Identification and characterization of negative regulatory elements of the human telomerase catalytic subunit (hTERT) gene promoter: possible role of MZF-2 in transcriptional repression of hTERT
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Human telomerase reverse transcriptase (hTERT) is a catalytic subunit of human telomerase and is a critical determinant of the enzymatic activity of telomerase. Expression of hTERT is known to be regulated mainly at the transcriptional level. In the present study, using transient expression assays, we identified a 400 bp silencer of the hTERT promoter between -776 and -378 upstream of the proximal core promoter. The inhibitory effects of this silencer were enhanced with cellular differentiation. A computer-assisted homology search identified multiple binding motifs for myeloid-specific zinc finger protein 2 (MZF-2) within this region. Mutation introduced in these sites resulted in significant activation of hTERT transcription. Gel shift assays demonstrated that MZF-2 proteins specifically bound to these sites. Overexpression of MZF-2 in cells led to down-regulation of hTERT transcription as well as telomerase activity. These findings suggest that the 400 bp region upstream of the hTERT core promoter that we identified functions as a negative regulatory region and that MZF-2 may be an effector of negative regulation of hTERT.
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WT1 and MZF-2 repress hTERT transcription by binding to specific sites on the promoter.
“Several transcriptional repressors, including Wilms' tumor 1 tumor suppressor (WT1) and myeloidspecific zinc finger protein-2 (MZF-2) are also known to repress hTERT transcription via binding to their specific sites on the promoter, although the mechanisms of repression remain unclear.(73,74)”
From Understanding and exploiting <i>hTERT</i> promoter regulation for diagnosis and treatment of human cancers (2008) · cites this paper as [74]
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Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · see citing works
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975 · see citing works
A survey of telomerase activity in human cancer
Shay, J. W., & Bacchetti, S. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00062-2 · Cited by 2,794 · see citing works
Telomerase Catalytic Subunit Homologs from Fission Yeast and Human
Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., & Cech, T. R. (1997) · Science · doi:10.1126/science.277.5328.955 · Cited by 2,256 · see citing works
The RNA Component of Human Telomerase
Feng, J., Funk, W. D., Wang, S.-S., Weinrich, S. L., Avilion, A. A., Chiu, C.-P., Adams, R. R., Chang, E., Allsopp, R. C., Yu, J., et al. (1995) · Science · doi:10.1126/science.7544491 · Cited by 2,227 · see citing works
Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., & Bacchetti, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05245.x · Cited by 2,096 · see citing works
Hörlein, A., Näär, A. M., Heinzel, T., Torchia, J., Gloss, B. R., Kurokawa, R., Ryan, A. K., Kamei, Y., Söderström, M., Glass, C. K., et al. (1995) · Nature · doi:10.1038/377397a0 · Cited by 2,035 · see citing works
Estimates of the worldwide incidence of 25 major cancers in 1990
Parkin, D. M., Pisani, P., & Ferlay, J. (1999) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19990315)80:6 · Cited by 2,013 · see citing works
Self-citationSmithers, D. W. (1956) · The Lancet · doi:10.1016/s0140-6736(56)91184-9 · Cited by 1,796 · see citing works
Meyerson, M., Counter, C. M., Eaton, E. N., Ellisen, L. W., Steiner, P., Caddle, S. D., Ziaugra, L., Beijersbergen, R. L., Davidoff, M. J., Liu, Q., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80538-3 · Cited by 1,784 · see citing works
WATSON, J. D. (1972) · Nature New Biology · doi:10.1038/newbio239197a0 · Cited by 1,632 · see citing works
Greider, C. W. (1996) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.65.070196.002005 · Cited by 1,021 · see citing works
Weinrich, S. L., Pruzan, R., Ma, L., Ouellette, M. M., Tesmer, V. M., Holt, S. E., Bodnar, A. G., Lichtsteiner, S., Kim, N. W., Trager, J. B., et al. (1997) · Nature Genetics · doi:10.1038/ng1297-498 · Cited by 963 · see citing works
Direct activation of TERT transcription by c-MYC
Wu, K.-J., Grandori, C., Amacker, M., Simon-Vermot, N., Polack, A., Lingner, J., & Dalla-Favera, R. (1999) · Nature Genetics · doi:10.1038/6010 · Cited by 893 · see citing works
Telomerase activity in human ovarian carcinoma.
Counter, C. M., Hirte, H. W., Bacchetti, S., & Harley, C. B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.2900 · Cited by 677 · see citing works
A Mammalian Telomerase-Associated Protein
Harrington, L. A., McPhail, T., Mar, V. L., Zhou, W., Oulton, R., Program, A. E., Bass, M. B., Arruda, I., & Robinson, M. O. (1997) · Science · doi:10.1126/science.275.5302.973 · Cited by 666 · see citing works
Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas
Nakayama, J., Tahara, H., 栄治, 田., Saito, M., Ito, K., Nakamura, H., Nakanishi, T., Nakanishi, E., Ide, T., & Ishikawa, F. (1998) · Nature Genetics · doi:10.1038/ng0198-65 · Cited by 602 · see citing works
Yudkin, J. S. (1972) · Nature · doi:10.1038/239197a0 · Cited by 543 · see citing works
Kyo, S. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.3.669 · Cited by 494 · see citing works
Self-citationCong, Y. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.1.137 · Cited by 485 · see citing works
高倉, 正. (2002) · Medical Entomology and Zoology · Cited by 475 · see citing works
Takakura, M., Kyo, S., Kanaya, T., Hirano, H., Takeda, J., Yutsudo, M., & Inoue, M. (1999) · PubMed · Cited by 446 · see citing works
Self-citationGreenberg, R. A., O’Hagan, R. C., Deng, H., Xiao, Q., Hann, S. R., Adams, R. R., Lichtsteiner, S., Chin, L., Morin, G. B., & DePinho, R. A. (1999) · Oncogene · doi:10.1038/sj.onc.1202669 · Cited by 411 · see citing works
Nakayama, J., Saito, M., Nakamura, H., Matsuura, A., & Ishikawa, F. (1997) · Cell · doi:10.1016/s0092-8674(00)81933-9 · Cited by 377 · see citing works
Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer.
Takakura, M., Kyo, S., Kanaya, T., Tanaka, M., & Inoue, M. (1998) · PubMed · Cited by 296 · see citing works
Self-citationIto, H., Kyo, S., Kanaya, T., Takakura, M., Inoue, M., & Namiki, M. (1998) · PubMed · Cited by 138 · see citing works
Self-citationVisual inspection with acetic acid in the early detection of cervical cancer and precursors
Sankaranarayanan, R., Shyamalakumary, B., Wesley, R., Amma, N. S., Parkin, D. M., & Nair, M. K. (1999) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19990105)80:1 · Cited by 114 · see citing works
Self-citationGreider, C. W. (1991) · Cell · doi:10.1016/0092-8674(91)90058-7 · Cited by 86 · see citing works
An altered repertoire of (AP-1) at the onset of replicative senescence
Irving, J., Feng, J., Wistrom, C., Pikaart, M. J., & Villeponteau, B. (1992) · Experimental Cell Research · doi:10.1016/0014-4827(92)90415-5 · Cited by 67 · see citing works
Myeloid-specific transcriptional activation by murine myeloid zinc-finger protein 2
Murai, K., Murakami, H., & Nagata, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3461 · Cited by 48 · see citing works
Mutations of the human MUT S homologue 6 gene in ampullary carcinoma and gastric cancer
Imai, Y., Inoue, T., & Ishikawa, T. (1998) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19981123)78:5 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 3
- Counter,C.M., Hirte,H.W., Bacchetti,S. and Harley,C.B. (1994) Proc. Natl Acad. Sci. USA, 91, 2900-2904.
- Murai,K., Murakami,H. and Nagata,S. (1998) Proc. Natl Acad. Sci. USA, 95, 3461-3466.
- Higuchi,R. (1990) In Innis,M.A., Gelfand,D.H., Sninsky,J.J. and White,T.J. (eds), PCR Protocols. Academic Press, San Diego, CA, pp. 177-183.
Cited by
Sorted by citations
Human Telomerase and Its Regulation
Cong, Y.-S., Wright, W. E., & Shay, J. W. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.3.407-425.2002 · Cited by 898 · see citing works
T cells and aging january 2002 update
Pawelec, G. (2002) · Frontiers in bioscience · doi:10.2741/a831 · Cited by 368 · see citing works
Natural and pharmacological regulation of telomerase
Mergny, J. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.4.839 · Cited by 351 · see citing works
Kyo, S., Takakura, M., Fujiwara, T., & Inoue, M. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00878.x · Cited by 347 · see citing works
Self-citationTERT—Regulation and Roles in Cancer Formation
Dratwa, M., Wysoczańska, B., Łacina, P., Kubik, T., & Bogunia‐Kubik, K. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.589929 · Cited by 314 · see citing works
Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT)
Poole, J. C., Andrews, L. G., & Tollefsbol, T. O. (2001) · Gene · doi:10.1016/s0378-1119(01)00440-1 · Cited by 275 · see citing works
Regulation of the human catalytic subunit of telomerase (hTERT)
Daniel, M. G., Peek, G. W., & Tollefsbol, T. O. (2012) · Gene · doi:10.1016/j.gene.2012.01.095 · Cited by 265 · see citing works
Telomerase regulation and stem cell behaviour
Flores, I., Benetti, R., & Blasco, M. A. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.03.003 · Cited by 232 · see citing works
Horikawa, I., & Barrett, J. C. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg085 · Cited by 207 · see citing works
Regulation of the human telomerase reverse transcriptase gene
Ducrest, A., Szutorisz, H., Lingner, J., & Nabholz, M. (2002) · Oncogene · doi:10.1038/sj.onc.1205081 · Cited by 184 · see citing works
Won, J., Yim, J., & Kim, T. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206064200 · Cited by 180 · see citing works
Kyo, S., & Inoue, M. (2002) · Oncogene · doi:10.1038/sj.onc.1205163 · Cited by 173 · see citing works
Self-citationTranscription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene
Ramlee, M. K., Wang, J., Toh, W. H., & Li, S. (2016) · Genes · doi:10.3390/genes7080050 · Cited by 149 · see citing works
CTCF binds the proximal exonic region of hTERT and inhibits its transcription
Renaud, S. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki989 · Cited by 137 · see citing works
Yang, H., Ou, C. C., Feldman, R. I., Nicosia, S. V., Kruk, P. A., & Cheng, J. Q. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2907 · Cited by 125 · see citing works
Genetic and epigenetic modulation of telomerase activity in development and disease
Liu, L., Lai, S. R., Andrews, L. G., & Tollefsbol, T. O. (2004) · Gene · doi:10.1016/j.gene.2004.06.011 · Cited by 121 · see citing works
Variation at theTERTlocus and predisposition for cancer
Baird, D. M. (2010) · Expert Reviews in Molecular Medicine · doi:10.1017/s146239941000147x · Cited by 115 · see citing works
On the road to immortality: hTERT upregulation in cancer cells
Janknecht, R. (2004) · FEBS Letters · doi:10.1016/s0014-5793(04)00356-4 · Cited by 116 · see citing works
Telomeres and immunological diseases of aging.
Andrews, N. P., Fujii, H., Goronzy, J. J., & Weyand, C. M. (2010) · Gerontology · doi:10.1159/000268620 · Cited by 108 · see citing works
Jagadeesh, S., Kyo, S., & Banerjee, P. P. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2494 · Cited by 106 · see citing works
Self-citationKnight, J. S., Cotter, M. A., & Robertson, E. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101890200 · Cited by 103 · see citing works
Biochemical aspects of telomerase function
Harrington, L. A. (2003) · Cancer Letters · doi:10.1016/s0304-3835(02)00701-2 · Cited by 100 · see citing works
Öğretmen, B., Kraveka, J. M., Schady, D. A., Usta, J. A., Hannun, Y. A., & Obeid, L. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101350200 · Cited by 100 · see citing works
Telomeres and telomerase as targets for anticancer drug development
Olaussen, K. A., Dubrana, K., Dômont, J., Spano, J., Sabatier, L., & Soria, J. (2006) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2005.08.007 · Cited by 92 · see citing works
Horikawa, I., Cable, P. L., Mazur, S. J., Appella, E., Afshari, C. A., & Barrett, J. C. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e01-11-0107 · Cited by 88 · see citing works
Ducrest, A., Amacker, M., Mathieu, Y., Cuthbert, A. P., Trott, D. A., Newbold, R. F., Nabholz, M., & Lingner, J. (2001) · PubMed · Cited by 85 · see citing works
Lopatina, N., Poole, J. C., Saldanha, S. N., Hansen, N. J., Key, J. S., Pita, M. A., Andrews, L. G., & Tollefsbol, T. O. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01033-7 · Cited by 82 · see citing works
Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene
Zhu, J., Zhao, Y., & Wang, S. (2010) · Protein & Cell · doi:10.1007/s13238-010-0014-1 · Cited by 81 · see citing works
Telomerase regulation at the crossroads of cell fate
Ćukušić, A., Vidaček, N. Š., Sopta, M., & Rubelj, I. (2008) · Cytogenetic and Genome Research · doi:10.1159/000167812 · Cited by 80 · see citing works
Cifuentes‐Rojas, C., & Shippen, D. E. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.10.003 · Cited by 75 · see citing works
Telomere stability and telomerase in mesenchymal stem cells
Serakıncı, N., Graakjær, J., & Kølvraa, S. (2007) · Biochimie · doi:10.1016/j.biochi.2007.09.005 · Cited by 72 · see citing works
Identification of PITX1 as a TERT Suppressor Gene Located on Human Chromosome 5
Qi, D.-L., Ohira, T., Fujisaki, C., Inoue, T., Ohta, T., Osaki, M., Ohshiro, E., Seko, T., Aoki, S., Oshimura, M., et al. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.00470-10 · Cited by 70 · see citing works
Wooten, L. G., Song, P., Senkal, C. E., & Öğretmen, B. (2007) · The FASEB Journal · doi:10.1096/fj.07-8621com · Cited by 69 · see citing works
The significance of human telomerase reverse transcriptase (hTERT) in cancer
Kirkpatrick, K. L., & Mokbel, K. (2001) · European Journal of Surgical Oncology · doi:10.1053/ejso.2001.1151 · Cited by 69 · see citing works
Human Papillomavirus E2 Down-regulates the Human Telomerase Reverse Transcriptase Promoter
Lee, D., Kim, H.-Z., Jeong, K. W., Shim, Y. S., Horikawa, I., Barrett, J. C., & Choe, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203706200 · Cited by 68 · see citing works
Mattson, M. P. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00221-4 · Cited by 62 · see citing works
Katzenellenbogen, R. A., Vliet-Gregg, P. A., Xu, M., & Galloway, D. A. (2009) · Journal of Virology · doi:10.1128/jvi.02556-08 · Cited by 61 · see citing works
Chau, M. N., Touny, L. H. E., Jagadeesh, S., & Banerjee, P. P. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm148 · Cited by 56 · see citing works
Telomerase Induction in HPV Infection and Oncogenesis
Katzenellenbogen, R. A. (2017) · Viruses · doi:10.3390/v9070180 · Cited by 56 · see citing works
Human telomerase expression regulation
Machnik, M., Wojtyla, A., & Rubiś, B. (2011) · Biochemistry and Cell Biology · doi:10.1139/o11-037 · Cited by 53 · see citing works
Telomerase as a useful target in cancer fighting—the breast cancer case
Hołysz, H., Lipińska, N., Paszel-Jaworska, A., & Rubiś, B. (2013) · Tumor Biology · doi:10.1007/s13277-013-0757-4 · Cited by 52 · see citing works
Sulforaphane modulates telomerase activity via epigenetic regulation in prostate cancer cell lines
Abbas, A., Hall, J. A., Patterson, W. L., Ho, E., Hsu, A., Al‐Mulla, F., & Georgel, P. T. (2015) · Biochemistry and Cell Biology · doi:10.1139/bcb-2015-0038 · Cited by 46 · see citing works
Role of Smad3 in the regulation of rat telomerase reverse transcriptase by TGFβ
Hu, B., Tack, D. C., Liu, T., Wu, Z., Ullenbruch, M. R., & Phan, S. H. (2005) · Oncogene · doi:10.1038/sj.onc.1209140 · Cited by 44 · see citing works
Chebel, A., Rouault, J.-P., Urbanowicz, I., Baseggio, L., Chien, W. W., Salles, G., & Ffrench, M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.009183 · Cited by 38 · see citing works
Murofushi, Y., Nagano, S., Kamizono, J., Takahashi, T., Fujiwara, H., Komiya, S., Matsuishi, T., & Kosai, K.-I. (2006) · International Journal of Oncology · doi:10.3892/ijo.29.3.681 · Cited by 38 · see citing works
Vitamin E suppresses telomerase activity in ovarian cancer cells
Bermudez, Y., Ahmadi, S., Lowell, N. E., & Kruk, P. A. (2007) · Cancer Detection and Prevention · doi:10.1016/j.cdp.2006.12.002 · Cited by 37 · see citing works
Telomerase as a new target for the treatment of hormone-refractory prostate cancer
Biroccio, A., & Leonetti, C. (2004) · Endocrine Related Cancer · doi:10.1677/erc.1.00764 · Cited by 37 · see citing works
Shieh, G.-S., Shiau, A., Yo, Y.-T., Lin, P., Chang, C.-C., Tzai, T., & Wu, C. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1138 · Cited by 35 · see citing works
Yago, M., Ohki, R., Hatakeyama, S., Fujita, T., & Ishikawa, F. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02757-6 · Cited by 34 · see citing works
Azouz, A., Wu, Y.-L., Hillion, J., Tárkányi, I., Karniguian, A., Aradi, J., Lanotte, M., Chen, G.-Q., Chehna, M. F., & Ségal-Bendirdjian, E. (2010) · Leukemia · doi:10.1038/leu.2009.283 · Cited by 33 · see citing works
Involvement of calcium/calmodulin‐dependent protein kinase II in the induction of mPer1
Nomura, K., Takeuchi, Y., Yamaguchi, S., Okamura, H., & Fukunaga, K. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10581 · Cited by 33 · see citing works
Zou, S.-Q., Qu, Z.-L., Li, Z., & Wang, X. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i15.2259 · Cited by 32 · see citing works
Activation of telomerase by HPVs
Katzenellenbogen, R. A. (2016) · Virus Research · doi:10.1016/j.virusres.2016.11.003 · Cited by 32 · see citing works
Renaud, S., Bosman, F. T., & Benhattar, J. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02775-4 · Cited by 31 · see citing works
Su, C., Sham, J. S. T., Xue, H., Wang, X.-H., Chua, D., Cui, Z.-F., Peng, L., Li, L.-F., Jiang, L., Wu, M., et al. (2004) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-004-0577-4 · Cited by 32 · see citing works
Stewart, R., Yang, C., Anyfantis, G., Przyborski, S. A., Hole, N., Strachan, T., Stojković, M., Keith, W. N., Armstrong, L., & Lako, M. (2008) · Regenerative Medicine · doi:10.2217/17460751.3.4.505 · Cited by 26 · see citing works
Xu, M., Katzenellenbogen, R. A., Grandori, C., & Galloway, D. A. (2013) · Virology · doi:10.1016/j.virol.2013.07.014 · Cited by 25 · see citing works
Yik, M. Y., Azlan, A., Rajasegaran, Y., Rosli, A. A., Yusoff, N. M., & Moses, E. J. (2021) · Genes · doi:10.3390/genes12081188 · Cited by 24 · see citing works
Jiao, Y., Huang, B., Chen, Y., Hong, G., Xu, J., Hu, C. Y., & Wang, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010271 · Cited by 24 · see citing works
Human chromosome 5 carries a putative telomerase repressor gene
Kugoh, H., Shigenami, K., Funaki, K., Barrett, J. C., & Oshimura, M. (2002) · Genes Chromosomes and Cancer · doi:10.1002/gcc.10135 · Cited by 24 · see citing works
Pericuesta, E., Ramírez, M. Á., Villa, A., Relaño-Ginés, A., Torres, J. M., Nieto, M., Pintado, B., & Gutiérrez‐Adán, A. (2006) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-4-5 · Cited by 24 · see citing works
Gančarčíková, M., Zemanová, Z., Březinová, J., Berková, A., Vcelikova, S., Šmigová, J., & Michalova, K. (2010) · PubMed · Cited by 22 · see citing works
Glasspool, R. M., Burns, S., Hoare, S. F., Svensson, C., & Keith, W. N. (2005) · Neoplasia · doi:10.1593/neo.04766 · Cited by 22 · see citing works
The secrets of telomerase: Retrospective analysis and future prospects
Kamal, S., Junaid, M., Ejaz, A., Bibi, I., Akash, M. S. H., & Rehman, K. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118115 · Cited by 19 · see citing works
Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology
Fajkus, J., Šimíčková, M., & Maláska, J. (2002) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2001.1053 · Cited by 20 · see citing works
Ma, Y., Hao, S., Wang, S., Zhao, Y., Lim, B., Lei, M., Spector, D. J., El‐Deiry, W. S., Zheng, S.-Y., & Zhu, J. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-14-0693 · Cited by 19 · see citing works
Cheng, D., Zhao, Y., Wang, S., Zhang, F., Russo, M., McMahon, S. B., & Zhu, J. (2016) · The FASEB Journal · doi:10.1096/fj.201601111r · Cited by 18 · see citing works
THOR is a targetable epigenetic biomarker with clinical implications in breast cancer
Apolónio, J. D., Dias, J. S., Fernandes, M. T., Komosa, M., Lipman, T., Zhang, C. H., Leao, R. R. N., Lee, D., Nunes, N. M., Maia, A.-T., et al. (2022) · Clinical Epigenetics · doi:10.1186/s13148-022-01396-3 · Cited by 18 · see citing works
Hsu, C.-C., Chen, C.-H., Hsu, T., Hung, J., Ko, J., Zhang, B., Lee, Y., Chen, H.-K., Chang, W., & Lin, D.-Y. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.12.004 · Cited by 17 · see citing works
Murugan, A. K., Kannan, S., & Alzahrani, A. S. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189243 · Cited by 16 · see citing works
Tang, Z., Zhao, Y., Mei, F., Yang, S., Li, X., Lv, J., Hou, L., & Zhang, B. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.09.201 · Cited by 15 · see citing works
Sohn, J. H., Yeh, B., Choi, J.-W., Yoon, J., Namkung, J., Park, K.-K., & Kim, H.-W. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0141 · Cited by 13 · see citing works
Jiang, S., Galindo, M. R., & Jarrett, H. W. (2009) · PROTEOMICS · doi:10.1002/pmic.200800693 · Cited by 14 · see citing works
Xu, Y., & Carr, L. G. (2001) · DNA and Cell Biology · doi:10.1089/104454901750361451 · Cited by 14 · see citing works
Ogawa, H., Murayama, A., Nagata, S., & Fukunaga, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207615200 · Cited by 13 · see citing works
Wang, X.-P., Zhang, Y., Deng, J., Pan, H.-Y., Zhou, F.-C., & Gao, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108026200 · Cited by 13 · see citing works
Edqvist, A., Rebetz, J., Järås, M., Rydelius, A., Skagerberg, G., Salford, L. G., Widegren, B., & Fan, X. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2005.12.018 · Cited by 12 · see citing works
Ulatowski, L. M. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh200 · Cited by 12 · see citing works
Antisense oligonucleotide targeting at the initiator of hTERT arrests growth of hepatoma cells
Liu, S., Sun, W., Cao, Y.-L., Ma, C., Han, L., Zhang, L., Wang, Z., & Zhu, F. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i3.366 · Cited by 12 · see citing works
Nishikimi, K., Nakagawa, K., Tate, S., Matsuoka, A., Iwamoto, M., Kiyokawa, T., & Shozu, M. (2018) · American Journal of Clinical Pathology · doi:10.1093/ajcp/aqx166 · Cited by 11 · see citing works
The importance of the telomere and telomerase system in hematological malignancies
Ram, R., Uziel, O., & Lahav, M. (2005) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190500125853 · Cited by 11 · see citing works
The Regulation of Telomerase in Oncogenesis
Skvortzov, D. A., Rubzova, M. P., Zvereva, M. I., Fl, K., & Donzova, O. A. (2009) · Acta Naturae · doi:10.32607/20758251-2009-1-1-51-67 · Cited by 11 · see citing works
Epigenetic regulation of telomerase expression in HIV-1-specific CD8+ T cells
Williams, K. L., Seiss, K., Beamon, J., Pereyra, F., Rosenberg, E. S., Walker, B. D., Yu, X. G., & Lichterfeld, M. D. (2010) · AIDS · doi:10.1097/qad.0b013e32833c7170 · Cited by 9 · see citing works
Bradfield, A., Button, L., Drury, J. A., Green, D. C., Hill, C. J., & Hapangama, D. K. (2020) · Methods and Protocols · doi:10.3390/mps3030063 · Cited by 9 · see citing works
Long, S., Argyle, D. J., Gault, E. A., Campbell, S., & Nasir, L. (2005) · Gene · doi:10.1016/j.gene.2005.05.030 · Cited by 9 · see citing works
Molecular mechanisms regulating telomerase activity
Liu, J. (2001) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(01)08003-8 · Cited by 9 · see citing works
The Superfamily of SCAN Domain Containing Zinc Finger Transcription Factors
Collins, T., & Sander, T. L. (2005) · Springer eBooks · doi:10.1007/0-387-27421-9_22 · Cited by 8 · see citing works
Qi, D.-L., Ohira, T., Oshimura, M., & Kugoh, H. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.07.003 · Cited by 7 · see citing works
Insights into the structure and function of Est3 from the Hansenula polymorpha telomerase
Shepelev, N. M., Mariasina, S. S., Mantsyzov, A. B., Malyavko, A. N., Vladimirovich, E. S., Petrova, O. A., Rodina, E. V., Zvereva, M. I., Донцова, О. А., & Polshakov, V. I. (2020) · Scientific Reports · doi:10.1038/s41598-020-68107-x · Cited by 6 · see citing works
Targeting eradication of malignant cells derived from human bone marrow mesenchymal stromal cells
Yang, Y., Cai, S., Yang, L., Yu, S., Jiang, J., Yan, X., Zhang, H., Liu, L., Liu, Q., Du, J., et al. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.02.014 · Cited by 5 · see citing works
Telomere Maintenance and Genome Stability
Hernandez-Sanchez, W. M., Xu, M., & Taylor, D. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803309-8.00021-5 · Cited by 4 · see citing works
Adenovirus-Based Gene Therapy for Cancer
Su, C. (2011) · InTech eBooks · doi:10.5772/19757 · Cited by 3 · see citing works
Cheng, Y., Fang, D.-C., Yao, P., Guo, L., Ning, X., & Wang, L. (2014) · Biomedical Reports · doi:10.3892/br.2014.398 · Cited by 3 · see citing works
Regulation of Telomerase Through Transcriptional and Posttranslational Mechanisms
Depcrynski, A., Sachs, P. C., Elmore, L. W., & Holt, S. E. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-879-9_3 · Cited by 2 · see citing works
Fujiwara, T., Urata, Y., & Tanaka, N. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-879-9_13 · Cited by 2 · see citing works
hMZF-2, the Elusive Transcription Factor
Chebly, A., Péloponèse, J., Ségal-Bendirdjian, E., Merlio, J., Tomb, R. R., & Chevret, E. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.581115 · Cited by 2 · see citing works
Telomerase, DNA damage and apoptosis
Mattson, M. P., Fu, W., & Zhang, P. (2001) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(01)08007-5 · Cited by 2 · see citing works
Gelmini, S., Malentacchi, F., Giannarini, G., Selli, C., & Orlando, C. (2005) · EAU Update Series · doi:10.1016/j.euus.2005.09.004 · Cited by 1 · see citing works
Growth factor-mediated telomerase activity in ovarian cancer cells
Bermudez, Y. (2007) · Digital Commons - University of South Florida (University of South Florida)
- Authors
- Fujimoto, K., Kyo, S., Takakura, M., Kanaya, T., Kitagawa, Y., Itoh, H., Takahashi, M., & Inoue, M.
- Affiliations
- Kanazawa University (JP)
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-07-01
- Volume
- 28
- Issue
- 13
- Pages
- 2557-2562
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- PMC
- PMC102701
- OpenAlex
- W2146670318
- Cited by
- 116
- References
- 33
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 5 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 5.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nucleic Acids Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- hTERT, human telomerase reverse transcriptase, telomerase, negative regulatory element, transcriptional repression, zinc finger transcription factor, cell differentiation, telomerase activity, transcriptional regulation
- MeSH terms
- Base Sequence, Binding Sites, Cell Differentiation, DNA, DNA-Binding Proteins, Humans, Mutation, Promoter Regions, Genetic, Repressor Proteins, RNA, RNA, Messenger, Transcription Factors, Transcription, Genetic, Transfection, Tumor Cells, Cultured, Down-Regulation, Zinc Fingers, Consensus Sequence, Telomerase, Reverse Transcriptase Polymerase Chain Reaction, Catalytic Domain, Response Elements, Gene Silencing, Kruppel-Like Transcription Factors
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