Unpredictable and uncontrollable stress impairs neuronal plasticity in the rat hippocampus
Abstract
Almost by definition, learning and the effect of stress on learning represent modifications of existing neuronal circuitry. Under some circumstances, this modification can be measured electrophysiologically. One such measure of plasticity is long-term potentiation (LTP), a long-lasting increase in synaptic efficacy following brief exposure to tetanic stimulation. In 1987, Foy et al. reported that hippocampal LTP was impaired by exposure to inescapable shock. We have recent evidence that the impairment in LTP can be prevented by allowing the animal to learn to escape the shock (Shors et al., 1989), indicating that the stress effect is to some extent mediated by "psychological" variables. Regardless of LTP's putative role in learning and memory processes, such a stress-induced decrease in neuronal plasticity is likely to have profound effects on the behaving organism.
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Acute stress or corticosterone administration blocks hippocampal LTP.
“Our findings are consistent with recent work from other laboratories indicating that acute stress or corticosterone administration blocks hippocampal LTP (Shors et al. [141]; Shors and Thompson [142]; Pavlides et al. [143]; Pavlides et al. [144]; Pavlides et al. [145]; Garcia et al. [146]; Pavlides and McEwen [147]; Akirav and Richter-Levin [148]; Zhou et al. [149]; Wang et al. [150]; Garcia [15];”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Shors et al. [141]
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- Authors
- Shors, T. J., Foy, M. R., Levine, S., & Thompson, R. F.
- Affiliations
- University of Southern California (US)
- Loyola Marymount University (US)
- Stanford University (US)
- Corresponding author
- Shors, Tracey J.
- ORCID
- Shors, Tracey J.
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 1990-05
- Volume
- 24
- Issue
- 5
- Pages
- 663-667
- ISSN
- 0361-9230 (ISSN-L)
- OpenAlex
- W2022291714
- Cited by
- 100
- References
- 4
- Citations by year
- 2024: 5 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2018: 3 · 2017: 2 · 2016: 1 · 2014: 2 · 2013: 5 · 2012: 4
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01hd002881-23, 5f32ag005500-02)
- National Institute on Aging (AG05500)
- National Institute of Mental Health (MH11936)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 02881)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- unpredictable stress, uncontrollable stress, hippocampus, neuroplasticity, long-term potentiation, inescapable shock, escape learning, synaptic plasticity, learning and memory
- MeSH terms
- Adaptation, Physiological, Animals, Hippocampus, Neuronal Plasticity, Stress, Physiological
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