Neurocognitive effects of switching from methylphenidate‐IR to OROS‐methylphenidate in children with ADHD
Abstract
Objectives: This study evaluated neurocognitive changes after switching from immediate release forms of methylphenidate (MPH‐IR) to osmotic release oral system methylphenidate (OROS‐MPH). Methods: 102 children with attention‐deficit/hyperactivity disorder (ADHD) participated in an open label, 28 day trial, performing neurocognitive test at baseline and at 28 days after the switch from MPH‐IR to OROS‐MPH. Results: There were significant improvements in the commission error and the reaction time of both visual and auditory continuous performance tests (CPTs) at 28 days after switching from MPH‐IR to OROS‐MPH. A positive correlation was observed between the improvement in parent/caregiver‐rated IOWA Conners total score (Δ IOWA) and the reduction in commission error (r = 0.3, p = 0.001) and reduction in reaction time variability (r = 0.3, p = 0.006) of visual CPT. In a linear regression model, the change in parent/caregiver‐rated IOWA Conners scale total scores were significant predictors of change in commission error (β = 0.3, p = 0.005, CI = 0.4–2.3, adjusted R2 = 0.12) and RT variability (β = 0.3, p = 0.004, CI = 0.5–2.4, adjusted R2 = 0.09) of visual CPT. Conclusions: These data suggest that MPH‐IR may be successfully switched to OROS‐MPH treatment with associated improvements in neurocognitive performance. Large‐scale controlled trials are needed to replicate these findings. Copyright © 2009 John Wiley & Sons, Ltd.
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OROS methylphenidate lessens ADHD symptoms throughout the day and has greater adherence, thought associated with convenience of once-daily dosing.
“Research has continued to suggest that osmotic-release oral system (OROS) methylphenidate lessens ADHD symptoms throughout the day and has greater adherence, thought to be associated with the convenience of once-daily dosing [39-41].”
From Advances in understanding and treating ADHD (2011) · cites this paper as [39]
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Advances in understanding and treating ADHD
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- Authors
- Kim, Y., Shin, M., Kim, J., Yoo, H., Cho, S., & Kim, B.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- Kim, Boong‐Nyun
- Venue
- Human Psychopharmacology: Clinical and Experimental
- Publisher
- Wiley
- Published
- 2009-02-18
- Volume
- 24
- Issue
- 2
- Pages
- 95-102
- ISSN
- 0885-6222 (ISSN-L)
- 1099-1077
- OpenAlex
- W2161957029
- Cited by
- 25
- References
- 36
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2022: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2014: 2 · 2013: 4 · 2012: 1
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Psychopharmacology Clinical and Experimental (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- Janssen Pharmaceuticals
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Keywords
- methylphenidate, OROS methylphenidate, immediate-release methylphenidate, attention deficit hyperactivity disorder, children, drug switching, neuropsychological performance, continuous performance test, commission errors, reaction time variability, parent ratings
- MeSH terms
- Administration, Oral, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Child, Cognition Disorders, Delayed-Action Preparations, Female, Humans, Male, Methylphenidate, Neuropsychological Tests, Reaction Time, Linear Models
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