The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
Open accessAbstract
Loss of telomeric DNA during cell proliferation may play a role in ageing and cancer. Since telomeres permit complete replication of eukaryotic chromosomes and protect their ends from recombination, we have measured telomere length, telomerase activity and chromosome rearrangements in human cells before and after transformation with SV40 or Ad5. In all mortal populations, telomeres shortened by approximately 65 bp/generation during the lifespan of the cultures. When transformed cells reached crisis, the length of the telomeric TTAGGG repeats was only approximately 1.5 kbp and many dicentric chromosomes were observed. In immortal cells, telomere length and frequency of dicentric chromosomes stabilized after crisis. Telomerase activity was not detectable in control or extended lifespan populations but was present in immortal populations. These results suggest that chromosomes with short (TTAGGG)n tracts are recombinogenic, critically shortened telomeres may be incompatible with cell proliferation and stabilization of telomere length by telomerase may be required for immortalization.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In primary cells deficient for Rb and p53, continued cellular growth beyond the Hayflick limit results in severe telomere shortening, marked genetic instability, and massive cell death—a period referred to as crisis (Counter et al. 1992”
From p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis (1999) · cites this paper as Counter et al. 1992
In the citing paper
“However, as these human fibroblasts undergo additional cell divisions, telomere erosion continues and the loss of telomere capping function produces rampant chromosomal instability and widespread apoptosis, a cellular state termed crisis (27).”
From Telomeres and telomerase in cancer (2010) · cites this paper as [27]
In the citing paper
“Crisis serves as the second checkpoint in tumor suppression and is characterized by multiple chromosomal fusions36.”
From Telomere dysfunction and tumour suppression: the senescence connection (2008) · cites this paper as [36]
In the citing paper
“Telomere maintenance is essential to the replicative potential of malignant cells and the inhibition of telomerase can lead to telomere shortening and cessation of unrestrained proliferation.”
From A highly selective telomerase inhibitor limiting human cancer cell proliferation (2001) · cites this paper as Counter et al., 1992
In the citing paper
“Eventually, telomeres shorten to a critical length and lose their ability to protect the ends of chromosomal DNA (Counter et al., 1992;Blasco et al., 1997).”
From A highly selective telomerase inhibitor limiting human cancer cell proliferation (2001) · cites this paper as Counter et al., 1992
In the citing paper
“Telomere maintenance is essential to the replicative potential of malignant cells and the inhibition of telomerase can lead to telomere shortening and cessation of unrestrained proliferation.”
From A highly selective telomerase inhibitor limiting human cancer cell proliferation (2001) · cites this paper as Counter et al., 1992
In the citing paper
“In cancer cells, the reactivation of telomerase is thought to stabilize telomere length, thereby compensating for the cell division-related telomere erosion and providing unlimited proliferative capacity to malignant cells (Counter et al., 1992;Kim et al., 1994).”
From A highly selective telomerase inhibitor limiting human cancer cell proliferation (2001) · cites this paper as Counter et al., 1992
In the citing paper
“In most normal human cells, telomerase activity is low or not detectable, and telomeric DNA is progressively lost at a rate of 30±120 bp with each replication cycle (Harley et al., 1990;Hastie et al., 1990;Counter et al., 1992).”
From A highly selective telomerase inhibitor limiting human cancer cell proliferation (2001) · cites this paper as Counter et al., 1992
Citations
Cites
A new technique for the assay of infectivity of human adenovirus 5 DNA
Graham, F. L., & van der Eb, A. J. (1973) · Virology · doi:10.1016/0042-6822(73)90341-3 · Cited by 9,302
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Self-citationCharacteristics of a human cell line transformed by DNA from human adenovirus type 5
Graham, F. L., Russell, W. C., Smiley, J., & Nairn, R. (1977) · Journal of General Virology · doi:10.1099/0022-1317-36-1-59 · Cited by 4,793
Structure and function of telomeres
Blackburn, E. H. (1991) · Nature · doi:10.1038/350569a0 · Cited by 3,596
Identification of a specific telomere terminal transferase activity in tetrahymena extracts
Greider, C. W., & Blackburn, E. H. (1985) · Cell · doi:10.1016/0092-8674(85)90170-9 · Cited by 3,400
Self-citationSouthern, P. J., & Berg, P. R. (1982) · PubMed · Cited by 2,740
Moyzis, R. K., Buckingham, J. M., Cram, L. S., Dani, M. A. C., Deaven, L. L., Jones, M. D., Meyne, J., Ratliff, R. L., & Wu, J. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6622 · Cited by 2,326
Olovnikov (1973) · doi:10.1016/0022-5193(73)90198-7 · Cited by 1,847
Telomere reduction in human colorectal carcinoma and with ageing
Hastie, N. D., Dempster, M., Dunlop, M. G., Thompson, A. M., Green, D. K., & Allshire, R. C. (1990) · Nature · doi:10.1038/346866a0 · Cited by 1,650
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
Greider, C. W., & Blackburn, E. H. (1989) · Nature · doi:10.1038/337331a0 · Cited by 1,643
Self-citation
Cited by
Sorted by citations
Items 401–500 of 1,003
Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase
Ting, N. S. Y. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki342 · Cited by 118
“A more intriguing observation was the fact that Ku immunoprecipitated with hTR from HA5 and GM847 cell lines, which do not express the hTERT transcript or protein (32,33).”
BackgroundMethodRAD50 function is essential for telomere maintenance in Arabidopsis
Gallego, M. E., & White, C. I. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1711 · Cited by 122
Telomere and Telomerase Biology
Giardini, M. A., Segatto, M., da Silva, M. S., Nunes, V. S., & Cano, M. I. N. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-397898-1.00001-3 · Cited by 131
Koziol, C., Borojević, R., Steffen, R., & Müller, W. E. G. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00120-6 · Cited by 117
Telomere length and proliferation potential of hematopoietic stem cells
Lansdorp, P. M. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.1.1 · Cited by 117
Fujimoto, K., Kyo, S., Takakura, M., Kanaya, T., Kitagawa, Y., Itoh, H., Takahashi, M., & Inoue, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.13.2557 · Cited by 116
Cuthbert, A. P., Bond, J., Trott, D. A., Gill, S., Broni, J., Marriott, A., Khoudoli, G., Parkinson, E. K., Cooper, C. S., & Newbold, R. F. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.1.37 · Cited by 114
Variation at theTERTlocus and predisposition for cancer
Baird, D. M. (2010) · Expert Reviews in Molecular Medicine · doi:10.1017/s146239941000147x · Cited by 117
Delany, M. E., Krupkin, A. B., & Miller, M. M. (2000) · Cytogenetic and Genome Research · doi:10.1159/000015649 · Cited by 119
“Lack of telomerase activity in terminally differentiated human somatic tissues correlates with shortening of telomere arrays as cells age in vivo and in vitro (Counter et al., 1992; Harley, 1995).”
BackgroundDNA Methylation, Smooth Muscle Cells, and Atherogenesis
Hiltunen, M., & Ylä‐Herttuala, S. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000092871.30563.41 · Cited by 116
Cell Senescence: A Challenge in Cartilage Engineering and Regeneration
Li, J., & Pei, M. (2012) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2011.0583 · Cited by 114
“116,117 Once telomere length decreases beyond a minimum critical length, it will trigger cellular senescence or apoptosis.”
Sizing the ends: Normal length of human telomeres
Samassékou, O., Gadji, M., Drouin, R., & Yan, J. (2010) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2010.07.005 · Cited by 124
Öztürk, S., Sözen, B., & Demir, N. (2013) · Molecular Human Reproduction · doi:10.1093/molehr/gat055 · Cited by 114
Regulation of Genome Stability by TEL1 and MEC1, Yeast Homologs of the Mammalian ATM and ATR Genes
Craven, R. J., Greenwell, P. W., Dominska, M., & Petes, T. D. (2002) · Genetics · doi:10.1093/genetics/161.2.493 · Cited by 115
Stöppler, H., Hartmann, D.-P., Sherman, L., & Schlegel, R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.20.13332 · Cited by 117
Altmeyer, A., Maki, R. G., Feldweg, A. M., Heike, M., Protopopov, V., Masur, S. K., & Srivastava, P. K. (1996) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19960822)69:4 · Cited by 174
Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases
Bär, C., & Blasco, M. A. (2016) · F1000Research · doi:10.12688/f1000research.7020.1 · Cited by 117
Liu, X., Yuan, H., Fu, B., Disbrow, G. L., Apolinario, T., Tomaić, V., Kelley, M. L., Baker, C. C., Huibregtse, J. M., & Schlegel, R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410343200 · Cited by 117
Wang, Z., Kyo, S., Takakura, M., Tanaka, M., Yatabe, N., Maida, Y., Fujiwara, M., Hayakawa, J., Ohmichi, M., Koike, K., et al. (2000) · PubMed · Cited by 116
Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres
Dagg, R. A., Pickett, H. A., Neumann, A. A., Napier, C. E., Henson, J. D., Teber, E., Arthur, J. W., Reynolds, C. P., Murray, J. E., Haber, M., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.087 · Cited by 110
Telomerase inhibitor GRN163L inhibits myeloma cell growth in vitro and in vivo
Shammas, M. A., Koley, H., Bertheau, R. C., Neri, P., Fulciniti, M., Tassone, P., Blotta, S., Protopopov, A. I., Mitsiades, C. S., Batchu, R. B., et al. (2008) · Leukemia · doi:10.1038/leu.2008.81 · Cited by 112
Telomeres and Human Somatic Fitness
Aviv, A. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.8.871 · Cited by 112
TRF1, a mammalian telomeric protein
Smith, S. H., & de Lange, T. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(96)10052-4 · Cited by 113
Miyazaki, T., Pan, Y., Joshi, K., Purohit, D., Hu, B., Demir, H., Mazumder, S., Okabe, S., Yamori, T., Viapiano, M. S., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-1795 · Cited by 111
“Immortalized cancer cells have an increased ability to extend their telomeres, which is one of the reasons that cancer cells can bypass replication senescence and subsequent cell death (4, 5).”
BackgroundWang, D., Uhrín, P., Mocan, A., Waltenberger, B., Breuss, J. M., Tewari, D., Mihaly‐Bison, J., Huminiecki, Ł., Starzyński, R. R., Tzvetkov, N. T., et al. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.04.006 · Cited by 111
A novel inhibitor of human telomerase derived from 10H-indolo[3,2-b]quinoline
Caprio, V. E., Guyen, B., Opoku‐Boahen, Y., Mann, J., Gowan, S. M., Kèlland, L. R., Read, M. A., & Neidle, S. (2000) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(00)00378-4 · Cited by 111
p16INK4a and the control of cellular proliferative life span
Huschtscha, L. I. (1999) · Carcinogenesis · doi:10.1093/carcin/20.6.921 · Cited by 110
Aging and cancer: are telomeres and telomerase the connection?
Shay, J. W. (1995) · Molecular Medicine Today · doi:10.1016/s1357-4310(95)93872-9 · Cited by 109
A three-state model of telomere control over human proliferative boundaries
Cesare, A. J., & Karlseder, J. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.08.007 · Cited by 106
Wu, H. L., Hsu, C. Y., Liu, W. H., & Yung, B. Y. (1999) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19990611)81:6 · Cited by 110
Use of exogenous hTERT to immortalize primary human cells
Lee, K. M., Choi, K. H., & Ouellette, M. M. (2004) · Cytotechnology · doi:10.1007/10.1007/s10616-004-5123-3 · Cited by 121
“Immortal clones can sometimes emerge from M2 (at a frequency of 10 ) that have gained the ability to maintain the size of their telomeres (Counter et al. 1992; Shay et al. 1993; Counter et al. 1994).”
BackgroundRole of Telomerase in Cell Senescence and Oncogenesis
Urquidi, V., Tarin, D., & Goodison, S. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.65 · Cited by 110
Alternative Lengthening of Telomeres in Human Cells
Reddel, R. R., Bryan, T. M., Colgin, L. M., Perrem, K., & Yeager, T. R. (2001) · Radiation Research · doi:10.1667/0033-7587(2001)155[0194:alotih]2.0.co;2 · Cited by 109
Xiao, Y., Dane, K. Y., Uzawa, T., Csordas, A. T., Qian, J., Soh, H. T., Daugherty, P. S., Lagally, E. T., Heeger, A. J., & Plaxco, K. W. (2010) · Journal of the American Chemical Society · doi:10.1021/ja106513f · Cited by 109
Kim, E., Kim, J.-H., Shin, H. Y., Lee, H., Yang, J. M., Kim, J., Sohn, J., Kim, H., & Yun, C. (2003) · Human Gene Therapy · doi:10.1089/104303403769211637 · Cited by 109
Telomere Length in Fibroblasts and Blood Cells from Healthy Centenarians
Mondello, C., Petropoulou, C., Monti, D., GONOS, E., Franceschi, C., & Nuzzo, F. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4398 · Cited by 109
Beyond average: potential for measurement of short telomeres
Vera, E., & Blasco, M. A. (2012) · Aging · doi:10.18632/aging.100462 · Cited by 112
C-Terminal Regions of the Human Telomerase Catalytic Subunit Essential for In Vivo Enzyme Activity
Banik, S. S. R., Guo, C., Smith, A. C., Margolis, S. S., Richardson, D. A., Tirado, C. A., & Counter, C. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.17.6234-6246.2002 · Cited by 108
“Consequently, HA5 cells continue to lose telomeric DNA until a critically short length is reached, at which time genomic instability ensues and the cells enter crisis and die (12).”
BackgroundMethodInfluentialSelf-citationAn in vitro assay for saccharomyces telomerase requires EST1
Lin, J., & Zakian, V. A. (1995) · Cell · doi:10.1016/s0092-8674(05)80017-0 · Cited by 108
Heilman, D. W., Teodoro, J. G., & Green, M. R. (2006) · Journal of Virology · doi:10.1128/jvi.02741-05 · Cited by 107
“(Middle) H1299 cells expressing GFP-Ap(1-48) or GFP-Ap(1-88) were treated in the presence of LMB.”
BackgroundMethodInfluentialNarala, S. R., Allsopp, R. C., Wells, T. B., Zhang, G., Prasad, P., Coussens, M. J., Rossi, D. J., Weissman, I. L., & Vaziri, H. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-09-0965 · Cited by 106
“Consistent with this model telomerase is reactivated in immortal human cells (Counter et al., 1992; Kim et al., 1994).”
BackgroundEdington, K. G., Loughran, Ö., Berry, I. J., & Parkinson, E. K. (1995) · Molecular Carcinogenesis · doi:10.1002/mc.2940130408 · Cited by 105
Telomerase Activity in Female and Male Rat Germ Cells Undergoing Meiosis and in Early Embryos1
Eisenhauer, K. M., Gerstein, R. M., Chiu, C., Conti, M., & Hsueh, A. J. W. (1997) · Biology of Reproduction · doi:10.1095/biolreprod56.5.1120 · Cited by 105
Vaziri, H., Squire, J. A., Pandita, T. K., Bradley, G., Kuba, R. M., Zhang, H., Gulyás, S., Hill, R. P., Nolan, G. P., & Benchimol, S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.2373 · Cited by 104
“The extension of the replicative life span and the bypass of senescence by DNA tumor viruses or p53 alterations (28) are frequently associated with chromosomal instability (37) and the formation of dicentric chromosomes near crisis (7).”
BackgroundMethodInfluentialAlbanell, J., Han, W., Mellado, B., Gunawardane, R. N., Scher, H. I., Dmitrovsky, E., & Moore, M. A. S. (1996) · PubMed · Cited by 104
Ho, G., Palan, P. R., Basu, J., Romney, S. L., Kadish, A. S., Mikhail, M. S., Wassertheil‐Smoller, S., Runowicz, C. D., & Burk, R. D. (1998) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19981123)78:5 · Cited by 84
Yudoh, K., Matsuno, H., Nakazawa, F., Katayama, R., & Kimura, T. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.8.1453 · Cited by 103
“(18,19) Thus, in these cells, telomerase apparently balances the telomere loss with de novo synthesis of telomeric DNA.”
BackgroundTelomere Length Dynamics in Telomerase-Positive Immortal Human Cell Populations
Bryan, T. M., Englezou, A., Dunham, M. A., & Reddel, R. R. (1998) · Experimental Cell Research · doi:10.1006/excr.1997.3907 · Cited by 105
Meeker, A. K., & Argani, P. (2004) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/b:jomg.0000048775.04140.92 · Cited by 100
“Abrogation of the senescence checkpoint allows continued division and the development of severe telomere shortening, resulting in dysfunctional telomeres (23).”
BackgroundExpression of POT1 is Associated with Tumor Stage and Telomere Length in Gastric Carcinoma
Kondo, T., Oue, N., Yoshida, K., Mitani, Y., Naka, K., Nakayama, H., & Yasui, W. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1196 · Cited by 102
“Severe telomere dysfunction is shown to be reduced in advanced tumors that survive after crisis (26, 32, 33).”
BackgroundA rapid biosensor chip assay for measuring of telomerase activity using surface plasmon resonance
Maesawa, C. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng004 · Cited by 102
“Telomerase extracts were prepared by the conventional method (12).”
MethodDing, C., Li, X., Ge, Y., & Zhang, S. (2010) · Analytical Chemistry · doi:10.1021/ac902818w · Cited by 101
Spontaneous and radiation-induced chromosomal breakage at interstitial telomeric sites
Slijepčević, P., Xiao, Y., Domı́nguez, I., & Natarajan, A. T. (1996) · Chromosoma · doi:10.1007/bf00352299 · Cited by 100
Dası́, F., Lledó, S., García‐Granero, E., Ripoll, R., Marugán, M., Tormo, M., García-Conde, J., & Aliño, S. F. (2001) · Laboratory Investigation · doi:10.1038/labinvest.3780285 · Cited by 100
“…cells leads to senescence (Bodnar et al, 1998), though continued telomere attrition and loss of telomere capping activity (mainly because of the neutralization of Rb and p53 functions) result in severe chromosomal instability and the massive cell death referred to as “crisis” (Counter et al, 1992).”
BackgroundThe length of telomeric G-rich strand 3'-overhang measured by oligonucleotide ligation assay
Cimino-Reale, G. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.7.e35 · Cited by 98
Major cutbacks at chromosome ends
Lansdorp, P. M. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.05.004 · Cited by 101
Harley, C. B., Liu, W., Flom, P. L., & Raffaele, J. M. (2013) · Rejuvenation Research · doi:10.1089/rej.2013.1430 · Cited by 102
Self-citationSathasivam, K. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.21.2425 · Cited by 100
“Normal human fibroblast cultures enter a state of irreversibly arrested cell growth after a finite number of cell divisions, which correlates with a shortening of telomere repeats (38).”
Lev, A., Denkberg, G., Cohen, C. J., Tzukerman, M., Skorecki, K. L., Chames, P., Hoogenboom, H. R., & Reiter, Y. (2002) · PubMed · Cited by 100
Roger, L., Jones, R. E., Heppel, N. H., Williams, G. T., Sampson, J. R., & Baird, D. M. (2013) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djt191 · Cited by 97
Boeck, G. D., Forsyth, R. G., Praet, M. M., & Hogendoorn, P. C. W. (2008) · The Journal of Pathology · doi:10.1002/path.2500 · Cited by 102
“Human cancers and some human somatic cells, such as stem cells, germ cells and activated lymphocytes, are able to maintain and/or extend their telomere lengths by two independent mechanisms: synthesis of telomere DNA by the holo-enzyme telomerase [19], or homologous recombination of telomeres by an alternative telomer…”
BackgroundEvaluation of telomere length in cumulus cells as a potential biomarker of oocyte and embryo quality
Cheng, E., Chen, S., Lee, T., Pai, Y.-P., Huang, L.-S., Huang, C., & Lee, M.-S. (2013) · Human Reproduction · doi:10.1093/humrep/det004 · Cited by 99
Telomere dysfunction in genome instability syndromes
Callén, E., & Surrallés, J. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2004.06.003 · Cited by 106
“During senescence, and thereafter (crisis), once telomeres become so short that cannot carry out their roles, most cells die because of their acquired genomic instability, but a few overcome crisis through activation of a mechanism that maintains telomere length although critically short [34,37,38,42].”
InfluentialEstimating age of humans based on telomere shortening
Tsuji, A., Ishiko, A., Takasaki, T., & Ikeda, N. (2002) · Forensic Science International · doi:10.1016/s0379-0738(02)00086-5 · Cited by 99
“Length of the telomere is stabilized by telomerase [3].”
BackgroundTelomere instability and cancer
Londoño‐Vallejo, A. (2007) · Biochimie · doi:10.1016/j.biochi.2007.07.009 · Cited by 100
Opitz, O. G., Suliman, Y., Hahn, W. C., Harada, H., Blum, H. E., & Rustgi, A. K. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11909 · Cited by 101
Fouladi, B., Sabatier, L., Miller, D., Pottier, G., & Murnane, J. P. (2000) · Neoplasia · doi:10.1038/sj.neo.7900107 · Cited by 96
Involvement of the INK4a/Arf gene locus in senescence
Collins, C. J., & Sedivy, J. M. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00048.x · Cited by 113
Differential expression of telomerase reverse transcriptase (hTERT) in lung tumours
Lantuéjoul, S., Soria, J., Moro‐Sibilot, D., Morat, L., Veyrenc, S., Lorimier, P., Brichon, P. Y., Sabatier, L., Brambilla, C., & Brambilla, E. M. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601643 · Cited by 98
“…a ribonucleoprotein complex composed of a reverse transcriptase catalytic subunit (hTERT) that copies a template region of RNA subunit (hTERC), can synthesise telomeric DNA, therefore, allowing cells to proliferate indefinitely (Counter et al, 1992; Nakamura and Cech, 1998; Holt and Shay 1999).”
BackgroundCell division is required for de novo methylation of CpG islands in bladder cancer cells.
Velicescu, M., Weisenberger, D. J., Gonzales, F. A., Tsai, Y., Nguyen, C. T., & Jones, P. A. (2002) · PubMed · Cited by 97
Lochmüller, H., Johns, T., & Shoubridge, E. A. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4407 · Cited by 97
Telomeres and telomerase in cancer stem cells
Ju, Z., & Rudolph, K. L. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.01.040 · Cited by 96
The snoRNA domain of vertebrate telomerase RNA functions to localize the RNA within the nucleus.
Lukowiak, A. A., Narayanan, A., Li, Z., Terns, R. M., & Terns, M. P. (2001) · Europe PMC (PubMed Central) · Cited by 98
Milošević, J., Schwarz, S. C., Krohn, K., Poppe, M., Storch, A., & Schwarz, J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02893.x · Cited by 97
“The unlimited replicative potential of transformed or immortalized cells is associated with high expression levels of the ribonucleoprotein complex telomerase, which functions to stabilize and maintain telomere length with subsequent cell divisions (Counter et al. 1992; Kim et al. 1994).”
BackgroundTelomere shortening in renal cell carcinoma.
Mehle, C., Ljungberg, B., & Roos, G. (1994) · PubMed · Cited by 96
WRN at telomeres: implications for aging and cancer
Multani, A. S., & Chang, S. (2007) · Journal of Cell Science · doi:10.1242/jcs.03397 · Cited by 95
“2) (Crabbe et al., 2004).”
BackgroundInfluentialModelling telomere shortening and the role of oxidative stress
Proctor, C. J., & Kirkwood, T. B. L. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00380-3 · Cited by 96
Short telomeres in short‐lived males: what are the molecular and evolutionary causes?
Jemielity, S., Kimura, M., Parker, K. M., Parker, J. D., Cao, X., Aviv, A., & Keller, L. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00279.x · Cited by 97
New developments in telomere length analysis
Baird, D. M. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.02.008 · Cited by 99
Telomere length, chromatin structure and chromosome fusigenic potential
Slijepčević, P., Hande, M. P., Bouffler, S. D., Lansdorp, P. M., & Bryant, P. E. (1997) · Chromosoma · doi:10.1007/s004120050263 · Cited by 96
“It has been speculated that telomere shortening that accompanies the progression of normal human cells towards immortalization and tumorigenicity may lead to a reduction in the capacity of telomeres to prevent chromosome fusions (Harley et al. 1990; Hastie et al. 1990; Counter et al. 1992).”
BackgroundResultLetsolo, B. T., Rowson, J., & Baird, D. M. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1183 · Cited by 99
Telomeres and Age-Related Diseases
Gruber, H., Semeraro, M. D., Renner, W., & Herrmann, M. (2021) · Biomedicines · doi:10.3390/biomedicines9101335 · Cited by 102
The shortest telomeres drive karyotype evolution in transformed cells
Der‐Sarkissian, H., Bacchetti, S., Cazes, L., & Londoño‐Vallejo, A. (2004) · Oncogene · doi:10.1038/sj.onc.1207152 · Cited by 97
“Such differences in the type and extent of chromosome abnormalities among postcrisis cells suggest that the karyotype evolution may have been interrupted at different times, most likely by the appearance of a telomere maintenance mechanism (Counter et al., 1992, 1994; Halvorsen et al., 1999).”
BackgroundInfluentialSelf-citationGuiducci, C., Cerone, M. A., & Bacchetti, S. (2001) · Oncogene · doi:10.1038/sj.onc.1204145 · Cited by 94
“In mammals, this has been amply documented for transformed cells undergoing crisis because of constitutive absence or inhibition of telomerase (Hahn et al., 1999; Zhang et al., 1999; Counter et al., 1992) and for cells from late generation mice deleted for the mTR gene (Hande Oncogene et al., 1999).”
BackgroundSelf-citationESTABLISHMENT OF AN IMMORTALIZED HUMAN-LIVER ENDOTHELIAL CELL LINE WITH SV40T AND hTERT
Matsumura, T., Takesue, M., Westerman, K. A., Okitsu, T., Sakaguchi, M., Fukazawa, T., Totsugawa, T., Noguchi, H., Yamamoto, S., Stolz, D. B., et al. (2004) · Transplantation · doi:10.1097/01.tp.0000124286.82961.7e · Cited by 95
“The arrest of cell proliferation (crisis) has been speculated to occur when telomere erosion has progressed beyond a second critical point and chromosomes become unstable (17, 18).”
BackgroundCharacterization of telomerase activity in the human oocyte and preimplantation embryo
Wright, D. L. (2001) · Molecular Human Reproduction · doi:10.1093/molehr/7.10.947 · Cited by 99
“In humans and most mammals, the sequence is TTAGGG (Counter et al., 1992).”
BackgroundPendino, F., Flexor, M., Delhommeau, F., Selimoglu‐Buet, D., Lanotte, M., & Ségal-Bendirdjian, E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111464998 · Cited by 101
Hsu, C., Hsu, N.-Y., Lee, L., & Ko, J. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.02.014 · Cited by 93
Telomeres, stem cells, and hematology
Lansdorp, P. M. (2008) · Blood · doi:10.1182/blood-2007-09-084913 · Cited by 97
Telomerase: regulation, function and transformation
Dong, C. K., Masutomi, K., & Hahn, W. C. (2005) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2004.12.005 · Cited by 96
Telomeres and telomerase in normal and malignant haematopoietic cells
Norrback, K., & Roos, G. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00059-2 · Cited by 94
Villa, R., Folini, M., Lualdi, S., Veronese, S. M., Daidone, M. G., & Zaffaroni, N. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01540-4 · Cited by 95
Multiple pathways for the regulation of telomerase activity
Holt, S. E., Wright, W. E., & Shay, J. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00066-x · Cited by 93
Autophagy, Cellular Aging and Age-related Human Diseases
Cheon, S. Y., Kim, H. J., Rubinsztein, D. C., & Lee, J. E. (2019) · Experimental Neurobiology · doi:10.5607/en.2019.28.6.643 · Cited by 95
“However, oncogene-transformed immortal cells have stable telomeres and telomerase reactivation after senescence/crisis [82].”
BackgroundChoi, S. H., Lyu, S. Y., & Park, W. B. (2004) · Archives of Pharmacal Research · doi:10.1007/bf02980049 · Cited by 94
The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity
Zhang, D.-H. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl029 · Cited by 97
“telomere elongation by telomerase (18,19).”
Seimiya, H., Muramatsu, Y., Smith, S. H., & Tsuruo, T. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.5.1944-1955.2004 · Cited by 95
“Again, ARCs IV and V recognized Myc-TRF1(2-210) whereas ARC I did not.”
BackgroundMethodInfluentialHernández, J., Garcia‐Pons, F., Lone, Y. C., Firat, H., Schmidt, J. D., Langlade‐Demoyen, P., & Zanetti, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182418399 · Cited by 93
Chromosome healing: Spontaneous and programmed de novo telomere formation by telomerase
Melek, M., & Shippen, D. E. (1996) · BioEssays · doi:10.1002/bies.950180408 · Cited by 91
Is telomerase activity in cancer due to selection of stem cells and differentiation arrest?
Greaves, M. F. (1996) · Trends in Genetics · doi:10.1016/0168-9525(96)30016-4 · Cited by 93
Metadata
- Authors
- Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., & Bacchetti, S.
- Affiliations
- McMaster University (CA)
- Venue
- The EMBO Journal
- Published
- 1992-05-01
- Volume
- 11
- Issue
- 5
- Pages
- 1921-1929
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC556651
- OpenAlex
- W1543500873
- Cited by
- 2,096
- References
- 53
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 25 · 2023: 25 · 2022: 27 · 2021: 35 · 2020: 29 · 2019: 28 · 2018: 39 · 2017: 42 · 2016: 48 · 2015: 53 · 2014: 51 · 2013: 65 · 2012: 55
- FWCI
- 23.80
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- The EMBO Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Keywords
- telomere shortening, telomerase, chromosomal instability, cell immortalization, telomere length, dicentric chromosomes, telomeric DNA, SV40 transformation, adenovirus type 5, cell transformation, telomere recombination, cell proliferation, aging, cancer
- MeSH terms
- Cell Transformation, Neoplastic, Cell Transformation, Viral, Chromosomes, Human, DNA, DNA Nucleotidylexotransferase, Humans, Karyotyping, Kidney, Transfection, Telomere, Cellular Senescence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
