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Cited by 69Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchStress Responses and Cortisol

Effects of complete immunotoxin lesions of the cholinergic basal forebrain on fear conditioning and spatial learning

Frick, Karyn M., Kim, Jeansok J., Baxter, Mark G.·2004·Hippocampus
DOI 10.1002/hipo.10169
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Abstract

Administration of muscarinic cholinergic antagonists such as scopolamine impairs the acquisition of contextual fear conditioning, but the role of the basal forebrain (BF) cholinergic system in consolidation is unclear. To test the hypothesis that BF cholinergic neurons are critical for acquisition and consolidation of fear conditioning, male Sprague‐Dawley rats with 192 IgG‐saporin lesions of the entire cholinergic BF made either before or after fear conditioning were tested for conditioned fear to context and tone by assessing freezing and 22 kHz ultrasonic vocalization (USV) responses. Spatial learning in a 1‐day water maze task provided a comparison for effects of the BF lesions on fear conditioning. In the test phase, neither pre‐training nor posttraining BF lesions affected freezing to the context or tone. During both training and testing, pre‐lesioned rats were impaired in production of USVs associated with fear. Postlesioned rats emitted fewer USVs only during testing. Acquisition of a spatial water maze task was mildly impaired in lesioned rats, although probe trial and cued performance was unimpaired. Nevertheless, these data suggest that conditioned fear‐induced USVs are more sensitive to the loss of BF cholinergic neurons than is conditioned fear‐induced freezing. The failure of BF cholinergic lesions to impair contextual fear conditioning indicates that scopolamine‐induced impairments in fear conditioning may not be mediated by affecting cholinergic input to the hippocampus and neocortex. © 2004 Wiley‐Liss, Inc.

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  • Removal of forebrain cholinergic neurons does not have strong effects on the performance of animals in tasks that do not explicitly tax attentional processes.

    “The robustness and the selectivity of the cognitive impairments produced by such lesions is further supported, albeit indirectly, by a substantial number of experiments which concluded that removal of forebrain cholinergic neurons does not have strong effects on the performance of animals in tasks that do not explicitly tax attentional processes (Vuckovich et al, 2004; Frick et al, 2004).”

    From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Frick et al, 2004

  • Cholinergic lesions of the entire basal forebrain cause only a mild impairment in learning the Morris water maze task.

    “and cholinergic lesions of the entire basal forebrain cause only a mild imairment in learning this task (Frick et al., 2004).”

    From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Frick et al., 2004

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Authors
Frick, K. M., Kim, J. J., & Baxter, M. G.
Affiliations
  • Yale University (US)
  • Harvard University (US)
Corresponding author
Frick, Karyn M.
ORCID
Venue
Hippocampus
Publisher
Wiley
Published
2004-01
Volume
14
Issue
2
Pages
244-254
ISSN
  • 1050-9631 (ISSN-L)
  • 1098-1063
DOI
10.1002/hipo.10169
OpenAlex
W2020728273
Cited by
69
References
57
Citations by year
2026: 1 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 1 · 2012: 1
FWCI
1.68
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 40 d)
Locations
  • Hippocampus (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
basal forebrain cholinergic system, fear conditioning, contextual fear, spatial learning, water maze, scopolamine, ultrasonic vocalizations, freezing behavior, fear consolidation
MeSH terms
Saporins, Animals, Antibodies, Monoclonal, Immunotoxins, Choline O-Acetyltransferase, Conditioning, Operant, Cues, Fear, Glutamate Decarboxylase, Immunohistochemistry, Male, Memory, N-Glycosyl Hydrolases, Parasympathetic Nervous System, Vocalization, Animal, Prosencephalon, Rats, Sprague-Dawley, Maze Learning, Rats, Ribosome Inactivating Proteins, Type 1

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