PRDM16 Regulating Adipocyte Transformation and Thermogenesis: A Promising Therapeutic Target for Obesity and Diabetes

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Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex

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Untitled work

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Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex

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Prdm16 Is Required for the Maintenance of Brown Adipocyte Identity and Function in Adult Mice

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EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex

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Prdm3 and Prdm16 are H3K9me1 Methyltransferases Required for Mammalian Heterochromatin Integrity

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MicroRNA-133 Controls Brown Adipose Determination in Skeletal Muscle Satellite Cells by Targeting Prdm16

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Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue

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TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue

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MyomiR-133 regulates brown fat differentiation through Prdm16

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AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis

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Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program

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A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate

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Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress

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Epigenetic Alterations in Human Liver From Subjects With Type 2 Diabetes in Parallel With Reduced Folate Levels

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Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis

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A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells

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Peroxisome-derived lipids regulate adipose thermogenesis by mediating cold-induced mitochondrial fission

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Adipose Subtype-Selective Recruitment of TLE3 or Prdm16 by PPARγ Specifies Lipid Storage versus Thermogenic Gene Programs

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PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional programPreprint

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The Multifaceted Roles of PRDM16: Adipose Biology and Beyond

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Glucocorticoids Transcriptionally Regulate miR-27b Expression Promoting Body Fat Accumulation Via Suppressing the Browning of White Adipose Tissue

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TRPV1 activation counters diet-induced obesity through sirtuin-1 activation and PRDM-16 deacetylation in brown adipose tissue

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l -Theanine Activates the Browning of White Adipose Tissue Through the AMPK/α-Ketoglutarate/Prdm16 Axis and Ameliorates Diet-Induced Obesity in Mice

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Genistein ameliorated obesity accompanied with adipose tissue browning and attenuation of hepatic lipogenesis in ovariectomized rats with high-fat diet

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EHMT1/EHMT2 in EMT, cancer stemness and drug resistance: emerging evidence and mechanisms

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Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice.

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Prdm16-mediated H3K9 methylation controls fibro-adipogenic progenitors identity during skeletal muscle repair

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Reprogrammed Functional Brown Adipocytes Ameliorate Insulin Resistance and Dyslipidemia in Diet-Induced Obesity and Type 2 Diabetes

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Liraglutide improves insulin sensitivity in high fat diet induced diabetic mice through multiple pathways

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PRDM16: the interconvertible adipo-myocyte switch

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PRDM16 Suppresses MLL1r Leukemia via Intrinsic Histone Methyltransferase Activity

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The duality of PRDM proteins: epigenetic and structural perspectives

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Genetic and epigenetic control of adipose development

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An Integrated Cell Purification and Genomics Strategy Reveals Multiple Regulators of Pancreas Development

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Prdm16 is crucial for progression of the multipolar phase during neural differentiation of the developing neocortex

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Role of brown adipose tissue in modulating adipose tissue inflammation and insulin resistance in high-fat diet fed mice

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Cryptotanshinone promotes commitment to the brown adipocyte lineage and mitochondrial biogenesis in C3H10T1/2 mesenchymal stem cells via AMPK and p38-MAPK signaling

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PR/SET Domain Family and Cancer: Novel Insights from The Cancer Genome Atlas

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Foxc2 coordinates inflammation and browning of white adipose by leptin-STAT3-PRDM16 signal in mice

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Beige Fat Maintenance; Toward a Sustained Metabolic Health

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Obesity-Associated miR-199a/214 Cluster Inhibits Adipose Browning via PRDM16–PGC-1α Transcriptional Network

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PRDM16 functions as a suppressor of lung adenocarcinoma metastasis

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Increasing evidence of pathogenic role of the Mediator (MED) complex in the development of cardiovascular diseases

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Resveratrol and Oxyresveratrol Activate Thermogenesis via Different Transcriptional Coactivators in High-Fat Diet-Induced Obese Mice

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The natural compound rutaecarpine promotes white adipocyte browning through activation of the AMPK-PRDM16 axis

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Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review

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