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Cited by 176Attention Deficit Hyperactivity DisorderDevelopmental and Educational NeuropsychologyNeural and Behavioral Psychology Studies

The Effect of Methylphenidate on Three Forms of Response Inhibition in Boys with AD/HD

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Scheres, Anouk, Oosterlaan, Jaap, Swanson, James, Morein-Zamir, Sharon, Meiran, Nachson, Schut, Harry, Vlasveld, Laurens, Sergeant, Joseph A.·2003·Journal of Abnormal Child Psychology
DOI 10.1023/a:1021729501230
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Abstract

The current study was aimed at (a) investigating the effect of three doses methylphenidate (MPH) and placebo on inhibition of a prepotent response, inhibition of an ongoing response, and interference control in Attention Deficit/Hyperactivity Disorder (AD/HD), and (b) studying dose-response relations for the three forms of response inhibition. To meet these aims, the following tasks were selected: two versions of the Stop Paradigm for inhibition of a prepotent response, a Circle Tracing Task and a recently developed Follow Task for inhibition of an ongoing response, and the Stroop Color-Word Test and an Eriksen Flanker Task for interference control. These tasks were administered to 23 boys with AD/HD during four treatment conditions: 5 mg MPH, 10 mg MPH, 20 mg MPH, and placebo. A pseudorandomized, multiple-blind, placebo-controlled, within-subject design was used. As hypothesized, inhibitory control in children with AD/HD improved under MPH compared to placebo. However, this effect was only significant for inhibition of a prepotent response and inhibition of an ongoing response (as measured by the Follow Task), but not for interference control. The relation between treatment condition and response was linear. However, this linear relation was due to improved inhibitory control under MPH compared to placebo, because no effects of MPH dose were observed for any of the response inhibition measures.

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  • Scheres et al. (2003) found in a double-blind, placebo-controlled, crossover study of three methylphenidate doses (5, 10, 20 mg) that the overall effect of medication was significant due to faster Stop-signal reaction times and lower reaction time variability, but the dose effect was not significant, suggesting maximum cognitive benefit may be elicited by a low dose.

    “Scheres et al (2003) provides an example of the use of a specific task (the STOP task) to evaluate dose-response to MP in a double-blind, placebo-controlled, crossover study of three doses (5, 10, and 20 mg).The overall effect of medication was significant owing to faster SSRTs and lower RT variability, but the dose effect was not significant, suggesting that the maximum cognitive benefit may be”

    From Understanding the Effects of Stimulant Medications on Cognition in Individuals with Attention-Deficit Hyperactivity Disorder: A Decade of Progress (2011) · cites this paper as Scheres et al (2003)

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Research works printed but not linked: 3

  1. Band, G. P. H., van der Molen, M. W., & Logan, G. D. (in press). Horse- race model simulations of stopping: Good news for stop-signal re- action time but bad news for slope of the inhibition function. Acta Psychologica, xxx, xxx-xxx.
  2. Morein-Zamir, S., & Meiran, N. (in press). Individual stopping times and cognitive control: Converging evidence from a new stop signal paradigm. Quarterly Journal of Experimental Psychology, xx, xxx- xxx.
  3. Sergeant, J. A., Oosterlaan, J., & Van der Meere, J. (1999). Information processing in Attention-Deficit/Hyperactivity Disorder. In H. C. Quay & A. E. Hogan (Eds.), Handbook of Disruptive Behavior Disorders (pp. 75-104). New York: Plenum.

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Authors
Scheres, A., Oosterlaan, J., Swanson, J., Morein-Zamir, S., Meiran, N., Schut, H., Vlasveld, L., & Sergeant, J. A.
Affiliations
  • Vrije Universiteit Amsterdam (NL)
  • University of California, Irvine (US)
  • Ben-Gurion University of the Negev (IL)
  • Parnassia Groep (NL)
  • Reinier de Graaf Hospital (NL)
Corresponding author
Scheres, Anouk
ORCID
Venue
Journal of Abnormal Child Psychology
Publisher
Springer Science and Business Media LLC
Published
2003-02
Volume
31
Issue
1
Pages
105-120
ISSN
  • 0091-0627 (ISSN-L)
  • 1573-2835
DOI
10.1023/a:1021729501230
OpenAlex
W2106367437
Cited by
176
References
66
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 2 · 2014: 6 · 2013: 11 · 2012: 11
FWCI
6.53
Type
journal article
Language
en
Open access
Licence
Locations
  • Research on Child and Adolescent Psychopathology (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
  • VU Research Portal (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
methylphenidate, attention deficit hyperactivity disorder, response inhibition, inhibitory control, prepotent response inhibition, interference control, dose-response relationship, boys, stimulant medication, Stroop task, flanker task
MeSH terms
Central Nervous System Stimulants, Attention, Attention Deficit Disorder with Hyperactivity, Child, Child Behavior Disorders, Dose-Response Relationship, Drug, Double-Blind Method, Humans, Inhibition, Psychological, Male, Methylphenidate, Neuropsychological Tests, Reaction Time, Treatment Outcome, Attention Deficit and Disruptive Behavior Disorders

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