The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Immune tolerance in liver disease
Open accessAbstract
UNLABELLED: Liver tolerance is manifest as a bias toward immune unresponsiveness, both in the context of a major histocompatibility complex-mismatched liver transplant and in the context of liver infection. Two broad classes of mechanisms account for liver tolerance. The presentation of antigens by different liver cell types results in incomplete activation of CD8(+) T cells, usually leading to initial proliferation followed by either clonal exhaustion or premature death of the T cell. Many liver infections result in relatively poor CD4(+) T-cell activation, which may be because liver antigen-presenting cells express a variety of inhibitory cytokines and coinhibitor ligands. Poor CD4(+) T-cell activation by liver antigens likely contributes to abortive activation, exhaustion, and early death of CD8(+) T cells. In addition, a network of active immunosuppressive pathways in the liver is mediated mostly by myeloid cells. Kupffer cells, myeloid-derived suppressor cells, and liver dendritic cells both promote activation of regulatory T cells and suppress CD8(+) and CD4(+) effector T cells. This suppressive network responds to diverse inputs, including signals from hepatocytes, sinusoidal endothelial cells, and hepatic stellate cells. CONCLUSION: Though liver tolerance may be exploited by pathogens, it serves a valuable purpose. Hepatitis A and B infections occasionally elicit a powerful immune response sufficient to cause fatal massive liver necrosis. More commonly, the mechanisms of liver tolerance limit the magnitude of intrahepatic immune responses, allowing the liver to recover. The cost of this adaptive mechanism may be incomplete pathogen eradication, leading to chronic infection.
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Cites
Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help
Sun, J. C., & Bevan, M. J. (2003) · Science · doi:10.1126/science.1083317 · Cited by 1,213
Lazear, H. M., Lancaster, A., Wilkins, C., Suthar, M. S., Huang, A., Vick, S. C., Clepper, L., Thackray, L., Brassil, M. M., Virgin, H. W., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003118 · Cited by 296 · cited 4×
“In humans, classic mDCs (BDCA11) are present in the liver and depleted from the blood, but enriched in the liver in the context of HCV infection,25 where they undergo classic activation with increased expression of multiple costimulatory molecules.26 Human liver pDCs express BCDA2 and CD123 and respond to HCV to secre…”
BackgroundInfluentialHuang, L.-R., Wohlleber, D., Reisinger, F., Jenne, C. N., Cheng, R.-L., Abdullah, Z., Schildberg, F. A., Odenthal, M., Dienes, H.-P., van Rooijen, N., et al. (2013) · Nature Immunology · doi:10.1038/ni.2573 · Cited by 216
Antigen-Specific Primary Activation of CD8+ T Cells Within the Liver
Bertolino, P., Bowen, D. G., McCaughan, G. W., & Fazekas de St. Groth, B. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.9.5430 · Cited by 209
Limmer, A., Ohl, J., Wingender, G., Berg, M., Jüngerkes, F., Schumak, B., Djandji, D., Scholz, K., Klevenz, A., Hegenbarth, S., et al. (2005) · European Journal of Immunology · doi:10.1002/eji.200526034 · Cited by 169
Sène, D., Levasseur, F., Abel, M., Lambert, M., Camous, X., Hernandez, C., Pène, V., Rosenberg, A. R., Jouvin-Marche, E., Marche, P. N., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001184 · Cited by 113
Human Hepatic Stellate Cells Inhibit T-Cell Response Through B7-H1 Pathway
Charles, R., Chou, H.-S., Wang, L., Fung, J. J., Lu, L., & Qian, S. (2013) · Transplantation · doi:10.1097/tp.0b013e318294caae · Cited by 72
Yang, H., Chou, H., Gu, X., Wang, L., Brown, K. E., Fung, J. J., Lu, L., & Qian, S. (2009) · Hepatology · doi:10.1002/hep.23202 · Cited by 71
Liu, H., Bakthavatsalam, R., Meng, Z., Li, Z., Li, W., Perkins, J. D., & Reyes, J. (2013) · Transplantation Proceedings · doi:10.1016/j.transproceed.2013.03.015 · Cited by 45
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Top 10 Challenges in Cancer Immunotherapy
Hegde, P. S., & Chen, D. S. (2020) · Immunity · doi:10.1016/j.immuni.2019.12.011 · Cited by 2,238
Liver immunology and its role in inflammation and homeostasis
Robinson, M. W., Harmon, C., & O’Farrelly, C. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2016.3 · Cited by 1,151
Andrade, R. J., Chalasani, N., Björnsson, E. S., Suzuki, A., Kullak-Ublick, G. A., Watkins, P. B., Devarbhavi, H., Merz, M., Lucena, M. I., Kaplowitz, N., et al. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0105-0 · Cited by 924
Adaptive immunity: an emerging player in the progression of NAFLD
Sutti, S., & Albano, E. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0210-2 · Cited by 374
IL-2high tissue-resident T cells in the human liver: Sentinels for hepatotropic infection
Pallett, L. J., Davies, J., Colbeck, E. J., Robertson, F., Hansi, N., Easom, N. J. W., Burton, A. R., Stegmann, K. A., Schurich, A., Swadling, L., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162115 · Cited by 347
Metadata
- Authors
- Crispe, I. N.
- Venue
- Hepatology
- Published
- 2014-09-26
- Volume
- 60
- Issue
- 6
- Pages
- 2109-2117
- ISSN
- 0270-9139 (ISSN-L)
- 1527-3350
- OpenAlex
- W2137969636
- Cited by
- 275
- References
- 9
- FWCI
- 8.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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