Various preference-based measures of health are available for use as an outcome measure in cost-utility analysis. The aim of this study is to compare two such measures EQ-5D and SF-6D in mental health patients. Baseline data from a Dutch multi-centre randomised trial of 616 patients with mood and/or anxiety disorders were used. Mean and median EQ-5D and SF-6D utilities were compared, both in the total sample and between severity subgroups based on quartiles of SCL-90 scores. Utilities were expected to decline with increased severity. Both EQ-5D and SF-6D utilities differed significantly between patients of adjacent severity groups. Mean utilities increased from 0.51 at baseline to 0.68 at 1.5 years follow-up for EQ-5D and from 0.58 to 0.70 for SF-6D. For all severity subgroups, the mean change in EQ-5D utilities as well as in SF-6D utilities was statistically significant. Standardised response means were higher for SF-6D utilities. We concluded that both EQ-5D and SF-6D discriminated between severity subgroups and captured improvements in health over time. However, the use of EQ-5D resulted in larger health gains and consequent lower cost-utility ratios, especially for the subgroup with the highest severity of mental health problems.
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Preference-based utilities derived from the EQ-5D-5L are suitable for calculating quality-adjusted life-years in the field of depression.
“This approach is evaluated suitable for this purpose in the field of depression (Lamers et al., 2006; Sapin et al., 2004).”
From The efficacy of automated feedback after internet-based depression screening: Study protocol of the German, three-armed, randomised controlled trial DISCOVER (2021) · cites this paper as Lamers et al., 2006
The Introduction describes an EQ-5D with three levels per dimension, not the EQ-5D-5L. The Discussion concludes that EQ-5D can capture improvement in patients with mood and/or anxiety disorders and is usable in cost-utility analysis, but cautions that instrument choice can affect the results. This supports the general approach, not the claim specifically about EQ-5D-5L utilities in depression. (LLM, conf=0.90)
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“This approach is evaluated suitable for this purpose in the field of depression (Lamers et al., 2006; Sapin et al., 2004).”
Background
- Authors
- Lamers, L. M., Bouwmans, C. A. M., van Straten, A., Donker, M. C. H., & Hakkaart, L.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Lamers, L. M.
- Venue
- Health Economics
- Publisher
- Wiley
- Published
- 2006
- Volume
- 15
- Issue
- 11
- Pages
- 1229-1236
- ISSN
- 1057-9230 (ISSN-L)
- 1099-1050
- OpenAlex
- W2105997341
- Cited by
- 145
- References
- 23
- Citations by year
- 2025: 2 · 2024: 6 · 2023: 1 · 2022: 5 · 2021: 15 · 2020: 4 · 2019: 12 · 2018: 4 · 2017: 10 · 2016: 7 · 2015: 6 · 2014: 9 · 2013: 10 · 2012: 8
- FWCI
- 19.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Health Economics (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- VU Research Portal (submittedVersion, other-oa)
- Funders
- ZonMw
- Topics
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Economic and Environmental Valuation
- Social Sciences › Sociology and Political Science › Delphi Technique in Research
- Keywords
- EQ-5D, SF-6D, health-related quality of life, preference-based health measures, mental health, mood disorders, anxiety disorders, disease severity, SCL-90, cost-utility analysis, standardized response mean
- MeSH terms
- Mental Disorders, Cost-Benefit Analysis, Humans, Netherlands, Surveys and Questionnaires, Multicenter Studies as Topic, Randomized Controlled Trials as Topic, Outcome Assessment, Health Care
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