Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice

FGF-21 as a novel metabolic regulator

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Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

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FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

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Acute liver failure

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Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

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Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

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The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

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The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21

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High Sensitivity of Nrf2 Knockout Mice to Acetaminophen Hepatotoxicity Associated with Decreased Expression of ARE-Regulated Drug Metabolizing Enzymes and Antioxidant Genes

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Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease

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FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

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Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury

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Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes

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C-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity

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Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21

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Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride

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Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity

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Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver

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Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice

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Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3′-hydroxyacetanilide, in mouse liver

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Current issues with acetaminophen hepatotoxicity—A clinically relevant model to test the efficacy of natural products

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Fibroblast growth factor 21: from pharmacology to physiology

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PGC-1 coactivators in the control of energy metabolism

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p53 Orchestrates the PGC-1α-Mediated Antioxidant Response Upon Mild Redox and Metabolic Imbalance

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Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice

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c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice

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Fibroblast Growth Factor 21 Reduces the Severity of Cerulein-Induced Pancreatitis in Mice

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Growth Hormone Induces Hepatic Production of Fibroblast Growth Factor 21 through a Mechanism Dependent on Lipolysis in Adipocytes

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FGF21 Is Increased by Inflammatory Stimuli and Protects Leptin-Deficient ob/ob Mice from the Toxicity of Sepsis

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Distinct Changes in Serum Fibroblast Growth Factor 21 Levels in Different Subtypes of Diabetes

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Transcribe to Survive: Transcriptional Control of Antioxidant Defense Programs for Neuroprotection in Parkinson’s Disease

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Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury†

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Aldo-keto reductase-7A protects liver cells and tissues from acetaminophen-induced oxidative stress and hepatotoxicity

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Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions

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The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic

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Metabolic messengers: FGF21

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Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice

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FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases

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Fibroblast growth factor 21 (FGF21) inhibits macrophage-mediated inflammation by activating Nrf2 and suppressing the NF-κB signaling pathway

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Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat

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FGF21 agonists: An emerging therapeutic for metabolic dysfunction-associated steatohepatitis and beyond

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FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1–7) Axis in Mice

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FGF21: A Novel Regulator of Glucose and Lipid Metabolism and Whole-Body Energy Balance

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FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases

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Cardioprotective effects of fibroblast growth factor 21 against doxorubicin-induced toxicity via the SIRT1/LKB1/AMPK pathway

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Minireview: Roles of Fibroblast Growth Factors 19 and 21 in Metabolic Regulation and Chronic Diseases

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Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress

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Up-regulation of Nrf2 is involved in FGF21-mediated fenofibrate protection against type 1 diabetic nephropathy

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Plasma Fibroblast Growth Factor 21 Is Associated With Severity of Nonalcoholic Steatohepatitis in Patients With Obesity and Type 2 Diabetes

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Fibroblast growth factor 21 attenuates hepatic fibrogenesis through TGF-β/smad2/3 and NF-κB signaling pathways

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Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic diet

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Lipometabolism and Glycometabolism in Liver Diseases

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Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity

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Circulating Fibroblast Growth Factor 21 Levels Predict Progressive Kidney Disease in Subjects With Type 2 Diabetes and Normoalbuminuria

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Urolithin A protects against acetaminophen-induced liver injury in mice via sustained activation of Nrf2

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Current status and future perspectives of FGF21 analogues in clinical trials

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The Ameliorative Effects of Saikosaponin in Thioacetamide-Induced Liver Injury and Non-Alcoholic Fatty Liver Disease in Mice

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Formononetin protects against acetaminophen-induced hepatotoxicity through enhanced NRF2 activity

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Fibroblast Growth Factor 21 Protects against Atherosclerosis via Fine-Tuning the Multiorgan Crosstalk

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Fibroblast Growth Factor 21 Mediates Glycemic Regulation by Hepatic JNK

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PGC-1α loss promotes mitochondrial protein lactylation in acetaminophen-induced liver injury via the LDHB-lactate axis

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Macrophage Signaling Pathways in Health and Disease: From Bench to Bedside Applications

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FGF21 Response to Critical Illness: Effect of Blood Glucose Control and Relation With Cellular Stress and Survival

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Carnosic acid protects against acetaminophen-induced hepatotoxicity by potentiating Nrf2-mediated antioxidant capacity in mice

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FGF21 alleviates acute liver injury by inducing the SIRT1‐autophagy signalling pathway

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Role of Circulating Fibroblast Growth Factor 21 Measurement in Primary Prevention of Coronary Heart Disease Among Chinese Patients With Type 2 Diabetes Mellitus

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Association between Circulating Fibroblast Growth Factor 21 and Aggressiveness in Thyroid Cancer

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Liver-derived FGF21 is essential for full adaptation to ketogenic diet but does not regulate glucose homeostasis

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PPAR-γ Activation Alleviates Osteoarthritis through Both the Nrf2/NLRP3 and PGC-1α/Δψm Pathways by Inhibiting Pyroptosis

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Short-Term Curcumin Gavage Sensitizes Insulin Signaling in Dexamethasone-Treated C57BL/6 Mice

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FGF21 is induced in cisplatin nephrotoxicity to protect against kidney tubular cell injury

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FGF21 and autophagy coordinately counteract kidney disease progression during aging and obesity

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Natural Products for Acetaminophen-Induced Acute Liver Injury: A Review

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The Ameliorative Effects of Fucoidan in Thioacetaide-Induced Liver Injury in Mice

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FGF21 ameliorates septic liver injury by restraining proinflammatory macrophages activation through the autophagy/HIF-1α axis

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Engineered fibroblast growth factor 19 protects from acetaminophen-induced liver injury and stimulates aged liver regeneration in mice

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Mitochondria in Acetaminophen-Induced Liver Injury and Recovery: A Concise Review

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The cholic acid extension study in Zellweger spectrum disorders: Results and implications for therapy

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Hepatic PRMT1 ameliorates diet-induced hepatic steatosis via induction of PGC1α

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Circulating Fibroblast Growth Factor 21 Is A Sensitive Biomarker for Severe Ischemia/reperfusion Injury in Patients with Liver Transplantation

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Loss of FGF21 in diabetic mouse during hepatocellular carcinogenetic transformation.

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Advances of Fibroblast Growth Factor/Receptor Signaling Pathway in Hepatocellular Carcinoma and its Pharmacotherapeutic Targets

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Diacerein protects liver against APAP-induced injury via targeting JNK and inhibiting JNK-mediated oxidative stress and apoptosis

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Diverse Changes of Circulating Fibroblast Growth Factor 21 Levels in Hepatitis B Virus-Related Diseases

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Chronic activation of PPARα with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21

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Acetaminophen Responsive miR-19b Modulates SIRT1/Nrf2 Signaling Pathway in Drug-Induced Hepatotoxicity

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Loss of pigment epithelium-derived factor leads to ovarian oxidative damage accompanied by diminished ovarian reserve in mice

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Hepatocyte-Secreted Autotaxin Exacerbates Nonalcoholic Fatty Liver Disease Through Autocrine Inhibition of the PPARα/FGF21 Axis

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FGF21 functions as a sensitive biomarker of APAP-treated patients and mice

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Fibroblast growth factor 21 deletion aggravates diabetes-induced pathogenic changes in the aorta in type 1 diabetic mice

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Long-Term Administration of Fibroblast Growth Factor 21 Prevents Chemically-Induced Hepatocarcinogenesis in Mice

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Brite Adipocyte FGF21 Attenuates Cardiac Ischemia/Reperfusion Injury in Rat Hearts by Modulating NRF2

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FGF21 mediates the protective effect of fenofibrate against acetaminophen -induced hepatotoxicity via activating autophagy in mice

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GADD45α alleviates acetaminophen-induced hepatotoxicity by promoting AMPK activation

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FGF21 mediates the protective effect of fenofibrate against acetaminophen -induced hepatotoxicity via activating autophagy in mice

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FGF1 protects against APAP-induced hepatotoxicity via suppression of oxidative and endoplasmic reticulum stress

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Fructose Protects Against Acetaminophen‐Induced Hepatotoxicity Mainly by Activating the Carbohydrate‐Response Element‐Binding Protein α–Fibroblast Growth Factor 21 Axis in Mice

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Fibroblast growth factor 15 deficiency increases susceptibility but does not improve repair to acetaminophen-induced liver injury in mice

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PLGA nanoparticles encapsulating fibroblast growth factor 21 alleviate acetaminophen-induced acute liver injury

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