Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease

Bile salt biotransformations by human intestinal bacteria

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The Lipid Research Clinics Coronary Primary Prevention Trial Results: I. Reduction in Incidence of Coronary Heart Disease

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Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

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Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

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A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

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Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice

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TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

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Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

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Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR

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A G Protein-coupled Receptor Responsive to Bile Acids

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Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

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The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

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Vitamin D Receptor As an Intestinal Bile Acid Sensor

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Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

Inagaki, T., Moschetta, A., Lee, Y.-K., Peng, L., Zhao, G., Downes, M., Yu, R. T., Shelton, J. M., Richardson, J. A., Repa, J. J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509592103 · Cited by 1,164 · see citing works

Consequences of bile salt biotransformations by intestinal bacteria

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Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity

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FXR is a molecular target for the effects of vertical sleeve gastrectomy

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Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease

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Farnesoid X receptor is essential for normal glucose homeostasis

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Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

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Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

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Human Bile Salt Export Pump Promoter Is Transactivated by the Farnesoid X Receptor/Bile Acid Receptor

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Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1

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Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

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Glucose Sensing in L Cells: A Primary Cell Study

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Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

Swann, J. R., Want, E. J., Geier, F. M., Spagou, K., Wilson, I. D., Sidaway, J. E., Nicholson, J. K., & Holmes, E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006734107 · Cited by 726 · see citing works

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

Li, F., Jiang, C., Krausz, K. W., Li, Y., Albert, I., Hao, H., Fabre, K. M., Mitchell, J. B., Patterson, A. D., & Gonzalez, F. J. (2013) · Nature Communications · doi:10.1038/ncomms3384 · Cited by 705 · see citing works

Bile acid receptors as targets for drug development

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Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Jiang, C., Xie, C., Li, F., Zhang, L., Nichols, R. G., Krausz, K. W., Cai, J., Qi, Y., Fang, Z.-Z., Takahashi, S., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76738 · Cited by 693 · see citing works

Regulation of metabolism by the innate immune system

Lackey, D. E., & Olefsky, J. M. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.189 · Cited by 667 · see citing works

The bile acid receptor FXR is a modulator of intestinal innate immunity

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FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

Kir, S., Beddow, S. A., Samuel, V. T., Miller, P., Previs, S. F., Suino-Powell, K., Xu, H. E., Shulman, G. I., Kliewer, S. A., & Mangelsdorf, D. J. (2011) · Science · doi:10.1126/science.1198363 · Cited by 637 · see citing works

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

Pols, T. W. H., Nomura, M., Harach, T., Sasso, G. L., Oosterveer, M. H., Thomas, C., Rizzo, G., Gioiello, A., Adorini, L., Pellicciari, R., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.11.006 · Cited by 622 · see citing works

Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut

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Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism

Patti, M., Houten, S. M., Bianco, A. C., Bernier, R., Larsen, P. R., Holst, J. J., Badman, M. K., Maratos‐Flier, E., Mun, E. C., Pihlajamaki, J., et al. (2009) · Obesity · doi:10.1038/oby.2009.102 · Cited by 591 · see citing works

Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity

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Fibroblast Growth Factor 19 Increases Metabolic Rate and Reverses Dietary and Leptin-Deficient Diabetes

Fu, L., John, L. M., Adams, S. H., Yu, X. X., Tomlinson, E., Renz, M. E., Williams, P. M., Soriano, R. H., Corpuz, R. T., Moffat, B., et al. (2004) · Endocrinology · doi:10.1210/en.2003-1671 · Cited by 580 · see citing works

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

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The Farnesoid X Receptor Modulates Adiposity and Peripheral Insulin Sensitivity in Mice

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Nutrient-sensing nuclear receptors coordinate autophagy

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The G-Protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice

Wang, Y., Chen, W., Yu, D. D., FORMAN, B. M., & Huang, W. (2011) · Hepatology · doi:10.1002/hep.24525 · Cited by 488 · see citing works

Microbiota-induced obesity requires farnesoid X receptor

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A biosynthetic pathway for a prominent class of microbiota-derived bile acids

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Human Insulin Resistance Is Associated With Increased Plasma Levels of 12α-Hydroxylated Bile Acids

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The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

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Transcriptional regulation of autophagy by an FXR–CREB axis

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Expression and function of the bile acid receptor TGR5 in Kupffer cells

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Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

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A Chemical, Genetic, and Structural Analysis of the Nuclear Bile Acid Receptor FXR

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Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease

Mouzaki, M., Wang, A. Y., Bandsma, R., Comelli, E. M., Arendt, B. M., Zhang, L., Fung, S., Fischer, S. E., McGilvray, I. G., & Allard, J. P. (2016) · PLOS ONE · doi:10.1371/journal.pone.0151829 · Cited by 385 · see citing works

The role of bile after Roux-en-Y gastric bypass in promoting weight loss and improving glycaemic control

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The TGR5 receptor mediates bile acid–induced itch and analgesia

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Bile Acids Regulate Gluconeogenic Gene Expression via Small Heterodimer Partner-mediated Repression of Hepatocyte Nuclear Factor 4 and Foxo1

Yamagata, K., Daitoku, H., Shimamoto, Y., Matsuzaki, H., Hirota, K., Ishida, J., & Fukamizu, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314322200 · Cited by 363 · see citing works

Pregnane X Receptor (PXR), Constitutive Androstane Receptor (CAR), and Benzoate X Receptor (BXR) Define Three Pharmacologically Distinct Classes of Nuclear Receptors

Moore, L. B., Maglich, J. M., McKee, D. D., Wisely, B., Willson, T. M., Kliewer, S. A., Lambert, M. H., & Moore, J. T. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.5.0828 · Cited by 356 · see citing works

Microbiota Modification with Probiotics Induces Hepatic Bile Acid Synthesis via Downregulation of the Fxr-Fgf15 Axis in Mice

Degirolamo, C., Rainaldi, S., Bovenga, F., Murzilli, S., & Moschetta, A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.032 · Cited by 356 · see citing works

Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein–Coupled Bile Acid Receptors

Brighton, C. A., Rievaj, J., Kuhre, R. E., Glasssmith, L. L., Schoonjans, K., Holst, J. J., Gribble, F. M., & Reimann, F. M. (2015) · Endocrinology · doi:10.1210/en.2015-1321 · Cited by 355 · see citing works

Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial

Reijnders, D., Goossens, G. H., Hermes, G. D. A., Neis, E. P. J. G., van der Beek, C. M., Most, J., Holst, J. J., Lenaerts, K., Kootte, R. S., Nieuwdorp, M., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.016 · Cited by 351 · see citing works

Farnesoid X-Activated Receptor Induces Apolipoprotein C-II Transcription: a Molecular Mechanism Linking Plasma Triglyceride Levels to Bile Acids

Kast-Woelbern, H. R., Nguyen, C., Sinal, C. J., Jones, S. A., Laffitte, B. A., Reue, K., Gonzalez, F. J., Willson, T. M., & Edwards, P. A. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.10.0712 · Cited by 337 · see citing works

Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis

Ferslew, B. C., Xie, G., Johnston, C., Su, M., Stewart, P. W., Jia, W. P., Brouwer, K. L. R., & Barritt, A. S. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3776-8 · Cited by 336 · see citing works

FXR Acetylation Is Normally Dynamically Regulated by p300 and SIRT1 but Constitutively Elevated in Metabolic Disease States

Kemper, J. K., Xiao, Z., Ponugoti, B., Miao, J., Fang, S., Kanamaluru, D., Tsang, S., Wu, S.-Y., Chiang, C.-M., & Veenstra, T. D. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.009 · Cited by 332 · see citing works

Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity

Mueller, M., Thorell, A., Claudel, T., Jha, P., Köfeler, H. C., Lackner, C., Hoesel, B., Fauler, G., Stojaković, T., Einarsson, C., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2014.12.034 · Cited by 314 · see citing works

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans

Takahashi, S., Fukami, T., Masuo, Y., Brocker, C. N., Xie, C., Krausz, K. W., Wolf, C. R., Henderson, C. J., & Gonzalez, F. J. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m071183 · Cited by 314 · see citing works

Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTα-OSTβ in cholestasis in humans and rodents

Boyer, J. L., Trauner, M. A., Mennone, A., Soroka, C. J., Cai, S., Moustafa, T., Zollner, G., Lee, J., & Ballatori, N. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00539.2005 · Cited by 305 · see citing works

Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element

Claudel, T., Sturm, E., Duez, H., Pineda‐Torra, I., Sirvent, A., Kosykh, V., Fruchart, J., Dallongeville, J., Hum, D. W., Kuipers, F., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14505 · Cited by 301 · see citing works

Regulation of Carbohydrate Metabolism by the Farnesoid X Receptor

Stayrook, K. R., Bramlett, K. S., Savkur, R. S., FICORILLI, J. V., Cook, T. G., Christe, M. E., Michael, L. F., & Burris, T. P. (2004) · Endocrinology · doi:10.1210/en.2004-0965 · Cited by 288 · see citing works

Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element

Claudel, T., Sturm, E., Duez, H., Pineda‐Torra, I., Sirvent, A., Kosykh, V., Fruchart, J., Dallongeville, J., Hum, D. W., Kuipers, F., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214505 · Cited by 280 · see citing works

Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass

Dirksen, C., Jørgensen, N. B., Bojsen-Møller, K. N., Kielgast, U., Jacobsen, S. H., Clausen, T. R., Worm, D., Hartmann, B., Rehfeld, J. F., Damgaard, M., et al. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.15 · Cited by 276 · see citing works

Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression

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Weight loss induced by Roux-en-Y gastric bypass but not laparoscopic adjustable gastric banding increases circulating bile acids

Kohli, R., Bradley, D., Setchell, K. D., Eagon, J. C., Abumrad, N., & Klein, S. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3736 · Cited by 265 · see citing works

The Farnesoid X Receptor Modulates Hepatic Carbohydrate Metabolism during the Fasting-Refeeding Transition

Durán-Sandoval, D., Cariou, B., Percevault, F., Hennuyer, N., Grefhorst, A., van Dijk, T. H., Gonzalez, F. J., Fruchart, J., Kuipers, F., & Staels, B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501931200 · Cited by 241 · see citing works

FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis

Verbeke, L., Mannaerts, I., Schierwagen, R., Govaere, O., Klein, S., Vander Elst, I., Windmolders, P., Farre, R., Wenes, M., Mazzone, M., et al. (2016) · Scientific Reports · doi:10.1038/srep33453 · Cited by 236 · see citing works

Bile acid-induced negative feedback regulation of the human ileal bile acid transporter

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