Conserved Hippocampal Cellular Pathophysiology but Distinct Behavioural Deficits in a New Rat Model of FXS

Genome sequence of the Brown Norway rat yields insights into mammalian evolution

Gibbs, R. A., Weinstock, G. M., Metzker, M. L., Muzny, D. M., Sodergren, E. J., Scherer, S. E., Scott, G., Steffen, D. L., Worley, K. C., Burch, P. E., et al. (2004) · Nature · doi:10.1038/nature02426 · Cited by 2,147 · see citing works

Altered synaptic plasticity in a mouse model of fragile X mental retardation

Huber, K. M., Gallagher, S. M., Warren, S. T., & Bear, M. F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122205699 · Cited by 1,349 · see citing works

Correction of Fragile X Syndrome in Mice

Dölen, G., Osterweil, E., Rao, B. S. S., Smith, G. B., Auerbach, B. D., Chattarji, S., & Bear, M. F. (2007) · Neuron · doi:10.1016/j.neuron.2007.12.001 · Cited by 979 · see citing works

Evidence that fragile X mental retardation protein is a negative regulator of translation

Laggerbauer, B. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.4.329 · Cited by 571 · see citing works

The translation of translational control by FMRP: therapeutic targets for FXS

Darnell, J. C., & Klann, E. (2013) · Nature Neuroscience · doi:10.1038/nn.3379 · Cited by 491 · see citing works

Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice

Michalon, A., Sidorov, M., Ballard, T. M., Ozmen, L., Spooren, W., Wettstein, J. G., Jaeschke, G., Bear, M. F., & Lindemann, L. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.009 · Cited by 489 · see citing works

The fragile X mental retardation protein inhibits translation via interacting with mRNA

Li, Z. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.11.2276 · Cited by 448 · see citing works

Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome

Osterweil, E. K., Krueger, D. D., Reinhold, K., & Bear, M. F. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3888-10.2010 · Cited by 384 · see citing works

Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice

Bhattacharya, A., Kaphzan, H., Alvarez-Dieppa, A. C., Murphy, J. P., Pierre, P., & Klann, E. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.022 · Cited by 316 · see citing works

Fragile X mouse: strain effects of knockout phenotype and evidence suggesting deficient amygdala function

Paradee, W., Melikian, H. E., Rasmussen, D. L., Kenneson, A., Conn, P. J., & Warren, S. T. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00285-7 · Cited by 305 · see citing works

Metabotropic Receptor-Dependent Long-Term Depression Persists in the Absence of Protein Synthesis in the Mouse Model of Fragile X Syndrome

Nosyreva, E. D., & Huber, K. M. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01316.2005 · Cited by 292 · see citing works

Postadolescent Changes in Regional Cerebral Protein Synthesis: An<i>In Vivo</i>Study in the<i>Fmr1</i>Null Mouse

Qin, M., Kang, J., Burlin, T. V., Jiang, C., & Smith, C. B. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0093-05.2005 · Cited by 263 · see citing works

Associative recognition and the hippocampus: Differential effects of hippocampal lesions on object‐place, object‐context and object‐place‐context memory

Langston, R. F., & Wood, E. R. (2009) · Hippocampus · doi:10.1002/hipo.20714 · Cited by 244 · see citing works

Analysing hippocampal function in transgenic mice: an ethological perspective

Gerlai, R. T., & Clayton, N. S. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01346-0 · Cited by 211 · see citing works

The FXG: a presynaptic fragile X granule expressed in a subset of developing brain circuits

Christie, S. B., Akins, M. R., Schwob, J. E., & Fallon, J. R. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3937-08.2009 · Cited by 208 · see citing works

Mildly impaired water maze performance in maleFmr1 knockout mice

D'Hooge, R., Nagels, G., Franck, F., Bakker, C. E., Reyniers, E., Storm, K., Kooy, R. F., Oostra, B. A., Willems, P. J., & De Deyn, P. P. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00224-2 · Cited by 208 · see citing works

The trouble with spines in fragile X syndrome: density, maturity and plasticity

He, C. X., & Portera‐Cailliau, C. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.049 · Cited by 206 · see citing works

Spatial learning, contextual fear conditioning and conditioned emotional response in Fmr1 knockout mice

Dam, D. V., D’Hooge, R., Hauben, E., Reyniers, E., Gantois, I., Bakker, C. E., Oostra, B. A., Kooy, R. F., & Deyn, P. P. D. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00296-5 · Cited by 145 · see citing works

Fmr1 and Nlgn3 knockout rats: Novel tools for investigating autism spectrum disorders.

Hamilton, S. M., Green, J. R., Veeraragavan, S., Yuva, L., McCoy, A., Wu, Y., Warren, J., Little, L., Ji, D., Cui, X., et al. (2014) · Behavioral Neuroscience · doi:10.1037/a0035988 · Cited by 144 · see citing works

Increased Expression of the PI3K Enhancer PIKE Mediates Deficits in Synaptic Plasticity and Behavior in Fragile X Syndrome

Gross, C., Chang, C.-W., Kelly, S. M., Bhattacharya, A., McBride, S. M. J., Danielson, S. W., Jiang, M. Q., Chan, C. B., Ye, K., Gibson, J. R., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.060 · Cited by 117 · see citing works

Male and female Fmr1 knockout mice on C57 albino background exhibit spatial learning and memory impairments

Baker, K. B., Wray, S. P., Ritter, R., Mason, S. M., Lanthorn, T. H., & Savelieva, K. V. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00585.x · Cited by 101 · see citing works

Altered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome

Till, S. M., Wijetunge, L. S., Seidel, V. G., Harlow, E., Wright, A. K., Bagni, C., Contractor, A., Gillingwater, T. H., & Kind, P. C. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds030 · Cited by 91 · see citing works

The Atlantis platform: a new design and further developments of Buresova's on-demand platform for the water maze.Preprint

Spooner, R. I., Thomson, A. C., Hall, J., Morris, R., & Salter, S. H. (1994) · Learning & Memory · doi:10.1101/lm.1.3.203 · Cited by 89 · see citing works

Evidence for Altered Fragile-X Mental Retardation Protein Expression in Response to Behavioral Stimulation

Irwin, S. A., Swain, R. A., Christmon, C. A., Chakravarti, A. B., Weiler, I. J., & Greenough, W. T. (2000) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1999.3914 · Cited by 84 · see citing works

Which Comes First in Fragile X Syndrome, Dendritic Spine Dysgenesis or Defects in Circuit Plasticity?

Portera‐Cailliau, C. (2011) · The Neuroscientist · doi:10.1177/1073858410395322 · Cited by 68 · see citing works

Stimulated Emission Depletion (STED) Microscopy Reveals Nanoscale Defects in the Developmental Trajectory of Dendritic Spine Morphogenesis in a Mouse Model of Fragile X Syndrome

Wijetunge, L. S., Angibaud, J., Frick, A., Kind, P. C., & Nägerl, U. V. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.5302-13.2014 · Cited by 65 · see citing works

Fragile X syndrome: From targets to treatments

Wijetunge, L. S., Chattarji, S., Wyllie, D. J. A., & Kind, P. C. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.11.028 · Cited by 49 · see citing works

Untitled work

(1999) · doi:10.1002/(sici)1098-1063(1999)9:2

Synaptopathology Involved in Autism Spectrum Disorder

Guang, S., Pang, N., Deng, X., Yang, L., He, F. P., Wu, L., Chen, C., Yin, F., & Peng, J. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00470 · Cited by 283 · see citing works

Lessons learned from studying syndromic autism spectrum disorders

Sztainberg, Y., & Zoghbi, H. Y. (2016) · Nature Neuroscience · doi:10.1038/nn.4420 · Cited by 286 · see citing works

Sensory Processing Phenotypes in Fragile X Syndrome

Rais, M., Binder, D. K., Razak, K. A., & Ethell, I. M. (2018) · ASN NEURO · doi:10.1177/1759091418801092 · Cited by 128 · see citing works

Pharmacological enhancement of KCC2 gene expression exerts therapeutic effects on human Rett syndrome neurons and Mecp2 mutant mice

Tang, X., Drotar, J., Li, K., Clairmont, C. D., Brumm, A. S., Sullins, A., Wu, H., Liu, X. S., Wang, J., Gray, N. S., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau0164 · Cited by 124 · see citing works

Of Men and Mice: Modeling the Fragile X Syndrome

Dahlhaus, R. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00041 · Cited by 118 · see citing works

FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory

Sawicka, K., Hale, C. R., Park, C. Y., Fak, J. J., Gresack, J. E., Driesche, S. J. V., Kang, J. J., Darnell, J. C., & Darnell, R. B. (2019) · eLife · doi:10.7554/elife.46919 · Cited by 113 · see citing works

Aberrant RNA translation in fragile X syndrome: From FMRP mechanisms to emerging therapeutic strategies

Banerjee, A., Ifrim, M. F., Valdez‐Sinon, A. N., Raj, N., & Bassell, G. J. (2018) · Brain Research · doi:10.1016/j.brainres.2018.04.008 · Cited by 103 · see citing works

Selective deletion of astroglial FMRP dysregulates glutamate transporter GLT1 and contributes to fragile X syndrome phenotypes in vivo.

Higashimori, H., Schin, C. S., Chiang, M. S. R., Morel, L., Shoneye, T. A., Nelson, D. L., & Yang, Y. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1069-16.2016 · Cited by 105 · see citing works

Metformin for treatment of fragile X syndrome and other neurological disorders

Gantois, I., Popic, J., Khoutorsky, A., & Sonenberg, N. (2019) · Annual Review of Medicine · doi:10.1146/annurev-med-081117-041238 · Cited by 87 · see citing works

Convergence of Hippocampal Pathophysiology in <i>Syngap</i> ^+/− and <i>Fmr1</i> ^{−/ <i>y</i>} Mice

Barnes, S. A., Wijetunge, L. S., Jackson, A. D., Katsanevaki, D., Osterweil, E. K., Komiyama, N. H., Grant, S. G. N., Bear, M. F., Nägerl, U. V., Kind, P. C., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1087-15.2015 · Cited by 84 · see citing works

Hippocampal deficits in neurodevelopmental disorders

Li, Y., Shen, M., Stockton, M. E., & Zhao, X. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.10.001 · Cited by 84 · see citing works

Loss of FMRP Impaired Hippocampal Long-Term Plasticity and Spatial Learning in Rats

Tian, Y., Yang, C., Shang, S., Cai, Y., Deng, X., Zhang, J., Shao, F., Zhu, D., Liu, Y., Chen, G., et al. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00269 · Cited by 82 · see citing works

Presynaptic dysfunction in neurodevelopmental disorders: Insights from the synaptic vesicle life cycle

Bonnycastle, K., Davenport, E. C., & Cousin, M. A. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15035 · Cited by 74 · see citing works

Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome

Asiminas, A., Jackson, A. D., Louros, S. R., Till, S. M., Spano, T., Dando, O., Bear, M. F., Chattarji, S., Hardingham, G. E., Osterweil, E. K., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aao0498 · Cited by 78 · see citing works

Hippocampal metabotropic glutamate receptor long‐term depression in health and disease: focus on mitogen‐activated protein kinase pathways

Sanderson, T. M., Hogg, E. L., Collingridge, G. L., & Corrêa, S. A. L. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13592 · Cited by 70 · see citing works

Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome

Booker, S. A., de Oliveira, L. S., Anstey, N. J., Kozić, Z., Dando, O., Jackson, A. D., Baxter, P. S., Isom, L. L., Sherman, D. L., Hardingham, G. E., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107988 · Cited by 66 · see citing works

Possible Therapeutic Doses of Cannabinoid Type 1 Receptor Antagonist Reverses Key Alterations in Fragile X Syndrome Mouse Model

Gomis‐González, M., Busquets-García, A., Matute, C., Maldonado, R. J., Mato, S., & Ozaita, A. (2016) · Genes · doi:10.3390/genes7090056 · Cited by 64 · see citing works

Impaired cognitive discrimination and discoordination of coupled theta–gamma oscillations in Fmr1 knockout mice

Radwan, B., Dvorak, D., & Fenton, A. A. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.01.003 · Cited by 63 · see citing works

BDNF controls object recognition memory reconsolidation

Radiske, A., Rossato, J. I., González, M. C., Köhler, C. A., Bevilaqua, L. R., & Cammarota, M. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.02.018 · Cited by 62 · see citing works

Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome

McCamphill, P. K., Stoppel, L. J., Senter, R. K., Lewis, M. C., Heynen, A. J., Stoppel, D. C., Sridhar, V., Collins, K. A., Shi, X., Pan, J. Q., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aam8572 · Cited by 57 · see citing works

Roles for Arc in metabotropic glutamate receptor-dependent LTD and synapse elimination: Implications in health and disease

Wilkerson, J. R., Albanesi, J. P., & Huber, K. M. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.09.035 · Cited by 57 · see citing works

Excess ribosomal protein production unbalances translation in a model of Fragile X Syndrome

Seo, S. S., Louros, S. R., Anstey, N. J., Gonzalez‐Lozano, M. A., Harper, C. B., Verity, N., Dando, O., Thomson, S. R., Darnell, J. C., Kind, P. C., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30979-0 · Cited by 50 · see citing works

Cell-type-specific synaptic imbalance and disrupted homeostatic plasticity in cortical circuits of ASD-associated Chd8 haploinsufficient mice

Ellingford, R. A., Panasiuk, M. J., de Meritens, E. R., Shaunak, R., Naybour, L., Browne, L., Basson, M. A., & Andreae, L. C. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01070-9 · Cited by 50 · see citing works

Hyperexcitability and homeostasis in fragile X Syndrome.

Liu, X., Kumar, V., Tsai, N.-P., & Auerbach, B. D. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.805929 · Cited by 53 · see citing works

Oxytocin as a Modulator of Synaptic Plasticity: Implications for Neurodevelopmental Disorders

Rajamani, K. T., Wagner, S., Grinevich, V., & Harony-Nicolas, H. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00017 · Cited by 53 · see citing works

Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome

Costa, L., Sardone, L. M., Bonaccorso, C. M., D’Antoni, S., Spatuzza, M., Gulisano, W., Tropea, M. R., Puzzo, D., Leopoldo, M., Lacivita, E., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00353 · Cited by 49 · see citing works

Gamma power abnormalities in a Fmr1-targeted transgenic rat model of fragile X syndrome

Kozono, N., Okamura, A., Honda, S., Matsumoto, M., & Mihara, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-75893-x · Cited by 47 · see citing works

Altered motor learning and coordination in mouse models of autism spectrum disorder

Cording, K. R., & Bateup, H. S. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1270489 · Cited by 45 · see citing works

Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome

Kashima, R., Redmond, P. L., Ghatpande, P., Roy, S., Kornberg, T. B., Hanke, T., Knapp, S., Lagna, G., & Hata, A. (2017) · Science Signaling · doi:10.1126/scisignal.aai8133 · Cited by 46 · see citing works

Disrupted Cortical State Regulation in a Rat Model of Fragile X Syndrome

Berzhanskaya, J., Phillips, M. A., Gorin, A., Lai, C., Shen, J., & Colonnese, M. T. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhv331 · Cited by 43 · see citing works

Sensory hypo-excitability in a rat model of fetal development in Fragile X Syndrome

Berzhanskaya, J., Phillips, M. A., Shen, J., & Colonnese, M. T. (2016) · Scientific Reports · doi:10.1038/srep30769 · Cited by 41 · see citing works

The Application of Adeno-Associated Viral Vector Gene Therapy to the Treatment of Fragile X Syndrome

Hampson, D. R., Hooper, A. W. M., & Niibori, Y. (2019) · Brain Sciences · doi:10.3390/brainsci9020032 · Cited by 36 · see citing works

Healing autism spectrum disorder with cannabinoids: a neuroinflammatory story

Carbone, E., Manduca, A., Cacchione, C., Vicari, S., & Trezza, V. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.12.009 · Cited by 37 · see citing works

Perinatal supplementation with omega-3 fatty acids corrects the aberrant social and cognitive traits observed in a genetic model of autism based on FMR1 deletion in rats

Schiavi, S., Carbone, E., Melancia, F., Buzzelli, V., Manduca, A., Campolongo, P., Pallottini, V., & Trezza, V. (2022) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1819107 · Cited by 34 · see citing works

Neurobiological Mechanisms of Autism Spectrum Disorder and Epilepsy, Insights from Animal Models

Sierra-Arregui, T., Llorente, J., Mı́nguez, P., Tønnesen, J., & Peñagarikano, O. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.02.043 · Cited by 32 · see citing works

Auditory hypersensitivity and processing deficits in a rat model of fragile X syndrome

Auerbach, B. D., Manohar, S., Radziwon, K. E., & Salvi, R. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105541 · Cited by 32 · see citing works

Modelling fragile X syndrome in the laboratory setting: A behavioral perspective

Melancia, F., & Trezza, V. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.04.042 · Cited by 29 · see citing works

Experiential contributions to social dominance in a rat model of fragile-X syndrome

Saxena, K., Webster, J., Hallas-Potts, A., Mackenzie, R., Spooner, P. A., Thomson, D., Kind, P. C., Chatterji, S., & Morris, R. (2018) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2018.0294 · Cited by 27 · see citing works

Deletion of the KH1 Domain of <i>Fmr1</i> Leads to Transcriptional Alterations and Attentional Deficits in Rats

Golden, C. E. M., Breen, M. S., Koro, L., Sonar, S., Niblo, K., Browne, A., Burlant, N., Di Marino, D., De Rubeis, S., Baxter, M. G., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz029 · Cited by 29 · see citing works

FMRP and CYFIP1 at the Synapse and Their Role in Psychiatric Vulnerability

Clifton, N. E., Thomas, K. L., Wilkinson, L. S., Hall, J., & Trent, S. (2020) · Complex Psychiatry · doi:10.1159/000506858 · Cited by 28 · see citing works

Sexually dimorphic patterns in electroencephalography power spectrum and autism-related behaviors in a rat model of fragile X syndrome

Wong, H., Hooper, A. W. M., Niibori, Y., Lee, S. J., Hategan, L. A., Zhang, L., Karumuthil‐Melethil, S., Till, S. M., Kind, P. C., Danos, O., et al. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105118 · Cited by 27 · see citing works

Anandamide and 2-arachidonoylglycerol differentially modulate autistic-like traits in a genetic model of autism based on FMR1 deletion in rats

Schiavi, S., Manduca, A., Carbone, E., Buzzelli, V., Rava, A., Feo, A., Ascone, F., Morena, M., Campolongo, P., Hill, M. N., et al. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01454-7 · Cited by 26 · see citing works

Updates on the Physiopathology of Group I Metabotropic Glutamate Receptors (mGluRI)-Dependent Long-Term Depression

Mango, D., & Ledonne, A. (2023) · Cells · doi:10.3390/cells12121588 · Cited by 24 · see citing works

NMDAR mediated translation at the synapse is regulated by MOV10 and FMRP

Kute, P. M., Ramakrishna, S., Neelagandan, N., Chattarji, S., & Muddashetty, R. S. (2019) · Molecular Brain · doi:10.1186/s13041-019-0473-0 · Cited by 23 · see citing works

Bridging the species gap in translational research for neurodevelopmental disorders

Ryan, A. M., Berman, R. F., & Bauman, M. D. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.10.006 · Cited by 24 · see citing works

Auditory Brain Stem Responses in the C57BL/6J Fragile X Syndrome-Knockout Mouse Model

Chawla, A., & McCullagh, E. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2021.803483 · Cited by 23 · see citing works

Psilocybin mitigates the cognitive deficits observed in a rat model of Fragile X syndrome

Buzzelli, V., Carbone, E., Manduca, A., Schiavi, S., Feo, A., Perederiy, J. V., Ambert, K. H., Hausman, M., & Trezza, V. (2023) · Psychopharmacology · doi:10.1007/s00213-022-06286-3 · Cited by 22 · see citing works

An “Omic” Overview of Fragile X Syndrome

Dionne, O., & Corbin, F. (2021) · Biology · doi:10.3390/biology10050433 · Cited by 22 · see citing works

Characterisation of Cdkl5 transcript isoforms in rat

Hector, R. D., Dando, O., Ritakari, T. E., Kind, P. C., Bailey, M. E. S., & Cobb, S. (2016) · Gene · doi:10.1016/j.gene.2016.12.001 · Cited by 20 · see citing works

Genetic rodent models of brain disorders: Perspectives on experimental approaches and therapeutic strategies

McGraw, C. M., Ward, C. S., & Samaco, R. C. (2017) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31570 · Cited by 19 · see citing works

Synaptic plasticity/dysplasticity, process memory and item memory in rodent models of mental dysfunction

O’Reilly, K. C., Perica, M. I., & Fenton, A. A. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.08.025 · Cited by 20 · see citing works

Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome

Asiminas, A., Booker, S. A., Dando, O., Kozić, Z., Arkell, D., Inkpen, F. H., Sumera, A., Akyel, I., Kind, P. C., & Wood, E. R. (2022) · Molecular Autism · doi:10.1186/s13229-022-00528-z · Cited by 19 · see citing works

Regional rates of brain protein synthesis are unaltered in dexmedetomidine sedated young men with fragile X syndrome: A L-[1-11C]leucine PET study

Schmidt, K., Loutaev, I., Quezado, Z., Sheeler, C. A., & Smith, C. B. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104978 · Cited by 19 · see citing works

Correction of amygdalar dysfunction in a rat model of fragile X syndrome

Fernandes, G., Mishra, P. K., Nawaz, M. S., Donlin-Asp, P., Rahman, M. M., Hazra, A., Kedia, S., Kayenaat, A., Songara, D., Wyllie, D. J. A., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109805 · Cited by 18 · see citing works

Memory deficits with intact cognitive control in the methylazoxymethanol acetate (MAM) exposure model of neurodevelopmental insult

O’Reilly, K. C., Perica, M. I., & Fenton, A. A. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.07.034 · Cited by 18 · see citing works

FMRP binding to a ranked subset of long genes is revealed by coupled CLIP and TRAP in specific neuronal cell typesPreprint

Driesche, S. J. V., Sawicka, K., Zhang, C., Hung, K. Y. S., Park, C. Y., Fak, J. J., Yang, C., Darnell, R. B., & Darnell, J. C. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/762500 · Cited by 17 · see citing works

Mechanisms regulating input-output function and plasticity of neurons in the absence of FMRP

Booker, S. A., & Kind, P. C. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.06.025 · Cited by 16 · see citing works

Myelination Deficits in the Auditory Brainstem of a Mouse Model of Fragile X Syndrome

Lucas, A., Poleg, S., Klug, A., & McCullagh, E. (2021) · bioRxiv · doi:10.3389/fnins.2021.772943 · Cited by 12 · see citing works

Reduced Levels of the Synaptic Functional Regulator FMRP in Dentate Gyrus of the Aging Sprague-Dawley Rat

Šmidák, R., Sialana, F. J., Kristofova, M., Stojanovic, T., Rajcic, D., Maliković, J., Feyissa, D. D., Korz, V., Hoeger, H., Wackerlig, J., et al. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00384 · Cited by 15 · see citing works

New Animal Models for Understanding FMRP Functions and FXS Pathology

Curnow, E. C., & Wang, Y. (2022) · Cells · doi:10.3390/cells11101628 · Cited by 14 · see citing works

Modelling Protein Synthesis as A Biomarker in Fragile X Syndrome Patient-Derived Cells

Pal, R., & Bhattacharya, A. (2019) · Brain Sciences · doi:10.3390/brainsci9030059 · Cited by 13 · see citing works

Brain Cholesterol Biosynthetic Pathway Is Altered in a Preclinical Model of Fragile X Syndrome

Parente, M., Tonini, C., Buzzelli, V., Carbone, E., Trezza, V., & Pallottini, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063408 · Cited by 11 · see citing works

mGluR7 allosteric modulator AMN082 corrects protein synthesis and pathological phenotypes in FXS

Kumar, V., Lee, K. Y., Acharya, A., Babik, M. S., Christian, C. A., Rhodes, J. S., & Tsai, N. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00038-w · Cited by 11 · see citing works

The mGluR Theory of Fragile X: From Mice to Men

Stoppel, L. J., Osterweil, E. K., & Bear, M. F. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804461-2.00009-3 · Cited by 9 · see citing works

Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function

Ntoulas, G., Brakatselos, C., Nakas, G., Asprogerakas, M.-Z., Delis, F., Leontiadis, L. J., Trompoukis, G., Papatheodoropoulos, C., Gkikas, D., Valakos, D., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02815-0 · Cited by 12 · see citing works

The same stress elicits different effects on anxiety-like behavior in rat models of Fmr1 and Pten

Dey, R., & Chattarji, S. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113892 · Cited by 9 · see citing works

Animal Models of Fragile X Syndrome

Kooy, R. F., Jin, P., Bao, H., Till, S. M., Kind, P. C., & Willemsen, R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804461-2.00007-x · Cited by 8 · see citing works

From wings to whiskers to stem cells: why every model matters in fragile X syndrome research

Sandoval, S. O., Méndez-Albelo, N. M., Xu, Z., & Zhao, X. (2024) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-024-09545-w · Cited by 8 · see citing works

Role of peroxisome proliferator-activated receptors α and γ in mediating the beneficial effects of β-caryophyllene in a rat model of fragile X syndrome

Rava, A., Buzzelli, V., Feo, A., Ascone, F., Trapano, M. D., Schiavi, S., Carbone, E., Pasquadibisceglie, A., Polticelli, F., Manduca, A., et al. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111234 · Cited by 8 · see citing works

The Known Unknowns: Missing Pieces in in vivo Models of Fragile X Syndrome

Kulkarni, P., & Sevilimedu, A. (2020) · Journal of Rare Diseases Research & Treatment · doi:10.29245/2572-9411/2020/1.1190 · Cited by 5 · see citing works

Reciprocal regulation of spontaneous synaptic vesicle fusion by Fragile X mental retardation protein and group I metabotropic glutamate receptors

Subrahmanyam, R., Dwivedi, D., Rashid, Z., Bonnycastle, K., Cousin, M. A., & Chattarji, S. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15484 · Cited by 5 · see citing works

Cross-species considerations in models of neurodevelopmental disorders

Till, S. M., Hickson, R. D. L., & Kind, P. C. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2021.12.005 · Cited by 5 · see citing works

Heterozygous deletion of SYNGAP enzymatic domains in rats causes selective learning, social and seizure phenotypesPreprint

Katsanevaki, D., Till, S., Buller‐Peralta, I., Watson, T., Nawaz, M., Arkell, D., Tiwari, S., Kapgal, V., Biswal, S. S., Smith, J., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.14.339192 · Cited by 5 · see citing works

Animal models of autism

Berg, E. L., & Silverman, J. L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-816393-1.00010-5 · Cited by 4 · see citing works

Hippocampal Place Cell Sequences Are Impaired in a Rat Model of Fragile X Syndrome

Donahue, M. M., Robson, E., & Colgin, L. L. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1978-24.2025 · Cited by 4 · see citing works

Behavioural difficulties in fragile X syndrome: current pharmacological options and potential future developments

Stanfield, A. C., & McKechanie, A. G. (2025) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2025.2510408 · Cited by 3 · see citing works

Drug Discovery for Targeted Pharmacotherapy of Fragile X Syndrome

Scharf, S., Gasparini, F., Spooren, W., & Lindemann, L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804461-2.00018-4 · Cited by 1 · see citing works

Developmental trajectory of episodic-like memory in rats

Asiminas, A., Lyon, S. A., Langston, R. F., & Wood, E. R. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.969871 · Cited by 3 · see citing works

iHELMET: A 3D-printing solution for safe endoscopic Ca2+ recording in social neuroscience

Saxena, K., Spooner, P. A., Mitchell‐Heggs, R., & Morris, R. (2021) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2021.109109 · Cited by 3 · see citing works

Hippocampal glial alterations are associated with Lamin B1 dysregulation and abnormal nuclear morphology in a rat model of fragile X syndrome

Rava, A., Feo, A., Bagnato, G., Doria, V., Pezzullo, M., Petrini, S., Buzzelli, V., Ascone, F., Trapano, M. D., Peruzzi, B., et al. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107304 · Cited by 2 · see citing works

Autism and Fragile X Syndrome

O’Leary, H., & Benke, T. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804066-9.00074-2 · Cited by 2 · see citing works

Hippocampal proteome comparison of infant and adult Fmr1 deficiency mice reveals adult-related changes associated with postsynaptic density

Yang, C., Huang, Y.-T., Yao, Y.-F., Fu, J., & Long, Y. (2024) · Journal of Proteomics · doi:10.1016/j.jprot.2024.105202 · Cited by 2 · see citing works

The Application Of Animal Personality In Conservation Biology: Investigating A New Tool In North Island Robin (Petroica longipes)

MacKinlay, R. D. (2022) · doi:10.26686/wgtn.19954310 · Cited by 2 · see citing works

Animal Models of Hyperacusis: Neural Hyperactivity in Auditory, Emotional, Arousal, Memory, and Motor Networks

Salvi, R., Chen, G., Liu, X., Auerbach, B. D., Ding, D., Chen, Y., & Manohar, S. (2024) · Springer eBooks · doi:10.1007/978-3-031-35647-6_23 · Cited by 1 · see citing works

Foundations of an Ovine Model of Fragile X Syndrome

Hawkins, V., Rudiger, S. R., McLaughlan, C. J., Kelly, J. M., Lehnert, K., Jacobsen, J. C., Handley, R. R., Henare, K. L., Verma, P. J., & Snell, R. G. (2026) · Genes · doi:10.3390/genes17020152 · Cited by 1 · see citing works

Electroencephalography signals in a female Fragile X Syndrome mouse model

Ahmed, A., Rasheva, V., Bae, M., Murari, K., & Cheng, N. (2026) · NeuroImage · doi:10.1016/j.neuroimage.2026.121866 · Cited by 1 · see citing works

Demystifying neuroscience laboratory techniques used to investigate single-gene disorders

Mizen, L. A. M., & Stanfield, A. C. (2020) · BJPsych Advances · doi:10.1192/bja.2020.30 · Cited by 1 · see citing works

Autism: Animal Models

Bauman, M. D., Crawley, J. N., & Berman, R. F. (2019) · Wiley eBooks · doi:10.1002/9780470015902.a0022368.pub2 · Cited by 1 · see citing works

Altered developmental profile of the cortical head-direction signal in a rat model of Fragile X SyndromePreprint

Moore, N., Duszkiewicz, A. J., Asiminas, A., Dudchenko, P. A., Peyrache, A., & Wood, E. R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.09.632139 · Cited by 1 · see citing works

FMRP and the Pathophysiology of Fragile X Syndrome

Barnes, S. A., Thomson, S. R., Kind, P. C., & Osterweil, E. K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800109-7.00008-x

Characteristics of cellular and synaptic function in rodent forebrain neurons with altered SynGAP expression

Mizen, L. A. M. (2018) · ERA

Excess ribosomal protein production unbalances translation in Fragile X SyndromePreprint

Seo, S. S., Louros, S. R., Anstey, N. J., Gonzalez‐Lozano, M. A., Harper, C. B., Verity, N., Dando, O., Thomson, S. R., Darnell, J. C., Kind, P. C., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.07.487442

Neurobiology of Autism Spectrum Disorder and Intellectual Disability

Costales, J. L., Rubeis, S. D., Foss‐Feig, J. H., Hof, P. R., Buxbaum, J. D., & Kolezvon, A. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780190681425.003.0063

Measuring Social Communication in Rodent Models of Neurodevelopmental Disorders

Berg, E. L., & Silverman, J. L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819641-0.00002-5

Fmr1 exon 14 skipping in late embryonic development of the rat forebrain

Corrêa-Velloso, J. C., Linardi, A., Glaser, T., Velloso, F. J., Rivas, M. P., Leite, R. E. P., Grinberg, L. T., Ulrich, H., Akins, M. R., Chiavegatto, S., et al. (2022) · BMC Neuroscience · doi:10.1186/s12868-022-00711-1

Bibliography

(2023) · The MIT Press eBooks · doi:10.7551/mitpress/15380.003.0024

Neurobiology of Autism Spectrum Disorder and Intellectual Disability

Massa, A. L., Costales, J. L., Rubeis, S. D., Foss‐Feig, J. H., Hof, P. R., & Kolevzon, A. L. (2025) · doi:10.1093/med/9780197640654.003.0063

RatDISCO, a tissue clearing and immunolabelling protocol for large rat brainsPreprint

Craigie, K. J., Till, S. M., van de Gevel, B., Vandrey, B., Strangward, P., Sieger, D., Gonzalez‐Sulser, A., Kind, P., Rochefort, N. L., Duguid, I., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.17.670723

Epigenetic inheritance of complex learning abilities in the mammalian brainPreprint

Zidan, S., Andreyanov, M., Saleh, A., Barnea, N., Kundu, S., Kumar, A., Bakman, N., Rosenberg, T., Hovav, M., Johenning, F. W., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.31.673327

Cooperative behavior in rat dyads reveals distinct social coordination strategies of increasing complexityPreprint

Shukla, A., Rivera, E., Bladon, J. H., & Jadhav, S. P. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.24.678380

Loss of FMRP Impaired Hippocampal Long-Term Plasticity and Spatial Learning in Rats

Tian, Y., Yang, C., Shang, S., Cai, Y., Deng, X., Zhang, J., Shao, F., Zhu, D., Liu, Y., Chen, G., et al. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00269 · Cited by 82 · see citing works

Cellular and synaptic pathophysiology in a rat model of Fragile X syndrome

Jackson, A. D. (2017) · ERA

Hippocampal Place Cell Sequences Are Impaired in a Rat Model of Fragile X Syndrome

Donahue, M. M., Robson, E., & Colgin, L. L. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1978-24.2025 · Cited by 4 · see citing works

Modelling fragile X syndrome in rats: new directions in translational research

Asiminas, A. (2017) · ERA

Fragile X mental retardation protein is required for chemically‐induced long‐term potentiation of the hippocampus in adult mice

Shang, Y., Wang, H., Mercaldo, V., Li, X., Chen, T., & Zhuo, M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06314.x · Cited by 72 · see citing works