Effect of cisapride on intestinal bacterial overgrowth and bacterial translocation in cirrhosis
Open accessAbstract
Deranged intestinal motility, which occurs in cirrhosis, may facilitate the development of intestinal bacterial overgrowth (IBO), which can lead to bacterial translocation (BT). To assess the effect of cisapride on IBO and BT in cirrhosis, cirrhotic rats received cisapride or a placebo for 7 days, and measurements of jejunal bacterial content and BT studies were performed. In addition, jejunal fluid from 46 cirrhotic patients was obtained for quantitative bacterial culture. Those patients in whom gram-negative IBO was detected were randomized to receive or not to receive cisapride (20 mg twice per day) for 1 week. Cisapride significantly reduced IBO in cirrhotic rats. In addition, no BT was documented in treated animals, whereas it occurred in 40% in nontreated cirrhotic rats. Total IBO was documented in 23 of 46 cirrhotic patients, which was caused by gram-negative organisms in 10 cases. Orocecal transit time (OCT) significantly decreased after cisapride therapy, and was associated with the abolishment of bacterial overgrowth caused by gram-negative organisms in 4 out of 5 treated patients, whereas it persisted in nontreated cases. Cisapride administration to cirrhotic rats resulted in a reduction of the IBO, which is associated with a marked decrease in BT. On the other hand, cisapride facilitates the abolition of IBO caused by gram-negative organisms in cirrhotic patients.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Cisapride decreases intestinal transit time and inhibits intestinal bacterial overgrowth and bacterial translocation in animal models and cirrhosis patients.
“The prokinetic drug cisapride not only decreases intestinal transit time but also inhibits intestinal bacterial overgrowth and bacterial translocation, both in animal models150,151 and in patients with cirrhosis150,152.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [150]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Chen, L., Li, N., & Ye, H. (2012) · Hepatogastroenterology · doi:10.5754/hge12469 · Cited by 3,199 · see citing works
Vantrappen, G., Janssens, J., Hellemans, J., & Ghoos, Y. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108740 · Cited by 815 · see citing works
Ginés, P., Rimola, A., Planas, R., Vargas, V., Marco, F., Almela, M., Forne, M., Miranda, M. L., Llach, J., Salmerón, J. M., et al. (1990) · Hepatology · doi:10.1002/hep.1840120416 · Cited by 627 · see citing works
Self-citationA prospective study of bacterial infections in patients with cirrhosis
Caly, W. R., & Strauss, E. (1993) · Journal of Hepatology · doi:10.1016/s0168-8278(05)80280-6 · Cited by 504 · see citing works
Llovet, J. M., Bruix, J., Fuster, J., Castells, A., García‐Valdecasas, J. C., Grande, L., França, A. V. C., Brú, C., Navasa, M., Ayuso, M. D. C., et al. (1998) · Hepatology · doi:10.1002/hep.510270616 · Cited by 381 · see citing works
Norfloxacin prevents bacterial infection in cirrhotics with gastrointestinal hemorrhage
Soriano, G., Guarner, C., Tomás, A., Villanueva, C., Torras, X., González, D., Sáinz, S., Anguera, A., Cussó, X., Balanzó, J., et al. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)91514-5 · Cited by 314 · see citing works
Jejunal microflora in patients with chronic alcohol abuse.
Jc, B., Bode, C., Heidelbach, R., Hk, D., & Ga, M. (1984) · PubMed · Cited by 303 · see citing works
Obstructive jaundice promotes bacterial translocation from the gut
Deitch, E. A., Sittig, K. M., Ma, L., Berg, R. D., & Specian, R. D. (1990) · The American Journal of Surgery · doi:10.1016/s0002-9610(05)80610-5 · Cited by 300 · see citing works
Chang, C., Chen, G., Lien, H., & Yeh, H. (1998) · Hepatology · doi:10.1002/hep.510280504 · Cited by 261 · see citing works
Bacterial translocation to mesenteric lymph nodes is increased in cirrhotic rats with ascites
García–Tsao, G., Lee, F., Barden, G. E., Cartun, R. W., & West, A. B. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90147-7 · Cited by 247 · see citing works
Small bowel bacterial overgrowth in patients with alcoholic cirrhosis
Morencos, F. C., Castano, G. D. L. H., Ramos, L. M., Arias, M. J. L., Ledesma, F., & Romero, F. P. (1996) · Digestive Diseases and Sciences · doi:10.1007/bf02282340 · Cited by 246 · see citing works
Intestinal bacterial overgrowth and bacterial translocation in cirrhotic rats with ascites
Guarner, C., Runyon, B. A., Young, S., Heck, M., & Sheikh, M. Y. (1997) · Journal of Hepatology · doi:10.1016/s0168-8278(97)80474-6 · Cited by 237 · see citing works
Selective intestinal decontamination prevents spontaneous bacterial peritonitis
Soriano, G., Guarner, C., Teixidó, M., Such, J. M., Barrios, J., Enríquez, J., & Vilardell, F. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90219-b · Cited by 224 · see citing works
Runyon, B. A., Squier, S. U., & Borzio, M. (1994) · Journal of Hepatology · doi:10.1016/s0168-8278(94)80241-6 · Cited by 218 · see citing works
Steffen, E. K., & Berg, R. D. (1983) · Infection and Immunity · doi:10.1128/iai.39.3.1252-1259.1983 · Cited by 187 · see citing works
Natural history of autonomic neuropathy in chronic liver disease
Hendrickse, M. T., Thuluvath, P. J., & Triger, D. R. (1992) · The Lancet · doi:10.1016/0140-6736(92)92042-e · Cited by 180 · see citing works
SPONTANEOUS BACTERIAL PERITONITIS
García–Tsao, G. (1992) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(21)00617-8 · Cited by 177 · see citing works
Martini, G. A., Phear, E. A., Ruebner, B. H., & Sherlock, S. (1957) · PubMed · Cited by 172 · see citing works
Bacterial translocation from the gastrointestinal tract.
Rd, B. (1992) · PubMed · Cited by 161 · see citing works
Llovet, J. M., Bartolí, R., March, F., Planas, R., Viñado, B., Cabré, E., Arnal, J., Coll, P., Ausina, V., & Gassull, M. A. (1998) · Journal of Hepatology · doi:10.1016/0168-8278(88)80018-7 · Cited by 146 · see citing works
Self-citationLlovet, J. M., Bartolí, R., Planas, R., Cabré, E., Jiménez, M., Urban, A., Ojanguren, I., Arnal, J., & Gassull, M. À. (1994) · Gut · doi:10.1136/gut.35.11.1648 · Cited by 135 · see citing works
Self-citationA rodent model of cirrhosis, ascites, and bacterial peritonitis
Runyon, B. A., Sugano, S., Kanel, G. C., & Mellencamp, M. A. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90221-6 · Cited by 133 · see citing works
Small bowel bacterial overgrowth in patients with alcoholic cirrhosis
Morencos, F. C., Castano, G. D. L. H., Ramos, L. M., Arias, M. J. L., Ledesma, F., & Romero, F. P. (1995) · Digestive Diseases and Sciences · doi:10.1007/bf02065533 · Cited by 132 · see citing works
Dupeyron, C., Mangeney, N., Sedrati, L., Campillo, B., Fouet, P., & Leluan, G. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.2.340 · Cited by 128 · see citing works
Abnormalities in proximal small bowel motility in patients with cirrhosis
Jaime Chesta, R., Defilippi, C., & Defilíppí, C. (1993) · Hepatology · doi:10.1002/hep.1840170513 · Cited by 127 · see citing works
Altered Small Bowel Motility in Patients with Liver Cirrhosis Depends on Severity of Liver Disease
Madrid, A. M., Cumsille, F., & Defilíppí, C. (1997) · Digestive Diseases and Sciences · doi:10.1023/a:1018899611006 · Cited by 110 · see citing works
McCallum, R. W. (1991) · PubMed · Cited by 110 · see citing works
Short-term prognosis of cirrhotics with spontaneous bacterial peritonitis: multivariate study.
Llovet, J. M., Planas, R., Morillas, R. M., Quer, J. C., Cabré, E., Boix, J., Humbert, P., Guilera, M., Domènech, E., & Bertrán, X. (1993) · PubMed · Cited by 105 · see citing works
Self-citationScholz, H., Baier, W. K., Ratcliffe, P. J., Eckardt, K., Zapf, J., Kurtz, A., & Bauer, C. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.263.2.c474 · Cited by 81 · see citing works
Bode, C., Kolepke, R., Schäfer, K., & Bode, J. C. (1993) · PubMed · Cited by 79 · see citing works
Runyon, B. A., Borzio, M., Young, S., Squier, S. U., Guarner, C., & Runyon, M. A. (1995) · Hepatology · doi:10.1002/hep.1840210634 · Cited by 77 · see citing works
Alterations in rat intestinal transit by morphine promote bacterial translocation
Runkel, N. S. F., Moody, F. G., Smith, G. S., Rodriguez, L. F., Chen, Y., LaRocco, M., & Miller, T. A. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01308616 · Cited by 70 · see citing works
The contaminated small bowel syndrome
Isaacs, P., & Kim, Y. S. (1979) · The American Journal of Medicine · doi:10.1016/0002-9343(79)90647-8 · Cited by 69 · see citing works
Llovet, J. M., Bartolí, R., Planas, R., Viñado, B., Perez, J., Cabré, E., Arnal, J., Ojanguren, I., Ausina, V., & Gassull, M. A. (1996) · Hepatology · doi:10.1002/hep.510230419 · Cited by 62 · see citing works
Self-citationA syndrome of cirrhosis, achlorhydria, small intestinal bacterial overgrowth, and fat malabsorption.
Shindo, K., MACHIDA, M., Miyakawa, K., & Fukumura, M. (1993) · PubMed · Cited by 59 · see citing works
Casafont, F., Sánchez, E., Martin, L., Calvo, J. A., & Romero, F. P. (1997) · Hepatology · doi:10.1002/hep.510250605 · Cited by 57 · see citing works
Small intestinal transit in the portal hypertensive rat
Reilly, J. A., Quigley, E. M. M., Forst, C. F., & Rikkers, L. F. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)80010-7 · Cited by 56 · see citing works
Lal, D., Gorbach, S. L., & Levitan, R. (1972) · Gastroenterology · doi:10.1016/s0016-5085(72)80180-x · Cited by 49 · see citing works
Wang, X. D., Soltesz, V. L., & Andersson, R. (2008) · European Surgical Research · doi:10.1159/000129484 · Cited by 30 · see citing works
Intestinal myoelectrical activity and transit time in chronic portal hypertension
Stewart, J. J., Battarbee, H. D., Farrar, G. E., & Betzing, K. W. (1992) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1992.263.4.g474 · Cited by 27 · see citing works
Small bowel wall function in patients with advanced liver cirrhosis and portal hypertension
Bac, D., Swart, G. R., van den Berg, J. W. O., & Wilson, J. H. P. (1993) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-199305000-00014 · Cited by 17 · see citing works
Flagged first, then by citations
1 of the 42 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Toskes PP, Kumar A. Enteric bacterial flora and bacterial overgrowth syndrome. In: Feldman M, Scharschmidt BF, Sleisenger MH, eds. Sleisenger & Fordtran' s Gastrointestinal and Liver Disease, 6th ed. Philadelphia: Saunders, 1998;1523-1535.
- Flexner S. Peritonitis caused by invasion of the micrococcus lanceolatus from the intestine. Johns Hopkins Hosp Bull 1895;6:64-67.
- PARDO ET AL. 863 15273350, 2000, 4, Downloaded from https://aasldpubs.onlinelibrary.wiley.com/doi/10.1053/he.2000.5746, Wiley Online Library on [13/08/2023]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License
Cited by
Sorted by citations
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works
Bacterial infections in cirrhosis: A position statement based on the EASL Special Conference 2013
Jalan, R., Fernandez, J., Wiest, R., Schnabl, B., Moreau, R., Angeli, P., Stadlbauer, V., Gustot, T., Bernardi, M., Canton, R., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.01.024 · Cited by 906 · see citing works
Pathological bacterial translocation in liver cirrhosis
Wiest, R., Lawson, M. A., & Geuking, M. B. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.07.044 · Cited by 815 · see citing works
Bacterial translocation (BT) in cirrhosis†
Wiest, R., & Garcia‐Tsao, G. (2005) · Hepatology · doi:10.1002/hep.20632 · Cited by 677 · see citing works
The gut microbiome and liver cancer: mechanisms and clinical translation
Yu, L.-X., & Schwabe, R. F. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.72 · Cited by 634 · see citing works
Bacterial Infections, Sepsis, and Multiorgan Failure in Cirrhosis
Tandon, P., & García–Tsao, G. (2008) · Seminars in Liver Disease · doi:10.1055/s-2008-1040319 · Cited by 549 · see citing works
García–Tsao, G. (2001) · Gastroenterology · doi:10.1053/gast.2001.22580 · Cited by 466 · see citing works
Sepsis in cirrhosis: report on the 7th meeting of the International Ascites Club
Wong, F. S.-H., Bernardi, M., Balk, R., Christman, B., Moreau, R., Garcia-Tsao, G., Patch, D., Soriano, G., Hoefs, J., & Navasa, M. (2005) · Gut · doi:10.1136/gut.2004.038679 · Cited by 390 · see citing works
Spontaneous bacterial peritonitis: recent guidelines and beyond
Wiest, R., Krag, A. A., & Gerbes, A. (2011) · Gut · doi:10.1136/gutjnl-2011-300779 · Cited by 384 · see citing works
Bacterial translocation: Overview of mechanisms and clinical impact
Balzan, S. M. P., Quadros, C. A., de Cleva, R., Zilberstein, B., & Cecconello, I. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.04933.x · Cited by 370 · see citing works
Small Intestinal Bacterial Overgrowth: Roles of Antibiotics, Prebiotics, and Probiotics
Quigley, E. M. M., & Quera, R. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.046 · Cited by 328 · see citing works
Lorenzo-Zúñiga, V., Bartolí, R., Planas, R., Hofmann, A. F., Viñado, B., Hagey, L. R., Hernández, J. M., Mañé, J., Alvarez, M. A., Ausina, V., et al. (2003) · Hepatology · doi:10.1053/jhep.2003.50116 · Cited by 321 · see citing works
Self-citationBauer, T., Steinbrückner, B., Brinkmann, F., Ditzen, A. K., Schwacha, H., Aponte, J. J., Pelz, K., Kist, M., & Blum, H. E. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.04668.x · Cited by 266 · see citing works
β‐Blockers protect against spontaneous bacterial peritonitis in cirrhotic patients: a meta‐analysis
Senzolo, M., Cholongitas, E., Burra, P., Leandro, G., Thalheimer, U., Patch, D., & Burroughs, A. K. (2009) · Liver International · doi:10.1111/j.1478-3231.2009.02038.x · Cited by 241 · see citing works
Microbiota and the gut-liver axis: Bacterial translocation, inflammation and infection in cirrhosis
Giannelli, V. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i45.16795 · Cited by 237 · see citing works
Dysbiosis of small intestinal microbiota in liver cirrhosis and its association with etiology
Chen, Y., Ji, F., Guo, J., Shi, D., Fang, D., & Li, L. (2016) · Scientific Reports · doi:10.1038/srep34055 · Cited by 205 · see citing works
Small intestinal bacterial overgrowth in human cirrhosis is associated with systemic endotoxemia
Bauer, T. M., Schwacha, H., Steinbruckner, B., Brinkmann, F. E., Ditzen, A. K., Aponte, J. J., Pelz, K., Berger, D., Kist, M., & Blum, H. E. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05791.x · Cited by 211 · see citing works
Review article: bacterial translocation in the critically ill – evidence and methods of prevention
Gatt, M., REDDY, B. S., & Macfie, J. M. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03174.x · Cited by 201 · see citing works
Teltschik, Z., Wiest, R., Beisner, J., Nuding, S., Hofmann, C., Schöelmerich, J., Bevins, C. L., Stange, E. F., & Wehkamp, J. (2011) · Hepatology · doi:10.1002/hep.24789 · Cited by 196 · see citing works
Leaky gut and the liver: a role for bacterial translocation in nonalcoholic steatohepatitis.
Ilan, Y. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i21.2609 · Cited by 209 · see citing works
Gut microflora in the pathogenesis of the complications of cirrhosis
García–Tsao, G., & Wiest, R. (2004) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2003.10.005 · Cited by 190 · see citing works
SHANAB, A. A. A., Scully, P., Crosbie, O. M., Buckley, M. J. M., O’Mahony, L., Shanahan, F., Gazareen, S., Murphy, E., & Quigley, E. M. M. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1447-3 · Cited by 189 · see citing works
DIGESTIVE TRACT MICROBIOTA IN HEALTHY VOLUNTEERS
Zilberstein, B., Quintanilha, A. G., Santos, M. A. A., Pajecki, D., de Moura, E. G. H., Alves, P. R. A., Maluf‐Filho, F., de Souza, J. A. U., & Gama-Rodrigues, J. J. (2007) · Clinics · doi:10.1590/s1807-59322007000100008 · Cited by 177 · see citing works
Bacterial translocation and its consequences in patients with cirrhosis
Guarner, C., & Soriano, G. (2005) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200501000-00006 · Cited by 174 · see citing works
Microbiota-Immune Interaction in the Pathogenesis of Gut-Derived Infection
Wang, C., Li, Q., & Ren, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01873 · Cited by 167 · see citing works
Riordan, S. M., Skinner, N. A., Nagree, A., McCallum, H., McIver, C. J., Kurtovic, J., Hamilton, J. A., Bengmark, S., Williams, R. L., & Visvanathan, K. (2003) · Hepatology · doi:10.1053/jhep.2003.50180 · Cited by 167 · see citing works
Madrid, A. M., Hurtado, C., Venegas, M., Cumsille, F., & Defilippi, C. (2001) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03636.x · Cited by 158 · see citing works
A sequential study of serum bacterial DNA in patients with advanced cirrhosis and ascites
Francés, R., Benlloch, S., Zapater, P., González, J. M., Lozano, B. R., Muñoz, C., Pascual, S., Casellas, J. A., Uceda, F., Palazón, J. M., et al. (2004) · Hepatology · doi:10.1002/hep.20055 · Cited by 153 · see citing works
Role of Gut Dysbiosis in Liver Diseases: What Have We Learned So Far?
Fukui, H. (2019) · Diseases · doi:10.3390/diseases7040058 · Cited by 151 · see citing works
Chiva, M., Soriano, G., Rochat, I., Peralta, C., Rochat, F., Llovet, T., Mirelis, B., Schiffrin, E. J., Guarner, C., & Balanzó, J. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00142-3 · Cited by 139 · see citing works
Cirrhotic ascites review: Pathophysiology, diagnosis and management
Moore, C. M. (2013) · World Journal of Hepatology · doi:10.4254/wjh.v5.i5.251 · Cited by 138 · see citing works
Gastrointestinal dysfunction in liver cirrhosis
Kalaitzakis, E. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i40.14686 · Cited by 127 · see citing works
Spontaneous bacterial peritonitis
Koulaouzidis, A., Bhat, S. K., & Saeed, A. A. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.1042 · Cited by 130 · see citing works
Baterial Translocation in Humans
Lichtman, S. N. (2001) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200107000-00001 · Cited by 126 · see citing works
Microbial Translocation in Chronic Liver Diseases
Pinzone, M. R., Celesia, B. M., Rosa, M. D., Cacopardo, B. S., & Nunnari, G. (2012) · International Journal of Microbiology · doi:10.1155/2012/694629 · Cited by 119 · see citing works
Bacterial infections in cirrhosis: treatment and prophylaxis
García–Tsao, G. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.12.006 · Cited by 119 · see citing works
The intestinal flora and bacterial infection in cirrhosis
Riordan, S. M., & Williams, R. L. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.08.001 · Cited by 112 · see citing works
Min, Y. W., Lim, K. S., Min, B., Gwak, G., Paik, Y., Choi, M. S., Lee, J., Kim, J. J., Koh, K. C., Paik, S. W., et al. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12875 · Cited by 110 · see citing works
Bauer, T., Fernández, J., Navasa, M., Vilà, J., & Rodés, J. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00003-x · Cited by 110 · see citing works
Gut flora and bacterial translocation in chronic liver disease
Almeida, J. A. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i10.1493 · Cited by 105 · see citing works
Merli, M., Lucidi, C., Gregorio, V. D., Giannelli, V., Giusto, M., Ceccarelli, G., Riggio, O., & Venditti, M. (2014) · Liver International · doi:10.1111/liv.12593 · Cited by 95 · see citing works
Fluid retention in cirrhosis: pathophysiology and management
Kashani, A., Landaverde, C. E., Medici, V., & Rossaro, L. (2008) · QJM · doi:10.1093/qjmed/hcm121 · Cited by 93 · see citing works
Small bowel bacterial overgrowth: Presentation, diagnosis, and treatment
Singh, V. V., & Toskes, P. P. (2004) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-004-0022-4 · Cited by 91 · see citing works
Møller, S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i42.15499 · Cited by 87 · see citing works
Bacterial translocation markers in liver cirrhosis
Alexopoulou, A. A. (2017) · Annals of Gastroenterology · doi:10.20524/aog.2017.0178 · Cited by 87 · see citing works
García–Tsao, G. (2016) · Digestive Diseases · doi:10.1159/000444551 · Cited by 85 · see citing works
The Role of Gut Microbiota in Some Liver Diseases: From an Immunological Perspective
Wang, L., Cao, Z.-M., Zhang, L., Li, J.-M., & Lv, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.923599 · Cited by 87 · see citing works
Spontaneous bacterial peritonitis
Koulaouzidis, A., Bhat, S., Karagiannidis, A., Tan, W. C., & Linaker, B. D. (2007) · Postgraduate Medical Journal · doi:10.1136/pgmj.2006.056168 · Cited by 86 · see citing works
Spontaneous bacterial peritonitis: A severe complication ofliver cirrhosis
Lata, J., Stibůrek, O., & Kopáčová, M. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.5505 · Cited by 84 · see citing works
Spontaneous bacterial peritonitis: a historical perspective
García–Tsao, G. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.09.001 · Cited by 80 · see citing works
Ultrastructural characteristics of distal duodenum mucosa in patients with cirrhosis
Such, J. M., Guardiola, J. V., Juan, J. D., Casellas, J. A., Pascual, S., Aparicio, J. R., Solá-Vera, J., & Pérez‐Mateo, M. (2002) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200204000-00006 · Cited by 79 · see citing works
Twardowska, A., Makaro, A., Binienda, A., Fichna, J., & Sałaga, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063204 · Cited by 78 · see citing works
Small bowel bacterial overgrowth: Presentation, diagnosis, and treatment
Singh, V. V., & Toskes, P. P. (2003) · Current Gastroenterology Reports · doi:10.1007/s11894-003-0048-0 · Cited by 70 · see citing works
Rashid, S. K., Idris-Khodja, N., Auger, C., Alhosin, M., Boehm, N., Oswald–Mammosser, M., & Schini‐Kerth, V. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097458 · Cited by 67 · see citing works
Gut Microbiota and Host Reaction in Liver Diseases
Fukui, H. (2015) · Microorganisms · doi:10.3390/microorganisms3040759 · Cited by 64 · see citing works
Spontaneous bacterial peritonitis—diagnosis, treatment and prevention
Mowat, C., & Stanley, A. J. (2001) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2001.01116.x · Cited by 65 · see citing works
Mahmud, N., Serper, M., Taddei, T. H., & Kaplan, D. E. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.03.052 · Cited by 55 · see citing works
Sánchez, E., Nieto, J. C., Boullosa, A., Vidal, S., Sancho, F. J., Rossi, G., Sancho‐Bru, P., Oms, R., Mirelis, B., Juárez, C., et al. (2014) · Liver International · doi:10.1111/liv.12566 · Cited by 52 · see citing works
Bacterial infections in cirrhosis: role of proton pump inhibitors and intestinal permeability
van Vlerken, L. G., Huisman, E. J., van Hoek, B., Renooij, W., de Rooij, F. W. M., Siersema, P. D., & van Erpecum, K. J. (2011) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2011.02643.x · Cited by 53 · see citing works
The role of gut microbiota in liver disease development and treatment
Wang, L., & Wan, Y. Y. (2019) · Liver Research · doi:10.1016/j.livres.2019.02.001 · Cited by 52 · see citing works
Zhang, W., GU, Y.-R., Chen, Y., Deng, H. X., Chen, L., Chen, S., Zhang, G., & Gao, Z. (2010) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32833eb8b0 · Cited by 50 · see citing works
Increased Orocecal Transit Time in Patients with Nonalcoholic Fatty Liver Disease
Soza, A., Riquelme, A. J., Gonzalez, R. G., Alvarez, M. G., Pérez‐Ayuso, R. M., Glasinovic, J. C., & Arrese, M. A. (2005) · Digestive Diseases and Sciences · doi:10.1007/s10620-005-2720-8 · Cited by 50 · see citing works
Sheth, A. A., & García–Tsao, G. (2008) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318169c44e · Cited by 50 · see citing works
Sharon A Center (2004) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2003.09.015 · Cited by 50 · see citing works
Intestinal permeability in a patient with liver cirrhosis
Aguirre-Valádez, J., Rivera-Espinosa, L., Méndez-Guerrero, O., Chávez-Pacheco, J. L., Juárez, I. G., & Torre, A. (2016) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s115902 · Cited by 50 · see citing works
Bacterial translocation: cause or consequence of decompensation in cirrhosis?
García–Tsao, G. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(00)00006-4 · Cited by 49 · see citing works
Albillos, A., & de la Hera, A. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00265-9 · Cited by 48 · see citing works
Kalaitzakis, E., Sadik, R., Holst, J. J., Öhman, L., & Bjornsson, E. S. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.11.022 · Cited by 46 · see citing works
Translocación de productos de origen bacteriano en la cirrosis
Bellot, P., Francés, R., & Such, J. M. (2008) · Gastroenterología y Hepatología · doi:10.1157/13127094 · Cited by 43 · see citing works
Sandhu, B. S., Gupta, R., Sharma, J., Singh, J., Murthy, N. S., & Sarin, S. K. (2005) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2005.03796.x · Cited by 43 · see citing works
Effect of cisapride on intestinal bacterial and endotoxin translocation in cirrhosis
Zhang, S.-C. (2003) · World Journal of Gastroenterology · doi:10.3748/wjg.v9.i3.534 · Cited by 42 · see citing works
Intestinal permeability and complications in liver cirrhosis: A prospective cohort study
Benjamin, J., Singla, V., Arora, I., Sood, S., & Joshi, Y. K. (2012) · Hepatology Research · doi:10.1111/j.1872-034x.2012.01054.x · Cited by 42 · see citing works
Gut microbiome and intestinal barrier failure – The “Achilles heel” in hepatology?
Benten, D., & Wiest, R. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.03.003 · Cited by 41 · see citing works
Spontaneous bacterial peritonitis: from pathophysiology to prevention
Bernardi, M. (2010) · Internal and Emergency Medicine · doi:10.1007/s11739-010-0446-x · Cited by 40 · see citing works
Sánchez, E., Casafont, F., Guerra, A., de Benito, I., & Pons‐Romero, F. (2005) · Revista Española de Enfermedades Digestivas · doi:10.4321/s1130-01082005001100005 · Cited by 40 · see citing works
Khan, M. A., Kamal, S., Khan, S., Lee‐Smith, W., & Howden, C. W. (2015) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000448 · Cited by 39 · see citing works
Chen, Y.-X., Lai, L.-N., Zhang, H.-Y., Bi, Y.-H., Li, M., Li, X.-J., Tian, X.-X., Wang, L.-M., Fan, Y., Zhao, Z.-F., et al. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i10.2949 · Cited by 37 · see citing works
Spontaneous bacterial peritonitis: How to deal with this life-threatening cirrhosis complication?
Ribeiro, T. C. D. R. (2008) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s2688 · Cited by 35 · see citing works
Lakshmi, C., Ghoshal, U. C., Kumar, S., Goel, A., Misra, A., Mohindra, S., & Choudhuri, G. (2009) · Digestive Diseases and Sciences · doi:10.1007/s10620-009-0826-0 · Cited by 37 · see citing works
Bacterial translocation: clinical implications and prevention
Macintire, D. K., & Bellhorn, T. L. (2002) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/s0195-5616(02)00037-2 · Cited by 37 · see citing works
Small Bowel Transit and Altered Gut Microbiota in Patients With Liver Cirrhosis
Liu, Y., Jin, Y., Li, J., Zhao, L., Li, Z., Xu, J., Zhao, F., Feng, J., Chen, H., Fang, C., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00470 · Cited by 35 · see citing works
Hepatosplanchnic circulation in cirrhosis and sepsis
Prin, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i9.2582 · Cited by 35 · see citing works
Spontaneous bacterial peritonitis: a therapeutic update
Strauss, E., & Caly, W. R. (2006) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.4.2.249 · Cited by 33 · see citing works
Electroacupuncture reduces blood glucose by regulating intestinal flora in type 2 diabetic mice
An, J., Wang, L., Song, S., Tian, L., Liu, Q., Mei, M., Li, W., & Liu, S. (2022) · Journal of Diabetes · doi:10.1111/1753-0407.13323 · Cited by 32 · see citing works
Is There a Role for Probiotics in Liver Disease?
Lo, R. S., Austin, A. S., & Freeman, J. G. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/874768 · Cited by 34 · see citing works
Epidemiological and clinical aspects.
Preux, P., & Odermatt, P. (2005) · HAL · Cited by 32 · see citing works
Bacterial translocation in critical illness
Krentz, T., & Allen, S. J. (2017) · Journal of Small Animal Practice · doi:10.1111/jsap.12626 · Cited by 31 · see citing works
Rostkowska, K., Szymanek-Pasternak, A., & Simon, K. A. (2018) · Clinical and Experimental Hepatology · doi:10.5114/ceh.2018.80123 · Cited by 32 · see citing works
Rasaratnam, B., Connelly, N. J., & Chin-Dusting, J. P. F. (2004) · Clinical Science · doi:10.1042/cs20040157 · Cited by 30 · see citing works
Attar, B. M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i9.2374 · Cited by 29 · see citing works
Gastrointestinal Motility Disorders and Their Clinical Implications in Cirrhosis
Theocharidou, E., Dhar, A., & Patch, D. (2017) · Gastroenterology Research and Practice · doi:10.1155/2017/8270310 · Cited by 29 · see citing works
Laboratory diagnostics of spontaneous bacterial peritonitis
Lippi, G., Danese, E., Cervellin, G., & Montagnana, M. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.01.023 · Cited by 29 · see citing works
Ascites and spontaneous bacterial peritonitis in patients with liver cirrhosis
van Erpecum, K. J. (2006) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520600664342 · Cited by 28 · see citing works
Alhumaid, S., Mutair, A. S. A., Alawi, Z. A., Zaidi, A. R. Z., Rabaan, A. A., Elhazmi, A., & Al‐Omari, A. (2021) · Gut Pathogens · doi:10.1186/s13099-021-00414-8 · Cited by 27 · see citing works
Influence of proton pump inhibitors in the development of spontaneous bacterial peritonitis
Miozzo, S. A. D. S., John, J. A., da Silva, M. C. A., Dossin, I. D. A., Tovo, C. V., & de Mattos, Â. A. (2017) · World Journal of Hepatology · doi:10.4254/wjh.v9.i35.1278 · Cited by 27 · see citing works
Gut Microbiota, Peroxisome Proliferator-Activated Receptors, and Hepatocellular Carcinoma
Yu, Q., Wu, L., Ji, J., Feng, J., Dai, W., Li, J., Wu, J., & Guo, C. (2020) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s277870 · Cited by 27 · see citing works
Palma, P., Mihaljevic, N., Hasenberg, T., Keese, M. A., & Koeppel, T. A. (2007) · Hepatology Research · doi:10.1111/j.1872-034x.2007.00004.x · Cited by 26 · see citing works
Ascites and spontaneous bacterial peritonitis: Recommendations from two United States centers
Al‐Osaimi, A. M. S., Sundaram, V., & Manne, V. (2014) · Saudi Journal of Gastroenterology · doi:10.4103/1319-3767.141686 · Cited by 26 · see citing works
Novel prevention strategies for bacterial infections in cirrhosis
Yan, K. G., & García–Tsao, G. (2016) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2016.1145663 · Cited by 26 · see citing works
Why do bacteria reach ascitic fluid?
Sola, R. L., & Soriano, G. (2002) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200204000-00002 · Cited by 24 · see citing works
- Authors
- Pardo, A., Bartolí, R., Lorenzo-Zúñiga, V., Planas, R., Viñado, B., Riba, J., Cabré, E., Santos, J., Luque, T., Ausina, V., & Gassull, M. A.
- Affiliations
- Hospital Universitari Germans Trias i Pujol (ES)
- Venue
- Hepatology
- Published
- 2000-04
- Volume
- 31
- Issue
- 4
- Pages
- 858-863
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2013027212
- Cited by
- 177
- References
- 42
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 9 · 2018: 6 · 2017: 7 · 2016: 10 · 2015: 8 · 2014: 12 · 2013: 2 · 2012: 7
- FWCI
- 5.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Gastroenterological Association
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- cisapride, intestinal bacterial overgrowth, bacterial translocation, liver cirrhosis, intestinal motility, Gram-negative bacteria, orocecal transit time
- MeSH terms
- Adolescent, Adult, Aged, Animals, Bacteria, Female, Gastrointestinal Agents, Humans, Intestines, Liver Cirrhosis, Liver Cirrhosis, Experimental, Male, Middle Aged, Pilot Projects, Rats, Sprague-Dawley, Bacterial Translocation, Cisapride, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
