The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Activation of the p62–Keap1–NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells
Open accessAbstract
Ferroptosis is a recently recognized form of regulated cell death caused by an iron‐dependent accumulation of lipid reactive oxygen species. However, the molecular mechanisms regulating ferroptosis remain obscure. Here, we report that nuclear factor erythroid 2‐related factor 2 (NRF2) plays a central role in protecting hepatocellular carcinoma (HCC) cells against ferroptosis. Upon exposure to ferroptosis‐inducing compounds (e.g., erastin, sorafenib, and buthionine sulfoximine), p62 expression prevented NRF2 degradation and enhanced subsequent NRF2 nuclear accumulation through inactivation of Kelch‐like ECH‐associated protein 1. Additionally, nuclear NRF2 interacted with transcriptional coactivator small v‐maf avian musculoaponeurotic fibrosarcoma oncogene homolog proteins such as MafG and then activated transcription of quinone oxidoreductase‐1, heme oxygenase‐1, and ferritin heavy chain‐1. Knockdown of p62, quinone oxidoreductase‐1, heme oxygenase‐1, and ferritin heavy chain‐1 by RNA interference in HCC cells promoted ferroptosis in response to erastin and sorafenib. Furthermore, genetic or pharmacologic inhibition of NRF2 expression/activity in HCC cells increased the anticancer activity of erastin and sorafenib in vitro and in tumor xenograft models. Conclusion: These findings demonstrate novel molecular mechanisms and signaling pathways of ferroptosis; the status of NRF2 is a key factor that determines the therapeutic response to ferroptosis‐targeted therapies in HCC cells. (H epatology 2016;63:173–184)
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Phosphorylation of p62 initiates its interaction with E3 ligase KEAP1, therefore competing out alternate KEAP1 target Nrf2 and stabilizing Nrf2 signaling [102].”
From Acetylation: a new target for protein degradation in cancer (2025) · cites this paper as [102]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 55,044
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Sorafenib in advanced hepatocellular carcinoma
Llovet, J. M., Ricci, S., Mazzaferro, V., Hilgard, P., Gane, E., Blanc, J.-F., de Oliveira, A. C., Santoro, A., Raoul, J.-L., Forner, A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708857 · Cited by 13,097
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
A New Era of Systemic Therapy for Hepatocellular Carcinoma with Regorafenib and Lenvatinib
Kudo, M. (2017) · Liver Cancer · doi:10.1159/000462153 · Cited by 5,974
Sorafenib in Advanced Hepatocellular Carcinoma
정, 재. (2008) · Cited by 5,586
Role of nrf2 in oxidative stress and toxicity
Ma, Q. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140320 · Cited by 4,903
Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732
Ferroptosis as a p53-mediated activity during tumour suppression
Jiang, L., Kon, N., Li, T., Wang, S.-J., Su, T., Hibshoosh, H., Baer, R., & Gu, W. (2015) · Nature · doi:10.1038/nature14344 · Cited by 3,398
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 1,001
Li, D., Liu, X., Pi, W., Zhang, Y., Yu, L., Cheng, X., Sun, Z., & Jiang, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.808480 · Cited by 194
Nrf2 attenuates ferroptosis-mediated IIR-ALI by modulating TERT and SLC7A11
Dong, H., Xia, Y., Jin, S., Xue, C., Wang, Y., Hu, R., & Jiang, H. (2021) · Cell Death & Disease · doi:10.1038/s41419-021-04307-1 · Cited by 196
Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma
Zhang, X., Xu, Y., Ma, L., Yu, K., Niu, Y., Xu, X., Shi, Y. Y., Guo, S., Xue, X., Wang, Y., et al. (2022) · 癌症：英文版 · doi:10.1002/cac2.12275 · Cited by 198
Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential
Ding, X.-S., Gao, L., Han, Z., Eleuteri, S., Shi, W., Shen, Y., Song, Z.-Y., Su, M., Yang, Q., Qu, Y., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102077 · Cited by 211
Induction of ferroptosis and mitochondrial dysfunction by oxidative stress in PC12 cells
Wu, C., Zhao, W., Yu, J. Z., Li, S., Lin, L., & Chen, X. (2018) · Scientific Reports · doi:10.1038/s41598-017-18935-1 · Cited by 195
Zhang, P., Chen, L., Zhao, Q., Du, X., Bi, M., Li, Y. H., Jiao, Q., & Jiang, H. F. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.03.015 · Cited by 192
TMEM164 is a new determinant of autophagy-dependent ferroptosis
Liu, J., Liu, Y., Wang, Y., Li, C., Xie, Y., Klionsky, D. J., Kang, R., & Tang, D. (2022) · Autophagy · doi:10.1080/15548627.2022.2111635 · Cited by 195
Self-citationFeng, R., Morine, Y., Ikemoto, T., Imura, S., Iwahashi, S., Saito, Y., & Shimada, M. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0262-x · Cited by 195
Sun, J., Zhou, C., Zhao, Y., Zhang, X.-F., Chen, W., Zhou, Q., Hu, B., Gao, D., Raatz, L., Wang, Z., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101942 · Cited by 190
The BRD7-P53-SLC25A28 axis regulates ferroptosis in hepatic stellate cells
Zhang, Z., Guo, M. L., Shen, M., Kong, D., Zhang, F., Shao, J., Tan, S., Wang, S., Chen, A., Cao, P., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101619 · Cited by 190
Takahashi, N., Cho, P., Selfors, L. M., Kuiken, H. J., Kaul, R., Fujiwara, T., Harris, I. S., Zhang, T., Gygi, S. P., & Brugge, J. S. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.10.010 · Cited by 187
NRF2: KEAPing Tumors Protected
Pillai, R., Hayashi, M., Zavitsanou, A.-M., & Papagiannakopoulos, T. Y. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0922 · Cited by 196
Autophagy and Ferroptosis—What Is the Connection?
Kang, R., & Tang, D. (2017) · Current Pathobiology Reports · doi:10.1007/s40139-017-0139-5 · Cited by 186
Self-citationDysregulation of Nrf2 in Hepatocellular Carcinoma: Role in Cancer Progression and Chemoresistance
Raghunath, A., Sundarraj, K., Arfuso, F., Sethi, G., & Perumal, E. (2018) · Cancers · doi:10.3390/cancers10120481 · Cited by 187
RETRACTED: Ferroptosis is governed by differential regulation of transcription in liver cancer
Zhang, X., Du, L., Qiao, Y., Zhang, X., Zheng, W., Wu, Q., Chen, Y., Zhu, G., Liu, Y., Bian, Z., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101211 · Cited by 188
RetractedMa, L., Zhang, X., Yu, K., Xu, X., Chen, T., Shi, Y. Y., Wang, Y., Qiu, S., Guo, S., Cui, J., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.03.023 · Cited by 184
Potential Applications of NRF2 Inhibitors in Cancer Therapy
Panieri, E., & Saso, L. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8592348 · Cited by 189
Molecular Mechanisms of Ferroptosis and Relevance to Cardiovascular Disease
Xie, L., Fefelova, N., Pamarthi, S. H., & Gwathmey, J. K. (2022) · Cells · doi:10.3390/cells11172726 · Cited by 195
Iron Overload, Oxidative Stress, and Ferroptosis in the Failing Heart and Liver
Mancardi, D., Mezzanotte, M., Arrigo, E., Barinotti, A., & Roetto, A. (2021) · Antioxidants · doi:10.3390/antiox10121864 · Cited by 188
Genetic alterations in hepatocellular carcinoma: An update
Niu, Z.-S., Niu, X.-J., & Wang, W. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i41.9069 · Cited by 193
Self-citationFerroptosis and ferritinophagy in diabetes complications
He, J., Li, Z., Xia, P., Shi, A., FuChen, X., Zhang, J., & Yu, P. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101470 · Cited by 187
Jin, X., Tang, J., Qiu, X., Nie, X., Ou, S., Wu, G., Zhang, R., & Zhu, J. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01825-7 · Cited by 188
The p53 Tumor Suppressor in the Control of Metabolism and Ferroptosis
Gnanapradeepan, K., Basu, S., Barnoud, T., Budina-Kolomets, A., Kung, C.-P., & Murphy, M. E. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00124 · Cited by 181
Zhang, X., Yu, K., Ma, L., Qian, Z., Tian, X., Miao, Y., Niu, Y., Xu, X., Guo, S., Yang, Y., et al. (2021) · Theranostics · doi:10.7150/thno.55482 · Cited by 176
PPARα alleviates iron overload‐induced ferroptosis in mouse liver
Xing, G., Meng, L., Cao, S., Liu, S., Wu, J., Li, Q., Huang, W., & Zhang, L. (2022) · EMBO Reports · doi:10.15252/embr.202052280 · Cited by 179
New insights into antiangiogenic therapy resistance in cancer: Mechanisms and therapeutic aspects
Huang, M., Lin, Y., Wang, C., Deng, L., Chen, M., Assaraf, Y. G., Chen, Z., Ye, W., & Zhang, D. (2022) · Drug Resistance Updates · doi:10.1016/j.drup.2022.100849 · Cited by 179
Ferroptosis in Cancer Treatment: Another Way to Rome
Wu, Y., Yu, C., Luo, M., Chen, C., Qiu, J., Zhang, S., & Hu, K. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.571127 · Cited by 183
Tang, H., Chen, D., Li, C., Zheng, C., Wu, X., Zhang, Y., Song, Q., & Fei, W. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118782 · Cited by 175
Self-citationNCOA4-mediated ferritinophagy promotes ferroptosis induced by erastin, but not by RSL3 in HeLa cells
Gryzik, M., Asperti, M., Denardo, A., Arosio, P., & Poli, M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118913 · Cited by 177
Iron Dyshomeostasis and Ferroptosis: A New Alzheimer’s Disease Hypothesis?
Wang, F., Wang, J., Shen, Y., Li, H., Rausch, W., & Huang, X. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.830569 · Cited by 180
The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis
Deng, W., Zhu, S., Zeng, L., Liu, J., Kang, R., Yang, M., Cao, L., Wang, H., Billiar, T. R., Jiang, J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.026 · Cited by 173
Self-citationThe Nrf-2/HO-1 Signaling Axis: A Ray of Hope in Cardiovascular Diseases
Zhang, X., Yu, Y., Lei, H., Cai, Y., Shen, J., Zhu, P., He, Q., & Zhao, M. (2020) · Cardiology Research and Practice · doi:10.1155/2020/5695723 · Cited by 173
Ren, J., Li, C., Yan, X., Qu, Y., Yang, Y., & Guo, Z. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6643382 · Cited by 176
The molecular mechanisms of ferroptosis and its role in cardiovascular disease
Zhang, Y., Xin, L., Xiang, M., Shang, C., Wang, Y., Wang, Y., Cui, X., & Lu, Y. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112423 · Cited by 175
A promising new approach to cancer therapy: Targeting iron metabolism in cancer stem cells
El-Hout, M., Santos, L. D., Hamaï, A., & Mehrpour, M. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.07.009 · Cited by 173
ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma
Ji, F., Lu, P.-Z., Zhu, G., Hooi, S. C., Wu, Y., Huang, X., Dai, H.-Q., Chen, P.-H., Li, Z., Su, W., et al. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-0439-x · Cited by 170
Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges
Torrente, L., & DeNicola, G. M. (2021) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-052220-104025 · Cited by 175
Non-coding RNAs and ferroptosis: potential implications for cancer therapy
Balihodzic, A., Prinz, F., Dengler, M. A., Călin, G. A., Jost, P. J., & Pichler, M. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00998-x · Cited by 175
Wang, X., Shen, T., Lian, J., Deng, K., Qu, C., Li, E., Gan, L., Ren, Y., Wang, Z., Jiang, Z., et al. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00730-6 · Cited by 172
Self-citationRedox Responsive Metal Organic Framework Nanoparticles Induces Ferroptosis for Cancer Therapy
He, H., Du, L., Guo, H., An, Y., Lu, L., Chen, Y., Wang, Y., Zhong, H., Shen, J., Wu, J., et al. (2020) · Small · doi:10.1002/smll.202001251 · Cited by 162
Sun, Y., He, L., Wang, T., Wan, H., Qin, H., Wang, J., Wang, L., Gu, W., Li, T., Li, N., et al. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02049-3 · Cited by 163
Sang, M., Luo, R., Bai, Y., Dou, J., Zhang, Z., Liu, F., Feng, F., Xu, J., & Liu, W. (2019) · Theranostics · doi:10.7150/thno.36283 · Cited by 163
Nanoparticle-induced ferroptosis: detection methods, mechanisms and applications
Zheng, H., Jiang, J., Xu, S., Liu, W., Xie, Q., Cai, X., Zhang, J., Liu, S., & Li, R. (2021) · Nanoscale · doi:10.1039/d0nr08478f · Cited by 167
Li, L., Li, W., Zheng, X., Liu, Q., Du, Q., Lai, Y., & Liu, S. (2022) · Molecular Medicine · doi:10.1186/s10020-022-00442-3 · Cited by 164
The Relationship between Ferroptosis and Tumors: A Novel Landscape for Therapeutic Approach
Xia, X., Fan, X., Zhao, M., & Zhu, P. (2019) · Current Gene Therapy · doi:10.2174/1566523219666190628152137 · Cited by 161
Jiang, T., Cheng, H., Su, J., Wang, X., Wang, Q., Chu, J., & Li, Q. (2019) · Toxicology in Vitro · doi:10.1016/j.tiv.2019.104715 · Cited by 160
Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal
Nishizawa, H., Yamanaka, M., & Igarashi, K. (2022) · FEBS Journal · doi:10.1111/febs.16382 · Cited by 164
Mitochondria, cholesterol and cancer cell metabolism
Ribas, V., García‐Ruiz, C., & Fernández-Checa, J. C. (2016) · Clinical and Translational Medicine · doi:10.1186/s40169-016-0106-5 · Cited by 166
Golgi stress mediates redox imbalance and ferroptosis in human cells
Alborzinia, H., Ignashkova, T. I., Dejure, F. R., Gendarme, M., Theobald, J., Wölfl, S., Lindemann, R. K., & Reiling, J. H. (2018) · Communications Biology · doi:10.1038/s42003-018-0212-6 · Cited by 163
Li, Y., Yan, H., Xu, X., Liu, H., Wu, C., & Zhao, L. (2019) · Oncology Letters · doi:10.3892/ol.2019.11066 · Cited by 159
RRM2 protects against ferroptosis and is a tumor biomarker for liver cancer
Yang, Y., Lin, J., Guo, S., Xue, X., Wang, Y., Qiu, S., Cui, J., Ma, L., Zhang, X., & Wang, J. (2020) · Cancer Cell International · doi:10.1186/s12935-020-01689-8 · Cited by 159
To eat or not to eat — the metabolic flavor of ferroptosis
Gao, M., & Jiang, X. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.11.001 · Cited by 160
Nrf2 protects against seawater drowning-induced acute lung injury via inhibiting ferroptosis
Qiu, Y.-B., Wan, B.-B., Liu, G., Wu, Y., Chen, D., Lu, M., Chen, J., Yu, R., Chen, D., & Pang, Q. (2020) · Respiratory Research · doi:10.1186/s12931-020-01500-2 · Cited by 159
Self-citationFerroptosis and NRF2: an emerging battlefield in the neurodegeneration of Alzheimer's disease
Lane, D. J. R., Metselaar, B., Greenough, M., Bush, A. I., & Ayton, S. (2021) · Essays in Biochemistry · doi:10.1042/ebc20210017 · Cited by 160
Identification of PRDX6 as a regulator of ferroptosis
Lu, B., Chen, X., Hong, Y., Zhu, H., He, Q., Yang, B., Ying, M., & Cao, J. (2019) · Acta Pharmacologica Sinica · doi:10.1038/s41401-019-0233-9 · Cited by 160
Morris, G., Berk, M., Carvalho, A. F., Maes, M. H. J., Walker, A. J., & Puri, B. K. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.036 · Cited by 155
Ferroptosis and Liver Fibrosis
Pan, Q., Luo, Y., Xia, Q., & He, K. (2021) · International Journal of Medical Sciences · doi:10.7150/ijms.62903 · Cited by 155
Therapeutic Targets for DOX-Induced Cardiomyopathy: Role of Apoptosis vs. Ferroptosis
Kitakata, H., Endo, J., Ikura, H., Moriyama, H., Shirakawa, K., Katsumata, Y., & Sano, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031414 · Cited by 153
Ferroptosis: a double-edged sword mediating immune tolerance of cancer
Dang, Q., Sun, Z., Wang, Y., Wang, L., Liu, Z., & Han, X. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05384-6 · Cited by 155
Sui, M., Jiang, X., Chen, J., Yang, H., & Zhu, Y. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.06.060 · Cited by 152
Wang, L., Zhang, Z., Li, M., Wang, F., Jia, Y., Zhang, F., Shao, J., Chen, A., & Zheng, S. (2018) · IUBMB Life · doi:10.1002/iub.1895 · Cited by 152
Zhou, Y., Shen, Y., Chen, C., Sui, X., Yang, J., Wang, L., & Zhou, J. (2019) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2019.0158 · Cited by 157
Role of Ferroptosis in Lung Diseases
Xu, W., Deng, H., Hu, S., Zhang, Y., Li, Z., Liu, M., Chen, Y., Wei, J., Yang, H., & Lv, X. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s307081 · Cited by 155
Huang, W., Chen, K., Lu, Y., Zhang, D., Cheng, Y., Li, L., Huang, W., He, G., Liao, H., Cai, L., et al. (2021) · Neoplasia · doi:10.1016/j.neo.2021.11.002 · Cited by 154
Sigma‐1 receptor protects against ferroptosis in hepatocellular carcinoma cells
Bai, T., Lei, P., Zhou, H., Liang, R., Zhu, R., Wang, W., Zhou, L., & Sun, Y. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14594 · Cited by 152
Ferroptosis in hepatocellular carcinoma: mechanisms and targeted therapy
Ajoolabady, A., Tang, D., Kroemer, G., & Ren, J. T. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01998-x · Cited by 157
Self-citationChen, Q., Ma, X., Xie, L., Chen, W., Xu, Z., Song, E., Zhu, X., & Song, Y. (2021) · Nanoscale · doi:10.1039/d0nr08757b · Cited by 150
Self-Adaptive Single-Atom Catalyst Boosting Selective Ferroptosis in Tumor Cells
Cao, F., Sang, Y., Liu, C., Bai, F., Zheng, L., Ren, J., & Qu, X. (2022) · ACS Nano · doi:10.1021/acsnano.1c08464 · Cited by 150
The Nrf2 induction prevents ferroptosis in Friedreich's Ataxia
Rosa, P. L., Petrillo, S., Turchi, R., Berardinelli, F., Schirinzi, T., Vasco, G., Lettieri‐Barbato, D., Fiorenza, M. T., Bertini, E., Aquilano, K., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101791 · Cited by 150
Ferritinophagy and ferroptosis in cardiovascular disease: Mechanisms and potential applications
Qin, Y., Qiao, Y., Wang, D., Tang, C., & Yan, G. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111872 · Cited by 150
Mitochondrial Metabolic Signatures in Hepatocellular Carcinoma
Lee, H.-Y., Nga, H. T., Tian, J., & Yi, H. (2021) · Cells · doi:10.3390/cells10081901 · Cited by 152
Role and mechanism of ferroptosis in neurological diseases
Ou, M., Jiang, Y., Ji, Y., Zhou, Q., Du, Z., Zhu, H., & Zhou, Z. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101502 · Cited by 150
Xu, Y., Li, K., Zhao, Y., Zhou, L., Liu, Y., & Zhao, J. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01196-6 · Cited by 151
Immunogenic ferroptosis and where to find it?
Demuynck, R., Efimova, I., Naessens, F., & Krysko, D. V. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003430 · Cited by 154
Role of ferroptosis in the process of acute radiation-induced lung injury in mice
Li, X., Zhuang, X., & Qiao, T. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.08.165 · Cited by 142
Inhibition of ferroptosis attenuates busulfan-induced oligospermia in mice
Zhao, X., Liu, Z., Gao, J., Li, H., Wang, X., Li, Y., & Sun, F. (2020) · Toxicology · doi:10.1016/j.tox.2020.152489 · Cited by 144
Iron overload: Effects on cellular biochemistry
Nogueira, L. S., Oliveira, M. M., Pessoa, M. T., & Barbosa, L. A. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.11.029 · Cited by 149
The emerging role of ferroptosis in non-cancer liver diseases: hype or increasing hope?
Mao, L., Zhao, T., Song, Y., Lin, L., Fan, X., Cui, B., Feng, H., Wang, X., Yu, Q., Zhang, J., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2732-5 · Cited by 141
Targeting ferroptosis in pancreatic cancer: a double-edged sword
Chen, X., Kang, R., Kroemer, G., & Tang, D. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.04.005 · Cited by 143
Self-citationTranscription factor NRF2 as a promising therapeutic target for Alzheimer’s disease
Qu, Z., Sun, J., Zhang, W., Yu, J., & Zhuang, C. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.06.028 · Cited by 145
Wang, H., Liu, D., Zheng, B., Yang, Y., Qiao, Y., Li, S., Pan, S., Liu, Y., Feng, Q., & Liu, Z. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.81892 · Cited by 147
Zhang, X., Tang, B., Luo, J., Yang, Y., Weng, Q., Fang, S., Zhao, Z., Tu, J., Chen, M., & Ji, J. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02130-8 · Cited by 148
MicroRNA-214-3p enhances erastin-induced ferroptosis by targeting ATF4 in hepatoma cells
Bai, T., Liang, R., Zhu, R., Wang, W., Zhou, L., & Sun, Y. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29496 · Cited by 125
Yang, Y., Chen, J., Gao, Q. F., Shan, X., Wang, J., & Lv, Z. (2020) · Toxicology · doi:10.1016/j.tox.2020.152599 · Cited by 141
Hou, K., Shen, J., Yan, J., Zhai, C., Zhang, J., Pan, J.-A., Zhang, Y., Jiang, Y., Wang, Y., Lin, R. Z., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103456 · Cited by 139
Induction and application of ferroptosis in cancer therapy
Nie, Q. H., Hu, Y., Yu, X. H., Li, X., & Fang, X. (2022) · Cancer Cell International · doi:10.1186/s12935-021-02366-0 · Cited by 146
Houessinon, A., François, C., Sauzay, C., Louandre, C., Mongélard, G., Godin, C., Bodeau, S., Takahashi, S., Saidak, Z., Gutierrez, L., et al. (2016) · Molecular Cancer · doi:10.1186/s12943-016-0526-2 · Cited by 137
Haloperidol, a sigma receptor 1 antagonist, promotes ferroptosis in hepatocellular carcinoma cells
Bai, T., Wang, S., Zhao, Y., Zhu, R., Wang, W., & Sun, Y. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.07.136 · Cited by 138
Recent advances in small-molecule fluorescent probes for studying ferroptosis
Qi, Y., Wang, H., Chen, L., Duan, Y., Yang, S., & Zhu, H. (2022) · Chemical Society Reviews · doi:10.1039/d1cs01167g · Cited by 138
Progress in Understanding Ferroptosis and Challenges in Its Targeting for Therapeutic Benefit
Zou, Y., & Schreiber, S. L. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.03.015 · Cited by 132
Implication of ferroptosis in aging
Mazhar, M., Din, A. U., Ali, H., Yang, G., Ren, W., Wang, L., Fan, X., & Yang, S. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00553-6 · Cited by 138
Hu, W., Zhou, C., Jing, Q., Li, Y., Yang, J., Yang, C., Wang, L., Hu, J., Li, Y., Wang, H., et al. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02420-x · Cited by 134
Ferroptosis of immune cells in the tumor microenvironment
Kim, R., Taylor, D. K., Vonderheide, R. H., & Gabrilovich, D. I. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.06.005 · Cited by 143
Zhang, D., Man, D., Lu, J., Jiang, Y., Ding, B., Su, R., Tong, R., Chen, J., Yang, B., Zheng, S., et al. (2023) · Advanced Science · doi:10.1002/advs.202206669 · Cited by 145
Self-citationNrf2 signaling pathway: current status and potential therapeutic targetable role in human cancers
Li, L., Wu, Q., Lu, F., Lei, J., Zhou, Y., Liu, Y., Zhu, N., You, Y., Ning, Z., She, T., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1184079 · Cited by 132
Insights on the crosstalk among different cell death mechanisms
Eskander, G., AbdelHamid, S. G., Wahdan, S. A., & Radwan, S. M. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02328-9 · Cited by 150
Tang, X., Li, X., Zhang, D., & Han, W. (2022) · Bioengineered · doi:10.1080/21655979.2022.2049471 · Cited by 133
Zheng, C., Zhang, B., Li, Y., Liu, K., Wei, W., Liang, S., Guo, H., Ma, K., Liu, Y., Wang, J., et al. (2023) · Advanced Science · doi:10.1002/advs.202206798 · Cited by 137
Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop
Wang, J., Lu, Q., Cai, J., Wang, Y., Lai, X., Qiu, Y., Huang, Y., Ke, Q., Zhang, Y., Guan, Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12925-9 · Cited by 130
Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?
Sena-dos-Santos, C., Braga-da-Silva, C., Marques, D., Pinheiro, J. A. D. S., Ribeiro‐dos‐Santos, Â., & Cavalcante, G. C. (2021) · Cells · doi:10.3390/cells10020479 · Cited by 132
Metadata
- Authors
- Sun, X., Ou, Z., Chen, R., Niu, X., Chen, D., Kang, R., & Tang, D.
- Affiliations
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- University of Pittsburgh (US)
- Corresponding author
- Tang, Daolin
- Venue
- Hepatology
- Published
- 2015-11-26
- Volume
- 63
- Issue
- 1
- Pages
- 173-184
- ISSN
- 0270-9139 (ISSN-L)
- 1527-3350
- PMC
- PMC4688087
- OpenAlex
- W2163005196
- Cited by
- 2,012
- References
- 40
- Citations by year
- 2026: 165 · 2025: 255 · 2024: 311 · 2023: 309 · 2022: 342 · 2021: 255 · 2020: 165 · 2019: 92 · 2018: 52 · 2017: 30 · 2016: 26 · 2015: 2
- FWCI
- 29.04
- Type
- journal article
- Language
- en
- Update notices
- correction (2025-08-01)
- Open access
- bronze
- doi.org
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Pittsburgh
- National Natural Science Foundation of China (201508020258, R01GM115366, 201400000003, R01CA160417, 81502445, 31171229, U1132005)
- National Institutes of Health (R01GM115366 to D.T.)
- National Cancer Institute (R01CA160417)
- National Institute of General Medical Sciences (R01GM115366)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- ferroptosis, Nrf2, p62, Keap1, hepatocellular carcinoma, erastin, sorafenib, buthionine sulfoximine, quinone oxidoreductase 1, heme oxygenase-1, FTH1, MAFG, ferroptosis-targeted therapy, iron-dependent lipid peroxidation
- MeSH terms
- Kelch-Like ECH-Associated Protein 1, Animals, Carcinoma, Hepatocellular, Humans, Iron, Liver Neoplasms, Mice, Inbred C57BL, Tumor Cells, Cultured, Signal Transduction, RNA-Binding Proteins, Cell Death, Intracellular Signaling Peptides and Proteins, NF-E2-Related Factor 2, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
