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Use of hepatocellular carcinoma surveillance in patients with cirrhosis: a systematic review and meta-analysis
Open accessAbstract
BACKGROUND AND AIMS: Hepatocellular carcinoma (HCC) surveillance is associated with early tumor detection and improved survival; however, it is often underused in clinical practice. We aimed to characterize surveillance use among patients with cirrhosis and the efficacy of interventions to increase surveillance. APPROACH AND RESULTS: We performed a systematic literature review using the MEDLINE database from January 2010 through August 2018 to identify cohort studies evaluating HCC surveillance receipt or interventions to increase surveillance in patients with cirrhosis. A pooled estimate for surveillance receipt with 95% confidence intervals was calculated. Correlates of surveillance use were defined from each study and prespecified subgroup analyses. Twenty-nine studies, with a total of 118,799 patients, met inclusion criteria, with a pooled estimate for surveillance use of 24.0% (95% confidence interval, 18.4-30.1). In subgroup analyses, the highest surveillance receipt was reported in studies with patients enrolled from subspecialty gastroenterology/hepatology clinics and lowest in studies characterizing surveillance in population-based cohorts (73.7% versus 8.8%, P < 0.001). Commonly reported correlates of surveillance included higher receipt among patients followed by subspecialists and lower receipt among those with alcohol-associated or nonalcoholic steatohepatitis (NASH)-related cirrhosis. All eight studies (n = 5,229) evaluating interventions including patient/provider education, inreach (e.g., reminder and recall systems), and population health outreach strategies reported significant increases (range 9.4%-63.6%) in surveillance receipt. CONCLUSIONS: HCC surveillance remains underused in clinical practice, particularly among patients with alcohol-associated or NASH-related cirrhosis and those not followed in subspecialty gastroenterology clinics. Interventions such as provider education, inreach including reminder systems, and population health outreach efforts can significantly increase HCC surveillance.
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“Cirrhosis in MASLD is under-recognised compared to other aetiologies, 248 with less than one in four individuals with cirrhosis undergoing HCC surveillance. 249”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [249]
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Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21492 · Cited by 84,109
EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma
Galle, P. R., Forner, A., Llovet, J. M., Mazzaferro, V., Piscaglia, F., Raoul, J.-L., Schirmacher, P., & Vilgrain, V. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.03.019 · Cited by 11,406
Rahib, L., Smith, B. D., Aizenberg, R., Rosenzweig, A. B., Fleshman, J. M., & Matrisian, L. M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0155 · Cited by 7,094
AASLD guidelines for the treatment of hepatocellular carcinoma
Heimbach, J. K., Kulik, L., Finn, R. S., Sirlin, C. B., Abecassis, M. M., Roberts, L. R., Zhu, A. X., Murad, M. H., & Marrero, J. A. (2017) · Hepatology · doi:10.1002/hep.29086 · Cited by 4,107
Self-citationEl-Serag, H. B. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1001683 · Cited by 3,529
Singal, A. G., Pillai, A., & Tiro, J. (2014) · PLoS Medicine · doi:10.1371/journal.pmed.1001624 · Cited by 817
Self-citationCancer Screening Test Use — United States, 2015
White, A. L., Thompson, T., White, M. C., Sabatino, S. A., de Moor, J. S., Doria-Rose, V. P., Geiger, A. M., & Richardson, L. C. (2017) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6608a1 · Cited by 602
Benvegnù, L., Gios, M., Boccato, S., & Alberti, A. (2004) · Gut · doi:10.1136/gut.2003.020263 · Cited by 452
Use of Surveillance for Hepatocellular Carcinoma Among Patients With Cirrhosis in the United States
Davila, J. A., Morgan, R. O., Richardson, P., Du, X. L., McGlynn, K. A., & El‐Serag, H. B. (2010) · Hepatology · doi:10.1002/hep.23615 · Cited by 392
Population-based risk factors and resource utilization for HCC: US perspective
Sanyal, A. J., Poklepovic, A. S., Moyneur, É., & Barghout, V. E. (2010) · Current Medical Research and Opinion · doi:10.1185/03007995.2010.506375 · Cited by 312
Davila, J. A., Henderson, L. M., Kramer, J. R., Kanwal, F., Richardson, P., Duan, Z., & El‐Serag, H. B. (2011) · Annals of Internal Medicine · doi:10.7326/0003-4819-154-2-201101180-00006 · Cited by 297
Utilization of Hepatocellular Carcinoma Surveillance Among American Patients: A Systematic Review
Singal, A. G., Yopp, A. C., Skinner, C. S., Packer, M., Lee, W. M., & Tiro, J. A. (2012) · Journal of General Internal Medicine · doi:10.1007/s11606-011-1952-x · Cited by 288
Self-citationSingal, A. G., Nehra, M. S., ADAMS-HUET, B. A., Yopp, A. C., Tiro, J. A., Marrero, J. A., Lok, A. S.-F., & Lee, W. M. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.449 · Cited by 225
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Singal, A. G., Yopp, A. C., Gupta, S. N., Skinner, C. S., Halm, E. A., Okolo, E., Nehra, M. S., Lee, W. M., Marrero, J. A., & Tiro, J. A. (2012) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-12-0046 · Cited by 210
Self-citationBaker, D. W., Brown, T., Buchanan, D. R., Weil, J., Balsley, K., Ranalli, L., Lee, J. Y., Cameron, K. A., Ferreira, M. R., Stephens, Q., et al. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2014.2352 · Cited by 201
Racial, Social, and Clinical Determinants of Hepatocellular Carcinoma Surveillance
Singal, A. G., Li, X., Tiro, J. A., Kandunoori, P., ADAMS-HUET, B. A., Nehra, M. S., & Yopp, A. C. (2014) · The American Journal of Medicine · doi:10.1016/j.amjmed.2014.07.027 · Cited by 186
Self-citationFarvardin, S., Patel, J., Khambaty, M., Yerokun, O. A., Mok, H., Tiro, J. A., Yopp, A. C., Parikh, N. D., Marrero, J. A., & Singal, A. G. (2017) · Hepatology · doi:10.1002/hep.28770 · Cited by 185
Self-citationMittal, S., Kanwal, F., Ying, J., Chung, R., Sada, Y. H., Temple, S., Davila, J. A., & El‐Serag, H. B. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.07.025 · Cited by 145
van Meer, S., de Man, R. A., Coenraad, M. J., Sprengers, D., van Nieuwkerk, K. M. J., Klümpen, H., Jansen, P. L. M., IJzermans, J. N. M., van Oijen, M. G. H., Siersema, P. D., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.06.012 · Cited by 139
Goldberg, D. S., Taddei, T. H., Serper, M., Mehta, R. L., Dieperink, E. W., Aytaman, A., Baytarian, M. L., Fox, R. K., Hunt, K. K., Pedrosa, M. C., et al. (2016) · Hepatology · doi:10.1002/hep.28765 · Cited by 134
Primary Care Provider Practice Patterns and Barriers to Hepatocellular Carcinoma Surveillance
Simmons, O. L., Feng, Y., Parikh, N. D., & Singal, A. G. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.07.029 · Cited by 127
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Choi, D. T., Kum, H., Park, S., Ohsfeldt, R. L., Shen, Y., Parikh, N. D., & Singal, A. G. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.10.031 · Cited by 125
Self-citationFactors That Affect Risk for Hepatocellular Carcinoma and Effects of Surveillance
Yang, J. D., Harmsen, W. S., Slettedahl, S. W., Chaiteerakij, R., Enders, F., Therneau, T. M., Orsini, L. S., Kim, W. R., & Roberts, L. R. (2011) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.03.027 · Cited by 123
Improved Surveillance for Hepatocellular Carcinoma With a Primary Care–Oriented Clinical Reminder
Beste, L. A., Ioannou, G. N., Yang, Y. H., Chang, M. F., Ross, D. B., & Dominitz, J. A. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.04.033 · Cited by 119
Dalton-Fitzgerald, E., Tiro, J. A., Kandunoori, P., Halm, E. A., Yopp, A. C., & Singal, A. G. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.06.031 · Cited by 103
Self-citationSingal, A. G., Tiro, J. A., Marrero, J. A., McCallister, K., Mejias, C. A., Adamson, B., Bishop, W. P., Santini, N. O., & Halm, E. A. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.10.042 · Cited by 102
Self-citationKuo, Y., Lu, S., Chen, C., Cheng, Y., Lin, C., Hung, C., Chen, C., Changchien, C., Hsu, H., Hu, T., et al. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2009.12.018 · Cited by 98
Singal, A. G., Volk, M. L., Rakoski, M. O., Fu, S., Su, G. L., McCurdy, H., & Marrero, J. A. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31820989d3 · Cited by 89
Self-citationSingal, A. G., Tiro, J. A., Murphy, C. C., Marrero, J. A., McCallister, K., Fullington, H., Mejias, C., Waljee, A. K., Pechero Bishop, W., Santini, N. O., et al. (2019) · Hepatology · doi:10.1002/hep.30129 · Cited by 89
Self-citationCirrhosis is under-recognised in patients subsequently diagnosed with hepatocellular cancer
Walker, M., El‐Serag, H. B., Sada, Y., Mittal, S., Ying, J., Duan, Z., Richardson, P., Davila, J. A., & Kanwal, F. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13505 · Cited by 84
The evolutionary scenario of hepatocellular carcinoma in Italy: an update
Bucci, L., Garuti, F., Lenzi, B., Pecorelli, A., Farinati, F., Giannini, E. G., Granito, A., Ciccarese, F., Rapaccini, G. L., Marco, M. D., et al. (2016) · Liver International · doi:10.1111/liv.13204 · Cited by 82
Edenvik, P., Davíðsdóttir, L. G., Oksanen, A., Isaksson, B., Hultcrantz, R. W., & Stal, P. I. (2014) · Liver International · doi:10.1111/liv.12764 · Cited by 72
Suboptimal Surveillance for and Knowledge of Hepatocellular Carcinoma Among Primary Care Providers
McGowan, C., Edwards, T., Luong, M.-U. T., & Hayashi, P. H. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.07.056 · Cited by 64
Turner, B. J., Weiner, M. G., Yang, C. P., & TenHave, T. R. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-7-200404060-00013 · Cited by 59
Aberra, F. B., Essenmacher, M., Fisher, N., & Volk, M. L. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2461-4 · Cited by 56
Singal, A. G., Tiro, J. A., Li, X., ADAMS-HUET, B. A., & Chubak, J. (2016) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000708 · Cited by 51
Self-citationHepatocellular Carcinoma Surveillance Among Cirrhotic Patients With Commercial Health Insurance
Goldberg, D. S., Valderrama, A., Kamalakar, R., Sansgiry, S. S., Babajanyan, S., & Lewis, J. D. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000411 · Cited by 46
Surveillance for Hepatocellular Carcinoma in a Medicaid Cirrhotic Population
Palmer, L. B., Kappelman, M. D., Sandler, R. S., & Hayashi, P. H. (2013) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318286fd97 · Cited by 46
Wang, C., Chen, V. L., Vu, V. D., Le, A. K., Nguyen, L., Zhao, C., Wong, C. R., Nguyen, N. H., Li, J., Zhang, J., et al. (2016) · Medicine · doi:10.1097/md.0000000000004744 · Cited by 41
Tran, S., Le, A. K., Zhao, C., Hoang, J. K., Yasukawa, L. A., Weber, S., Henry, L. L., & Nguyen, M. H. (2018) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2017-000192 · Cited by 35
Kennedy, N. A., Rodgers, A., Altus, R., McCormick, R., Wundke, R., & Wigg, A. J. (2013) · Internal Medicine Journal · doi:10.1111/imj.12166 · Cited by 33
Stroffolini, T., Trevisani, F., Pinzello, G., Brunello, F., Tommasini, M., Iavarone, M. A., Marco, V. D., Farinati, F., Poggio, P. D., Borzio, F., et al. (2011) · Digestive and Liver Disease · doi:10.1016/j.dld.2011.05.002 · Cited by 33
Poggio, P. D., Olmi, S., Ciccarese, F., Mazzoleni, M., Jazzetti, M., Jamoletti, C., Mattiello, M., Poggio, A. D., Portugali, V., & Stroffolini, T. (2015) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000404 · Cited by 31
Robinson, A., Tavakoli, H., Cheung, R. C., Liu, B., Bhuket, T. P., & Wong, R. J. (2018) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001024 · Cited by 31
Patwardhan, V. R., Paul, S., Corey, K. E., Mazhar, S. M., Richter, J. M., Thiim, M., & Chung, R. T. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1836-2 · Cited by 30
Epidemiology, clinical-treatment patterns and outcome in 256 hepatocellular carcinoma cases
Fenoglio, L. M. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i21.3207 · Cited by 27
Aby, E. S., Phan, J., Truong, E., Grotts, J. F., & Saab, S. (2018) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001075 · Cited by 26
Thein, H., Campitelli, M. A., Yeung, L., Zaheen, A., Yoshida, E. M., & Earle, C. C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138907 · Cited by 25
Nazareth, S., Leembruggen, N., Tuma, R., Chen, S., Rao, S., Kontorinis, N., & Cheng, W. (2016) · International Journal of Nursing Practice · doi:10.1111/ijn.12472 · Cited by 25
Factors affecting screening for hepatocellular carcinoma
Hasani, F. A., Knöpfli, M., Gemperli, A., Kollár, A., Banz, V. M., Kettenbach, J., Jüni, P., & Dufour, J. (2014) · Annals of Hepatology · doi:10.1016/s1665-2681(19)30883-x · Cited by 22
Mata, A. M., González-Diéguez, M. L., Navascués, C. Á., Cadahía, V., Varela, M., Pérez, R., Rodrigo, L., & Rodríguez, M. (2016) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000734 · Cited by 19
Farrell, C., Halpen, A., Cross, T. J. S., Richardson, P., Johnson, P. J., & Joekes, E. C. (2016) · Clinical Radiology · doi:10.1016/j.crad.2016.10.019 · Cited by 19
Socioeconomic disparities in access to a hepatocellular carcinoma screening program in Brazil
Signorelli, I. V., Gonçalves, P. L., Gonçalves, L. L., Ferreira, L. S. E., Mendonça, A. T., Franklin, G. L., & Gomes, M. D. P. Z. (2016) · Clinics · doi:10.6061/clinics/2016(07)01 · Cited by 12
Nam, J. Y., Lee, J., Kim, H. Y., Kim, J. E., Lee, D. H., Chang, Y. W., Cho, H., Yoo, J., Lee, M., Cho, Y. Y., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0166188 · Cited by 9
Bui, H. T., Rangchi, A., Tran, D. K., Malik, A., Kumar, N. G., & Balasubramanian, S. (2017) · Gastroenterology · doi:10.1016/s0016-5085(17)33973-2 · Cited by 3
Research works printed but not linked: 1
- 2018, Medical monitoring among cirrhotic patients in real world practice: a nationwide US study with 43,915 cirrhotics, Hepatology
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“[91,94,95] The AASLD recommends use of these evidence-based interventions to increase surveillance utilization in clinical practice.”
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Metadata
- Authors
- Wolf, E., Rich, N. E., Marrero, J. A., Parikh, N. D., & Singal, A. G.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- University of Michigan (US)
- Corresponding author
- Singal, Amit G.
- Venue
- Hepatology
- Published
- 2020-11-20
- Volume
- 73
- Issue
- 2
- Pages
- 713-725
- ISSN
- 0270-9139 (ISSN-L)
- 1527-3350
- PMC
- PMC7648722
- OpenAlex
- W3021721319
- Cited by
- 333
- References
- 56
- Citations by year
- 2026: 47 · 2025: 69 · 2024: 66 · 2023: 57 · 2022: 48 · 2021: 33 · 2020: 13
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (U01CA230694, U01CA230669)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
- Keywords
- HCC surveillance, liver cirrhosis, alcoholic cirrhosis, nonalcoholic steatohepatitis, provider education, early cancer detection
- MeSH terms
- Carcinoma, Hepatocellular, Humans, Liver Cirrhosis, Liver Neoplasms, Mass Screening, Patient Acceptance of Health Care, Practice Patterns, Physicians', Guideline Adherence, Early Detection of Cancer
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