The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Microrna-27b Is a Regulatory Hub in Lipid Metabolism and Is Altered in Dyslipidemia
Open accessAbstract
Cellular and plasma lipid levels are tightly controlled by complex gene regulatory mechanisms. Elevated plasma lipid content, or hyperlipidemia, is a significant risk factor for cardiovascular morbidity and mortality. MicroRNAs (miRNAs) are posttranscriptional regulators of gene expression and have emerged as important modulators of lipid homeostasis, but the extent of their role has not been systematically investigated. In this study we performed high-throughput small RNA sequencing and detected ≈150 miRNAs in mouse liver. We then employed an unbiased, in silico strategy to identify miRNA regulatory hubs in lipid metabolism, and miR-27b was identified as the strongest such hub in human and mouse liver. In addition, hepatic miR-27b levels were determined to be sensitive to plasma hyperlipidemia, as evidenced by its ≈3-fold up-regulation in the liver of mice on a high-fat diet (42% calories from fat). Further, we showed in a human hepatocyte cell line (Huh7) that miR-27b regulates the expression (messenger RNA [mRNA] and protein) of several key lipid-metabolism genes, including Angptl3 and Gpam . Finally, we demonstrated that hepatic miR-27b and its target genes are inversely altered in a mouse model of dyslipidemia and atherosclerosis. Conclusion: miR-27b is responsive to lipid levels and controls multiple genes critical to dyslipidemia.
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Cites
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Self-citationmiR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
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miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling
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Expanding the MicroRNA Targeting Code: Functional Sites with Centered Pairing
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Cited by
Bile acid signaling in metabolic disease and drug therapy
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DNA methylation‐based prognosis and epidrivers in hepatocellular carcinoma
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MicroRNA-mediated regulation of glucose and lipid metabolism
Agbu, P., & Carthew, R. W. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00354-w · Cited by 363
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MicroRNAs in Metabolic Disease
Fernández-Hernando, C., Ramírez, C. M., Goedeke, L., & Suárez, Y. (2013) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.112.300144 · Cited by 257
Metadata
- Authors
- Vickers, K. C., Shoucri, B. M., Levin, M. G., Wu, H., Pearson, D. S., Osei-Hwedieh, D., Collins, F. S., Remaley, A. T., & Sethupathy, P.
- Venue
- Hepatology
- Published
- 2013-02
- Volume
- 57
- Issue
- 2
- Pages
- 533-542
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2060264439
- Cited by
- 237
- References
- 13
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Vickers, K. C., Shoucri, B. M., Levin, M. G., Wu, H., Pearson, D. S., Osei-Hwedieh, D., Collins, F. S., Remaley, A. T., & Sethupathy, P. (2013). Microrna-27b Is a Regulatory Hub in Lipid Metabolism and Is Altered in Dyslipidemia. Hepatology. https://doi.org/10.1002/hep.25846
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