Cited by 1,374Chromosomal and Genetic VariationsEvolution and Genetic DynamicsGenomics and Phylogenetic Studies

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Origin and evolution of retroelements based upon their reverse transcriptase sequences

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Xiong, Y., Eickbush, T. H.·1990·The EMBO Journal

DOI 10.1002/j.1460-2075.1990.tb07536.xPMC PMC552073

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Abstract

To study the evolutionary relationship of reverse transcriptase (RT) containing genetic elements, a phylogenetic tree of 82 retroelements from animals, plants, protozoans and bacteria was constructed. The tree was based on seven amino acid domains totalling 178 residues identified in all RTs. We have also identified these seven domains in the RNA-directed RNA polymerases from various plus-strand RNA viruses. The sequence similarity of these RNA polymerases to RT suggests that these two enzymes evolved from a common ancestor, and thus RNA polymerase can be used as an outgroup to root the RT tree. A comparison of the genetic organization of the various RT containing elements and their position on the tree allows several inferences concerning the origin and evolution of these elements. The most probable ancestor of current retroelements was a retrotransposable element with both gag-like and pol-like genes. On one major branch of the tree, organelle and bacterial sequences (e.g. group II introns and bacterial msDNA) appear to have captured the RT sequences from retrotransposons which lack long terminal repeats (LTRs). On the other major branch, acquisition of LTRs gave rise to two distinct groups of LTR retrotransposons and three groups of viruses: retroviruses, hepadnaviruses and caulimoviruses.

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The neighbor-joining method: a new method for reconstructing phylogenetic trees.
Saitou, N., & Nei, M. (1987) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040454 · Cited by 59,959
Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of Rous Sarcoma Virus
TEMIN, H. M., & MIZUTANI, S. (1970) · Nature · doi:10.1038/2261211a0 · Cited by 2,128
Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses
BALTIMORE, D. (1970) · Nature · doi:10.1038/2261209a0 · Cited by 2,068
Progressive sequence alignment as a prerequisitetto correct phylogenetic trees
Feng, D.-F., & Doolittle, R. F. (1987) · Journal of Molecular Evolution · doi:10.1007/bf02603120 · Cited by 1,883
Identification of four conserved motifs among the RNA‐dependent polymerase encoding elements.
Poch, O., Sauvaget, I., Delarue, M. H., & Tordo, N. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08565.x · Cited by 1,202
NONVIRAL RETROPOSONS: GENES, PSEUDOGENES, AND TRANSPOSABLE ELEMENTS GENERATED BY THE REVERSE FLOW OF GENETIC INFORMATION
Weiner, A. M., Deininger, P. L., & Efstratiadis, A. (1986) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.55.070186.003215 · Cited by 1,019
Molecular Evolutionary Genetics
Wallace, B. B. (1988) · Journal of Heredity · doi:10.1093/oxfordjournals.jhered.a110475 · Cited by 964
Primary structural comparison of RNA-dependent polymerases from plant, animal and bacterial viruses
Kamer, G., & Argos, P. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.18.7269 · Cited by 837
Origins and evolutionary relationships of retroviruses
Doolittle, R. F., Johnson, M. S., & McClure, M. A. (1989) · The Quarterly Review of Biology · doi:10.1086/416128 · Cited by 577
The Origin and Evolution of Retroposons
ROGERS, J. H. (1985) · International review of cytology · doi:10.1016/s0074-7696(08)61375-3 · Cited by 548

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SanMiguel, P. J., & Vitte, C. (2009) · Springer eBooks · doi:10.1007/978-0-387-77863-1_15 · Cited by 37
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Extrachromosomal circular forms of the tobacco retrotransposon Ttol
Hirochika, H., & Otsuki, H. (1995) · Gene · doi:10.1016/0378-1119(95)00581-p · Cited by 37
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Deragon, J., & Capy, P. (2000) · Annals of Medicine · doi:10.3109/07853890009011768 · Cited by 37
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Vicient, C. M., & Schulman, A. H. (2002) · Genome Letters · doi:10.1166/gl.2002.002 · Cited by 37
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Koll, F., Boulay, J., Belcour, L., & d’Aubenton-Carafa, Y. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.9.1734 · Cited by 36
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Xiong, Y., & Eickbush, T. H. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.5.1318 · Cited by 36
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Endogenous retroviruses of the chicken genome
Huda, A., Polavarapu, N., Jordan, I. K., & McDonald, J. F. (2008) · Biology Direct · doi:10.1186/1745-6150-3-9 · Cited by 36
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Klarmann, G. J., Me, H., & Grice, S. F. J. L. (2002) · PubMed · Cited by 35
An In Vivo Assay for the Reverse Transcriptase of Human Retrotransposon L1 in Saccharomyces cerevisiae
Dombroski, B. A., Feng, Q., Mathias, S. L., Sassaman, D. M., Scott, A. F., Kazazian, H. H., & Boeke, J. D. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.7.4485-4492.1994 · Cited by 36
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Toro, N., Molina-Sánchez, M. D., & Fernández‐López, M. (2002) · Gene · doi:10.1016/s0378-1119(02)01079-x · Cited by 36
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Elrouby, N., & Bureau, T. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105850200 · Cited by 36
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Pardue, M. L., Danilevskaya, O. N., Lowenhaupt, K., Wong, J., & Erby, K. (1996) · Journal of Molecular Evolution · doi:10.1007/bf02202105 · Cited by 36
LINEs
Martin, S. L. (1991) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(05)80199-6 · Cited by 36
Identification of RNA binding motifs in the R2 retrotransposon-encoded reverse transcriptase
Jamburuthugoda, V. K., & Eickbush, T. H. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku514 · Cited by 35
Self-citation
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Chen, J. E., Cui, G., Wang, X., Liew, Y. J., & Aranda, M. (2017) · The ISME Journal · doi:10.1038/ismej.2017.179 · Cited by 35

Authors: Xiong, Y., & Eickbush, T. H.
Affiliations: University of Rochester (US)
ORCID: Xiong, Y.
Venue: The EMBO Journal
Publisher: Springer Science and Business Media LLC
Published: 1990-10-01
Volume: 9
Issue: 10
Pages: 3353-3362
ISSN: 0261-4189 (ISSN-L)
1460-2075
DOI: 10.1002/j.1460-2075.1990.tb07536.x
PMC: PMC552073
OpenAlex: W1554644662
Cited by: 1,374
References: 77
Citations by year: 2026: 16 · 2025: 19 · 2024: 12 · 2023: 20 · 2022: 21 · 2021: 20 · 2020: 15 · 2019: 18 · 2018: 22 · 2017: 28 · 2016: 29 · 2015: 34 · 2014: 32 · 2013: 44 · 2012: 29
FWCI: 87.47
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: The EMBO Journal (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords: retroelements, reverse transcriptase, retrotransposons, RNA-dependent RNA polymerase, positive-strand RNA viruses, LTR retrotransposons, retroviral evolution, hepadnaviruses, group II introns, organelle DNA, common ancestor, horizontal gene transfer
MeSH terms: Amino Acid Sequence, Animals, DNA Transposable Elements, Biological Evolution, Humans, Introns, Molecular Sequence Data, Phylogeny, RNA-Directed DNA Polymerase, DNA-Directed RNA Polymerases, Sequence Homology, Nucleic Acid

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Origin and evolution of retroelements based upon their reverse transcriptase sequences

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