Molecular Therapy for Obesity and Diabetes Based on a Long-Term Increase in Hepatic Fatty-Acid Oxidation §Δ

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Obesity, Inflammation, and Insulin Resistance

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Insulin and insulin resistance:

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Ceramides in insulin resistance and lipotoxicity

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The Hyperglycemia-induced Inflammatory Response in Adipocytes

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Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

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Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2

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Hepatic Glucokinase Is Required for the Synergistic Action of ChREBP and SREBP-1c on Glycolytic and Lipogenic Gene Expression

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Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

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A potential link between muscle peroxisome proliferator- activated receptor-α signaling and obesity-related diabetes

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Cloning, sequencing, and expression of a cDNA encoding rat liver carnitine palmitoyltransferase I. Direct evidence that a single polypeptide is involved in inhibitor interaction and catalytic function.

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A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels

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Mitochondrial injury in steatohepatitis

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T-ing up inflammation in fat

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Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity

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Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1α: implications for metabolic disease

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Flux control exerted by mitochondrial outer membrane carnitine palmitoyltransferase over β-oxidation, ketogenesis and tricarboxylic acid cycle activity in hepatocytes isolated from rats in different metabolic states

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CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance

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14CO2 production is no adequate measure of [14C]fatty acid oxidation

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Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretion

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Alteration of the Malonyl-CoA/Carnitine Palmitoyltransferase I Interaction in the β-Cell Impairs Glucose-Induced Insulin Secretion

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Identification of Conserved Amino Acid Residues in Rat Liver Carnitine Palmitoyltransferase I Critical for Malonyl-CoA Inhibition

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Modulation of the hepatic malonyl-CoA–carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation of de novo fatty acids

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Identification of the two histidine residues responsible for the inhibition by malonyl‐CoA in peroxisomal carnitine octanoyltransferase from rat liver

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The interaction of hepatic lipid and glucose metabolism in liver diseases

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Molecular pathways in non-alcoholic fatty liver disease

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A metabolic prosurvival role for PML in breast cancer

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Mitochondrial fatty acid oxidation in obesity

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Alterations of the gut microbiota in high-fat diet mice is strongly linked to oxidative stress

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Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation

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Mitochondrial Oxidative Stress and Antioxidants Balance in Fatty Liver Disease

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Assessment of the Anti-Hyperglycaemic, Anti-Inflammatory and Antioxidant Activities of the Methanol Extract of Moringa Oleifera in Diabetes-Induced Nephrotoxic Male Wistar Rats

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PGC-1α overexpression results in increased hepatic fatty acid oxidation with reduced triacylglycerol accumulation and secretion

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Diosgenin ameliorates palmitic acid-induced lipid accumulation via AMPK/ACC/CPT-1A and SREBP-1c/FAS signaling pathways in LO2 cells

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Maresin 1 mitigates liver steatosis in ob/ob and diet-induced obese mice

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Macrophage fatty acid oxidation and its roles in macrophage polarization and fatty acid-induced inflammation

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Hepatic Fatty Acid Trafficking: Multiple Forks in the Road

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Transkingdom interactions between Lactobacilli and hepatic mitochondria attenuate western diet-induced diabetes

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Nonalcoholic fatty liver disease: A main driver of insulin resistance or a dangerous liaison?

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PXR Ablation Alleviates Diet-Induced and Genetic Obesity and Insulin Resistance in Mice

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Naringenin prevents cholesterol-induced systemic inflammation, metabolic dysregulation, and atherosclerosis in Ldlr mice

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Stress-activated miR-21/miR-21* in hepatocytes promotes lipid and glucose metabolic disorders associated with high-fat diet consumption

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Fatty acid metabolism and the basis of brown adipose tissue function

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Ceramides and mitochondrial fatty acid oxidation in obesity

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Association between DNA Methylation in Whole Blood and Measures of Glucose Metabolism: KORA F4 Study

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Mitochondrial dysfunction in non-alcoholic fatty liver disease and insulin resistance: Cause or consequence?

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Origins of metabolic complications in obesity

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Sustained activation of PPARα by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob mice

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Recent insights into the molecular pathophysiology of lipid droplet formation in hepatocytes

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Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels

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Liver CPT1A gene therapy reduces diet‐induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD

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circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling

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Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis

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Purple sweet potato color attenuates hepatic insulin resistance via blocking oxidative stress and endoplasmic reticulum stress in high-fat-diet-treated mice

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Prevention of Diet-Induced Metabolic Dysregulation, Inflammation, and Atherosclerosis in Ldlr −/− Mice by Treatment With the ATP-Citrate Lyase Inhibitor Bempedoic Acid

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Enhancing liver mitochondrial fatty acid oxidation capacity in obese mice improves insulin sensitivity independently of hepatic steatosis

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The Interconnection between Hepatic Insulin Resistance and Metabolic Dysfunction-Associated Steatotic Liver Disease—The Transition from an Adipocentric to Liver-Centric Approach

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Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose Intolerance

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A reduced‐energy intake, well‐balanced diet improves weight control in children with Prader‐Willi syndrome

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Diabetes mellitus: new challenges and innovative therapies

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Inhibition of macrophage fatty acid β-oxidation exacerbates palmitate-induced inflammatory and endoplasmic reticulum stress responses

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Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting

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Carnitine Palmitoyltransferase 1 Increases Lipolysis, UCP1 Protein Expression and Mitochondrial Activity in Brown Adipocytes

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Stearoyl-CoA Desaturase: A Vital Checkpoint in the Development and Progression of Obesity

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Nutrition Supplements to Stimulate Lipolysis: A Review in Relation to Endurance Exercise Capacity

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Essential role of Nrf2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes

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