The impact of obesity and metabolic syndrome on alcoholic liver disease
Open accessAbstract
Alcoholic liver disease (ALD) remains a major cause of chronic liver diseases and liver failure. Population-based prospective studies and patient cohort studies have demonstrated that obesity and the metabolic syndrome exacerbate progression of ALD and increase hepatocellular carcinoma (HCC) incidence and mortality. Emerging evidence also suggests a synergism between alcohol and obesity in mortality and HCC incidence. Recognition of these increased risks and detection of early-stage liver disease may offer the opportunity to address these modifiable risk factors and prevent disease progression in these patients.
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MASLD may accelerate the progression of liver disease in individuals with ALD and chronic hepatitis B, and synergistically induce cirrhosis or HCC development.
“Notably, MASLD may accelerate the progression of liver disease in individuals with ALD and chronic hepatitis B, and synergistically induce cirrhosis or HCC development. 8,10,11”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [11]
The Conclusion (page unavailable) says obesity and metabolic syndrome exacerbate ALD progression and increase HCC incidence; the hepatic carcinogenesis section reports a synergistic increase in HCC risk with obesity and alcohol. The paper does not establish these findings specifically for MASLD or for people with chronic hepatitis B, and it does not establish synergistic cirrhosis development. (LLM, conf=0.87)
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- Authors
- Chiang, D. J., & McCullough, A. J.
- Affiliations
- Cleveland Clinic (US)
- Corresponding author
- McCullough, Arthur J.
- Venue
- Clinics in Liver Disease
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 18
- Issue
- 1
- Pages
- 157-163
- ISSN
- 1089-3261 (ISSN-L)
- PMC
- PMC6130318
- OpenAlex
- W2036024170
- Cited by
- 99
- References
- 45
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 11 · 2023: 14 · 2022: 8 · 2021: 5 · 2020: 15 · 2019: 7 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 4
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Clinics in Liver Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (4u01aa021893-05)
- National Institute on Alcohol Abuse and Alcoholism (AA021893, U01-AA021893)
- National Institute of Diabetes and Digestive and Kidney Diseases (U01DK061732)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- alcoholic liver disease, obesity, metabolic syndrome, hepatocellular carcinoma, liver disease progression, liver failure, risk factors, early detection of liver disease
- MeSH terms
- Carcinoma, Hepatocellular, Humans, Liver Diseases, Alcoholic, Liver Neoplasms, Obesity, Risk Factors, Disease Progression, Metabolic Syndrome, Diabetes Complications
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