Long non‐coding RNA uc.80‐ overexpression promotes M2 polarization of microglias to ameliorate depression in rats
Open accessAbstract
Microglia polarization is associated with the pathogenesis of depression. A previous study shows that long non‐coding RNA uc.80‐ is down‐regulated in the hippocampus of depressed rats. Thus, this article aims to investigate the role of uc.80‐ in microglia polarization in depression. We first established depression model rats by chronic unpredictable mild stress (CUMS) regiment. We found that hippocampus of depressed rats exhibited an increase of M1 microglias and a decrease of M2 microglias. uc.80‐ was down‐regulated in hippocampus of depressed rats. Furthermore, the detection of behaviouristics of depressed rats showed that uc.80‐ overexpression alleviated depression of rats. In addition, uc.80‐ overexpression promoted M2 polarization of microglias in vivo and in vitro. uc.80‐ overexpression led to a decrease in apoptosis of hippocampal neurons in vivo and in vitro. In conclusion, our study confirms that lncRNA uc.80‐ overexpression ameliorates depression in rats by promoting M2 polarization of microglias. Thus, our work suggests that uc.80‐ may be a target gene for depression treatment.
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Elevated expression of lncRNA uc.80 can reduce depression-like behaviors in rats and hippocampal neuron apoptosis in vitro and in vivo.
“Elevated expression of lncRNA uc.80 can reduce depression-like behaviors in rats and hippocampal neuron apoptosis in vitro and in vivo.315”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [315]
lncRNA uc.80 may be a potential target of treatment for depression.
“Consequently, lncRNA uc.80 may be a potential target of treatment for depression.”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [315]
More M1 microglia were found in the hippocampus of depressed rats and fewer M2 microglia, as well as a negative regulation factor of the lncRNA uc.80.
“More M1 microglia were found in the hippocampus of depressed rats and fewer M2 microglia, as well as a negative regulation factor of the lncRNA uc.80.315”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [315]
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Cites
Malhi, G. S., & Mann, J. J. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31948-2 · Cited by 4,099 · see citing works
Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases
Tang, Y., & Le, W. (2016) · Molecular Neurobiology · doi:10.1007/s12035-014-9070-5 · Cited by 2,190 · see citing works
Neuroinflammation and M2 Microglia: The Good, the Bad, and the Inflamed
Cherry, J. D., Olschowka, J. A., & O’Banion, M. K. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-98 · Cited by 1,748 · see citing works
Microglia in neurodegeneration
Hickman, S., Izzy, S., Sen, P., Morsett, L., & El Khoury, J. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0242-x · Cited by 1,710 · see citing works
Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia
Ohsawa, K., Imai, Y., Kanazawa, H., Sasaki, Y., & Kohsaka, S. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.17.3073 · Cited by 420 · see citing works
Iba1 Is an Actin-Cross-Linking Protein in Macrophages/Microglia
Sasaki, Y., Ohsawa, K., Kanazawa, H., Kohsaka, S., & Imai, Y. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5388 · Cited by 373 · see citing works
Ponjavic, J., Oliver, P. L., Lunter, G. A., & Ponting, C. P. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000617 · Cited by 368 · see citing works
Switching of the Microglial Activation Phenotype Is a Possible Treatment for Depression Disorder
Zhang, L., Zhang, J., & You, Z. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00306 · Cited by 279 · see citing works
Microglia: An Interface between the Loss of Neuroplasticity and Depression
Singhal, G., & Baune, B. T. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00270 · Cited by 252 · see citing works
Microglia of Prefrontal White Matter in Suicide
Schnieder, T. P., Trencevska, I., Rosoklija, G., Stankov, A., Mann, J. J., Smiley, J., & Dwork, A. J. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000107 · Cited by 202 · see citing works
Zhao, Q., Wu, X., Yan, S., Xie, X., Fan, Y., Zhang, J., Peng, C. Y., & You, Z. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0728-y · Cited by 142 · see citing works
Liu, Z., Li, X., Sun, N., Xu, Y. J., Meng, Y.-Q., Yang, C., Wang, Y., & Zhang, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093388 · Cited by 121 · see citing works
Tang, J., Yu, W., Chen, S., Gao, Z., & Xiao, B. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2504-0 · Cited by 101 · see citing works
The link between long noncoding RNAs and depression
Huang, X., Luo, Y., Mao, Y.-S., & Jian-lin, J. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.06.004 · Cited by 92 · see citing works
Role of microglia-neuron interactions in diabetic encephalopathy
Liu, Y., Li, M., Zhang, Z., Ye, Y., & Zhou, J. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.12.005 · Cited by 87 · see citing works
Long Non-Coding RNA: Potential Diagnostic and Therapeutic Biomarker for Major Depressive Disorder
Cui, X., Sun, X., Niu, W., Kong, L., He, M., Zhong, A., Chen, S., Jiang, K., Zhang, L.-Y., & Cheng, Z. (2016) · Medical Science Monitor · doi:10.12659/msm.899372 · Cited by 82 · see citing works
Exploring the role of microglia in cortical spreading depression in neurological disease
Shibata, M., & Suzuki, N. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17690537 · Cited by 81 · see citing works
Tian, X., Liu, H., Xiang, F., Xu, L., & Dong, Z. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116915 · Cited by 76 · see citing works
Self-citationThe importance of long non-coding RNAs in neuropsychiatric disorders
Hosseini, E., Bagheri‐Hosseinabadi, Z., Toma, I. D., Jafarisani, M., & Sadeghi, I. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.07.004 · Cited by 70 · see citing works
Plastira, I., Bernhart, E. M., Goeritzer, M., DeVaney, T. T. J., Reicher, H., Hammer, A., Lohberger, B., Wintersperger, A., Zucol, B., Graier, W. F., et al. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-1024-1 · Cited by 60 · see citing works
S100B promotes microglia M1 polarization and migration to aggravate cerebral ischemia
Zhou, S., Zhu, W., Zhang, Y., Pan, S., & Bao, J. (2018) · Inflammation Research · doi:10.1007/s00011-018-1187-y · Cited by 53 · see citing works
Microglial CD206 Gene Has Potential as a State Marker of Bipolar Disorder
Ohgidani, M., Kato, T. A., Haraguchi, Y., Matsushima, T., Mizoguchi, Y., Murakawa‐Hirachi, T., Sagata, N., Monji, A., & Kanba, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00676 · Cited by 46 · see citing works
Roy, B., Wang, Q., & Dwivedi, Y. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy010 · Cited by 38 · see citing works
Ni, X., Liao, Y., Li, L., Zhang, X., & Wu, Z. (2018) · Journal of Integrative Neuroscience · doi:10.31083/jin-170052 · Cited by 37 · see citing works
MicroRNAs in Major Depressive Disorder
Fries, G. R., Zhang, W., Benevenuto, D., & Quevedo, J. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-05542-4_9 · Cited by 31 · see citing works
Relationships of Non-coding RNA with diabetes and depression
An, T., Zhang, J., Ma, Y., Lian, J., Wu, Y.-X., Lv, B.-H., Ma, M.-H., Meng, J.-H., Zhou, Y.-T., Zhang, Z.-Y., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-47077-9 · Cited by 27 · see citing works
Ni, X., Liao, Y., Li, L., Zhang, X., & Wu, Z. (2018) · Journal of Integrative Neuroscience · doi:10.3233/jin-170052 · Cited by 26 · see citing works
Liu, S., Zhou, B., Wang, L., Hu, H., Yao, C., Cai, Z., & Cui, X. (2018) · Medical Science Monitor · doi:10.12659/msm.908543 · Cited by 18 · see citing works
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Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works
“80 can reduce depression-like behaviors in rats and hippocampal neuron apoptosis in vitro and in vivo.(315) Consequently, lncRNA uc.”
Background
- Authors
- Gu, X., Xu, L., Zheng, L., Yang, Y., Tang, Z., Wu, H., Chen, Z., & Wang, W.
- Affiliations
- Department of Neurology The Second Affiliated Hospital of Nanchang University Nanchang Jiangxi China
- Second Affiliated Hospital of Nanchang University (CN)
- Jiangxi Maternal and Child Health Hospital (CN)
- Jiangxi Mental Health Center (CN)
- Corresponding author
- Wang, Wei
- Venue
- IUBMB Life
- Publisher
- Wiley
- Published
- 2020-08-11
- Volume
- 72
- Issue
- 10
- Pages
- 2194-2203
- ISSN
- 1521-6543 (ISSN-L)
- 1521-6551
- OpenAlex
- W3048667503
- Cited by
- 21
- References
- 28
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 1 · 2022: 7 · 2021: 4 · 2020: 1
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- IUBMB Life (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Jiangxi Province (20192BAB205038)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- depression, microglial polarization, M2 microglia, M1 microglia, hippocampus, chronic unpredictable mild stress, neuronal apoptosis
- MeSH terms
- Animals, Cells, Cultured, Depression, Disease Models, Animal, Gene Expression Regulation, Hippocampus, Male, Neurons, Stress, Psychological, Culture Media, Conditioned, Rats, Sprague-Dawley, Apoptosis, Microglia, RNA, Long Noncoding
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