Cited by 72Liver physiology and pathologyAngiogenesis and VEGF in CancerOrgan Transplantation Techniques and Outcomes

Angiocrine signaling in the hepatic sinusoids in health and disease

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Kostallari, Enis, Shah, Vijay H.·2016·American Journal of Physiology-Gastrointestinal and Liver Physiology

Abstract

The capillary network irrigating the liver is important not only for nutrient and oxygen delivery, but also for the signals distributed to other hepatic cell types necessary to maintain liver homeostasis. During development, endothelial cells are a key component in liver zonation. In adulthood, they maintain hepatic stellate cells and hepatocytes in quiescence. Their importance in pathobiology is highlighted in liver regeneration and chronic liver diseases, where they coordinate paracrine cell behavior. During regeneration, liver sinusoidal endothelial cells induce hepatocyte proliferation and angiogenesis. During fibrogenesis, they undergo morphological and functional changes, which are reflected by their role in hepatic stellate cell activation, inflammation, and distorted sinusoidal structure. Therapeutic strategies to target angiocrine signaling are in progress but are in the early stages. Here, we offer a short synthesis of recent studies on angiocrine signaling in liver homeostasis, regeneration, and fibrogenesis.

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Crossref · 10.1152/ajpgi.00118.2016

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Authors
Kostallari, E., & Shah, V. H.
Affiliations
Mayo Clinic (US)
Corresponding author
Shah, Vijay H.
Venue
American Journal of Physiology-Gastrointestinal and Liver Physiology
Published
2016-08-01
Volume
311
Issue
2
Pages
G246-G251
ISSN
  • 0193-1857 (ISSN-L)
  • 1522-1547
OpenAlex
W2418919916
Cited by
71
References
66
Citations by year
2026: 5 · 2025: 5 · 2024: 16 · 2023: 9 · 2022: 6 · 2021: 12 · 2020: 4 · 2019: 4 · 2018: 7 · 2017: 3
FWCI
0.58
Type
journal article
Language
en
Open access
Locations
  • American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
NIH (DK59615, AA21171)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
Keywords
angiocrine signaling, liver sinusoidal endothelial cells, hepatic stellate cells, liver regeneration, liver fibrosis, liver homeostasis, paracrine signaling, hepatocyte proliferation, angiogenesis, chronic liver disease, inflammation, endothelial heterogeneity
MeSH terms
Animals, Capillaries, Humans, Liver, Liver Cirrhosis, Liver Regeneration, Phenotype, Signal Transduction, Paracrine Communication, Hepatocytes, Endothelial Cells, Hepatic Stellate Cells, Cellular Microenvironment

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