SAMP1/YitFc mouse strain: A spontaneous model of Crohnʼs disease-like ileitis

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591 · see citing works

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030 · see citing works

Interleukin-10-deficient mice develop chronic enterocolitis

Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248 · see citing works

IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines

Schmitz, J., Owyang, A. M., Oldham, E. R., Song, Y., Murphy, E., McClanahan, T. K., Zurawski, G., Moshrefi, M., Qin, J., Li, X., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.09.015 · Cited by 3,701 · see citing works

A Genome-Wide Association Study Identifies <i>IL23R</i> as an Inflammatory Bowel Disease Gene

Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039 · see citing works

Inflammatory bowel disease

Abraham, C., & Cho, J. H. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804647 · Cited by 2,712 · see citing works

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

Hampe, J., Franke, A., Rosenstiel, P. C., Till, A., Teuber, M., Huse, K., Albrecht, M., Gabriele Mayr, B., Vega, F. M. D. L., Briggs, J. C., et al. (2006) · Nature Genetics · doi:10.1038/ng1954 · Cited by 1,899 · see citing works

PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

Tontonoz, P., Nagy, L., Alvarez, J. G. A., Thomázy, V. A., & Evans, R. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81575-5 · Cited by 1,800 · see citing works

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

Rioux, J. D., Xavier, R. J., Taylor, K. D., Silverberg, M. S., Goyette, P., Huett, A., Green, T., Kuballa, P., Barmada, M. M., Datta, L. W., et al. (2007) · Nature Genetics · doi:10.1038/ng2032 · Cited by 1,769 · see citing works

Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: A double-blind, placebo-controlled trial

Gionchetti, P., Rizzello, F., Venturi, A., Brigidi, P., Matteuzzi, D., Bazzocchi, G., Poggioli, G., Miglioli, M., & Campieri, M. (2000) · Gastroenterology · doi:10.1053/gast.2000.9370 · Cited by 1,485 · see citing works

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

Glocker, E., Kotlarz, D., Boztuǧ, K., Gertz, E. M., Schäffer, A. A., Noyan, F., Perro, M., Diestelhorst, J., Saborowski, A. L., Murugan, D., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0907206 · Cited by 1,464 · see citing works

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

Kaser, A., Lee, A., Franke, A., Glickman, J. N., Zeißig, S., Tilg, H., Nieuwenhuis, E. E. S., Higgins, D. E., Schreiber, S., Glimcher, L. H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.07.021 · Cited by 1,411 · see citing works

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

Kontoyiannis, D. L., Pasparakis, M., Pizarro, T. T., Cominelli, F., & Kollias, G. A. (1999) · Immunity · doi:10.1016/s1074-7613(00)80038-2 · Cited by 1,329 · see citing works

Interleukin-13 Is the Key Effector Th2 Cytokine in Ulcerative Colitis That Affects Epithelial Tight Junctions, Apoptosis, and Cell Restitution

Heller, F., Florian, P., Bojarski, C., Richter, J. F., Christ, M., Hillenbrand, B., Mankertz, J., Gitter, A. H., Bürgel, N., Fromm, M., et al. (2005) · Gastroenterology · doi:10.1016/j.gastro.2005.05.002 · Cited by 1,237 · see citing works

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils

Takeda, K., Clausen, B. E., Kaisho, T., Tsujimura, T., Terada, N., Förster, I., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80005-9 · Cited by 1,220 · see citing works

Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease

Zeißig, S., Bürgel, N., Günzel, D., Richter, J. F., Mankertz, J., Wahnschaffe, U., Kroesen, A. J., Zeitz, M., Fromm, M., & Schulzke, J. (2006) · Gut · doi:10.1136/gut.2006.094375 · Cited by 1,218 · see citing works

The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene

Lluis Fajas, A., Auboeuf, D., Raspé, E., Schoonjans, K., Lefebvre, A., Saladin, R., Najib, J., Laville, M., Fruchart, J., Deeb, S. S., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18779 · Cited by 1,188 · see citing works

The X-files in immunity: sex-based differences predispose immune responses

Fish, E. N. (2008) · Nature reviews. Immunology · doi:10.1038/nri2394 · Cited by 1,164 · see citing works

A genetic map of the mouse suitable for typing intraspecific crosses.

Dietrich, W., Katz, H., Lincoln, S. E., Shin, H., Friedman, J. M., Dracopoli, N. C., & Lander, E. S. (1992) · Genetics · doi:10.1093/genetics/131.2.423 · Cited by 1,080 · see citing works

Epithelial NEMO links innate immunity to chronic intestinal inflammation

Nenci, A., Becker, C., Wullaert, A., Gareus, R., Loo, G., Danese, S., Huth, M., Nikolaev, A., Neufert, C. F., Madison, B., et al. (2007) · Nature · doi:10.1038/nature05698 · Cited by 1,077 · see citing works

The Natural History of Adult Crohn's Disease in Population-Based Cohorts

Peyrin‐Biroulet, L., Loftus, E. V., Colombel, J., & Sandborn, W. J. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.579 · Cited by 1,043 · see citing works

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

Afkarian, M., Šedý, J. R., Yang, J., Jacobson, N. G., Cereb, N., Yang, S. Y., Murphy, T. L., & MURPHY, K. M. M. (2002) · Nature Immunology · doi:10.1038/ni794 · Cited by 1,038 · see citing works

Interleukin-13 Is the Key Effector Th2 Cytokine in Ulcerative Colitis That Affects Epithelial Tight Junctions, Apoptosis, and Cell Restitution

Heller, F., Florian, P., Bojarski, C., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.002 · Cited by 1,016 · see citing works

Emerging roles of PPARS in inflammation and immunity

Daynes, R. A., & Jones, D. C. (2002) · Nature reviews. Immunology · doi:10.1038/nri912 · Cited by 922 · see citing works

A new murine model of accelerated senescence

Takeda, T., HOSOKAWA, M., TAKESHITA, S., Irino, M., Higuchi, K., Matsushita, T., Tomita, Y., Yasuhira, K., Hamamoto, H., & Shimizu, K. (1981) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(81)90084-1 · Cited by 871 · see citing works

Functional variants of OCTN cation transporter genes are associated with Crohn disease

Peltekova, V. D., Wintle, R. F., Rubin, L. A., Amos, C. I., Huang, Q., Gu, X., Newman, W. G., Oene, M. V., Cescon, D. W., Greenberg, G. R., et al. (2004) · Nature Genetics · doi:10.1038/ng1339 · Cited by 837 · see citing works

Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives

Hollander, D., Vadheim, C. M., Brettholz, E., Petersen, G. M., Delahunty, T., & Rotter, J. I. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-6-883 · Cited by 762 · see citing works

VSL#3 Probiotic-Mixture Induces Remission in Patients with Active Ulcerative Colitis

Bibiloni, R., Fedorak, R. N., Tannock, G. W., Madsen, K. L., Gionchetti, P., Campieri, M., Simone, C. D., & Sartor, R. B. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41794.x · Cited by 743 · see citing works

Conversion of Zonulae Occludentes from Tight to Leaky Strand Type by Introducing Claudin-2 into Madin-Darby Canine Kidney I Cells

Furuse, M., Furuse, K., Sasaki, H., & Tsukita, S. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.2.263 · Cited by 719 · see citing works

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

Mombaerts, P., Mizoguchi, E., Grusby, M. J., Glimcher, L. H., Bhan, A. K., & Tonegawa, S. (1993) · Cell · doi:10.1016/0092-8674(93)80069-q · Cited by 718 · see citing works

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

Ouyang, W., Löhning, M., Gao, Z., Assenmacher, M., Ranganath, S. H., Radbruch, A., & MURPHY, K. M. M. (2000) · Immunity · doi:10.1016/s1074-7613(00)80156-9 · Cited by 702 · see citing works

Two stage genome–wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12

Satsangi, J., Parkes, M., Louis, E. J., Hashimoto, L., Kato, N., Welsh, K. I., Terwilliger, J. D., Lathrop, M. G., Bell, J. I., & Jewell, D. P. (1996) · Nature Genetics · doi:10.1038/ng1096-199 · Cited by 694 · see citing works

Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms.

Zhu, Y., Qi, C., Korenberg, J. R., Chen, X. N., Noya, D., Rao, M. S. R., & Reddy, J. K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7921 · Cited by 653 · see citing works

Occludin is a functional component of the tight junction

McCarthy, K. M., Skare, I. B., Stankewich, M. C., Furuse, M., Tsukita, S., Rogers, R. A., Lynch, R. D., & Schneeberger, E. E. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.9.2287 · Cited by 640 · see citing works

IL-18, a Novel Immunoregulatory Cytokine, Is Up-Regulated in Crohn’s Disease: Expression and Localization in Intestinal Mucosal Cells

Pizarro, T. T., Michie, M. H., Bentz, M., Woraratanadharm, J., Smith, M. F., Foley, E. F., Moskaluk, C. A., Bickston, S. J., & Cominelli, F. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.11.6829 · Cited by 573 · see citing works

A Novel Model of Inflammatory Bowel Disease: Mice Deficient for the Multiple Drug Resistance Gene, mdr1a, Spontaneously Develop Colitis

Panwala, C. M., Jones, J. C., & Viney, J. L. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.10.5733 · Cited by 567 · see citing works

Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator–activated receptor-γ

Rousseaux, C., Lefebvre, B., Dubuquoy, L., Lefèbvre, P., Romano, O., Auwerx, J. H., METZGER, D., Wahli, W., Desvergne, B., Naccari, G. C., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041948 · Cited by 528 · see citing works

Neutrophil Transmigration in Inflammatory Bowel Disease Is Associated with Differential Expression of Epithelial Intercellular Junction Proteins

Kucharzik, T. F., Walsh, S. V., Chen, J. Z., Parkos, C. A., & Nusrat, A. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63051-9 · Cited by 523 · see citing works

Genetic variation in DLG5 is associated with inflammatory bowel disease

Stoll, M., Corneliussen, B., Costello, C. M., Waetzig, G. H., Mellgård, B., Koch, W. A., Rosenstiel, P. C., Albrecht, M., Croucher, P. J. P., Seegert, D., et al. (2004) · Nature Genetics · doi:10.1038/ng1345 · Cited by 469 · see citing works

Impaired expression of peroxisome proliferator-activated receptor γ in ulcerative colitis

Dubuquoy, L., Jansson, E. Å., Deeb, S. S., Rakotobé, S., Karoui, M., Colombel, J., Auwerx, J. H., Pettersson, S., & Desreumaux, P. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00271-3 · Cited by 425 · see citing works

Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis

Pastorelli, L., Garg, R. R., Hoang, S. B., Spina, L., Mattioli, B., Scarpa, M., Fiocchi, C., Vecchi, M. L., & Pizarro, T. T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912678107 · Cited by 418 · see citing works

Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: Evidence for epistasis between 1p and IBD1

Cho, J. H., Nicolae, D. L., Gold, L. H., Fields, C. T., LaBuda, M. C., Rohal, P. M., Pickles, M., Li, Q., Fu, Y., Mann, J., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7502 · Cited by 380 · see citing works

Probiotics promote gut health through stimulation of epithelial innate immunity

Pagnini, C., Saeed, R., Bamias, G., Arseneau, K. O., Pizarro, T. T., & Cominelli, F. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910307107 · Cited by 358 · see citing works

Expression, Localization, and Functional Activity of TL1A, a Novel Th1-Polarizing Cytokine in Inflammatory Bowel Disease

Bamias, G., Martin, C. T., Marini, M., Hoang, S. B., Mishina, M., Ross, W. G., Sachedina, M. A., Friel, C. M., Mize, J., Bickston, S. J., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.9.4868 · Cited by 299 · see citing works

Inflammatory bowel disease-like enteritis and caecitis in a senescence accelerated mouse P1/Yit strain

Matsumoto, S., Okabe, Y., Setoyama, H., Takayama, K., Ohtsuka, J., Funahashi, H., Imaoka, A., Okada, Y., & Umesaki, Y. (1998) · Gut · doi:10.1136/gut.43.1.71 · Cited by 272 · see citing works

Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis

Kobori, A., Yagi, Y., Imaeda, H., Ban, H., Bamba, S., Tsujikawa, T., Saito, Y., Fujiyama, Y., & Andoh, A. (2010) · Journal of Gastroenterology · doi:10.1007/s00535-010-0245-1 · Cited by 251 · see citing works

Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn’s disease

Kosiewicz, M. M., Nast, C. C., Krishnan, A., Rivera–Nieves, J., Moskaluk, C. A., Matsumoto, S., Kozaiwa, K., & Cominelli, F. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10956 · Cited by 248 · see citing works

Characterization of the novel ST2/IL-33 system in patients with inflammatory bowel disease

Beltrán, C. J., Núñez, L. E., Díaz-Jiménez, D., Farfán, N., Candía, E., Heine, C., López, F., González, M. J., Quera, R., & Hermoso, M. A. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21175 · Cited by 239 · see citing works

Probiotic Lactobacillus -induced improvement in murine chronic inflammatory bowel disease is associated with the down-regulation of pro-inflammatory cytokines in lamina propria mononuclear cells

Matsumoto, S., Hara, T., Hori, T., Mitsuyama, K., Nagaoka, M., Tomiyasu, N., Suzuki, A., & Sata, M. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02790.x · Cited by 224 · see citing works

New Concepts in the Pathophysiology of Inflammatory Bowel Disease

Bamias, G., Nyce, M. R., Rue, S. A. D. L., & Cominelli, F. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-143-12-200512200-00007 · Cited by 221 · see citing works

Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease

Desreumaux, P., Brandt, E. B., Gambiez, L. P., Émilie, D., Geboes, K., Klein, O., Ectors, N., Cortot, A., Capron, M., & Colombel, J.-F. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70116-1 · Cited by 219 · see citing works

Intestinal Permeability Test As A Predictor of Clinical Course in Crohn's Disease

Renata D'Incà, Leo, V. D., Corrao, G., Martines, D., D’Odorico, A., Mestriner, C., Venturi, C., Longo, G., & Sturniolo, G. C. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01444.x · Cited by 218 · see citing works

Antibody blockade of ICAM-1 and VCAM-1 ameliorates inflammation in the SAMP-1/Yit adoptive transfer model of Crohn's disease in mice

Burns, R. C., Rivera–Nieves, J., Moskaluk, C. A., Matsumoto, S., Cominelli, F., & Ley, K. F. (2001) · Gastroenterology · doi:10.1053/gast.2001.29568 · Cited by 210 · see citing works

Activation of A2A Adenosine Receptor Attenuates Intestinal Inflammation in Animal Models of Inflammatory Bowel Disease

Odashima, M., Bamias, G., Rivera–Nieves, J., Linden, J. M., Nast, C. C., Moskaluk, C. A., Marini, M., Sugawara, K., Kozaiwa, K., Otaka, M., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.032 · Cited by 205 · see citing works

Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-α production in mice

ten Hove, T., Corbaz, A., Amitai, H., Aloni, S., Belzer, I., Graber, P., Drillenburg, P., van Deventer, S. J. H., Chvatchko, Y., & Velde, A. A. T. (2001) · Gastroenterology · doi:10.1053/gast.2001.29579 · Cited by 203 · see citing works

TNF-αneutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis

Marini, M., Bamias, G., Rivera–Nieves, J., Moskaluk, C. A., Hoang, S. B., Ross, W. G., Pizarro, T. T., & Cominelli, F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432897100 · Cited by 198 · see citing works

Role of peroxisome proliferator-activated receptor γ and retinoid X receptor heterodimer in hepatogastroenterological diseases

Dubuquoy, L., Dharancy, S., Nutten, S., Pettersson, S., Auwerx, J. H., & Desreumaux, P. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11395-x · Cited by 197 · see citing works

Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease

Kugathasan, S., Saubermann, L. J., Smith, L. A., Kou, D., Itoh, J., Binion, D. G., Levine, A. D., Blumberg, R. S., & Fiocchi, C. (2007) · Gut · doi:10.1136/gut.2006.116467 · Cited by 192 · see citing works

The primary defect in experimental ileitis originates from a nonhematopoietic source

Olson, T. S., Reuter, B. K., Scott, K. G. –., MORRIS, M. A., Wang, X.-M., Hancock, L. N., Burcin, T. L., Cohn, S. M., Ernst, P. B., Cominelli, F., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20050407 · Cited by 172 · see citing works

Mouse models for the study of Crohn's disease

Pizarro, T. T., Arseneau, K. O., Bamias, G., & Cominelli, F. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00052-2 · Cited by 169 · see citing works

Role of TL1A and its receptor DR3 in two models of chronic murine ileitis

Bamias, G., Mishina, M., Nyce, M. R., Ross, W. G., Kollias, G., Rivera–Nieves, J., Pizarro, T. T., & Cominelli, F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510903103 · Cited by 169 · see citing works

Peroxisome proliferator-activated receptor gamma is induced during differentiation of colon epithelium cells

Lefebvre, A., Paulweber, B., Lluis Fajas, A., Woods, J. W., McCrary, C. T., Colombel, J. F., Najïb, J., Fruchart, J., Datz, C., Vidal, H., et al. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1620331 · Cited by 167 · see citing works

Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammation

Bamias, G., Martin, C. T., Mishina, M., Ross, W. G., Rivera–Nieves, J., Marini, M., & Cominelli, F. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.053 · Cited by 166 · see citing works

Emergence of perianal fistulizing disease in the SAMP1/YitFc mouse, a spontaneous model of chronic ileitis

Rivera–Nieves, J., Bamias, G., Vidrich, A., Marini, M., Pizarro, T. T., MCDUFFIE, M. J., Moskaluk, C. A., Cohn, S. M., & Cominelli, F. (2003) · Gastroenterology · doi:10.1053/gast.2003.50148 · Cited by 160 · see citing works

IL-33 is upregulated in colonocytes of ulcerative colitis

Seidelin, J. B., Bjerrum, J. T., Coskun, M., Widjaya, B., Vainer, B., & Nielsen, O. H. (2009) · Immunology Letters · doi:10.1016/j.imlet.2009.11.001 · Cited by 144 · see citing works

T Helper 1 and T Helper 2 Cells Are Pathogenic in an Antigen-specific Model of Colitis

Iqbal, N., Oliver, J. R., Wagner, F. H., Lazenby, A. J., Elson, C. O., & Weaver, C. T. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.2001889 · Cited by 141 · see citing works

The B-Cell System in Inflammatory Bowel Disease

Brandtzæg, P., Carlsen, H. S., & Halstensen, T. S. (2006) · Advances in experimental medicine and biology · doi:10.1007/0-387-33778-4_10 · Cited by 138 · see citing works

L-Selectin, α4β1, and α4β7 Integrins Participate in CD4+ T Cell Recruitment to Chronically Inflamed Small Intestine

Rivera–Nieves, J., Olson, T. S., Bamias, G., Bruce, A. C., Solga, M. D., Knight, R. F., Hoang, S. B., Cominelli, F., & Ley, K. F. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2343 · Cited by 138 · see citing works

PPARγ in Monocytes: Less Pain, Any Gain?

Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81567-6 · Cited by 135 · see citing works

Antibody Blockade of CCL25/CCR9 Ameliorates Early but not Late Chronic Murine Ileitis

Rivera–Nieves, J., Ho, J., Bamias, G., Ивашкина, Н. Ю., Ley, K. F., Oppermann, M., & Cominelli, F. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.08.031 · Cited by 135 · see citing works

Infliximab retreatment in adults and children with Crohn's disease: risk factors for the development of delayed severe systemic reaction

Kugathasan, S., Levy, M. B., Saeian, K., Vasilopoulos, S., Kim, J. P., Prajapati, D. N., Emmons, J. E., Martínez, A., Kelly, K. J., & Binion, D. G. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05784.x · Cited by 123 · see citing works

STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice

Mitsuyama, K., Matsumoto, S., Rose‐John, S., Suzuki, A., Hara, T., Tomiyasu, N., Handa, K., Tsuruta, O., Funabashi, H., Scheller, J., et al. (2006) · Gut · doi:10.1136/gut.2005.079343 · Cited by 120 · see citing works

Targeting Mucosal Addressin Cellular Adhesion Molecule (MAdCAM)-1 to Noninvasively Image Experimental Crohn’s Disease

Bachmann, C., Klibanov, A. L., Olson, T. S., Sonnenschein, J. R., Rivera–Nieves, J., Cominelli, F., Ley, K. F., Lindner, J. R., & Pizarro, T. T. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.009 · Cited by 111 · see citing works

Immunopathogenesis of inflammatory bowel disease: current concepts

Bamias, G., & Cominelli, F. (2007) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3281c55eb2 · Cited by 107 · see citing works

Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease

Olson, T. S., Bamias, G., Naganuma, M., Rivera–Nieves, J., Burcin, T. L., Ross, W., MORRIS, M. A., Pizarro, T. T., Ernst, P. B., Cominelli, F., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20855 · Cited by 106 · see citing works

Genetic Analysis of Susceptibility to Dextran Sulfate Sodium-Induced Colitis in Mice

Mähler, M., Bristol, I. J., Sundberg, J. P., Churchill, G. A., Birkenmeier, E. H., Elson, C. O., & Leiter, E. H. (1999) · Genomics · doi:10.1006/geno.1998.5636 · Cited by 101 · see citing works

Linkage to peroxisome proliferator-activated receptor-γ in SAMP1/YitFc mice and in human Crohn’s disease

Sugawara, K., Olson, T. S., Moskaluk, C. A., Stevens, B. K., Hoang, S. B., Kozaiwa, K., Cominelli, F., Ley, K. F., & MCDUFFIE, M. J. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.001 · Cited by 98 · see citing works

Evolution of osteopenia in inflammatory bowel disease

Dinca, M. (1999) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(99)00135-5 · Cited by 97 · see citing works

Absence of bacterially induced RELMβ reduces injury in the dextran sodium sulfate model of colitis

McVay, L. D., Keilbaugh, S. A., Wong, T., Kierstein, S., Shin, M. E., Lehrke, M., Lefterova, M. I., Shifflett, D. E., Barnes, S. L., Cominelli, F., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28121 · Cited by 95 · see citing works

Evolution of Osteopenia in Inflammatory Bowel Disease

Dinca, M., Fries, W., Luisetto, G., et al. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01079.x · Cited by 94 · see citing works

Down-Regulation of Intestinal Lymphocyte Activation and Th1 Cytokine Production by Antibiotic Therapy in a Murine Model of Crohn’s Disease

Bamias, G., Marini, M., Moskaluk, C. A., Odashima, M., Ross, W. G., Rivera–Nieves, J., & Cominelli, F. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.9.5308 · Cited by 90 · see citing works

Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitis

Rivera–Nieves, J., Burcin, T. L., Olson, T. S., MORRIS, M. A., MCDUFFIE, M. J., Cominelli, F., & Ley, K. F. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052530 · Cited by 89 · see citing works

Commensal Bacteria Exacerbate Intestinal Inflammation but Are Not Essential for the Development of Murine Ileitis

Bamias, G., Okazawa, A., Rivera–Nieves, J., Arseneau, K. O., Rue, S. A. D. L., Pizarro, T. T., & Cominelli, F. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.3.1809 · Cited by 88 · see citing works

IL18 polymorphism is associated with an increased risk of Crohn’s disease

Tamura, K., Fukuda, Y., Sashio, H., Takeda, N., Bamba, H., Kosaka, T., Fukui, S., Sawada, K., Tamura, K., Satomi, M., et al. (2002) · Journal of Gastroenterology · doi:10.1007/bf03326428 · Cited by 84 · see citing works

Innate and adaptive immune responses related to IBD pathogenesis

Arseneau, K. O., Tamagawa, H., Pizarro, T. T., & Cominelli, F. (2007) · Current Gastroenterology Reports · doi:10.1007/s11894-007-0067-3 · Cited by 80 · see citing works

IL-4 Exacerbates Disease in a Th1 Cell Transfer Model of Colitis

Fort, M. M., Lesley, R., Davidson, N. J., Menon, S., Brombacher, F., Leach, M. W., & Rennick, D. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.4.2793 · Cited by 80 · see citing works

Fine mapping of the chromosome 3p susceptibility locus in inflammatory bowel disease

Hampe, J., Lynch, N. J., Daniels, S., Bridger, S., Macpherson, A. J. S., Stokkers, P. C. F., Forbes, A., Lennard‐Jones, J. E., Mathew, C. G., Curran, M. E., et al. (2001) · Gut · doi:10.1136/gut.48.2.191 · Cited by 80 · see citing works

Hyperactivated B cells in human inflammatory bowel disease

Noronha, A. M., Liang, Y., Hetzel, J. T., Hastürk, H., Kantarcı, A., Stucchi, A. F., Zhang, Y., Nikolajczyk, B. S., Farraye, F. A., & Ganley-Leal, L. M. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0309203 · Cited by 80 · see citing works

Experimental murine colitis is regulated by two genetic loci, including one on chromosome 11 that regulates IL-12 responses

Bouma, G., Kaushiva, A., & Strober, W. (2002) · Gastroenterology · doi:10.1053/gast.2002.34752 · Cited by 75 · see citing works

Preventive Effects of Bifidobacterium- and Lactobacillus-Fermented Milk on the Development of Inflammatory Bowel Disease in Senescence-Accelerated Mouse P1/Yit Strain Mice

Matsumoto, S., Watanabe, N., Imaoka, A., & Okabe, Y. (2001) · Digestion · doi:10.1159/000048846 · Cited by 72 · see citing works

Leukocyte adhesion molecules in animal models of inflammatory bowel disease

Rivera–Nieves, J., Gorfu, G., & Ley, K. F. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20501 · Cited by 67 · see citing works

Identification of a quantitative trait locus for ileitis in a spontaneous mouse model of Crohn’s disease: SAMP1/YitFc

Kozaiwa, K., Sugawara, K., Smith, M. F., Carl, V. S., Yamschikov, V., Belyea, B., McEwen, S. B., Moskaluk, C. A., Pizarro, T. T., Cominelli, F., et al. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00876-x · Cited by 66 · see citing works

Identification of a Chemokine Network That Recruits FoxP3+ Regulatory T Cells Into Chronically Inflamed Intestine

Kang, S. G., Piniecki, R. J., HogenEsch, H., Lim, H. W., Wiebke, E. A., Braun, S. E., Matsumoto, S., & Kim, C. H. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.01.008 · Cited by 61 · see citing works

Altered Epithelial Cell Lineage Allocation and Global Expansion of the Crypt Epithelial Stem Cell Population Are Associated with Ileitis in SAMP1/YitFc Mice

Vidrich, A., Buzan, J. M., Barnes, S., Reuter, B. K., Skaar, K., Ilo, C., Cominelli, F., Pizarro, T. T., & Cohn, S. M. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62326-7 · Cited by 50 · see citing works

Blockade of PSGL-1 attenuates CD14+ monocytic cell recruitment in intestinal mucosa and ameliorates ileitis in SAMP1/Yit mice

Inoue, T., Tsuzuki, Y., Matsuzaki, K., Matsunaga, H., Miyazaki, J., Hokari, R., Okada, Y., Kawaguchi, A., Nagao, S., Itoh, K., et al. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0204104 · Cited by 49 · see citing works

Association Between Il-18 Gene Promoter Polymorphisms and Inflammatory Bowel Disease in a Japanese Population

Takagawa, T., Tamura, K., Takeda, N., Tomita, T., Ohda, Y., Fukunaga, K., Hida, N., Ohnishi, K., Hori, K., Kosaka, T., et al. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000182868.67025.b9 · Cited by 47 · see citing works

Interleukin‐5 participates in the pathogenesis of ileitis in SAMP1/Yit mice

Takedatsu, H., Mitsuyama, K., Matsumoto, S., Handa, K., Suzuki, A., Takedatsu, H., Funabashi, H., Okabe, Y., Hara, T., Toyonaga, A., et al. (2004) · European Journal of Immunology · doi:10.1002/eji.200324680 · Cited by 45 · see citing works

Genetic analysis in Finnish families with inflammatory bowel disease supports linkage to chromosome 3p21

Paavola, P., Heliö, T. M., Kiuru, M. H., Halme, L., Turunen, U., Terwilliger, J. D., Karvonen, A., Julkunen, R. J. K., Niemelä, S., Nurmi, H., et al. (2001) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200626 · Cited by 43 · see citing works

High-frequency Haplotypes in the X Chromosome Locus TLR8 Are Associated With Both CD and UC in Females

Saruta, M., Targan, S. R., Mei, L., Ippoliti, A., Taylor, K. D., & Rotter, J. I. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20754 · Cited by 41 · see citing works

Genetic characterization of senescence-accelerated mouse (SAM)

Higuchi, K. (1997) · Experimental Gerontology · doi:10.1016/s0531-5565(96)00060-5 · Cited by 40 · see citing works

Mechanisms of Tight Junction Dysregulation in the SAMP1/YitFc Model of Crohn's Disease–like Ileitis

Reuter, B. K., & Pizarro, T. T. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04035.x · Cited by 39 · see citing works

Resistin-Like Molecule β (RELMβ/FIZZ2) Is Highly Expressed in the Ileum of SAMP1/YitFc Mice and Is Associated with Initiation of Ileitis

Barnes, S. L., Vidrich, A., Wang, M., Wu, G. D., Cominelli, F., Rivera–Nieves, J., Bamias, G., & Cohn, S. M. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.10.7012 · Cited by 37 · see citing works

Evidence for an inflammatory bowel disease locus on chromosome 3p26: linkage, transmission/disequilibrium and partitioning of linkage

Duerr, R. H. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.21.2599 · Cited by 36 · see citing works

Pit pattern and three-dimensional configuration of isolated crypts from the patients with colorectal neoplasm

Tamura, S., Furuya, Y., Tadokoro, T., Higashidani, Y., Yokoyama, Y., Araki, K., & Onishi, S. (2002) · Journal of Gastroenterology · doi:10.1007/s005350200133 · Cited by 32 · see citing works

β7 Integrin Deficiency Suppresses B Cell Homing and Attenuates Chronic Ileitis in SAMP1/YitFc Mice

Gorfu, G., Rivera–Nieves, J., Hoang, S. B., Abbott, D. W., Arbenz‐Smith, K., Azar, D., Pizarro, T. T., Cominelli, F., MCDUFFIE, M. J., & Ley, K. F. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903938 · Cited by 26 · see citing works

The Liver's Dance with Death

Cazanave, S. C., & Gores, G. J. (2009) · Hepatology · doi:10.1002/hep.23188 · Cited by 20 · see citing works

−137 (G/C) IL-18 promoter polymorphism in patients with inflammatory bowel disease

Haas, S., Koch, W. A., Schreiber, S., Reinhard, I., Koyama, N., Singer, M. V., & Böcker, U. (2005) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520510023738 · Cited by 20 · see citing works

Elevated Expression of Paneth Cell CRS4C in Ileitis-prone SAMP1/YitFc Mice

Shanahan, M. T., Vidrich, A., Shirafuji, Y., Dubois, C. L., Henschen-Edman, A. H., Hagen, S. J., Cohn, S. M., & Ouellette, A. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.083220 · Cited by 19 · see citing works

Maturation of the mucosal immune system underlies colitis susceptibility in interleukin-10-deficient (IL-10−/−) mice

Etling, M. R., Davies, S. A., Campbell, M., Redline, R. W., Fu, P., & Levine, A. D. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0606396 · Cited by 12 · see citing works

Early and Late Gut Immune Responses in IBD

Cominelli, F. (2008) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000313833.47207.47 · Cited by 9 · see citing works

Chemically induced mouse models of acute and chronic intestinal inflammation

Wirtz, S., Popp, V., Kindermann, M., Gerlach, K., Weigmann, B., Fichtner-Feigl, S., & Neurath, M. F. (2017) · Nature Protocols · doi:10.1038/nprot.2017.044 · Cited by 1,575 · see citing works

Inflammation and aging: signaling pathways and intervention therapies

Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443 · see citing works

Central Role of the Gut Epithelial Barrier in the Pathogenesis of Chronic Intestinal Inflammation: Lessons Learned from Animal Models and Human Genetics

Pastorelli, L., Salvo, C. D., Mercado, J. R., Vecchi, M. L., & Pizarro, T. T. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00280 · Cited by 434 · see citing works

The Gut Microbiome and Inflammatory Bowel Diseases

Shan, Y., Lee, M., & Chang, E. B. (2021) · Annual Review of Medicine · doi:10.1146/annurev-med-042320-021020 · Cited by 420 · see citing works

Porcine models of digestive disease: the future of large animal translational research

Gonzalez, L. M., Moeser, A. J., & Blikslager, A. T. (2015) · Translational research · doi:10.1016/j.trsl.2015.01.004 · Cited by 279 · see citing works

The Artificial Sweetener Splenda Promotes Gut Proteobacteria, Dysbiosis, and Myeloperoxidase Reactivity in Crohn’s Disease–Like Ileitis

Rodriguez-Palacios, A., Harding, A., Menghini, P., Himmelman, C., Retuerto, M., Nickerson, K. P., Lam, M., Croniger, C. M., McLean, M. H., Durum, S. K., et al. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy060 · Cited by 225 · see citing works

Large Animal Models: The Key to Translational Discovery in Digestive Disease Research

Ziegler, A. L., Gonzalez, L. M., & Blikslager, A. T. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.09.003 · Cited by 203 · see citing works

Innate Lymphoid Cells in Intestinal Homeostasis and Inflammatory Bowel Disease

Saéz, Á., Gómez-Bris, R., Herrero‐Fernández, B., Mingorance, C., Rius, C., & González, J. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147618 · Cited by 199 · see citing works

Intestinal Epithelium in Inflammatory Bowel Disease

Coskun, M. (2014) · Frontiers in Medicine · doi:10.3389/fmed.2014.00024 · Cited by 197 · see citing works

Dysbiosis in intestinal inflammation: Cause or consequence

Buttó, L. F., & Haller, D. (2016) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2016.02.010 · Cited by 189 · see citing works

Results of the 4th scientific workshop of the ECCO (I): Pathophysiology of intestinal fibrosis in IBD

Latella, G., Rogler, G., Bamias, G., Breynaert, C. M., Florholmen, J., Pellino, G., Reif, S. S., Speca, S., & Lawrance, I. C. (2014) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2014.03.008 · Cited by 165 · see citing works

Sex matters: impact on pathogenesis, presentation and treatment of inflammatory bowel disease

Goodman, W. A., Erkkila, I. P., & Pizarro, T. T. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0354-0 · Cited by 149 · see citing works

Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease

Basson, A. R., Trotter, A., Rodriguez‐Palacios, A., & Cominelli, F. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00290 · Cited by 136 · see citing works

Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease

Lopetuso, L. R., Chowdhry, S., & Pizarro, T. T. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00181 · Cited by 131 · see citing works

TL1A (TNFSF15) and DR3 (TNFRSF25): A Co-stimulatory System of Cytokines With Diverse Functions in Gut Mucosal Immunity

Valatas, V., Kolios, G. C., & Bamias, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00583 · Cited by 126 · see citing works

IL-33 promotes recovery from acute colitis by inducing miR-320 to stimulate epithelial restitution and repair

Lopetuso, L. R., Salvo, C. D., Pastorelli, L., Rana, N., Senkfor, H. N., Petito, V., Martino, L. D., Scaldaferri, F., Gasbarrini, A., Cominelli, F., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1803613115 · Cited by 119 · see citing works

Probiotic bacteria regulate intestinal epithelial permeability in experimental ileitis by a TNF-dependent mechanism

Corridoni, D., Pastorelli, L., Mattioli, B., Locovei, S., Ishikawa, D., Arseneau, K. O., Chieppa, M., Cominelli, F., & Pizarro, T. T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042067 · Cited by 118 · see citing works

In Vivo Inhibition of RIPK2 Kinase Alleviates Inflammatory Disease

Tigno-Aranjuez, J. T., Benderitter, P., Rombouts, F. J. R., Deroose, F. D., Bai, X., Mattioli, B., Cominelli, F., Pizarro, T. T., Hoflack, J., & Abbott, D. W. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.591388 · Cited by 115 · see citing works

Inflammatory bowel disease

Corridoni, D., Arseneau, K. O., & Cominelli, F. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.04.004 · Cited by 111 · see citing works

Antibiotics in the pathogenesis of diabetes and inflammatory diseases of the gastrointestinal tract

Fenneman, A. C., Weidner, M., Chen, L. A., Nieuwdorp, M., & Blaser, M. J. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00685-9 · Cited by 107 · see citing works

Differently surface-labeled polystyrene nanoplastics at an environmentally relevant concentration induced Crohn’s ileitis-like features via triggering intestinal epithelial cell necroptosis

Xu, D., Ma, Y., Peng, C., Gan, Y., Wang, Y., Chen, Z., Han, X., & Chen, Y. (2023) · Environment International · doi:10.1016/j.envint.2023.107968 · Cited by 102 · see citing works

The Oral-Gut Axis: Periodontal Diseases and Gastrointestinal Disorders

Lam, G., Albarrak, H. A., McColl, C., Pizarro, A., Sanaka, H., Gomez-Nguyen, A., Cominelli, F., & da Silva, A. P. B. (2022) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izac241 · Cited by 98 · see citing works

New insights into the dichotomous role of innate cytokines in gut homeostasis and inflammation

Bamias, G., Corridoni, D., Pizarro, T. T., & Cominelli, F. (2012) · Cytokine · doi:10.1016/j.cyto.2012.06.014 · Cited by 97 · see citing works

Mechanisms of Microbe–Host Interaction in Crohn’s Disease: Dysbiosis vs. Pathobiont Selection

Buttó, L. F., Schaubeck, M., & Haller, D. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00555 · Cited by 92 · see citing works

Emerging role of the interleukin (IL)-33/ST2 axis in gut mucosal wound healing and fibrosis

Lopetuso, L. R., Scaldaferri, F., & Pizarro, T. T. (2012) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-5-18 · Cited by 89 · see citing works

Impaired estrogen signaling underlies regulatory T cell loss-of-function in the chronically inflamed intestine

Goodman, W. A., Bedoyan, S., Havran, H. L., Richardson, B., Cameron, M. J., & Pizarro, T. T. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002266117 · Cited by 90 · see citing works

An Update of Research Animal Models of Inflammatory Bowel Disease

Baydi, Z., Limami, Y., Khalki, L., Zaïd, N., Naya, A., Mtairag, E. M., Oudghiri, M., & Zaid, Y. (2021) · The Scientific World JOURNAL · doi:10.1155/2021/7479540 · Cited by 86 · see citing works

Miniaturized implantable temperature sensors for the long-term monitoring of chronic intestinal inflammation

Madhvapathy, S. R., Bury, M. I., Wang, L. W., Ciatti, J. L., Avila, R. O., Huang, Y. Y., Sharma, A. K., & Rogers, J. A. (2024) · Nature Biomedical Engineering · doi:10.1038/s41551-024-01183-w · Cited by 83 · see citing works

Challenges in IBD Research: Preclinical Human IBD Mechanisms

Pizarro, T. T., Stappenbeck, T. S., Rieder, F., Rosen, M. J., Colombel, J., Donowitz, M., Towne, J. E., Mazmanian, S. K., Faith, J. J., Hodin, R. A., et al. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz075 · Cited by 80 · see citing works

Murine Models of Inflammatory Bowel Disease (IBD)

DeVoss, J., & Diehl, L. J. (2013) · Toxicologic Pathology · doi:10.1177/0192623313509729 · Cited by 78 · see citing works

IL-33 Drives Eosinophil Infiltration and Pathogenic Type 2 Helper T-Cell Immune Responses Leading to Chronic Experimental Ileitis

Salvo, C. D., Wang, X.-M., Pastorelli, L., Mattioli, B., Omenetti, S., Buela, K.-A. G., Chowdhry, S., Garg, R. R., Goodman, W. A., Rodriguez‐Palacios, A., et al. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.11.028 · Cited by 77 · see citing works

The interplay between microbes and the immune response in inflammatory bowel disease

Goethel, A., Croitoru, K., & Philpott, D. J. (2018) · The Journal of Physiology · doi:10.1113/jp275396 · Cited by 74 · see citing works

Stereomicroscopic 3D-pattern profiling of murine and human intestinal inflammation reveals unique structural phenotypes

Rodriguez‐Palacios, A., Kodani, T., Kaydo, L., Pietropaoli, D., Corridoni, D., Howell, S. J., Katz, J., Xin, W., Pizarro, T. T., & Cominelli, F. (2015) · Nature Communications · doi:10.1038/ncomms8577 · Cited by 73 · see citing works

Opposing diet, microbiome, and metabolite mechanisms regulate inflammatory bowel disease in a genetically susceptible host

Pereira, G. V., Boudaud, M., Wolter, M., Alexander, C., Sciscio, A. D., Grant, E. T., Trindade, B. C., Pudlo, N. A., Singh, S., Campbell, A., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.03.001 · Cited by 69 · see citing works

The Role of IL-33 in Gut Mucosal Inflammation

Pastorelli, L., Salvo, C. D., Vecchi, M. L., & Pizarro, T. T. (2013) · Mediators of Inflammation · doi:10.1155/2013/608187 · Cited by 69 · see citing works

Uncovering Pathogenic Mechanisms of Inflammatory Bowel Disease Using Mouse Models of Crohn’s Disease–Like Ileitis: What is the Right Model?

Cominelli, F., Arseneau, K. O., Rodriguez‐Palacios, A., & Pizarro, T. T. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.02.010 · Cited by 68 · see citing works

Compositional changes to the ileal microbiome precede the onset of spontaneous ileitis in SHIP deficient mice

Dobranowski, P., Tang, C., Sauvé, J. P., Menzies, S. C., & Sly, L. M. (2019) · Gut Microbes · doi:10.1080/19490976.2018.1560767 · Cited by 68 · see citing works

Parabacteroides distasonis induces depressive-like behavior in a mouse model of Crohn’s disease

Gomez-Nguyen, A., Basson, A. R., Dark, L. M., Hsu, K., Ösme, A., Menghini, P., Pizarro, T. T., & Cominelli, F. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.08.218 · Cited by 62 · see citing works

T Lymphocyte Dynamics in Inflammatory Bowel Diseases: Role of the Microbiome

Larmonier, C. B., Shehab, K. W., Ghishan, F. K., & Kiela, P. R. (2015) · BioMed Research International · doi:10.1155/2015/504638 · Cited by 60 · see citing works

Neutralization of IL-1α ameliorates Crohn’s disease-like ileitis by functional alterations of the gut microbiome

Menghini, P., Corridoni, D., Buttó, L. F., Ösme, A., Shivaswamy, S., Lam, M. C., Bamias, G., Pizarro, T. T., Rodriguez‐Palacios, A., Dinarello, C. A., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1915043116 · Cited by 61 · see citing works

Targeting TL1A and DR3: the new frontier of anti-cytokine therapy in IBD

Bamias, G., Menghini, P., Pizarro, T. T., & Cominelli, F. (2024) · Gut · doi:10.1136/gutjnl-2024-332504 · Cited by 59 · see citing works

Nr4A1 modulates inflammation-associated intestinal fibrosis and dampens fibrogenic signaling in myofibroblasts

Venu, V. K. P., Alston, L. A., Iftinca, M., Tsai, Y.-C., Stephens, M., Vineetha Warriyar, K. V., Rehal, S., Hudson, G., Szczepanski, H. E., von der Weid, P., et al. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00338.2019 · Cited by 56 · see citing works

Immunological Regulation of Intestinal Fibrosis in Inflammatory Bowel Disease

Bamias, G., Pizarro, T. T., & Cominelli, F. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izab251 · Cited by 56 · see citing works

Colitis-associated colon cancer: Is it in your genes?

Kraak, L. V. D. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i41.11688 · Cited by 56 · see citing works

Human small intestinal organotypic culture model for drug permeation, inflammation, and toxicity assays

Markus, J., Landry, T., Stevens, Z., Scott, H., Llanos, P., Debatis, M. E., Armento, A. J., Klausner, M., & Ayehunie, S. (2020) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-020-00526-6 · Cited by 56 · see citing works

Inflammatory Th1 and Th17 in the Intestine Are Each Driven by Functionally Specialized Dendritic Cells with Distinct Requirements for MyD88

Liang, J., Huang, H.-I., Benzatti, F. P., Karlsson, A., Zhang, J. J., Youssef, N. H., Ma, A. I., Hale, L. P., & Hammer, G. E. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.091 · Cited by 55 · see citing works

Eosinophils, probiotics, and the microbiome

Rosenberg, H. F., Masterson, J. C., & Furuta, G. T. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ri0416-202r · Cited by 52 · see citing works

Immunoglobulin A–specific deficiency induces spontaneous inflammation specifically in the ileum

Nagaishi, T., Watabe, T., Kotake, K., KUMAZAWA, T., Aida, T., Tanaka, K., Ono, R., Ishino, F., Usami, T., Miura, T., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-322873 · Cited by 51 · see citing works

Koch's postulates, microbial dysbiosis and inflammatory bowel disease

Singh, V., Proctor, S. D., & Willing, B. P. (2016) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2016.04.018 · Cited by 51 · see citing works

Implantable bioelectronics and wearable sensors for kidney health and disease

Madhvapathy, S. R., Cho, S., Gessaroli, E., Forte, E., Xiong, Y., Gallon, L. G., & Rogers, J. A. (2025) · Nature Reviews Nephrology · doi:10.1038/s41581-025-00961-2 · Cited by 53 · see citing works

Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn’s disease model mice

Shimizu, Y., Nakamura, K., Yoshii, A., Yokoi, Y., Kikuchi, M., Shinozaki, R., Nakamura, S., Ohira, S., Sugimoto, R., & Ayabe, T. (2020) · Life Science Alliance · doi:10.26508/lsa.201900592 · Cited by 50 · see citing works

Central role of IL-17/Th17 immune responses and the gut microbiota in the pathogenesis of intestinal fibrosis

Ray, S., Salvo, C. D., & Pizarro, T. T. (2014) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000119 · Cited by 50 · see citing works

Loss of estrogen-mediated immunoprotection underlies female gender bias in experimental Crohn's-like ileitis

Goodman, W. A., Garg, R. R., Reuter, B. K., Mattioli, B., Rissman, E. F., & Pizarro, T. T. (2014) · Mucosal Immunology · doi:10.1038/mi.2014.15 · Cited by 49 · see citing works

In vitro Models of the Small Intestine for Studying Intestinal Diseases

Jung, S.-M., & Kim, S. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.767038 · Cited by 49 · see citing works

Occurrence of Spontaneous Periodontal Disease in the SAMP1/YitFc Murine Model of Crohn Disease

Pietropaoli, D., Pinto, R. D., Corridoni, D., Rodriguez‐Palacios, A., Stefano, G. D., Monaco, A., Weinberg, A., & Cominelli, F. (2014) · Journal of Periodontology · doi:10.1902/jop.2014.140316 · Cited by 48 · see citing works

Facing Terminal Ileitis: Going Beyond Crohn’s Disease

Goulart, R. D. Á., Barbalho, S. M., Gasparini, R. G., & de Carvalho, A. D. C. A. (2016) · Gastroenterology Research · doi:10.14740/gr698w · Cited by 47 · see citing works

Assessment of Inflammation in an Acute on Chronic Model of Inflammatory Bowel Disease with Ultrasound Molecular Imaging

Machtaler, S., Knieling, F., Luong, R. H., Tian, L., & Willmann, J. K. (2015) · Theranostics · doi:10.7150/thno.13048 · Cited by 46 · see citing works

NOD2 drives early IL-33–dependent expansion of group 2 innate lymphoid cells during Crohn’s disease–like ileitis

Salvo, C. D., Buela, K.-A. G., Creyns, B., Corridoni, D., Rana, N., Wargo, H. L., Cominelli, C. L., Delaney, P. G., Rodriguez‐Palacios, A., Cominelli, F., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci140624 · Cited by 45 · see citing works

Secreted Klotho Attenuates Inflammation-Associated Aortic Valve Fibrosis in Senescence-Accelerated Mice P1

Chen, J., Fan, J., Wang, S., & Sun, Z. (2018) · Hypertension · doi:10.1161/hypertensionaha.117.10560 · Cited by 44 · see citing works

‘Cyclical Bias’ in Microbiome Research Revealed by A Portable Germ-Free Housing System Using Nested Isolation

Rodriguez‐Palacios, A., Aladyshkina, N. A., Ezeji, J. C., Erkkila, H. L., Conger, M., Ward, J., Webster, J., & Cominelli, F. (2018) · Scientific Reports · doi:10.1038/s41598-018-20742-1 · Cited by 44 · see citing works

A Novel Probiotic Combination Ameliorates Crohn’s Disease–Like Ileitis by Increasing Short-Chain Fatty Acid Production and Modulating Essential Adaptive Immune Pathways

Martino, L. D., Ösme, A., Ghannoum, M. A., & Cominelli, F. (2023) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izac284 · Cited by 41 · see citing works

Pathway-based approaches to the treatment of inflammatory bowel disease

Bamias, G., Pizarro, T. T., & Cominelli, F. (2015) · Translational research · doi:10.1016/j.trsl.2015.09.002 · Cited by 40 · see citing works

Tumor Necrosis Factor–like Cytokine TL1A and Its Receptors DR3 and DcR3

Siakavellas, S. I., & Bamias, G. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000492 · Cited by 40 · see citing works

γδ T Cells Coexpressing Gut Homing α4β7 and αE Integrins Define a Novel Subset Promoting Intestinal Inflammation

Do, J., Kim, S., Keslar, K. S., Jang, E., Huang, E. H., Fairchild, R. L., Pizarro, T. T., & Min, B. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1601060 · Cited by 40 · see citing works

TL1A: A New Potential Target in the Treatment of Inflammatory Bowel Disease

Furfaro, F., Alfarone, L., Gilardi, D., Correale, C., Allocca, M., Fiorino, G., ARGOLLO, M. C., Zilli, A., Zacharopoulou, E., Loy, L., et al. (2021) · Current Drug Targets · doi:10.2174/1389450122999210120205607 · Cited by 39 · see citing works

MSCs mediate long-term efficacy in a Crohn’s disease model by sustained anti-inflammatory macrophage programming via efferocytosis

Dave, M., Dev, A., Somoza, R. A., Zhao, N., Viswanath, S. E., Mina, P. R., Chirra, P. V., Obmann, V. C., Mahabeleshwar, G. H., Menghini, P., et al. (2024) · npj Regenerative Medicine · doi:10.1038/s41536-024-00347-1 · Cited by 39 · see citing works

Replacing Animal Protein with Soy-Pea Protein in an “American Diet” Controls Murine Crohn Disease–Like Ileitis Regardless of Firmicutes: Bacteroidetes Ratio

Basson, A. R., Gomez-Nguyen, A., LaSalla, A., Buttó, L. F., Kulpins, D., Warner, A. N., Martino, L. D., Ponzani, G., Ösme, A., Rodriguez‐Palacios, A., et al. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa386 · Cited by 38 · see citing works

Animal models for studying epithelial barriers in neonatal necrotizing enterocolitis, inflammatory bowel disease and colorectal cancer

Xing, T., Salazar, R. C., & Chen, Y. (2017) · Tissue Barriers · doi:10.1080/21688370.2017.1356901 · Cited by 38 · see citing works

Mouse models of inflammatory bowel disease for investigating mucosal immunity in the intestine

Bamias, G., Arseneau, K. O., & Cominelli, F. (2017) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000402 · Cited by 38 · see citing works

Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn’s disease strictures

Bauer-Rowe, K. E., Pham, B., Griffin, M., Liang, N. E., Kim, A., Lu, J. M., Januszyk, M., Guo, J. L., Santis, S. D., Xing, Y., et al. (2025) · Cell · doi:10.1016/j.cell.2025.08.029 · Cited by 38 · see citing works

Murine Adherent and InvasiveE. coliInduces Chronic Inflammation and Immune Responses in the Small and Large Intestines of Monoassociated IL-10-/- Mice Independent of Long Polar Fimbriae Adhesin A

Schmitz, J., Tonkonogy, S. L., Dogan, B., Leblond, A., Whitehead, K. J., Kim, S. C., Simpson, K. W., & Sartor, R. B. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy386 · Cited by 37 · see citing works

Role of MicroRNA in Inflammatory Bowel Disease: Clinical Evidence and the Development of Preclinical Animal Models

Suri, K., Bubier, J. A., Wiles, M. V., Shultz, L. D., Amiji, M. M., & Hosur, V. (2021) · Cells · doi:10.3390/cells10092204 · Cited by 37 · see citing works

Dysregulated NOD2 predisposes SAMP1/YitFc mice to chronic intestinal inflammation

Corridoni, D., Kodani, T., Rodriguez‐Palacios, A., Pizarro, T. T., Xin, W., Nickerson, K. P., McDonald, C., Ley, K. F., Abbott, D. W., & Cominelli, F. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311657110 · Cited by 35 · see citing works

E-cadherin activating antibodies limit barrier dysfunction and inflammation in mouse inflammatory bowel disease

Bandyopadhyay, C., Schecterson, L. C., & Gumbiner, B. M. (2021) · Tissue Barriers · doi:10.1080/21688370.2021.1940741 · Cited by 29 · see citing works

Epithelial-specific Toll-like receptor (TLR)5 activation mediates barrier dysfunction in experimental ileitis

Lopetuso, L. R., Jia, R., Wang, X.-M., Jia, L.-G., Petito, V., Goodman, W. A., Meddings, J. B., Cominelli, F., Reuter, B. K., & Pizarro, T. T. (2017) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000001035 · Cited by 28 · see citing works

Inflammatory Bowel Disease: Pathophysiology, Treatment, and Disease Modeling

Jang, J., & Jeong, S. (2023) · BioChip Journal · doi:10.1007/s13206-023-00118-y · Cited by 29 · see citing works

SAMP1/YitFc Mice Develop Ileitis via Loss of CCL21 and Defects in Dendritic Cell Migration

Mikulski, Z., Johnson, R., Shaked, I., Kim, G., Nowyhed, H. N., Goodman, W. A., Chodaczek, G., Pizarro, T. T., Cominelli, F., & Ley, K. F. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.01.027 · Cited by 28 · see citing works

Diet prevents the expansion of segmented filamentous bacteria and ileo-colonic inflammation in a model of Crohn’s disease

Metwaly, A., Jović, J., Waldschmitt, N., Khaloian, S., Heimes, H., Häcker, D., Ahmed, M., Hammoudi, N., Bourhis, L. L., Mayorgas, A., et al. (2023) · Microbiome · doi:10.1186/s40168-023-01508-y · Cited by 27 · see citing works

Human Gut Microbiome Transplantation in Ileitis Prone Mice: A Tool for the Functional Characterization of the Microbiota in Inflammatory Bowel Disease Patients

Basson, A. R., Gomez-Nguyen, A., Menghini, P., Buttó, L. F., Martino, L. D., Aladyshkina, N. A., Ösme, A., LaSalla, A., Fischer, D., Ezeji, J. C., et al. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz242 · Cited by 26 · see citing works

Chronic stress induces colonic tertiary lymphoid organ formation and protection against secondary injury through IL-23/IL-22 signaling

Gomez-Nguyen, A., Gupta, N., Sanaka, H., Gruszka, D., Pizarro, A., DiMartino, L., Basson, A. R., Menghini, P., Ösme, A., Salvo, C. D., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2208160119 · Cited by 26 · see citing works

Death Receptor 3 Signaling Controls the Balance between Regulatory and Effector Lymphocytes in SAMP1/YitFc Mice with Crohn’s Disease-Like Ileitis

Li, Z., Buttó, L. F., Buela, K.-A. G., Jia, L.-G., Lam, M. C., Ward, J., Pizarro, T. T., & Cominelli, F. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00362 · Cited by 25 · see citing works

Mouse Models of Intestinal Fibrosis

Li, J., Dejanovic, D., Zangara, M. T., Chandra, J., McDonald, C., & Rieder, F. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1382-5_26 · Cited by 25 · see citing works

Factors Promoting Development of Fibrosis in Crohn’s Disease

Rogler, G., & Hausmann, M. (2017) · Frontiers in Medicine · doi:10.3389/fmed.2017.00096 · Cited by 25 · see citing works

Multi-omics Comparative Analysis Reveals Multiple Layers of Host Signaling Pathway Regulation by the Gut Microbiota

Manes, N. P., Shulzhenko, N., Nuccio, A. G., Azeem, S., Morgun, A., & Nita‐Lazar, A. (2017) · mSystems · doi:10.1128/msystems.00107-17 · Cited by 24 · see citing works

Heterogeneity of ILC2s in the Intestine; Homeostasis and Pathology

Sunaga, S., Tsunoda, J., Teratani, T., Mikami, Y., & Kanai∥, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.867351 · Cited by 26 · see citing works

Genetic deletion of the bacterial sensor NOD2 improves murine Crohn's disease-like ileitis independent of functional dysbiosis

Corridoni, D., Rodriguez‐Palacios, A., Stefano, G. D., Martino, L. D., Antonopoulos, D., Chang, E. B., Arseneau, K. O., Pizarro, T. T., & Cominelli, F. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.98 · Cited by 24 · see citing works

The tumor necrosis factor-like cytokine 1A/death receptor 3 cytokine system in intestinal inflammation

Bamias, G., Jia, L.-G., & Cominelli, F. (2013) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e328365d3a2 · Cited by 23 · see citing works

Intestinal Organoids as a Novel Complementary Model to Dissect Inflammatory Bowel Disease

Schulte, L.-A., Hohwieler, M., Müller, M., & Klaus, J. (2019) · Stem Cells International · doi:10.1155/2019/8010645 · Cited by 22 · see citing works

Exploring the Early Phase of Crohn’s Disease

Bamias, G., & Cominelli, F. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.09.023 · Cited by 21 · see citing works

Spontaneous and transgenic rodent models of inflammatory bowel disease

Prattis, S. M., & Jurjus, A. R. (2015) · Laboratory Animal Research · doi:10.5625/lar.2015.31.2.47 · Cited by 21 · see citing works

The Role of the Gut Microbiota and Microbial Metabolites in the Pathogenesis of Alzheimer’s Disease

Wang, Y. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220417005115 · Cited by 21 · see citing works

Elafin Reverses Intestinal Fibrosis by Inhibiting Cathepsin S-Mediated Protease-Activated Receptor 2

Xie, Y., Fontenot, L., Estrada, A. C., Nelson, B., Wang, J., Shih, D. Q., Ho, W. W., Mattai, S. A., Rieder, F., Jensen, D. D., et al. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.06.011 · Cited by 20 · see citing works

Fusobacterium nucleatum infection activates the noncanonical inflammasome and exacerbates inflammatory response in DSS‐induced colitis

Boonyaleka, K., Okano, T., Iida, T., Leewananthawet, A., Sasai, M., Yamamoto, M., Ashida, H., & Suzuki, T. (2023) · European Journal of Immunology · doi:10.1002/eji.202350455 · Cited by 20 · see citing works

Functional defects in NOD2 signaling in experimental and human Crohn disease

Corridoni, D., Arseneau, K. O., & Cominelli, F. (2014) · Gut Microbes · doi:10.4161/gmic.28404 · Cited by 20 · see citing works

NR4A1 modulates intestinal smooth muscle cell phenotype and dampens inflammation‐associated intestinal remodeling

Szczepanski, H. E., Flannigan, K. L., Mainoli, B., Alston, L. A., Baruta, G., Lee, J. W., Venu, V. K. P., Shearer, J., Dufour, A., & Hirota, S. A. (2022) · The FASEB Journal · doi:10.1096/fj.202101817rr · Cited by 19 · see citing works

Trends in 3D models of inflammatory bowel disease

Ferreira, B., Barros, A. S., Pereira, C. L., Viegas, J. S. R., das Neves, J., Nunes, R., & Sarmento, B. F. C. C. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167042 · Cited by 19 · see citing works

Chronic Model of Inflammatory Bowel Disease in IL-10-/- Transgenic Mice: Evaluation with Ultrasound Molecular Imaging

Wang, H., Vilches-Moure, J. G., Cherkaoui, S., Tardy, I., Alleaume, C., Bettinger, T., Lutz, A. M., & Paulmurugan, R. (2019) · Theranostics · doi:10.7150/thno.37397 · Cited by 19 · see citing works

NADPH oxidase 4 is protective and not fibrogenic in intestinal inflammation

Stenke, E., Aviello, G., Singh, A. K., Martin, S., Winter, D. C., Sweeney, B., McDermott, M., Bourke, B., Hussey, S., & Knaus, U. G. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101752 · Cited by 19 · see citing works

Mechanisms and Models for Intestinal Fibrosis in IBD

Salvo, C. D., Ray, S., & Pizarro, T. T. (2014) · Digestive Diseases · doi:10.1159/000367822 · Cited by 19 · see citing works

Characterization of an intelectin-1 (Itln1) knockout mouse model

Nonnecke, E. B., Castillo, P. A., Akahoshi, D. T., Goley, S. M., Bevins, C. L., & Lönnerdal, B. L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.894649 · Cited by 18 · see citing works

The SAMP1/Yit mouse: another step closer to modeling human inflammatory bowel disease

Strober, W., Nakamura, K., & Kitani, A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12559 · Cited by 49 · see citing works

Uncovering Pathogenic Mechanisms of Inflammatory Bowel Disease Using Mouse Models of Crohn’s Disease–Like Ileitis: What is the Right Model?

Cominelli, F., Arseneau, K. O., Rodriguez‐Palacios, A., & Pizarro, T. T. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.02.010 · Cited by 68 · see citing works

Emergence of perianal fistulizing disease in the SAMP1/YitFc mouse, a spontaneous model of chronic ileitis

Rivera–Nieves, J., Bamias, G., Vidrich, A., Marini, M., Pizarro, T. T., MCDUFFIE, M. J., Moskaluk, C. A., Cohn, S. M., & Cominelli, F. (2003) · Gastroenterology · doi:10.1053/gast.2003.50148 · Cited by 160 · see citing works

Mouse models for the study of Crohn's disease

Pizarro, T. T., Arseneau, K. O., Bamias, G., & Cominelli, F. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00052-2 · Cited by 169 · see citing works

The roles of enteric bacteria on the development of Crohn's disease-like intestinal inflammation in SAMP1/Yit mice

Matsumoto, S. (2003) · International Congress Series · doi:10.1016/s0531-5131(03)01602-9