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Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse

Mineur, Yann S., Sluyter, Frans, de Wit, Sanne, Oostra, Ben A., Crusio, Wim E.·2002·Hippocampus

DOI 10.1002/hipo.10005

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Abstract

Previous studies showed the Fmr1 knockout (KO) mouse to be an excellent animal model for human fragile-X syndrome. The aim of this study was to further characterize the phenotype of these animals. Neuroanatomically, KO male mice were compared to wild-types (littermates) with respect to their sizes of hippocampal intra- and infrapyramidal mossy fiber (IIPMF) terminal fields. Behaviorally, they were tested in four different paradigms, each measuring different aspects of cognitive and emotional behavior: elevated plus maze (anxiety), neutral cage (aggression), open field (exploration), and radial maze (spatial memory). The results showed a diminished ability for radial maze learning associated with smaller sizes of IIPMF terminal fields. In addition, Fmr1 knockout animals exhibited increased locomotor activity, while no differences were found for aggression and anxiety. These data suggest the involvement of FMRP protein in the development of spatial learning and the sprouting of IIPMF terminal fields.

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Authors: Mineur, Y. S., Sluyter, F., de Wit, S., Oostra, B. A., & Crusio, W. E.
Affiliations: Centre National de la Recherche Scientifique (FR)
Erasmus University Rotterdam (NL)
King's College London (GB)
Corresponding author: Crusio, Wim E.
ORCID: Mineur, Yann S.
Crusio, Wim E.
Venue: Hippocampus
Publisher: Wiley
Published: 2002-01
Volume: 12
Issue: 1
Pages: 39-46
ISSN: 1050-9631 (ISSN-L)
1098-1063
DOI: 10.1002/hipo.10005
OpenAlex: W2042310987
Cited by: 216
References: 56
Citations by year: 2026: 2 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 10 · 2017: 12 · 2016: 11 · 2015: 10 · 2014: 21 · 2013: 14 · 2012: 16
FWCI: 4.77
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 28 d)
Locations: Hippocampus (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: National Institutes of Health
Eunice Kennedy Shriver National Institute of Child Health and Human Development (5R01 HD 38038, R01HD038038)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: Fmr1 knockout mice, fragile X syndrome, FMRP, spatial learning, radial maze, anxiety, aggression, locomotor activity, neuroanatomy, cognitive behavior
MeSH terms: Animals, Anxiety, Behavior, Animal, Disease Models, Animal, Exploratory Behavior, Fragile X Syndrome, Hippocampus, Humans, Male, Memory, Mice, Inbred C57BL, Motor Activity, Nerve Tissue Proteins, RNA-Binding Proteins, Mice, Knockout, Maze Learning, Mossy Fibers, Hippocampal, Mice, Fragile X Messenger Ribonucleoprotein 1

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Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse

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