The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Intestinal bacterial translocation in rats with cirrhosis is related to compromised paneth cell antimicrobial host defense
Open accessAbstract
Liver cirrhosis is associated with bacterial translocation (BT) and endotoxemia. Most translocating bacteria belong to the common intestinal microbiota, suggesting a breakdown of intestinal barrier function. We hypothesized that diminished mucosal antimicrobial host defense could predispose to BT. Two rodent models of portal hypertension with increased BT were used, CCl 4-induced ascitic cirrhosis and 2-day portal vein–ligated (PVL) animals. BT was assessed by standard microbiological techniques on mesenteric lymph nodes. Total RNA was isolated systematically throughout the intestinal tract, and expression of Paneth cell α-cryptdins and β-defensins was determined by real-time quantitative polymerase chain reaction (qPCR). To determine functional consequences, mucosal antimicrobial activity was assessed with a fluorescence-activated cell sorting assay. BT was detectable in 40% of rats with cirrhosis. Compared with the group without BT, these animals exhibited diminished intestinal Paneth cell α-cryptdin 5 and 7 expression. In contrast, PVL was associated with BT in all animals but did not affect antimicrobial peptides. The decrease in Paneth cell antimicrobials was most pronounced in the ileum and the coecum. Other antimicrobials showed no changes or even an induction in the case of BT at different sites. Antimicrobial activity toward different commensal strains was reduced, especially in the distal ileum and the cecum in experimental cirrhosis with BT (excluding PVL). Conclusion: Compromised Paneth cell antimicrobial host defense seems to predispose to BT in experimental cirrhosis. Understanding this liver–gut axis including the underlying mechanisms could help us to find new treatment avenues. (Hepatology 2012)
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Cites
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
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Symbiotic bacteria direct expression of an intestinal bactericidal lectin
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Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
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Enteric dysbiosis associated with a mouse model of alcoholic liver disease
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Small intestinal bacterial overgrowth in human cirrhosis is associated with systemic endotoxemia
Bauer, T. M., Schwacha, H., Steinbruckner, B., Brinkmann, F. E., Ditzen, A. K., Aponte, J. J., Pelz, K., Berger, D., Kist, M., & Blum, H. E. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05791.x · Cited by 211
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Effect of cisapride on intestinal bacterial overgrowth and bacterial translocation in cirrhosis
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Cirrhosis-associated immune dysfunction: Distinctive features and clinical relevance
Albillos, A., Lario, M., & Álvarez-Mon, M. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.08.010 · Cited by 1,242
Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives
Roehlen, N., Crouchet, E., & Baumert, T. F. (2020) · Cells · doi:10.3390/cells9040875 · Cited by 1,237
Altered profile of human gut microbiome is associated with cirrhosis and its complications
Bajaj, J. S., Heuman, D. M., Hylemon, P. B., Sanyal, A. J., White, M. B., Monteith, P., Noble, N. A., Unser, A. B., Daita, K., Fisher, A. R., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.12.019 · Cited by 1,099
Interactions Between the Intestinal Microbiome and Liver Diseases
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Metadata
- Authors
- Teltschik, Z., Wiest, R., Beisner, J., Nuding, S., Hofmann, C., Schoelmerich, J., Bevins, C. L., Stange, E. F., & Wehkamp, J.
- Venue
- Hepatology
- Published
- 2012-04
- Volume
- 55
- Issue
- 4
- Pages
- 1154-1163
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2004604298
- Cited by
- 194
- References
- 9
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Teltschik, Z., Wiest, R., Beisner, J., Nuding, S., Hofmann, C., Schoelmerich, J., Bevins, C. L., Stange, E. F., & Wehkamp, J. (2012). Intestinal bacterial translocation in rats with cirrhosis is related to compromised paneth cell antimicrobial host defense. Hepatology. https://doi.org/10.1002/hep.24789
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