Hepatic Stellate Cells and Liver Fibrosis

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

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Liver fibrosis

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Autophagy regulates lipid metabolism

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

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Genomic responses in mouse models poorly mimic human inflammatory diseases

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Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

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Mechanisms of Hepatic Fibrogenesis

Friedman, S. L. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.003 · Cited by 2,640 · see citing works

Molecular Regulation of Hepatic Fibrosis, an Integrated Cellular Response to Tissue Injury

Friedman, S. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2247 · Cited by 2,090 · see citing works

Senescence of activated stellate cells limits liver fibrosis

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Senescence of Activated Stellate Cells Limits Liver Fibrosis

Krizhanovsky, V., Yon, M., Dickins, R. A., Hearn, S., Simon, J., Miething, C., Yee, H., Zender, L., & Lowe, S. W. (2008) · Cell · doi:10.1016/j.cell.2008.09.015 · Cited by 2,027

TLR4 enhances TGF-β signaling and hepatic fibrosis

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Pathogenesis of Liver Fibrosis

Hernandez-Gea, V., & Friedman, S. L. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130246 · Cited by 1,809 · see citing works

The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

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Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

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Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors

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Latent TGF-β structure and activation

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Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

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Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ

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Hepatic lipocytes: the principal collagen-producing cells of normal rat liver.

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Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

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Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis

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Non-Cell-Autonomous Tumor Suppression by p53

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History, Heterogeneity, Developmental Biology, and Functions of Quiescent Hepatic Stellate Cells

Geerts, A. (2001) · Seminars in Liver Disease · doi:10.1055/s-2001-17550 · Cited by 740 · see citing works

Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice

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Therapy for Fibrotic Diseases: Nearing the Starting Line

Friedman, S. L., Sheppard, D., Duffield, J. S., & Violette, S. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3004700 · Cited by 655 · see citing works

Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues

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Toll-Like Receptor 4 Mediates Inflammatory Signaling by Bacterial Lipopolysaccharide in Human Hepatic Stellate Cells

Paik, Y.-H., Schwabe, R. F., Bataller, R., Russo, M. P., Jobin, C., & Brenner, D. A. (2003) · Hepatology · doi:10.1053/jhep.2003.50182 · Cited by 651 · see citing works

Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration

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Natural Killer Cells Ameliorate Liver Fibrosis by Killing Activated Stellate Cells in NKG2D-Dependent and Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Dependent Manners

Radaeva, S., Sun, R., Jaruga, B., Nguyen, V. T., Tian, Z., & Gao, B. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.10.055 · Cited by 610 · see citing works

Local control of the immune response in the liver

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Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis

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Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver.

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Perisinusoidal Stellate Cells (Fat-Storing Cells, Interstitial Cells, Lipocytes), Their Related Structure in and around the Liver Sinusoids, and Vitamin A-Storing Cells in Extrahepatic Organs

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Collagen Types in Normal and Cirrhotic Liver

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Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

Troeger, J. S., Mederacke, I., Gwak, G., Dapito, D. H., Mu, X., Hsu, C. C., Pradere, J., Friedman, R. A., & Schwabe, R. F. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.036 · Cited by 515 · see citing works

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

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The morphology of cirrhosis. Recommendations on definition, nomenclature, and classification by a working group sponsored by the World Health Organization.

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Kupffer Cell Engulfment of Apoptotic Bodies Stimulates Death Ligand and Cytokine Expression

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Spontaneous recovery from micronodular cirrhosis: Evidence for incomplete resolution associated with matrix cross-linking☆

Issa, R., Zhou, X., Constandinou, C. M., Fallowfield, J. A., Millward‐Sadler, H., Gaça, M. D. A., Sands, E., Suliman, I., Trim, N., & Knorr, A. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.009 · Cited by 455 · see citing works

Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis.

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Inhibition of Apoptosis of Activated Hepatic Stellate Cells by Tissue Inhibitor of Metalloproteinase-1 Is Mediated via Effects on Matrix Metalloproteinase Inhibition

Murphy, F. R., Issa, R., Zhou, X., Ratnarajah, S., Arthur, M. J. P., Benyon, C., Iredale, J. P., & Nagase, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111490200 · Cited by 432 · see citing works

CCR1 and CCR5 promote hepatic fibrosis in mice

Seki, E., De Minicis, S., Gwak, G.-Y., Kluwe, J., Inokuchi, S., Bursill, C. A., Llovet, J. M., Brenner, D. A., & Schwabe, R. F. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37444 · Cited by 431 · see citing works

Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct

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Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo.

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Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity

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Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation.

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The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis

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Apoptotic Body Engulfment by a Human Stellate Cell Line Is Profibrogenic

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CCR2 promotes hepatic fibrosis in mice #

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StellaTUM: current consensus and discussion on pancreatic stellate cell research

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Role of Differentiation of Liver Sinusoidal Endothelial Cells in Progression and Regression of Hepatic Fibrosis in Rats

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Roles of TGF-beta in hepatic fibrosis

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Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells

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MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis

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“Sternzellen” in the liver: Perisinusoidal cells with special reference to storage of vitamin A

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Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases

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Reversal of Hepatic Fibrosis — Fact or Fantasy?

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Structure of the Extracellular Matrix in Normal and Fibrotic Liver: Collagens and Glycoproteins

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Maintenance of Differentiated Phenotype of Cultured Rat Hepatic Lipocytes by Basement Membrane Matrix

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Mechanisms of liver fibrosis

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Hepatic fibrosis—Overview

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Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture.

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Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice

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Hepatic Stellate Cell Behavior during Resolution of Liver Injury

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Purified Rat Liver Fat-Storing Cells in Culture Divide and Contain Collagen

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Pancreatic stellate cells: a starring role in normal and diseased pancreas

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Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors

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Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: regulation by TNF-α and TGF-β1

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Septum Transversum-Derived Mesothelium Gives Rise to Hepatic Stellate Cells and Perivascular Mesenchymal Cells in Developing Mouse Liver §Δ

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Vascular endothelial growth factor and receptor interaction is a prerequisite for murine hepatic fibrogenesis

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Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture.

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Fas enhances fibrogenesis in the bile duct ligated mouse: A link between apoptosis and fibrosis

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Signal Transduction by the Chemokine Receptor CXCR3

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Over‐expressed microRNA‐27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation

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Hepatic stellate cells: role in microcirculation and pathophysiology of portal hypertension

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Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat.

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Hepatic Stellate Cells Secrete Angiopoietin 1 That Induces Angiogenesis in Liver Fibrosis

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Vitamin D inhibits proliferation and profibrotic marker expression in hepatic stellate cells and decreases thioacetamide-induced liver fibrosis in rats

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Liver fibrosis: Insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors

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miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: An essential role for apoptosis

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Increased Caffeine Consumption Is Associated With Reduced Hepatic Fibrosis

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Attenuated liver fibrosis in the absence of B cells

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Expression of the gene of the α-smooth muscle-actin isoform in rat liver and in rat fat-storing (ITO) cells

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Portal fibroblasts: Underappreciated mediators of biliary fibrosis†

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Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases

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Inhibition of inhibitor of κB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis

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Perisinusoidal fat-storing cells are the main vitamin A storage sites in rat liver

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Hepatic Nonparenchymal Cells and Liver-Associated Lymphoid Cells

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Amphiphilic lipid-peptide engineered placenta-derived mesenchymal stem cells for liver fibrosis treatment

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Multimaterial printing for medical design

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Nanomedicines to alleviate hepatic metabolic disorders

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A hepatocyte membrane-based culture system recapitulating the physiological microenvironment of hepatic stellate cells

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Autophagy-mediated Kupffer cell polarization in liver cirrhosis reversal: Mechanistic insights and therapeutic strategies

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Rôle des cellules endothéliales dans le carcinome hépatocellulaire associé au syndrome métabolique

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Rôle de LECT2 dans les maladies stéatosiques non alcooliques du foie

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Rôle du récepteur nucléaire CAR dans la pathogénèse dimorphique de la NAFLD (Non-Alcoholic Fatty Liver Disease), induite par un régime gras ou par l'exposition à des contaminants alimentaires

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Impact de la stéatohépatite non alcoolique sur le remodelage myocardique et sur les complications cardiovasculaires

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The Role of Neutrophil, Monocyte and Macrophage Calprotectin and S100A12 in the Fibrotic Process

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Cell phenotypic remodeling based on HGF mRNA-LNPs for liver fibrosis alleviation

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Ethnic-specific ZJU index thresholds for hepatic steatosis and fibrosis in Chinese MASLD

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Indole-3-lactic acid attenuates hepatic stellate cell pyroptosis and liver fibrosis associated with NLRP3 signaling

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Targeted attenuation of liver fibrosis using microbubble-enhanced protease-activated receptor 1 chimeric antigen receptor T cells

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Microtubule‐Targeting Drugs Induce Mesenchymal–Epithelial Transition in Hepatic Stellate Cells

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Single-cell insights into hepatic fibroblasts and stellate cells: heterogeneity in matrix remodelling in development, health, and disease

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Modified Citrus Pectin-Mediated Gal-3 Reduction Attenuates Metabolic Dysfunction-Associated Steatohepatitis in an Experimental Model

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FBXW7 mitigates hepatic fibrosis by degrading NOTCH1 to transcriptionally silence SEMA3G in liver sinusoidal endothelial cells

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Cell Senescence and the Aging Liver

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PE11 Protein of Mycobacterium tuberculosis is Associated with Increased Inflammation and Fibrosis in the Liver

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