The DOI matches its Crossref record; 55 of the 56 references it cites were found in a registry or an index.
Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse
Abstract
Previous studies showed the Fmr1 knockout (KO) mouse to be an excellent animal model for human fragile-X syndrome. The aim of this study was to further characterize the phenotype of these animals. Neuroanatomically, KO male mice were compared to wild-types (littermates) with respect to their sizes of hippocampal intra- and infrapyramidal mossy fiber (IIPMF) terminal fields. Behaviorally, they were tested in four different paradigms, each measuring different aspects of cognitive and emotional behavior: elevated plus maze (anxiety), neutral cage (aggression), open field (exploration), and radial maze (spatial memory). The results showed a diminished ability for radial maze learning associated with smaller sizes of IIPMF terminal fields. In addition, Fmr1 knockout animals exhibited increased locomotor activity, while no differences were found for aggression and anxiety. These data suggest the involvement of FMRP protein in the development of spatial learning and the sprouting of IIPMF terminal fields.
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“Among the behavioral phenotypes displayed in Fmr1 KO are deficits in object recognition memory (including a failure to habituate to objects), and impairment of spatial memory (Mineur et al., 2002).”
From Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders (2014) · cites this paper as Mineur et al., 2002
In the citing paper
“Several studies indicate that Fmr1 KO mice are hyperactive and show indications of increased anxiety (Bakker et al., 1994; Mineur et al., 2002; Spencer et al., 2005) and sensory hyperre-sponsiveness, especially to auditory stimuli (Chen and Toth, 2001; Frankland et al., 2004; Nielsen et al., 2002).”
From Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders (2014) · cites this paper as Mineur et al., 2002
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Cites
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Self-citationFmr1 knockout mice: A model to study fragile X mental retardation
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Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits
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“Previous studies indicated that FMRP expression appears principally near synapses following neurotransmitter activation and that FMRP plays an important role in maturation and synaptic plasticity (Comery et al., 1997; Weiler et al., 1997; Weiler and Greenough, 1999; Irwin et al., 2000).”
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1 of the 56 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
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Giampetruzzi, A. (2014) · OpenCommons at University of Connecticut (University of Connecticut)
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Liao, Y., Liu, J., Zhang, J., Chen, D., Liu, Y., Li, Z., Su, H., Tang, J., & Chen, S. (2024) · Neurological Sciences and Neurophysiology · doi:10.4103/nsn.nsn_25_24
Astrocytic contribution to auditory hypersensitivity in a mouse model of fragile X syndromePreprint
Bergdolt, L., Anding, A., Alshaqi, O., Arbabi, Z., Douchey, M., Eldridge, E., Hoffman, K., Reid, A., Sapkota, K., Padmashri, R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.14.638346
Oxytocin and Vasopressin in Autism and Genetic Syndromes
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FMRP dependent synaptic delivery of messenger RNA
Kao, D.-I. (2011) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Involvement of mGluR5/Homer crosstalk disruption in the pathophysiology of Fragile X Syndrome
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BKCa channels as therapeutic targets in neurodevelopmental disorders : focus on acoustic dysfunction
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Socio-communicative and nucleus accumbens core dysfunctions in fragile X syndrome
Giua, G. (2023) · theses.fr (ABES) · doi:10.70675/e45d048ez2538z4905zba74z1de16201406a
Vadher, A., Duszkiewicz, A. J., Wood, E. R., & Dudchenko, P. A. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1929983
Metadata
- Authors
- Mineur, Y. S., Sluyter, F., de Wit, S., Oostra, B. A., & Crusio, W. E.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Erasmus University Rotterdam (NL)
- King's College London (GB)
- Corresponding author
- Crusio, Wim E.
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2002-01
- Volume
- 12
- Issue
- 1
- Pages
- 39-46
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- OpenAlex
- W2042310987
- Cited by
- 216
- References
- 56
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 10 · 2017: 12 · 2016: 11 · 2015: 10 · 2014: 21 · 2013: 14 · 2012: 16
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (5R01 HD 38038, R01HD038038)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- Fmr1 knockout mice, fragile X syndrome, FMRP, spatial learning, radial maze, anxiety, aggression, locomotor activity, neuroanatomy, cognitive behavior
- MeSH terms
- Animals, Anxiety, Behavior, Animal, Disease Models, Animal, Exploratory Behavior, Fragile X Syndrome, Hippocampus, Humans, Male, Memory, Mice, Inbred C57BL, Motor Activity, Nerve Tissue Proteins, RNA-Binding Proteins, Mice, Knockout, Maze Learning, Mossy Fibers, Hippocampal, Mice, Fragile X Messenger Ribonucleoprotein 1
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