Osmotic release oral system-methylphenidate improves neural activity during low reward processing in children and adolescents with attention-deficit/hyperactivity disorder
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Attention-deficit/hyperactivity disorder (ADHD) is neurobehavioral disorder characterized by inattention, hyperactivity/impulsivity and impaired reward system function, such as delay aversion and low reward sensitivity. The pharmacological treatment for ADHD includes methylphenidate (MPH), or osmotic release oral system-MPH (OROS-MPH), which increases extrasynaptic dopamine and noradrenaline levels by blocking their reuptake. Although previous functional magnetic resonance imaging (fMRI) studies revealed that acute treatment with MPH alters activation of the nucleus accumbens during delay aversion in children and adolescents with ADHD, the effects a relatively long period of OROS-MPH treatment on delay aversion as well as reward sensitivity remain unclear. Thus, we evaluated brain activation with fMRI during a reward sensitivity paradigm that consists of high monetary reward and low monetary reward conditions before and after a 3-month treatment with OROS-MPH in 17 children and adolescents with ADHD (mean age, 13.3 ± 2.2) and 17 age- and sex-matched healthy controls (mean age, 13.0 ± 1.9). We found that before treatment there was decreased activation of the nucleus accumbens and thalamus in patients with ADHD during only the low monetary reward condition, which was improved to same level as those of the healthy controls after the treatment. The observed change in brain activity was associated with improved ADHD symptom scores, which were derived from Japanese versions of the ADHD rating scale-IV. These results suggest that treatment with OROS-MPH for a relatively long period is effective in controlling reward sensitivity in children and adolescents with ADHD.
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A previous study suggested specific dysfunction within a 'low reward' level in ADHD.
“These findings suggest consistently reduced activation in the ventral striatum, regardless of reward level; conversely, our previous study suggested specific dysfunction within a ‘low reward’ level in ADHD.30”
From Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: functional MRI study (2015) · cites this paper as [30]
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Attention Deficit–Hyperactivity Disorder
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Imaging the ADHD brain: disorder-specificity, medication effects and clinical translation
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- Authors
- Mizuno, K., Yoneda, T., Komi, M., Hirai, T., Watanabe, Y., & Tomoda, A.
- Affiliations
- Osaka City University (JP)
- Kumamoto University (JP)
- University of Fukui (JP)
- Corresponding author
- Tomoda, Akemi
- Venue
- NeuroImage: Clinical
- Publisher
- Elsevier BV
- Published
- 2013
- Volume
- 2
- Pages
- 366-376
- ISSN
- 2213-1582 (ISSN-L)
- PMC
- PMC3777787
- OpenAlex
- W2062008415
- Cited by
- 30
- References
- 98
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 5
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- NeuroImage Clinical (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (23650223, 24300149)
- University of Fukui (210201)
- Hayao Nakayama Foundation for Science and Technology and Culture (H22-A053)
- RIKEN (K24232)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- attention deficit hyperactivity disorder, osmotic-release oral system, methylphenidate, reward sensitivity, delay aversion, nucleus accumbens, thalamus, brain activation, children and adolescents, ADHD symptom severity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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