Alcohol‐associated cirrhosis
Abstract
Alcohol-associated cirrhosis (AC) contributes up to 50% of the overall cirrhosis burden in the United States. AC is typically a comorbid condition in association with alcohol-use disorder. AC is often coexistent with other conditions. Several noninvasive methods are available to assist in recognizing the presence of AC. The natural history of AC is governed by the patients continued drinking or abstinence. All treatment starts with abstinence. After decompensation, the progression to acute-on-chronic liver failure heralds death. When patients who have deteriorated are declined liver transplant, palliative care should be considered.
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Compared to other chronic diseases, chronic liver disease is associated with higher health care use and worsening mortality over time.
“Compared to other chronic diseases, CLD is associated with higher health care use and worsening mortality over time.6”
From A Behavioral Health Program for Alcohol Use Disorder, Substance Abuse, and Depression in Chronic Liver Disease (2019) · cites this paper as [6]
Cites
The Health consequences of smoking—50 years of progress : a report of the Surgeon General
Lushniak, B. D., Samet, J. M., Pechacek, T. F., Norman, L., & Taylor, P. A. (2014) · Cited by 4,990 · see citing works
AASLD guidelines for the treatment of hepatocellular carcinoma
Heimbach, J. K., Kulik, L., Finn, R. S., Sirlin, C. B., Abecassis, M. M., Roberts, L. R., Zhu, A. X., Murad, M. H., & Marrero, J. A. (2017) · Hepatology · doi:10.1002/hep.29086 · Cited by 4,072 · see citing works
Moreau, R., Jalan, R., Ginès, P., Pavesi, M., Angeli, P., Córdoba, J., Durand, F., Gustot, T., Saliba, F., Domenicali, M., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.042 · Cited by 3,041 · see citing works
Garcia‐Tsao, G., Abraldes, J. G., Berzigotti, A., & Bosch, J. (2017) · Hepatology · doi:10.1002/hep.28906 · Cited by 2,154 · see citing works
Ascha, M. S., Hanouneh, I. A., Lopez, R., Tamimi, T. A.-R., Feldstein, A. F., & Zein, N. N. (2010) · Hepatology · doi:10.1002/hep.23527 · Cited by 1,296 · see citing works
Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study
Tapper, E. B., & Parikh, N. D. (2018) · BMJ · doi:10.1136/bmj.k2817 · Cited by 858 · see citing works
Global burden of alcoholic liver diseases
Rehm, J., Samokhvalov, A. V., & Shield, K. D. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.03.007 · Cited by 740 · see citing works
Excess weight risk factor for alcoholic liver disease
Naveau, S., Giraud, V., Borotto, E., Aubert, A., Capron, F., & Chaput, J. (1997) · Hepatology · doi:10.1002/hep.510250120 · Cited by 666 · see citing works
Intraductal carcinoma of the breast: Follow-up after biopsy only
Page, D. L., Dupont, W. D., Rogers, L. W., & Landenberger, M. (1982) · Cancer · doi:10.1002/1097-0142(19820215)49:4 · Cited by 600 · see citing works
Clinical Course of Alcoholic Liver Cirrhosis: A Danish Population-Based Cohort Study
Jepsen, P., Ott, P., Andersen, P. K., Sørensen, H. T., & Vilstrup, H. (2009) · Hepatology · doi:10.1002/hep.23500 · Cited by 536 · see citing works
Beste, L. A., Leipertz, S. L., Green, P. K., Dominitz, J. A., Ross, D. B., & Ioannou, G. N. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.07.056 · Cited by 460 · see citing works
Use of Liver Imaging and Biopsy in Clinical Practice
Tapper, E. B., & Lok, A. S.-F. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1610570 · Cited by 452 · see citing works
Model for end stage liver disease score predicts mortality across a broad spectrum of liver disease
Said, A. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.02.010 · Cited by 430 · see citing works
Duration of survival in patients with Laennec's cirrhosis
Powell, W. J., & Klatskin, G. (1968) · The American Journal of Medicine · doi:10.1016/0002-9343(68)90111-3 · Cited by 351 · see citing works
Corrao, G., & Aricò, S. (1998) · Hepatology · doi:10.1002/hep.510270404 · Cited by 316 · see citing works
Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis
Fletcher, L. M., Dixon, J. L., Purdie, D. M., Powell, L. W., & Crawford, D. H. (2002) · Gastroenterology · doi:10.1053/gast.2002.30992 · Cited by 285 · see citing works
Poonja, Z., Brisebois, A., van Zanten, S. V., Tandon, P., Meeberg, G., & Karvellas, C. J. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.08.027 · Cited by 226 · see citing works
Louvet, A., Labreuche, J., Artru, F., Bouthors, A., Rolland, B., Saffers, P., Lollivier, J., Lemaître, E., Dharancy, S., Lassailly, G., et al. (2017) · Hepatology · doi:10.1002/hep.29240 · Cited by 219 · see citing works
The high burden of alcoholic cirrhosis in privately insured persons in the United States
Mellinger, J. L., Shedden, K., Winder, G. S., Tapper, E. B., Adams, M. A., Fontana, R. J., Volk, M. L., Blow, F. C., & Lok, A. S.-F. (2018) · Hepatology · doi:10.1002/hep.29887 · Cited by 210 · see citing works
Altamirano, J., López‐Pelayo, H., Michelena, J., Jones, P. D., Ortega, L., Ginès, P., Caballería, J., Gual, A., Bataller, R., & Lligoña, A. (2017) · Hepatology · doi:10.1002/hep.29338 · Cited by 162 · see citing works
Faure, S., Herrero, A., Jung, B., Duny, Y., Daurès, J., Mura, T., Assénat, E., Bismuth, M., Bouyabrine, H., Donnadieu‐Rigole, H., et al. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.03.014 · Cited by 150 · see citing works
Westin, J., Lagging, M., Spak, F., Aires, N., Svensson, E., Lindh, M., Dhillon, A. P., Norkrans, G., & Wejstål, R. (2002) · Journal of Viral Hepatitis · doi:10.1046/j.1365-2893.2002.00356.x · Cited by 144 · see citing works
Rush, B. N. M., Walley, K. R., Celi, L. A., Rajoriya, N., & Brahmania, M. (2017) · Hepatology · doi:10.1002/hep.29297 · Cited by 105 · see citing works
Tobacco Use Following Liver Transplantation for Alcoholic Liver Disease: An Underestimated Problem
DiMartini, A. F., Javed, L., Russell, S., Dew, M. A., Fitzgerald, M. G., Jain, A. K., & Fung, J. J. (2005) · Liver Transplantation · doi:10.1002/lt.20385 · Cited by 102 · see citing works
Guirguis, J. K., Chhatwal, J., Dasarathy, J., Rivas, J. M., McMichael, D., Nagy, L. E., McCullough, A. J., & Dasarathy, S. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12887 · Cited by 86 · see citing works
Why do patients die after a liver transplantation?
Daniel, K. E., Eickhoff, J. C., & Lucey, M. R. (2016) · Clinical Transplantation · doi:10.1111/ctr.12906 · Cited by 57 · see citing works
Self-citationAlcohol Consumption by Cirrhotic Subjects: Patterns of Use and Effects on Liver Function
Lucey, M. R., Connor, J. T., BOYER, T. D., Henderson, J. M., Rikkers, L. F., & the DIVERT Study Group (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.01837.x · Cited by 54 · see citing works
Self-citationOxidative stress and steatosis are cofactors of liver injury in primary biliary cirrhosis
Sorrentino, P., Terracciano, L., D’Angelo, S., Ferbo, U., Bracigliano, A., Tarantino, L., Perrella, A., Perrella, O., Chiara, G. D., Panico, L., et al. (2010) · Journal of Gastroenterology · doi:10.1007/s00535-010-0249-x · Cited by 54 · see citing works
Short-term and Long-term Causes of Death in Patients With Alcoholic Hepatitis in Denmark
Ørntoft, N. W., Sandahl, T. D., Jepsen, P., & Vilstrup, H. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.04.020 · Cited by 54 · see citing works
Otete, H. E., Deleuran, T., Fleming, K. M., Card, T. R., Aithal, G. P., Jepsen, P., & West, J. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.04.002 · Cited by 54 · see citing works
Gianni, E., Forte, P., Galli, V., Razzolini, G., Bardazzi, G., & Annese, V. (2016) · Alcohol and Alcoholism · doi:10.1093/alcalc/agw053 · Cited by 50 · see citing works
Alcoholic Cirrhosis and Hepatocellular Carcinoma
Stickel, F. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-09614-8_7 · Cited by 48 · see citing works
Kelly, S. G., Campbell, T. C., Hillman, L., Said, A., Lucey, M. R., & Agarwal, P. D. (2017) · Annals of Hepatology · doi:10.5604/01.3001.0009.8594 · Cited by 44 · see citing works
Self-citationKelly, S. G., Campbell, T. C., Hillman, L., et al. (2017) · PubMed · doi:10.5604/16652681.1235482 · Cited by 31 · see citing works
Verrill, C. L., Smith, S., & Sheron, N. (2006) · Substance Abuse Treatment Prevention and Policy · doi:10.1186/1747-597x-1-16 · Cited by 24 · see citing works
Morling, J. R., & Guha, I. N. (2016) · Clinical Liver Disease · doi:10.1002/cld.555 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Current Medical Treatment for Alcohol-Associated Liver Disease.
Ayares, G., Idalsoaga, F., Díaz, L., Arnold, J., & Arab, J. (2022) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2022.02.001 · Cited by 61 · see citing works
Verma, M., Horrow, J., & Navarro, V. (2019) · Hepatology Communications · doi:10.1002/hep4.1328 · Cited by 23 · see citing works
“647 associated with complex psychosocial comorbidities, including alcohol use disorder (increasingly among the young population)(7,8) and substance abuse, both of which occur more frequently and at a greater severity among patients with CLD than the general population.”
BackgroundKirpich, I., Warner, D. R., Feng, W., Joshi‐Barve, S., McClain, C. J., Seth, D., Zhong, W. H., Zhou, Z., Osna, N. A., & Kharbanda, K. K. (2019) · Alcohol · doi:10.1016/j.alcohol.2019.05.004 · Cited by 22 · see citing works
Zeng, D., Huang, Q., Yu, Z., & Wu, H. (2021) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23855 · Cited by 19 · see citing works
Maatman, T. K., & Zyromski, N. J. (2020) · Current Problems in Surgery · doi:10.1016/j.cpsurg.2020.100858 · Cited by 15 · see citing works
Gut Microbiome-Centered Therapies for Alcohol-Associated Liver Disease
Ranjbarian, T., & Schnabl, B. (2023) · Seminars in Liver Disease · doi:10.1055/a-2145-7331 · Cited by 16 · see citing works
Ren, A., He, W., Rao, J., Ye, D., Cheng, P., Qian, J., Fu, Z., Zhang, X., Deng, R., Gao, Y., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1034356 · Cited by 15 · see citing works
Substance Use Disorders in Recently Hospitalized Patients With Cirrhosis
Haque, L., Jakab, S., Deng, Y., Ciarleglio, M. M., & Tetrault, J. M. (2020) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000000677 · Cited by 14 · see citing works
López-Lazcano, A., Gual, A., Colmenero, J., Caballería, E., Lligoña, A., Navasa, M., Crespo, G., López, E., & López‐Pelayo, H. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092710 · Cited by 13 · see citing works
Myeloid cells in alcoholic liver diseases: Mechanism and prospect
Xu, W., Wu, M., Chen, B., & Wang, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.971346 · Cited by 11 · see citing works
Feng, X., Huang, N., Wu, Y., Gao, F., Chen, X., Zhang, C., Zhang, B., & Sun, T. (2024) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2024.00034 · Cited by 10 · see citing works
Global Burden of Alcohol‐Associated Liver Disease Across 204 Countries, 1990–2021: GBD 2021 Findings
Wang, Y., Han, X., Zhang, X., Yuan, X., Wei, Q., Sang, L.-X., Chang, B., & Quan-sheng, L. (2025) · Liver International · doi:10.1111/liv.70283 · Cited by 11 · see citing works
Xu, K., Shi, M., Zhang, W., Shi, Y., Dong, Q., Shen, X., Chen, X.-L., & Lin, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.655343 · Cited by 10 · see citing works
Zhang, N., Xue, F., Wu, X., Zhang, W., Hou, J., Xiang, J., Lv, Y., & Zhang, X. (2023) · Alcohol and Alcoholism · doi:10.1093/alcalc/agad046 · Cited by 11 · see citing works
Chen, Y., Liu, H., Yu, Z., Yang, Y., Huang, Q., Deng, C., Rao, H., & Wu, H. (2022) · International Journal of General Medicine · doi:10.2147/ijgm.s356761 · Cited by 10 · see citing works
Huang, T., Lin, M., Wang, J., Chang, K., Yen, Y., Kuo, F., Huang, C., Hsiao, C., Chiu, S. Y., Lu, S., et al. (2020) · International Journal of Clinical Practice · doi:10.1111/ijcp.13945 · Cited by 9 · see citing works
Zhang, D., Wang, T., Yue, Z., Wang, L., Fan, Z., Wu, Y., & Liu, F. (2023) · World Journal of Gastrointestinal Surgery · doi:10.4240/wjgs.v15.i11.2490 · Cited by 7 · see citing works
Chen, L., Liu, Q., Li, X., Zhang, L., Dong, W., Li, Q., Su, H., Luo, G., Huang, Y., & Yang, X. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177320 · Cited by 6 · see citing works
Yeo, Y. H., Mehravar, S., Choi, E., Yang, J., Kim, H.-S., Wang, Y., Vipani, A., Trivedi, H. D., Ayoub, W. S., Naji, P., et al. (2026) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.70619 · Cited by 6 · see citing works
Sak, J. J., Prystupa, A., Kiciński, P., Luchowska-Kocot, D., Kurys-Denis, E., & Bis-Wencel, H. (2021) · World Journal of Hepatology · doi:10.4254/wjh.v13.i12.2071 · Cited by 6 · see citing works
Lin, S., Chen, W., Tsai, M.-H., Liu, L.-T., Kuo, W.-L., Lin, Y., Wang, S., Chen, B.-H., Lee, C., Huang, C., et al. (2024) · Internal and Emergency Medicine · doi:10.1007/s11739-024-03536-4 · Cited by 4 · see citing works
Jiménez-Luévano, M. Á., Jiménez-Partida, A. E., Díaz, E. S., Orozco‐Alonso, E., Villaseñor-Garcı́a, M. M., Bravo‐Cuéllar, A., Gutiérrez-Ortiz, J. A., Bravo‐Cuéllar, A., & Hernández‐Flores, G. (2024) · Biomedical Reports · doi:10.3892/br.2024.1861 · Cited by 3 · see citing works
Lin, S., Chen, W.-T., Tsai, M.-H., Kuo, W.-L., Wang, S.-F., Liu, Y., Chiu, Y.-T., Chen, B.-H., Huang, C., & Chien, R. (2023) · Diagnostics · doi:10.3390/diagnostics13203160 · Cited by 3 · see citing works
GLP-1 receptor agonism results in reduction in hepatic ethanol metabolism
Zahrawi, F. M., Arumugam, S., Banini, B. A., & Mehal, W. Z. (2025) · npj Metabolic Health and Disease · doi:10.1038/s44324-025-00077-y · Cited by 3 · see citing works
Kasztelan‐Szczerbińska, B., Zygo, B., Rycyk, A., Surdacka, A., Roliński, J., & Cichoż‐Lach, H. (2023) · PLoS ONE · doi:10.1371/journal.pone.0280068 · Cited by 3 · see citing works
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Bayraktar, E. A., & Salvatore, M. M. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07449-4 · Cited by 2 · see citing works
Mandot, A., & Shah, S. R. (2026) · Springer eBooks · doi:10.1007/978-981-95-2624-6_12 · Cited by 1 · see citing works
Jagdish, B., Murone, J. N., & Venkat, D. (2025) · Digestive Diseases and Sciences · doi:10.1007/s10620-025-08846-x · Cited by 1 · see citing works
Esparza, A. G. P., Sánchez-Castillo, F. A., Rada-Rada, M., Noguera-Fonseca, J., Pinzón-Rodríguez, L. D., & Ávila-Espitia, T. J. (2024) · Revista Investigación en Salud Universidad de Boyacá · doi:10.24267/23897325.1037 · Cited by 1 · see citing works
Maatman, T. K., & Zyromski, N. J. (2020) · Current Problems in Surgery · doi:10.1016/j.cpsurg.2020.100859
Gavurová, B., & Ivanková, V. (2022) · Springer eBooks · doi:10.1007/978-3-030-67928-6_188-1
Gavurová, B., & Ivanková, V. (2022) · Springer eBooks · doi:10.1007/978-3-030-92392-1_188
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Tang, Z., Zhang, P., Li, L., Guo, Y., You, Y., & Liao, Y. (2023) · Journal of Men s Health · doi:10.22514/jomh.2023.119
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Rais, N., Ved, A., Ahmad, R., & Kumar, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15535-2.00002-5
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Codés, L., Bittencourt, P. L., Mussi, F. C., Thibes, M. Z., Ferraz, M. L. G., & de Andrade, A. G. (2024) · Arquivos de Gastroenterologia · doi:10.1590/s0004-2803.24612023-175
Deschamps, A., Légaré, A.-A., Auger, A.-M., Gómez, N. M., & Brodeur, M. (2025) · Drug and Alcohol Dependence Reports · doi:10.1016/j.dadr.2025.100383
Ding, S., Lu, S., Cui, L., Li, J., Qin, X., & Liu, X. (2025) · BMC Gastroenterology · doi:10.1186/s12876-025-04444-3
- Authors
- Lucey, M. R.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Lucey, Michael R.
- ORCID
- Lucey, Michael R.
- Venue
- Clinics in Liver Disease
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 23
- Issue
- 1
- Pages
- 115-126
- ISSN
- 1089-3261 (ISSN-L)
- OpenAlex
- W2900761630
- Cited by
- 39
- References
- 35
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 5 · 2021: 3 · 2020: 5 · 2019: 2
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinics in Liver Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- alcoholic cirrhosis, alcoholism, non-invasive diagnosis, natural history (disease), alcohol abstinence, acute-on-chronic liver failure, hepatic decompensation, liver transplantation, palliative care
- MeSH terms
- Cigarette Smoking, Alcoholism, Cause of Death, Hemochromatosis, Carcinoma, Hepatocellular, Humans, Liver Cirrhosis, Alcoholic, Liver Neoplasms, Palliative Care, Comorbidity, Liver Transplantation, Disease Progression, Disease Management, Hepatitis B, Chronic, Hepatitis C, Chronic, Alcohol Abstinence, Non-alcoholic Fatty Liver Disease
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