Activation of the p62–Keap1–NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

Global cancer statistics

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Regulation of Ferroptotic Cancer Cell Death by GPX4

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Role of nrf2 in oxidative stress and toxicity

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An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

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Ferroptosis as a p53-mediated activity during tumour suppression

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Co-delivery of sorafenib and an FSP1 inhibitor triggers dual ferroptosis in tumor cells and immunosuppressive macrophages for enhanced immunotherapy in mouse models of hepatocellular carcinoma

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Potential mechanism of ferroptosis in pancreatic cancer (Review)

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Inhibitors of the protein–protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line

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Heme Oxygenase-1 in Central Nervous System Malignancies

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DUSP1 Blocks autophagy-dependent ferroptosis in pancreatic cancer

Xie, Y., Kuang, F., Liu, J., Tang, D., & Kang, R. (2020) · Journal of Pancreatology · doi:10.1097/jp9.0000000000000054 · Cited by 36

The Role of Ferroptosis in Cardiovascular Disease and Its Therapeutic Significance

Chen, Z., Yan, Y., Qi, C., Liu, J., Li, L., & Wang, J. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.733229 · Cited by 36

PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ

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Ferroptosis in hematological malignancies and its potential network with abnormal tumor metabolism

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FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells

Liu, H., Zhao, L., Wang, M., Yang, K., Jin, Z., Zhao, C., & Shi, G. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.852095 · Cited by 36

Orlistat Resensitizes Sorafenib-Resistance in Hepatocellular Carcinoma Cells through Modulating Metabolism

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Identification of GPX4 as a therapeutic target for lung adenocarcinoma after EGFR-TKI resistance

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Targeting the Macrophage-Ferroptosis Crosstalk: A Novel Insight into Tumor Immunotherapy

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The crosstalk effect between ferrous and other ions metabolism in ferroptosis for therapy of cancer

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Biomarker discovery and application—An opportunity to resolve the challenge of liver cancer diagnosis and treatment

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Research progress and insights on the role of ferroptosis in wound healing

Bi, M., Li, D., & Zhang, J. (2023) · International Wound Journal · doi:10.1111/iwj.14102 · Cited by 34

The role of ferroptosis in metabolic diseases

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Camptothecin Sensitizes Hepatocellular Carcinoma Cells to Sorafenib- Induced Ferroptosis Via Suppression of Nrf2

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Nrf2-mediated redox balance alleviates LPS-induced vascular endothelial cell inflammation by inhibiting endothelial cell ferroptosis

Hou, H., Qin, X., Li, G., Cui, Z., Zhang, J., Dong, B., Wang, Z., & Zhao, H. (2024) · Scientific Reports · doi:10.1038/s41598-024-53976-3 · Cited by 35

Therapeutic targeting of cell death-immune crosstalk in cancer to rewire the tumor immune microenvironment

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Regulation and role of nuclear factor-E2-related factor 2 (Nrf2) in multidrug resistance of hepatocellular carcinoma

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Interaction of Nrf2 with dimeric STAT3 induces IL-23 expression: Implications for breast cancer progression

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Activation of Nrf2 signaling protects hypoxia‐induced HTR ‐8/ SVneo cells against ferroptosis

Wang, Y., Zhang, L., & Zhou, X. (2021) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.15009 · Cited by 35

Hemin enhances radiosensitivity of lung cancer cells through ferroptosis

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GPX7 Is Targeted by miR-29b and GPX7 Knockdown Enhances Ferroptosis Induced by Erastin in Glioma

Zhou, Y., Wu, H., Wang, F., Xu, L., Yan, Y., Tong, X., & Yan, H. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2021.802124 · Cited by 35

Global Characteristics and Trends in Research on Ferroptosis: A Data‐Driven Bibliometric Study

Dong, X., Tan, Y., Zhuang, D., Hu, T., & Zhao, M. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8661864 · Cited by 35

Glycolysis-Related LINC02432/Hsa-miR-98–5p/HK2 Axis Inhibits Ferroptosis and Predicts Immune Infiltration, Tumor Mutation Burden, and Drug Sensitivity in Pancreatic Adenocarcinoma

Tan, P., Li, M., Liu, Z., Li, T., Zhao, L., & Fu, W. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.937413 · Cited by 36

LncRNA A2M-AS1 Promotes Ferroptosis in Pancreatic Cancer via Interacting With PCBP3

Qiu, X., Shi, Q., Zhang, X., Shi, X., Jiang, H., & Qin, S. (2022) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-22-0024 · Cited by 35

Berberine hydrochloride alleviates imatinib mesylate – induced cardiotoxicity through the inhibition of Nrf2-dependent ferroptosis

Song, C., Li, D., Zhang, J., & Zhao, X. (2023) · Food & Function · doi:10.1039/d2fo03331c · Cited by 35

The role and regulation of Maf proteins in cancer

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Meningioma achieves malignancy and erastin-induced ferroptosis resistance through FOXM1-AURKA-NRF2 axis

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Ficolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesis

Yuan, Y., Xu, J., Jiang, Q., Yang, C., Wang, N., Liu, X., Piao, H.-L., Lu, S., Zhang, X., Liu, H., et al. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03047-2 · Cited by 34

From mechanisms to medicine: Ferroptosis as a Therapeutic target in liver disorders

He, Y., Lin, Y., Song, J., Song, M., Nie, X., Sun, H. J., Xu, C., Han, Z., & Cai, J. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02121-2 · Cited by 36

Identification of a novel oxidative stress induced cell death by Sorafenib and oleanolic acid in human hepatocellular carcinoma cells

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Ferroptosis As Ultimate Target of Cancer Therapy

Motooka, Y., & Toyokuni, S. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0048 · Cited by 36

FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3

Jiang, H., Fang, Y., Wang, Y., Li, T., Lin, H., Lin, J., Pan, T., Liu, Q., Lv, J., Chen, D., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109762 · Cited by 34

Transferrin Receptor is Associated with Sensitivity to Ferroptosis Inducers in Hepatocellular Carcinoma

Hiromatsu, M., Toshida, K., Itoh, S., Harada, N., Kohashi, K., Oda, Y., & Yoshizumi, T. (2023) · Annals of Surgical Oncology · doi:10.1245/s10434-023-14053-7 · Cited by 33

A guide to ferroptosis, the biological rust of cellular membranes

Veeckmans, G., San, E. V., & Berghe, T. V. (2023) · FEBS Journal · doi:10.1111/febs.16993 · Cited by 35

Erastin induces ferroptosis in cervical cancer cells via Nrf2/HO-1 signaling pathway

Wei, X., Huang, Q., Huang, J., Yu, L., & Chen, J. (2023) · International Journal of Immunopathology and Pharmacology · doi:10.1177/03946320231219348 · Cited by 33

BHLHE40 Inhibits Ferroptosis in Pancreatic Cancer Cells via Upregulating SREBF1

Cao, Y., Wang, X., Liu, Y., Liu, P., Qin, J., Zhu, Y., Zhai, S., Jiang, Y., Liu, Y., Han, L., et al. (2023) · Advanced Science · doi:10.1002/advs.202306298 · Cited by 36

KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC

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CRISPR-Cas9 gene editing strengthens cuproptosis/chemodynamic/ferroptosis synergistic cancer therapy

Wu, X., Bai, Z., Wang, H., Wang, H., Hou, D., Xu, Y., Wo, G., Cheng, H., Sun, D., & Tao, W. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.05.029 · Cited by 35

The Role of Nrf2 in the Regulation of Mitochondrial Function and Ferroptosis in Pancreatic Cancer

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Ferroptosis and its contribution to cognitive impairment in Alzheimer’s disease: mechanisms and therapeutic potential

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Nrf2: A unifying transcription factor in the pathogenesis of Fuchs’ endothelial corneal dystrophy

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Adaptive Changes Allow Targeting of Ferroptosis for Glioma Treatment

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A case–control study in Taiwanese cohort and meta-analysis of serum ferritin in pancreatic cancer

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Propofol protects cardiomyocytes from doxorubicin-induced toxic injury by activating the nuclear factor erythroid 2-related factor 2/glutathione peroxidase 4 signaling pathways

Lu, Z., Liu, Z., & Fang, B. (2022) · Bioengineered · doi:10.1080/21655979.2022.2036895 · Cited by 32

Apatinib Induces Ferroptosis of Glioma Cells through Modulation of the VEGFR2/Nrf2 Pathway

Xia, L., Gong, M., Zou, Y., Wang, Z., Wu, B., Zhang, S., Li, L., Jin, K., & Sun, C. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9925919 · Cited by 33

MCTR1 inhibits ferroptosis by promoting NRF2 expression to attenuate hepatic ischemia-reperfusion injury

Ye, J., Peng, J., Liu, K., Zhang, T., & Huang, W. (2022) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00354.2021 · Cited by 35

Ferroptosis: From Basic Research to Clinical Therapeutics in Hepatocellular Carcinoma

Huang, Z., Xia, H., Cui, Y., Yam, J. W. P., & Xu, Y. (2022) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2022.00255 · Cited by 34

Targeting PCSK9 in Liver Cancer Cells Triggers Metabolic Exhaustion and Cell Death by Ferroptosis

Alannan, M., Fatrouni, H., Trézéguet, V., Dittrich-Domergue, F., Moreau, P., Siegfried, G., Liet, B., Khatib, A., Grosset, C. F., Badran, B. M., et al. (2022) · Cells · doi:10.3390/cells12010062 · Cited by 35

Nanomedicine-mediated ferroptosis targeting strategies for synergistic cancer therapy

Yin, W., Chang, J., Sun, J., Zhang, T., Zhao, Y., Li, Y., & Dong, H. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb02161g · Cited by 32

The potential of ferroptosis combined with radiotherapy in cancer treatment

Lu, Z., Xiao, B., Chen, W., Tang, T., Zhuo, Q., & Chen, X. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1085581 · Cited by 35

A review of how the saffron (Crocus sativus) petal and its main constituents interact with the Nrf2 and NF-κB signaling pathways

Rahbardar, M. G., & Hosseinzadeh, H. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02487-5 · Cited by 32

The mechanistic insights of the antioxidant Keap1-Nrf2 pathway in oncogenesis: a deadly scenario

Mukherjee, A. G., & Gopalakrishnan, A. V. (2023) · Medical Oncology · doi:10.1007/s12032-023-02124-4 · Cited by 33

The molecular mechanisms and potential drug targets of ferroptosis in myocardial ischemia–reperfusion injury

Zhang, C.-H., Yan, Y.-J., & Luo, Q. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122439 · Cited by 38

Ferroptosis and its role in osteoarthritis: mechanisms, biomarkers, and therapeutic perspectives

Lu, S., Liu, Z., Qi, M., Wang, Y., Chang, L., Bai, X., Jiao, Y., Chen, X., & Zhen, J. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1510390 · Cited by 33

Moxibustion Exerts a Neuroprotective Effect through Antiferroptosis in Parkinson’s Disease

Lu, J., Liu, X., Tian, Y., Li, H., Ren, Z., Liang, S., Zhang, G., Zhao, C., Li, X., Wang, T., et al. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/2735492 · Cited by 32

Role of the KEAP1-NRF2 Axis in Renal Cell Carcinoma

Clerici, S., & Boletta, A. (2020) · Cancers · doi:10.3390/cancers12113458 · Cited by 36

A Novel Ferroptosis-Related Prognostic Signature Reveals Macrophage Infiltration and EMT Status in Bladder Cancer

Yan, Y., Cai, J., Huang, Z., Cao, X., Tang, P., Wang, Z., Zhang, F., Xia, S., & Shen, B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.712230 · Cited by 33

Thymosin β4 Is an Endogenous Iron Chelator and Molecular Switcher of Ferroptosis

Lachowicz, J. I., Pichiri, G., Piludu, M., Fais, S., Orrù, G., Congiu, T., Piras, M., Faa, G., Fanni, D., Torre, G. D., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010551 · Cited by 32

Frontiers of ferroptosis research: An analysis from the top 100 most influential articles in the field

Cheng, K., Guo, Q., Shen, Z., Yang, W., Zhou, Y., Sun, Z., Yao, X., & Wu, H. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.948389 · Cited by 33

Ferroptosis: Shedding Light on Mechanisms and Therapeutic Opportunities in Liver Diseases

You, H., Wang, L., Bu, F., Meng, H., Huang, C., Fang, G.-Y., & Li, J. (2022) · Cells · doi:10.3390/cells11203301 · Cited by 33

A bibliometric analysis of ferroptosis, necroptosis, pyroptosis, and cuproptosis in cancer from 2012 to 2022

Miao, Y., Quan, W., Dong, X., Gan, J., Ji, C.-F., Wang, J., & Zhang, F. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01421-1 · Cited by 33

PFKFB4 Drives the Oncogenicity in TP53-Mutated Hepatocellular Carcinoma in a Phosphatase-Dependent Manner

Kam, C. S., Ho, D. W., Ming, V. S., Tian, L., Sze, K. M., Zhang, V. X., Tsui, Y., Husain, A., Lee, J. M., Wong, C. C., et al. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.02.004 · Cited by 31

TXNDC12 inhibits lipid peroxidation and ferroptosis

Tang, L., Yu, Y., Deng, W., Liu, J., Wang, Y., Ye, F., Kang, R., Tang, D., & He, Q. (2023) · iScience · doi:10.1016/j.isci.2023.108393 · Cited by 30

A Deep Insight into Ferroptosis in Renal Disease: Facts and Perspectives

Han, Z., Luo, Y., Chen, H., Zhang, G., You, L., Zhang, M., Lin, Y., Lan, Y., & Zhou, S. (2024) · Kidney Diseases · doi:10.1159/000538106 · Cited by 32

ML385 promotes ferroptosis and radiotherapy sensitivity by inhibiting the NRF2-SLC7A11 pathway in esophageal squamous cell carcinoma

Yan, L., Hu, H., Feng, L., Li, Z., Chunyan, Z., Zhang, J., Yin, X., & Li, B. (2024) · Medical Oncology · doi:10.1007/s12032-024-02483-6 · Cited by 33

METTL3 inhibition promotes radiosensitivity in hepatocellular carcinoma through regulation of SLC7A11 expression

Zhang, C., Yang, T., Chen, H., Ding, X., Chen, H., Liang, Z., Zhao, Y., Ma, S., & Liu, X. (2025) · Cell Death and Disease · doi:10.1038/s41419-024-07317-x · Cited by 35

Mitochondrial CCN1 drives ferroptosis via fatty acid β-oxidation

Guo, W., Zhang, C.-C., Zhou, Q., Chen, T., Xu, X., Zhang, J., Yu, X., Wu, H., Zhang, X., Ma, L., et al. (2025) · Developmental Cell · doi:10.1016/j.devcel.2025.04.004 · Cited by 33

Prediction of overall survival based upon a new ferroptosis-related gene signature in patients with clear cell renal cell carcinoma

Sun, Z., Li, T., Xiao, C., Zou, S., Zhang, M., Zhang, Q., Wang, Z., Zhan, H., & Wang, H. (2022) · World Journal of Surgical Oncology · doi:10.1186/s12957-022-02555-9 · Cited by 32

Ferroptosis: A new strategy for traditional Chinese medicine treatment of stroke

Lou, Y., Ma, M., Jiang, Y., Xu, H., Gao, Z., Gao, L., & Wang, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113806 · Cited by 32

Inhibitory Effects of Esculetin on Liver Cancer Through Triggering NCOA4 Pathway-Mediation Ferritinophagy in vivo and in vitro

Xiu, Z., Li, Y., Fang, J., Han, J., Li, S., Li, Y., Yang, X., Song, G., Li, Y., Jin, N., et al. (2023) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s395617 · Cited by 32

TRIM25 promotes temozolomide resistance in glioma by regulating oxidative stress and ferroptotic cell death via the ubiquitination of keap1

Wei, J., Wang, L., Zhang, Y., Sun, T., Zhang, C., Hu, Z., Zhou, L., Liu, X., Wan, J., & Ma, L. (2023) · Oncogene · doi:10.1038/s41388-023-02717-3 · Cited by 31

Iron metabolism and ferroptosis in diabetic bone loss: from mechanism to therapy

Bao, J., Yan, Y., Zuo, D., Zhuo, Z., Sun, T., Lin, H., Han, Z., Zhao, Z., & Yu, H. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1178573 · Cited by 33

Ferrostatin-1 attenuates pathological angiogenesis in oxygen-induced retinopathy via inhibition of ferroptosis

Liu, C., Liu, X., Ouyang, P.-W., Liu, Q., Huang, X., Xiao, F., Cui, Y., Zhou, Q., & Pan, H. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.109347 · Cited by 30

Ferroptosis: Mechanism and potential applications in cervical cancer

Chang, X., & Miao, J. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1164398 · Cited by 30

The suppression of hyperlipid diet‐induced ferroptosis of vascular smooth muscle cells protests against atherosclerosis independent of p53/SCL7A11/GPX4 axis

You, J., Ouyang, S., Xie, Z., Zhi, C., Jiang, Y. L., Tan, X., Li, P., Lin, X., Ma, W., Liu, Z., et al. (2023) · Journal of Cellular Physiology · doi:10.1002/jcp.31045 · Cited by 30

Co‐Delivery of siNRF2 and Sorafenib by a “Click” Dual Functioned Hyperbranched Nanocarrier for Synergistically Inducing Ferroptosis in Hepatocellular Carcinoma

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Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

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