Coffee increases state anxiety in males but not in females
Abstract
Coffee, reproducing the conditions under which caffeine is normally ingested, containing 3, 75, 150 or 300 mg of caffeine was given to healthy male and female volunteers. 25-30 min after drinking the beverage, they completed the Spanish version of the state-trait anxiety inventory (STAI). The beverage increased state anxiety, in a dose-dependent manner, in males but not in females. This could be due to a lesser sensitivity of females to coffee.
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In a cohort of students aged 11-17, caffeine had no significant effect on anxiety in girls, but anxiety increased with caffeine intake in boys.
“As a result from a cohort study of 3323 students aged 11–17 years (boys 48.5%, girl 51.5%), the effect of caffeine on anxiety was not significant in girls, but in boys, anxiety increased with caffeine intake [115].”
From Effect of Caffeine Consumption on the Risk for Neurological and Psychiatric Disorders: Sex Differences in Human (2020) · cites this paper as [115]
Consuming less than 1000 mg caffeine per week increased incidence of depression in girls compared to boys.
“As a result, consuming less than 1000 mg of caffeine per week increased the incidence of depression in girls compared to boys [115].”
From Effect of Caffeine Consumption on the Risk for Neurological and Psychiatric Disorders: Sex Differences in Human (2020) · cites this paper as [115]
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- Authors
- Botella, P., & Parra, A.
- Affiliations
- Universitat de València (ES)
- Corresponding author
- Parra, Andrés
- ORCID
- Parra, Andrés
- Venue
- Human Psychopharmacology Clinical and Experimental
- Publisher
- Wiley
- Published
- 2003-02-17
- Volume
- 18
- Issue
- 2
- Pages
- 141-143
- ISSN
- 0885-6222 (ISSN-L)
- 1099-1077
- OpenAlex
- W2081916425
- Cited by
- 47
- References
- 12
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 2 · 2019: 1 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Psychopharmacology Clinical and Experimental (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- coffee, caffeine, state anxiety, sex differences, dose-dependent effects, caffeine sensitivity
- MeSH terms
- Adolescent, Adult, Central Nervous System Stimulants, Anxiety, Blood Pressure, Caffeine, Chromatography, High Pressure Liquid, Coffee, Dose-Response Relationship, Drug, Female, Heart Rate, Humans, Male
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