MicroRNAs in Metabolic Disease
Open accessAbstract
Alterations in the metabolic control of lipid and glucose homeostasis predispose an individual to develop cardiometabolic diseases, such as type 2-diabetes mellitus and atherosclerosis. Work over the last years has suggested that microRNAs (miRNAs) play an important role in regulating these physiological processes. The contribution of miRNAs in regulating metabolism is exemplified by miR-33, an intronic miRNA encoded in the Srebp genes. miR-33 controls cellular cholesterol export and fatty acid degradation, whereas its host genes stimulate cholesterol and fatty acid synthesis. Other miRNAs, such as miR-122, also play a critical role in regulating lipid homeostasis by controlling cholesterol synthesis and lipoprotein secretion in the liver. This review article summarizes the recent findings in the field, highlighting the contribution of miRNAs in regulating lipid and glucose metabolism. We will also discuss how the modulation of specific miRNAs may be a promising strategy to treat metabolic diseases.
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microRNAs can alter the expression of genes in insulin-producing and insulin-sensitive tissues, including the pancreas, liver, and vasculature.
“microRNAs can alter the expression of genes in insulin-producing and insulin-sensitive tissues, including the pancreas, liver, and vasculature.”
From The Vasculature in Prediabetes (2018) · cites this paper as [134]
The most abundant microRNA in the liver is miR-122.
“The most abundant microRNA in the liver is miR-122.”
From The Vasculature in Prediabetes (2018) · cites this paper as [134]
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Galicia-Garcia, U., Jebari, S., Larrea-Sebal, A., Uribe, K., Siddiqi, H., Ostolaza, H., Benito-Vicente, A., & Martín, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134725 · Cited by 141 · see citing works
Goedeke, L., Salerno, A., Ramírez, C. M., Guo, L., Allen, R. M., Yin, X., Langley, S. R., Esau, C., Wanschel, A., Fisher, E. A., et al. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201404046 · Cited by 145 · see citing works
“…carnitine palmitoyltransferase 1A (CPT1A), hydroxyacyl-CoA dehydrogenase-3-ketoacyl-CoA (HADHB), AMP-activated protein kinase (AMPK), phosphoenolpyruvate carboxy-kinase (PCK1), and glucose-6-phosphatase (G6PC) (Rayner et al , 2010; Davalos et al , 2011; Goedeke et al , 2013; Ramirez et al , 2013).”
Self-citationThe Vasculature in Prediabetes
Wasserman, D. H., Wang, T. J., & Brown, N. J. (2018) · Circulation Research · doi:10.1161/circresaha.118.311912 · Cited by 137 · see citing works
“The most abundant microRNA in the liver is miR-122.(134,140) Inhibition of miR-122 reduces plasma cholesterol and hepatic steatosis, though the specific gene regulatory pathways involved are unclear.”
BackgroundA Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus
He, Y., Ding, Y., Liang, B., Lin, J., Kim, T., Yu, H., Hang, H., & Wang, K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030456 · Cited by 130 · see citing works
Genetic dissection of the impact of miR-33a and miR-33b during the progression of atherosclerosis
Price, N. L., Rotllan, N., Canfrán-Duque, A., Zhang, X., Pati, P., Arias, N., Moen, J., Mayr, M., Ford, D. A., Baldán, Á., et al. (2017) · Cell reports · doi:10.1016/j.celrep.2017.10.023 · Cited by 129 · see citing works
“…(miRNAs) have been demonstrated to play a key role in the control of mRNA translation and degradation, constituting an entirely new level of posttranscriptional regulation that is involved in nearly all biological processes (Ambros, 2004; Bartel, 2009; Fernández-Hernando et al., 2011, 2013).”
BackgroundSelf-citationMiR-146a Negatively Regulates TLR2-Induced Inflammatory Responses in Keratinocytes
Meisgen, F., Xu Landén, N., Wang, A., Réthi, B., Bouez, C., Zuccolo, M., Gueniche, A., Ståhle, M., Sonkoly, E., Breton, L., et al. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.89 · Cited by 124 · see citing works
“Key roles for miRNAs have been found in nearly all biological processes and altered miRNA expression is associated with diseases (Farazi et al., 2013; Fernandez-Hernando et al., 2013).”
BackgroundExosomal miRNAs as potential biomarkers of cardiovascular risk in children
Khalyfa, A., & Gozal, D. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-162 · Cited by 126 · see citing works
“Recently, the role of miRNAs in inflammation and metabolic and cardiovascular diseases has been highlighted [113-115].”
BackgroundLiver microRNAs: potential mediators and biomarkers for metabolic and cardiovascular disease?
Willeit, P., Skroblin, P., Kiechl, S., Fernández-Hernando, C., & Mayr, M. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw146 · Cited by 124 · see citing works
Microvesicles as Emerging Biomarkers and Therapeutic Targets in Cardiometabolic Diseases
Chen, Y., Li, G., & Liu, M.-L. (2018) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2017.03.006 · Cited by 125 · see citing works
Ortíz, M., Soto-Alarcón, S. A., Orellana, P., Espinosa, A., Campos, C., López‐Arana, S., Rincón‐Cervera, M. Á., Illesca, P., Valenzuela, R., & Videla, L. A. (2020) · Digestive and Liver Disease · doi:10.1016/j.dld.2020.04.019 · Cited by 124 · see citing works
Lv, Y.-C., Tang, Y., Peng, J., Zhao, G., Yang, J., Yao, F., Ouyang, X.-P., He, P., Xie, W., Tan, Y. L., et al. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.07.005 · Cited by 120 · see citing works
McGill, M. R., & Jaeschke, H. (2014) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2014.920823 · Cited by 119 · see citing works
“Interestingly, it has been shown that miR-122 has functional roles in hepatocyte differentiation [100], tumor suppression [101], viral replication [102], lipid metabolism [103] and possibly alcoholic liver disease [104].”
BackgroundZawada, A. M., Rogacev, K. S., Müller, S., Rotter, B., Winter, P., Fliser, D., & Heine, G. H. (2013) · Epigenetics · doi:10.4161/epi.26931 · Cited by 114 · see citing works
“These network analyses underscore the notion that single miRNAs regulate multiple genes within specific signaling pathways, leading to a profound dysregulation of downstream gene networks when miRNA expression is disturbed.(23) In summary, we provide a first comprehensive miRNA analysis in CKD which allows to link dys…”
BackgroundKontaraki, J. E., Marketou, M. E., Zacharis, E. A., Parthenakis, F. I., & Vardas, P. E. (2013) · Journal of Human Hypertension · doi:10.1038/jhh.2013.117 · Cited by 114 · see citing works
MicroRNA-mediated mechanisms of the cellular stress response in atherosclerosis
Schober, A., Nazari-Jahantigh, M., & Weber, C. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.38 · Cited by 113 · see citing works
microRNAs in lipoprotein metabolism and cardiometabolic disorders
Rotllán, N., Price, N. L., Pati, P., Goedeke, L., & Fernandez-Hernando, C. F. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.01.025 · Cited by 111 · see citing works
Self-citationEsteves, J. V. D. C., Enguita, F. J., & Machado, U. F. (2017) · Journal of Diabetes Research · doi:10.1155/2017/7267910 · Cited by 109 · see citing works
“Over the last few years, several known miRNAs were described as involved in the pathophysiology of diabetes [11, 95], especially in the impaired glycemic homeostasis [10, 80, 96].”
BackgroundDicer Cleavage by Calpain Determines Platelet microRNA Levels and Function in Diabetes
Elgheznawy, A., Shi, L., Hu, J., Wittig, I., Laban, H., Pircher, J., Mann, A. W., Provost, P., Randriamboavonjy, V., & Fleming, I. (2015) · Circulation Research · doi:10.1161/circresaha.117.305784 · Cited by 109 · see citing works
Price, N. L., Singh, A. K., Rotllan, N., Goedeke, L., Wing, A., Canfrán-Duque, A., Diaz-Ruiz, A., Araldi, E., Baldán, Á., Camporez, J.-P., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.074 · Cited by 110 · see citing works
“…these, miRNAs have been demonstrated to regulate key functions in a variety of important metabolic organs including the liver, brain, pancreas, muscle, and adipose tissue, which can have a substantial impact on the development of obesity and metabolic dysfunction (Fernández-Hernando et al., 2013).”
Self-citationKontaraki, J. E., Marketou, M. E., Zacharis, E. A., PARTHENAKIS, F. I., & Vardas, P. E. (2014) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2014.03.324 · Cited by 109 · see citing works
microRNA Therapeutics in Cardiovascular Disease Models
Dangwal, S., & Thum, T. (2013) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-135957 · Cited by 109 · see citing works
Yang, M., Liu, W., Pellicane, C., Sahyoun, C., Joseph, B. K., Ebert, C., Donigan, M., Pandya, D., Giordano, C., Bata, A., et al. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m041335 · Cited by 105 · see citing works
Obesity, energy balance and spermatogenesis
Oliveira, P. F., Sousa, M., Silva, B. M., Monteiro, M. P., & Alves, M. G. (2017) · Reproduction · doi:10.1530/rep-17-0018 · Cited by 104 · see citing works
Hassani, F. V., Mehri, S., Abnous, K., Birner‐Gruenberger, R., & Hosseinzadeh, H. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.07.007 · Cited by 97 · see citing works
Noncoding RNAs and Atherosclerosis
Aryal, B. K., Rotllán, N., & Fernandez-Hernando, C. F. (2014) · Current Atherosclerosis Reports · doi:10.1007/s11883-014-0407-3 · Cited by 94 · see citing works
MicroRNA expression and its clinical implications in Ewing's sarcoma
Li, Z., Yu, X., Shen, J., Wu, W. K. K., & Chan, M. T. V. (2014) · Cell Proliferation · doi:10.1111/cpr.12160 · Cited by 89 · see citing works
Blood-Based Biomarkers for Metabolic Syndrome
O’Neill, S., Bohl, M., Gregersen, S., Hermansen, K., & O’Driscoll, L. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.03.012 · Cited by 88 · see citing works
“miR-370 is another miRNA associated with MetS [39].”
Male obesity and subfertility, is it really about increased adiposity?
McPherson, N. O., & Lane, M. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.148076 · Cited by 87 · see citing works
Raitoharju, E., Seppälä, I., Lyytikäinen, L., Viikari, J. S. A., Ala‐Korpela, M., Soininen, P., Kangas, A. J., Waldenberger, M., Klopp, N., Illig, T., et al. (2016) · Scientific Reports · doi:10.1038/srep38262 · Cited by 86 · see citing works
Fernández-de Frutos, M., Galán-Chilet, I., Goedeke, L., Kim, B., Pardo-Marqués, V., Pérez-García, A., Herrero, J. I., Fernández-Hernando, C., Kim, J., & Ramírez, C. M. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00170-19 · Cited by 82 · see citing works
“MicroRNAs have been shown to play a major role in the regulation of metabolism, primarily in peripheral tissues (23).”
BackgroundSelf-citationMechanisms of MicroRNAs in Atherosclerosis
Schober, A., & Weber, C. (2016) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012615-044135 · Cited by 78 · see citing works
Non-coding RNA regulation of endothelial and macrophage functions during atherosclerosis
Aryal, B. K., & Suárez, Y. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2018.03.001 · Cited by 78 · see citing works
Self-citationZhang, L., He, S., Guo, S., Xie, W., Xin, R., Yu, H. J., Yang, F., Qiu, J. Y., Zhang, D., Zhou, S., et al. (2014) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2014.01.002 · Cited by 74 · see citing works
Diabetic Cardiomyopathy: An Immunometabolic Perspective
Mishra, P. K., Ying, W., Nandi, S. S., Bandyopadhyay, G. K., Patel, K. P., & Mahata, S. K. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00072 · Cited by 73 · see citing works
“Further, miRNAs play a vital role in the regulation of metabolism (47) and since DM is a metabolic disease it is logical to examine the role of miRNAs in DM.”
BackgroundFerreira, D. M. S., Afonso, M. B., Rodrigues, P. M., Simão, A. L., Pereira, D. M., Borralho, P. M., Rodrigues, C. M. P., & Castro, R. E. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00420-13 · Cited by 70 · see citing works
MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers
Portius, D., Sobolewski, C., & Foti, M. (2017) · PPAR Research · doi:10.1155/2017/7058424 · Cited by 71 · see citing works
Differential MicroRNA-Signatures in Thyroid Cancer Subtypes
Santiago, K. R., Wongworawat, Y. C., & Khan, S. (2020) · Journal of Oncology · doi:10.1155/2020/2052396 · Cited by 69 · see citing works
“Data also show that miRNAs can be used as potential biomarkers for the diagnosis and prognosis of a variety of diseases such as cancer, neurological disorders, cardiovascular diseases, and type-II diabetes; they can not only be used to monitor treatments but also for patient stratification [35, 36].”
BackgroundXu, P. A., Li, Y., Zhang, H., Li, M., & Zhu, H. (2015) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2015.09.038 · Cited by 67 · see citing works
Cell-Specific Dysregulation of MicroRNA Expression in Obese White Adipose Tissue
Oger, F., Gheeraert, C., Mogilenko, D. A., Benomar, Y., Molendi‐Coste, O., Bouchaert, E., Caron, S., Dombrowicz, D., Pattou, F. N., Duez, H., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4259 · Cited by 65 · see citing works
“Since the description of miRNAs in the early 1990s (14), they have been shown to participate in most cellular processes including metabolic homeostasis (15).”
BackgroundCirculatory miRNA biomarkers of metabolic syndrome
Ramzan, F., D’Souza, R. F., Durainayagam, B. R., Milan, A. M., Markworth, J. F., Miranda-Soberanis, V., Sequeira, I. R., Roy, N. C., Poppitt, S. D., Mitchell, C. J., et al. (2019) · Acta Diabetologica · doi:10.1007/s00592-019-01406-6 · Cited by 63 · see citing works
Suppression of Endothelial AGO1 Promotes Adipose Tissue Browning and Improves Metabolic Dysfunction
Tang, X., Miao, Y., Luo, Y., Sriram, K., Qi, Z., Lin, F., Gu, Y., Lai, C., Hsu, C., Peterson, K. L., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.041231 · Cited by 62 · see citing works
Vegter, E. L., Schmitter, D., Hagemeijer, Y. P., Ovchinnikova, E. S., van der Harst, P., Teerlink, J. R., O’Connor, C. M., Metra, M., Davison, B. A., Bloomfield, D. M., et al. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.09.010 · Cited by 60 · see citing works
“Similarly, no literature was found supporting the association between let-7i-5p and triglycerides in the failure-intermediate group, although involvement of the let-7 family in lipid metabolism has been previously reported [43,44].”
BackgroundSREBP-1c/MicroRNA 33b Genomic Loci Control Adipocyte Differentiation
Price, N., Holtrup, B., Kwei, S. L., Wabitsch, M., Rodeheffer, M. S., Bianchini, L., Suárez, Y., & Fernández-Hernando, C. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00745-15 · Cited by 54 · see citing works
Self-citationGottmann, P., Ouni, M., Saussenthaler, S., Roos, J., Stirm, L., Jähnert, M., Kamitz, A., Hallahan, N., Jonas, W., Fritsche, A., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.03.005 · Cited by 59 · see citing works
“Thus, they are potent regulators and suitable candidates in polygenic diseases like obesity or T2D [10,11].”
BackgroundZhao, R., Feng, J., & He, G. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.04.052 · Cited by 58 · see citing works
Dietary lipids modulate the expression of miR-107, an miRNA that regulates the circadian system
Daimiel, L., Klett‐Mingo, M., Konstantinidou, V., Micó, V., Aranda, J. F., García, B., Martı́nez-Botas, J., Dávalos, A., Fernandez-Hernando, C. F., & Ordovás, J. M. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400616 · Cited by 58 · see citing works
“The role of miRNAs in metabolic diseases including atherosclerosis, CVD, metabolic syndrome, obesity, and type 2 diabetes (T2D) has been extensively reviewed recently [23, 24].”
BackgroundCanfrán‐Duque, A., Ramírez, C. M., Goedeke, L., Lin, C., & Fernandez-Hernando, C. F. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu140 · Cited by 58 · see citing works
Self-citationmicroRNAs in lipoprotein and lipid metabolism: from biological function to clinical application
Desgagné, V., Bouchard, L., & Guérin, R. (2016) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2016-0575 · Cited by 56 · see citing works
Relevance of microRNA in metabolic diseases
Price, N., Ramírez, C., & Fernández-Hernando, C. (2014) · Critical reviews in clinical laboratory sciences · doi:10.3109/10408363.2014.937522 · Cited by 52 · see citing works
Self-citationCHANG, F., ZHANG, L.-H., XU, W.-P., JING, P., & ZHAN, P.-Y. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2013 · Cited by 58 · see citing works
“Currently, >700 miRNAs have been identified, and are essential in a number of cellular processes, including cell polarity, migration, apoptosis and synaptic plasticity (13).”
BackgroundCirculating microRNAs and diabetes: potential applications in medical practice
Raffort, J., Hinault, C., Dumortier, O., & OBBERGHEN, E. V. (2015) · Diabetologia · doi:10.1007/s00125-015-3680-y · Cited by 56 · see citing works
“no rm oa lb um in ur ia :m iR -1 55 ,42 4, -1 30 a, -1 45 B ar ut ta et al ,2 01 3 [6 5]”
BackgroundInfluentialProfiling peripheral micro RNA s in obesity and type 2 diabetes mellitus
Wu, L., Dai, X., Zhan, J., Zhang, Y., Zhang, H., Zhang, H., Zeng, S.-H., & Xi, W. (2015) · Apmis · doi:10.1111/apm.12389 · Cited by 55 · see citing works
“The miRNA expression can be modulated through various pathways including transcription factors and processing precursors (6).”
BackgroundPosttranscriptional regulation of lipid metabolism by non-coding RNAs and RNA binding proteins
Singh, A. K., Aryal, B. K., Zhang, X., Fan, Y., Price, N. L., Suárez, Y., & Fernandez-Hernando, C. F. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.11.026 · Cited by 54 · see citing works
“Dysregulation of miRNA expression or genetic variants associated with miRNAs or miRNA binding site loci have been associated with cardiometabolic diseases such as obesity, insulin resistance and atherosclerosis [6, 7].”
BackgroundSelf-citationYan, Y., Salazar, T. E., Dominguez, J. M., Nguyen, D. V., Calzi, S. L., Bhatwadekar, A. D., Qi, X., Busik, J. V., Boulton, M. E., & Grant, M. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080029 · Cited by 54 · see citing works
“Several studies demonstrated an important role of miRNA in metabolic regulation[47] and aging[48,49].”
BackgroundNon-coding RNAs in Lipid Metabolism
Zhang, X.-B., Price, N., & Fernández-Hernando, C. (2018) · Vascular pharmacology · doi:10.1016/j.vph.2018.06.011 · Cited by 52 · see citing works
“metabolism and promising therapeutic targets for the treatment of CVD [8, 10-13].”
Role of microRNA-30c in lipid metabolism, adipogenesis, cardiac remodeling and cancer
Irani, S., & Hussain, M. M. (2015) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000162 · Cited by 50 · see citing works
Zhu, Z., Xu, Y., Su, Q.-J., Du, J., Tan, X.-L., Tu, Y., Tan, J.-W., & Jiao, H.-B. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1897-y · Cited by 49 · see citing works
microRNAs: A connection between cholesterol metabolism and neurodegeneration
Goedeke, L., & Fernandez-Hernando, C. F. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.05.034 · Cited by 49 · see citing works
“…cholesterol levels (i.e. SREBPs), work over the last few years has uncovered a critical role for miRNAs in controlling cholesterol homeostasis (Fernandez-Hernando et al, 2013; Fernandez-Hernando et al, 2011; Moore et al, 2010). miRNAs are small (~22 nucleotide) single-stranded, noncoding…”
BackgroundSelf-citationMicroRNA as Crucial Regulators of Gene Expression in Estradiol-Treated Human Endothelial Cells
Vidal‐Gómez, X., Pérez‐Cremades, D., Mompeón, A., Dantas, A. P., Novella, S., & Hermenegildo, C. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000487910 · Cited by 49 · see citing works
Kontaraki, J. E., Marketou, M. E., PARTHENAKIS, F. I., Maragkoudakis, S., Zacharis, E. A., Petousis, S., KOCHIADAKIS, G. E., & Vardas, P. E. (2015) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2015.07.013 · Cited by 48 · see citing works
Analysis of Serum miRNA Profiles of Myasthenia Gravis Patients
Nogales‐Gadea, G., Fransi, A. R., Suárez‐Calvet, X., Navas‐Madroñal, M., Rojas‐García, R., Mosquera, J. L., Díaz‐Manera, J., Querol, L., Gallardo, E., & Illa, I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091927 · Cited by 48 · see citing works
“These molecules are key in several cellular functions, and changes in their expression patterns have been associated with several diseases [19,20,21,22].”
BackgroundBiological roles of microRNAs in the control of insulin secretion and action
Caldérari, S., Diawara, M. R., Garaud, A., & Gauguier, D. (2016) · Physiological Genomics · doi:10.1152/physiolgenomics.00079.2016 · Cited by 47 · see citing works
“Particular attention has focused on mechanisms associated with altered expression of miR-122, miR-33a, miR-33b, and Let-7, which illustrate specific aspects of miRNA biology (17, 71).”
BackgroundInsight into miRNAs related with glucometabolic disorder
Zhang, B., Shen, C., Zhu, B.-W., An, H., Zheng, B. J., Xu, S., Sun, J., Sun, P.-C., Zhang, W., Wang, J., et al. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.123 · Cited by 47 · see citing works
Giardina, S., Hernández‐Alonso, P., Díaz‐López, A., Salas‐Huetos, A., Salas‐Salvadó, J., & Bulló, M. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.11.014 · Cited by 47 · see citing works
Mechanisms contributing to adverse outcomes of COVID-19 in obesity
Sudhakar, M., Beaula, W. S., Meiyazhagan, G., & Parvathi, V. D. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04356-w · Cited by 48 · see citing works
MicroRNAs in cardiovascular ageing
Seeger, T., & Boon, R. A. (2015) · The Journal of Physiology · doi:10.1113/jp270557 · Cited by 46 · see citing works
“The role of miRs in these age-associated diseases is reviewed in Fernández-Hernando et al. (2013), Paneni et al. (2013) and Beltrami et al. (2014).”
BackgroundWang, H., Yan, C., Shi, X., Zheng, J., Deng, L., Yang, L., Yu, F., Yang, Y., & Shao, Y. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.02.013 · Cited by 43 · see citing works
“MicroRNAs (miRNAs) are endogenous single-stranded non-coding RNA that regulate gene expression by base pairing with target mRNAs, leading to mRNA cleavage or translational repression [7,8].”
BackgroundRetractedChung, J., Kim, K. H., Yu, N., An, S. H., Lee, S., & Kwon, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031314 · Cited by 43 · see citing works
MiR-486 regulates cholesterol efflux by targeting HAT1
Liu, D., Zhang, M., Xie, W., Lan, G., Cheng, H., Gong, D., Huang, C., Lv, Y.-C., Yao, F., Tan, Y. L., et al. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.11.128 · Cited by 42 · see citing works
Noncoding RNAs in Regulation of Cancer Metabolic Reprogramming
Yang, D., Sun, L., Li, Z., & Gao, P. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-1498-7_7 · Cited by 42 · see citing works
Identification of microRNA that represses IRS-1 expression in liver
Ono, K., Igata, M., Kondo, T., Kitano, S., Takaki, Y., Hanatani, S., Sakaguchi, M., Goto, R., Senokuchi, T., Kawashima, J., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191553 · Cited by 42 · see citing works
Baselga‐Escudero, L., Bladé, C., Ribas‐Latre, A., Casanova, E., Salvadó, M. J., Arola, L., & Arola‐Arnal, A. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.09.014 · Cited by 41 · see citing works
“In the latter, miR-33 [10,11] and miR-122 [10] have emerged as key regulators of lipid metabolism in the liver and have been related to metabolic disease [12].”
BackgroundOrtega, R., Liu, B., & Persaud, S. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310777 · Cited by 41 · see citing works
Posadas‐Sánchez, R., Pérez‐Hernández, N., Rodrı́guez-Pérez, J. M., Coral‐Vázquez, R. M., Roque‐Ramírez, B., Llorente, L., Lima, G., Flores-Domı́nguez, C., Villarreal-Molina, M. T., Posadas‐Romero, C., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16223 · Cited by 40 · see citing works
“They participate in the regulation of lipid metabolism, insulin biosynthesis, adipogenesis, endothelial dysfunction, neoangiogenesis, plaque development and rupture, as well as glucose homeostasis, among others [26-27].”
BackgroundIRS-2 Partially Compensates for the Insulin Signal Defects in IRS-1−/− Mice Mediated by miR-33
Tang, C.-Y., Man, X., Guo, Y., Tang, H., Tang, J., Zhou, C., Tan, S., Wang, M., & Zhou, H. (2017) · Molecules and Cells · doi:10.14348/molcells.2017.2228 · Cited by 39 · see citing works
“In addition, miRNAs lead dominant roles in cellular differentiation, proliferation, apoptosis, cholesterol biosynthesis, and cancer development (Fernandez-Hernando et al., 2013).”
Daimiel, L., Micó, V., Valls, R. M., Pedret, A., Motilva, M., Rubió, L., Fitó, M., Farràs, M., Covas, M. I., Solà, R., et al. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000049 · Cited by 39 · see citing works
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Protocols for the Analysis of microRNA Expression, Biogenesis, and Function in Immune Cells
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Profiling the rainbow trout hepatic miRNAome under diet-induced hyperglycemia
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“Given that hepatic miRNAs have emerged as important regulators of hepatic glucose metabolism (37, 48) and are indeed markers (26, 27, 36, 82) and functional contributors (22, 63, 65) of GI in mammalian models of metabolic disease by targeting intermediary metabolic pathways of glucose and lipid metabolism and/or upstr…”
BackgroundPosttranscriptional Regulation of Insulin Resistance: Implications for Metabolic Diseases
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“MiRNAs (miRs) are a class of small non-coding RNAs measuring 18–25 nucleotides in length that regulate gene expression at the posttranscriptional level and have an important role in many basic biological functions such as cell growth, differentiation, development, and apoptosis [73,74].”
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“In the current study, miR-33a expression was observed to be upregulated, whilst the expression levels of ABCA1 and ABCG1 were reduced in the liver tissues of HLP rats, which further supports that ABCA1 and ABCG1 are the miR-33a target genes.”
InfluentialMicroRNA and Diabetic Complications: A Clinical Perspective
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“These changes can lead to overproduction and accumulation of extracellular matrix (ECM) culminating in fibrosis (51, 90).”
- Authors
- Fernández-Hernando, C., Ramírez, C. M., Goedeke, L., & Suárez, Y.
- Affiliations
- From the Departments of Medicine and Cell Biology, Leon H. Charney Division of Cardiology and the Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, NY.
- New York University (US)
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2013-02
- Volume
- 33
- Issue
- 2
- Pages
- 178-185
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- PMC
- PMC3740757
- OpenAlex
- W2042714431
- Cited by
- 257
- References
- 67
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 12 · 2023: 12 · 2022: 21 · 2021: 15 · 2020: 18 · 2019: 21 · 2018: 24 · 2017: 25 · 2016: 21 · 2015: 21 · 2014: 30 · 2013: 21
- FWCI
- 10.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL105945, R01HL106063, R01HL107953)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- microRNA, metabolic disorders, lipid homeostasis, glucose homeostasis, type 2 diabetes, atherosclerosis, miR-33, SREBP, miR-122, cholesterol biosynthesis, lipoprotein secretion, liver, cholesterol export, fatty acid degradation, miRNA-based therapy
- MeSH terms
- Animals, Gene Expression Regulation, Glucose, Homeostasis, Humans, Insulin, Metabolic Diseases, Genetic Therapy, Signal Transduction, MicroRNAs, Carbohydrate Metabolism, Lipid Metabolism
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