Phthalic Acid Amygdalopetal Lesion of the Nucleus Basalis Magnocellularis Induces Reversible Memory Deficits in Rats
Abstract
The basolateral amygdala (BLA) is extensively implicated in emotional learning and memory. The current study investigated the contribution of cholinergic afferents to the BLA from the nucleus basalis magnocellularis in influencing aversive learning and memory. Sprague-Dawley rats were given permanent unilateral phthalic acid (300 ng) lesions of the nucleus basalis magnocellularis and were chronically implanted with cannulas aimed at the ipsilateral BLA. Lesioned rats showed a pronounced inhibitory avoidance task retention deficit that was attenuated by acute posttraining infusions of the muscarinic cholinergic agonist oxotremorine (4 ng) or the indirect agonist physostigmine (1 microg) into the BLA. Continuous multiple-trial inhibitory avoidance training and testing revealed that lesioned rats have a mild acquisition deficit, requiring approximately 1 additional shock to reach the criterion, and a pronounced consolidation deficit as indicated by a shorter latency to enter the shock compartment on the retention test. Because lesioned rats did not differ from sham-operated controls in performance on a spatial water maze task or in shock sensitivity, it is not likely that the memory impairments produced by the phthalic acid lesions are due to any general sensory or motor deficits. These findings suggest that the dense cholinergic projection from the nucleus basalis magnocellularis to the BLA is involved in both the acquisition and the consolidation of the aversive inhibitory avoidance task.
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Cholinergic input is required for memory consolidation, possibly promoting memory encoding during sustained attention to visual stimuli.
“This cholinergic input is required for memory consolidation (58,59), possibly promoting the encoding of memory during sustained attention to visual stimuli.”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [59]
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“This cholinergic input is required for memory consolidation (58,59), possibly promoting the encoding of memory during sustained attention to visual stimuli.”
BackgroundSpecific basal forebrain-cortical cholinergic circuits coordinate cognitive operations
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- Authors
- Power, A. E., & McGaugh, J. L.
- Affiliations
- University of California, Irvine (US)
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2002-05
- Volume
- 77
- Issue
- 3
- Pages
- 372-388
- ISSN
- 1074-7427 (ISSN-L)
- OpenAlex
- W1976294207
- Cited by
- 57
- References
- 74
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 1 · 2012: 3
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH12526)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- nucleus basalis magnocellularis, basolateral amygdala, cholinergic afferents, muscarinic receptors, passive avoidance, aversive learning, memory consolidation, memory acquisition, memory retention, oxotremorine, physostigmine
- MeSH terms
- Amygdala, Animals, Male, Memory Disorders, Phthalic Acids, Spatial Behavior, Rats, Sprague-Dawley, Maze Learning, Basal Nucleus of Meynert, Rats
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