The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Identification of metastasis-related microRNAs in hepatocellular carcinoma
Open accessAbstract
MicroRNAs (miRNAs) have been used as cancer-related biomarkers. Hepatocellular carcinoma (HCC) is an aggressive cancer with a dismal outcome largely due to metastasis and postsurgical recurrence. We investigated whether the expression of certain miRNAs are associated with HCC metastasis. We examined the miRNA expression profiles of 482 cancerous and noncancerous specimens from radical resection of 241 patients with HCC. Using a supervised algorithm and a clinically well-defined cohort of 131 cases, we built a unique 20-miRNA metastasis signature that could significantly predict ( P < 0.001) primary HCC tissues with venous metastases from metastasis-free solitary tumors with 10-fold cross-validation. However, significant miRNAs could not be identified from the corresponding noncancerous hepatic tissues. A survival risk prediction analysis revealed that a majority of the metastasis-related miRNAs were associated with survival. Furthermore, the 20-miRNA tumor signature was validated in 110 additional cases as a significant independent predictor of survival ( P = 0.009) and was significantly associated with both survival and relapse in 89 cases of early stage HCC ( P = 0.022 and 0.002, respectively). These 20 miRNAs may provide a simple profiling method to assist in identifying patients with HCC who are likely to develop metastases/recurrence. In addition, functional analysis of these miRNAs may enhance our biological understanding of HCC metastasis.
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MicroRNA expression profiles classify human cancers
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Self-citationCalin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., Aldler, H., Rattan, S., Keating, M., Rai, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242606799 · Cited by 5,111
Self-citationIdentification of Novel Genes Coding for Small Expressed RNAs
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MicroRNA Gene Expression Deregulation in Human Breast Cancer
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Self-citationDissemination and growth of cancer cells in metastatic sites
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Cited by
Genetic landscape and biomarkers of hepatocellular carcinoma
Zucman-Rossi, J., Villanueva, A., Nault, J.-C., & Llovet, J. M. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.05.061 · Cited by 1,325
A microRNA DNA methylation signature for human cancer metastasis
Lujambio, A., Calin, G. A., Villanueva, A., Ropero, S., Sánchez-Céspedes, M., Blanco, D., Montuenga, L. M., Rossi, S., Nicoloso, M. S., Faller, W. J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803055105 · Cited by 1,078
Self-citationMichelotti, G. A., Machado, M. V., & Diehl, A. M. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.183 · Cited by 974
Ma, J., Yang, F., Zhou, C., Liu, F., Yuan, J., Wang, F., Wang, T., Xu, Q., Zhou, W., & Sun, S. (2017) · Hepatology · doi:10.1002/hep.28885 · Cited by 912
MicroRNA Expression, Survival, and Response to Interferon in Liver Cancer
Ji, J., Shi, J., Budhu, A., Yu, Z., Forgues, M., Roessler, S., Ambs, S., Chen, Y., Meltzer, P. S., Croce, C. M., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0901282 · Cited by 802
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Metadata
- Authors
- Budhu, A., Jia, H.-L., Forgues, M., Liu, C.-G., Goldstein, D., Lam, A., Zanetti, K. A., Ye, Q.-H., Qin, L.-X., Croce, C. M., Tang, Z.-Y., & Wang, X. W.
- Venue
- Hepatology
- Published
- 2008-03
- Volume
- 47
- Issue
- 3
- Pages
- 897-907
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2056353125
- Cited by
- 697
- References
- 48
- FWCI
- 18.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Budhu, A., Jia, H.-L., Forgues, M., Liu, C.-G., Goldstein, D., Lam, A., Zanetti, K. A., Ye, Q.-H., Qin, L.-X., Croce, C. M., Tang, Z.-Y., & Wang, X. W. (2008). Identification of metastasis-related microRNAs in hepatocellular carcinoma. Hepatology. https://doi.org/10.1002/hep.22160
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