The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Expression of microRNA‐221 is progressively reduced in aggressive prostate cancer and metastasis and predicts clinical recurrence
Open accessAbstract
Emerging evidence shows that microRNAs (miR) are involved in the pathogenesis of a variety of cancers, including prostate carcinoma (PCa). Little information is available regarding miR expression levels in lymph node metastasis of prostate cancer or the potential of miRs as prognostic markers in this disease. Therefore, we analyzed the global expression of miRs in benign, hyperplastic prostate tissue (BPH), primary PCa of a high risk group of PCa patients, and corresponding metastatic tissues by microarray analysis. Consistent with the proposal that some miRs are oncomirs, we found aberrant expression of several miRs, including the downregulation of miR‐221, in PCa metastasis. Downregulation of miR‐221 was negatively correlated with the expression of the proto‐oncogen c‐kit in primary carcinoma. In a large study cohort, the prostate‐specific oncomir miR‐221 was progressively downregulated in aggressive forms of PCa. Downregulation of miR‐221 was associated with clinicopathological parameters, including the Gleason score and the clinical recurrence during follow up. Kaplan–Meier estimates and Cox proportional hazard models showed that miR‐221 downregulation was linked to tumor progression and recurrence in a high risk prostate cancer cohort. Our results showed that progressive miR‐221 downregulation hallmarks metastasis and presents a novel prognostic marker in high risk PCa. This suggests that miR‐221 has potential as a diagnostic marker and therapeutic target in PCa.
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Cites
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“This result is consistent with a clonal development of metastasis from the primary tumor.(27) It shows that miR-expression is not substantially altered in metastasising PCa.”
ResultMicroRNA Gene Expression Deregulation in Human Breast Cancer
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The impact of microRNAs on protein output
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The polycomb group protein EZH2 is involved in progression of prostate cancer
Varambally, S., Dhanasekaran, S. M., Zhou, M., Barrette, T. R., Kumar-Sinha, C., Sanda, M. G., Ghosh, D., Pienta, K. J., Sewalt, R. G. A. B., Otte, A. P., et al. (2002) · Nature · doi:10.1038/nature01075 · Cited by 2,717
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
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Extensive modulation of a set of microRNAs in primary glioblastoma
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Cited by
MicroRNAs in Development and Disease
Sayed, D., & Abdellatif, M. (2011) · Physiological Reviews · doi:10.1152/physrev.00006.2010 · Cited by 1,078
Androgen receptor signaling in prostate cancer
Culig, Z., & Santer, F. R. (2014) · Cancer and Metastasis Reviews · doi:10.1007/s10555-013-9474-0 · Cited by 283
Diagnostic and prognostic signatures from the small non-coding RNA transcriptome in prostate cancer
Martens-Uzunova, E. S., Jalava, S. E., Dits, N. F., van Leenders, G. J. L. H., Møller, S., Trapman, J., Bangma, C. H., Litman, T., Visakorpi, T., & Jenster, G. (2012) · Oncogene · doi:10.1038/onc.2011.304 · Cited by 271
MicroRNAs in tumorigenesis, metastasis, diagnosis and prognosis of gastric cancer
Jiang, C., Chen, X., Alattar, M., Wei, J., & Liu, H. (2015) · Cancer Gene Therapy · doi:10.1038/cgt.2015.19 · Cited by 111
Metadata
- Authors
- Spahn, M., Kneitz, S., Scholz, C., Stenger, N., Rüdiger, T., Ströbel, P., Riedmiller, H., & Kneitz, B.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2010-05-20
- Volume
- 127
- Issue
- 2
- Pages
- 394-403
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W1966101011
- Cited by
- 228
- References
- 8
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Spahn, M., Kneitz, S., Scholz, C., Stenger, N., Rüdiger, T., Ströbel, P., Riedmiller, H., & Kneitz, B. (2010). Expression of microRNA‐221 is progressively reduced in aggressive prostate cancer and metastasis and predicts clinical recurrence. International Journal of Cancer. https://doi.org/10.1002/ijc.24715
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