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The Kennedy pathway—De novo synthesis of phosphatidylethanolamine and phosphatidylcholine

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Gibellini, Federica, Smith, Terry K.·2010·IUBMB Life
DOI 10.1002/iub.337
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Abstract

The glycerophospholipids phosphatidylcholine (PC) and phosphatidylethanolamine (PE) account for greater than 50% of the total phospholipid species in eukaryotic membranes and thus play major roles in the structure and function of those membranes. In most eukaryotic cells, PC and PE are synthesized by an aminoalcoholphosphotransferase reaction, which uses sn‐1,2‐diradylglycerol and either CDP‐choline or CDP‐ethanolamine, respectively. This is the last step in a biosynthetic pathway known as the Kennedy pathway, so named after Eugene Kennedy who elucidated it over 50years ago. This review will cover various aspects of the Kennedy pathway including: each of the biosynthetic steps, the functions androles of the phospholipid products PC and PE, and how the Kennedy pathway has the potential of being a chemotherapeutic target against cancer and various infectious diseases. © 2010 IUBMB IUBMB Life, 62(6): 414–428, 2010

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  • Molecular dissection of autophagy: two ubiquitin-like systems

    Ohsumi, Y. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35056522 · Cited by 1,240 · cited 1×

    “PE or PE-derived ethanolamine-phosphoglycerol can be in some specialized circumstances attached to protein residues (such as the elongation factor 1A or to ATG8 in autophagy) as a posttranslational modification in some specialized circumstances (26, 27).”
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Metadata

Authors
Gibellini, F., & Smith, T. K.
Venue
IUBMB Life
Publisher
Wiley
Published
2010-05-06
Volume
62
Issue
6
Pages
414-428
ISSN
  • 1521-6543 (ISSN-L)
  • 1521-6551
DOI
10.1002/iub.337
OpenAlex
W2066207556
Cited by
830
References
1
FWCI
7.43
Type
journal article
Language
en
Open access
bronze
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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Gibellini, F., & Smith, T. K. (2010). The Kennedy pathway—De novo synthesis of phosphatidylethanolamine and phosphatidylcholine. IUBMB Life. https://doi.org/10.1002/iub.337

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