Cited by 879Cancer-related Molecular PathwaysCervical Cancer and HPV ResearchUbiquitin and proteasome pathways

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A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

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Huibregtse, J.M., Scheffner, M., Howley, P.M.·1991·The EMBO Journal

DOI 10.1002/j.1460-2075.1991.tb04990.xPMC PMC453163

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Abstract

The E6 protein of human papillomavirus types 16 and 18 (HPV-16 and HPV-18) can stably associate with the p53 protein in vitro. In the presence of rabbit reticulocyte lysate, this association leads to the specific degradation of p53 through the ubiquitin-dependent proteolysis system. We have examined the E6-p53 complex in more detail and have found that association of E6 with p53 is mediated by an additional cellular factor. This factor is present in rabbit reticulocyte lysate, primary human keratinocytes and in each of five human cell lines examined. The factor is designated E6-AP, for E6-associated protein, based on the observation that the E6 proteins of HPV-16 and 18 can form a stable complex with the factor in the absence of p53, whereas p53 association with the factor can be detected only in the presence of E6. Gel filtration and coprecipitation experiments indicate that E6-AP is a monomeric protein of approximately 100 kDa.

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Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
Smith, D. B., & Johnson, K. S. (1988) · Gene · doi:10.1016/0378-1119(88)90005-4 · Cited by 5,844
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
Scheffner, M., Werness, B. A., Huibregtse, J. M., Levine, A. J., & Howley, P. M. (1990) · Cell · doi:10.1016/0092-8674(90)90409-8 · Cited by 3,995
Self-citation
The human papilloma virus-16 E7-oncoprotein is able to bind to the retinoblastoma gene product
Dyson, N., Howley, P. M., Münger, K., & Harlow, E. (1989) · Science · doi:10.1126/science.2537532 · Cited by 3,017
Self-citation
Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53
Werness, B. A., Levine, A. J., & Howley, P. M. (1990) · Science · doi:10.1126/science.2157286 · Cited by 2,562
Self-citation
T antigen is bound to a host protein in SY40-transformed cells
Lane, D. P., & Crawford, L. V. (1979) · Nature · doi:10.1038/278261a0 · Cited by 2,456
Cyclin is degraded by the ubiquitin pathway
Glotzer, M., Murray, A. W., & Kirschner, M. W. (1991) · Nature · doi:10.1038/349132a0 · Cited by 2,359
Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
Linzer, D. I. H., & Levine, A. J. (1979) · Cell · doi:10.1016/0092-8674(79)90293-9 · Cited by 1,814
Structure and transcription of human papillomavirus sequences in cervical carcinoma cells
Schwarz, E., Freese, U. K., Gissmann, L., Mayer, W., Roggenbuck, B., Stremlau, A., & Hausen, H. Z. (1985) · Nature · doi:10.1038/314111a0 · Cited by 1,483
SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
DeCaprio, J. A., Ludlow, J. W., Figge, J., Shew, J.-Y., Huang, C.-M., Lee, W.-H., Marsilio, E., Paucha, E., & Livingston, D. M. (1988) · Cell · doi:10.1016/0092-8674(88)90559-4 · Cited by 1,459
Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product
Whyte, P., Buchkovich, K. J., Horowitz, J. M., Friend, S. H., Raybuck, M., Weinberg, R. A., & Harlow, E. (1988) · Nature · doi:10.1038/334124a0 · Cited by 1,403

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Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes
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Natural variants of the human papillomavirus type 16 E6 protein differ in their abilities to alter keratinocyte differentiation and to induce p53 degradation
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Physical Interaction between Specific E2 and Hect E3 Enzymes Determines Functional Cooperativity
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Cloning of Human Ubiquitin-conjugating Enzymes UbcH6 and UbcH7 (E2-F1) and Characterization of Their Interaction with E6-AP and RSP5
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HTLV-1 HBZ suppresses AP-1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein
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Molecular Mechanisms of Human Papillomavirus-Induced Carcinogenesis
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Sherman, L., & Schlegel, R. (1996) · Journal of Virology · doi:10.1128/jvi.70.5.3269-3279.1996 · Cited by 113
The high risk human papillomaviruses and oral cancer: evidence for and against a causal relationship
Sugerman, P. B., & Ej, S. (1997) · Oral Diseases · doi:10.1111/j.1601-0825.1997.tb00025.x · Cited by 112
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Oh, S. T., Longworth, M. S., & Laimins, L. A. (2004) · Journal of Virology · doi:10.1128/jvi.78.5.2620-2626.2004 · Cited by 112
The ubiquitin-mediated proteolytic pathway as a therapeutic area
Rolfe, M., Chiu, M. I., & Pagano, M. (1997) · Journal of Molecular Medicine · doi:10.1007/s001090050081 · Cited by 112
Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4
Jolliffe, C. N., Harvey, K. F., Haines, B. P., Parasivam, G., & Kumar, S. (2000) · Biochemical Journal · doi:10.1042/bj3510557 · Cited by 112
Differential regulation of the pocket domains of the retinoblastoma family proteins by the HPV16 E7 oncoprotein.
Berezutskaya, E., Yu, B., Morozov, A., Raychaudhuri, P., & Bagchi, S. (1997) · PubMed · Cited by 110
The Global Transcriptional Effects of the Human Papillomavirus E6 Protein in Cervical Carcinoma Cell Lines Are Mediated by the E6AP Ubiquitin Ligase
Kelley, M. L., Keiger, K., Lee, C. J., & Huibregtse, J. M. (2005) · Journal of Virology · doi:10.1128/jvi.79.6.3737-3747.2005 · Cited by 110
Self-citation
Infections as a major preventable cause of human cancer
Kuper, H., Adami, H., & Trichopoulos, D. (2001) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2001.00742.x · Cited by 110
Ubiquitin and the Enigma of Intracellular Protein Degradation
Jennissen, H. P. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.0001f.x · Cited by 120
Pub1 acts as an E6‐AP‐like protein ubiquitiin ligase in the degradation of cdc25.
NEFSKY, B., & Beach, D. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00472.x · Cited by 107
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An, J., Mo, D., Liu, H., Veena, M. S., Srivatsan, E. S., Massoumi, R., & Rettig, M. B. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.10.007 · Cited by 115
The interaction of p53 with replication protein A mediates suppression of homologous recombination
Romanova, L. Y., Willers, H., Blagosklonny, M. V., & Powell, S. N. (2004) · Oncogene · doi:10.1038/sj.onc.1207982 · Cited by 105
Tissue-specific variation of Ube3a protein expression in rodents and in a mouse model of Angelman syndrome
Gustin, R. M., Bichell, T. J., Bubser, M., Daily, J., Filonova, I., Mrelashvili, D., Deutch, A. Y., Colbran, R. J., Weeber, E. J., & Haas, K. F. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.04.012 · Cited by 105
Biochemical Analysis of Angelman Syndrome-associated Mutations in the E3 Ubiquitin Ligase E6-associated Protein
Cooper, E. M., Hudson, A. W., Amos, J., Wagstaff, J. E., & Howley, P. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401302200 · Cited by 107
Self-citation
Dysregulated microRNAs in the pathogenesis and progression of cervical neoplasm
Cheung, T.-H., Man, K. N. M., Yu, M., Yim, S. F., Siu, N. S. S., Lo, K. W. K., Doran, G., Wong, R. R. Y., Wang, V. W., Smith, D. I., et al. (2012) · Cell Cycle · doi:10.4161/cc.21278 · Cited by 106
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Nishimura, A., Ono, T., Ishimoto, A., Dowhanick, J. J., Frizzell, M. A., Howley, P. M., & Sakai, H. (2000) · Journal of Virology · doi:10.1128/jvi.74.8.3752-3760.2000 · Cited by 105
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Ming, J., Bohl, J., Brimer, N., Kinter, M. T., & Pol, S. V. (2006) · Journal of Virology · doi:10.1128/jvi.01979-06 · Cited by 112
Development of the Ocular Lens
(2004) · Cambridge University Press eBooks · doi:10.1017/cbo9780511529825 · Cited by 105
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Hu, J. C., Kornacker, M. G., & Hochschild, A. (2000) · Methods · doi:10.1006/meth.1999.0908 · Cited by 103

Authors: Huibregtse, J. M., Scheffner, M., & Howley, P. M.
Affiliations: National Institutes of Health (US)
ORCID: Huibregtse, J.M.
Scheffner, M.
Howley, P.M.
Venue: The EMBO Journal
Publisher: Springer Science and Business Media LLC
Published: 1991-12-01
Volume: 10
Issue: 13
Pages: 4129-4135
ISSN: 0261-4189 (ISSN-L)
1460-2075
DOI: 10.1002/j.1460-2075.1991.tb04990.x
PMC: PMC453163
OpenAlex: W140061535
Cited by: 879
References: 46
Citations by year: 2026: 8 · 2025: 15 · 2024: 16 · 2023: 26 · 2022: 21 · 2021: 25 · 2020: 27 · 2019: 18 · 2018: 28 · 2017: 29 · 2016: 19 · 2015: 26 · 2014: 29 · 2013: 28 · 2012: 41
FWCI: 5.96
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: The EMBO Journal (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
National Cancer Institute
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords: p53, E6 oncoprotein, HPV16, HPV 18, UBE3A, ubiquitin-mediated proteolysis, p53 degradation, protein-protein interaction, keratinocytes, tumor suppressor
MeSH terms: Animals, Cell Line, Chromatography, Gel, DNA-Binding Proteins, Electrophoresis, Polyacrylamide Gel, Humans, Hydrolysis, Oncogene Proteins, Viral, Plasmids, Protein Binding, Proteins, Repressor Proteins, Reticulocytes, Tumor Suppressor Protein p53, Papillomaviridae

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A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

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