Angiocrine signaling in the hepatic sinusoids in health and disease
Open accessAbstract
The capillary network irrigating the liver is important not only for nutrient and oxygen delivery, but also for the signals distributed to other hepatic cell types necessary to maintain liver homeostasis. During development, endothelial cells are a key component in liver zonation. In adulthood, they maintain hepatic stellate cells and hepatocytes in quiescence. Their importance in pathobiology is highlighted in liver regeneration and chronic liver diseases, where they coordinate paracrine cell behavior. During regeneration, liver sinusoidal endothelial cells induce hepatocyte proliferation and angiogenesis. During fibrogenesis, they undergo morphological and functional changes, which are reflected by their role in hepatic stellate cell activation, inflammation, and distorted sinusoidal structure. Therapeutic strategies to target angiocrine signaling are in progress but are in the early stages. Here, we offer a short synthesis of recent studies on angiocrine signaling in liver homeostasis, regeneration, and fibrogenesis.
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Endothelial cells play a crucial role in homeostasis in the liver.
“Endothelial cells play a crucial role in homeostasis in the liver [285, 286].”
From Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells (2025) · cites this paper as [286]
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- Authors
- Kostallari, E., & Shah, V. H.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Shah, Vijay H.
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 2016-08-01
- Volume
- 311
- Issue
- 2
- Pages
- G246-G251
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- PMC
- PMC5007289
- OpenAlex
- W2418919916
- Cited by
- 71
- References
- 66
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 16 · 2023: 9 · 2022: 6 · 2021: 12 · 2020: 4 · 2019: 4 · 2018: 7 · 2017: 3
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NIH (DK59615, AA21171)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- angiocrine signaling, liver sinusoidal endothelial cells, hepatic stellate cells, liver regeneration, liver fibrosis, liver homeostasis, paracrine signaling, hepatocyte proliferation, angiogenesis, chronic liver disease, inflammation, endothelial heterogeneity
- MeSH terms
- Animals, Capillaries, Humans, Liver, Liver Cirrhosis, Liver Regeneration, Phenotype, Signal Transduction, Paracrine Communication, Hepatocytes, Endothelial Cells, Hepatic Stellate Cells, Cellular Microenvironment
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