MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

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The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

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Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases

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Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

Whitmarsh, A. J., & Davis, R. J. (1996) · Journal of Molecular Medicine · doi:10.1007/s001090050063 · Cited by 1,543

Role of Translocation in the Activation and Function of Protein Kinase B

Andjelkovic, M., Alessi, D. R., Meier, R., Fernandez, A., Lamb, N. J. C., Frech, M., Cron, P., Cohen, P., Lucocq, J. M., & Hemmings, B. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.50.31515 · Cited by 1,051

Inactivation of glycogen synthase kinase-3 β by phosphorylation: new kinase connections in insulin and growth-factor signalling

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MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis

Kotlyarov, A., Neininger, A., Schubert, C., Eckert, R., Birchmeier, C., Volk, H.-D., & Gaestel, M. (1999) · Nature Cell Biology · doi:10.1038/10061 · Cited by 763

c-Src-mediated Phosphorylation of the Epidermal Growth Factor Receptor on Tyr845 and Tyr1101 Is Associated with Modulation of Receptor Function

Biscardi, J. S., Maa, M.-C., Tice, D. A., Cox, M. E., Leu, T.-H., & Parsons, S. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.8335 · Cited by 649

The MAP kinase signaling cascades: a system of hundreds of components regulates a diverse array of physiological functions

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Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase

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Hepatocyte Necrosis Induced by Oxidative Stress and IL-1α Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis

Sakurai, T., He, G., Matsuzawa, A., Yu, G.-Y., Maeda, S., Hardiman, G., & Karin, M. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.06.016 · Cited by 487

MAPKAP kinases — MKs — two's company, three's a crowd

Gaestel, M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1834 · Cited by 413

Mitogenic Activation, Phosphorylation, and Nuclear Translocation of Protein Kinase Bβ

Meier, R., Alessi, D. R., Cron, P., Andjelković, M., & Hemmings, B. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.48.30491 · Cited by 378

Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein

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Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines

Alessi, D. R., Gomez, N., Moorhead, G., Lewis, T., Keyse, S. M., & Cohen, P. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00059-5 · Cited by 365

Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability

BEUGNET, A., TEE, A. R., TAYLOR, P. M., & PROUD, C. G. (2003) · Biochemical Journal · doi:10.1042/bj20021266 · Cited by 307

5′-AMP-activated Protein Kinase Phosphorylates IRS-1 on Ser-789 in Mouse C2C12 Myotubes in Response to 5-Aminoimidazole-4-carboxamide Riboside

Jakobsen, S. N., Hardie, D. G., Morrice, N., & Tornqvist, H. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100483200 · Cited by 238

Crystal Structure of the P38α-MAPKAP Kinase 2 Heterodimer

Haar, E. T., Prabakhar, P., Liu, X., & Lepre, C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611165200 · Cited by 100

Catalytically Active MAP KAP Kinase 2 Structures in Complex with Staurosporine and ADP Reveal Differences with the Autoinhibited Enzyme

Underwood, K. W., Parris, K. D., Federico, E., Mosyak, L., Czerwinski, R. M., Shane, T., Taylor, M., Svenson, K., Liu, Y., Hsiao, C.-L., et al. (2003) · Structure · doi:10.1016/s0969-2126(03)00092-3 · Cited by 62

Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli

Zhuang, Z.-H., Zhou, Y., Yu, M.-C., Silverman, N., & Ge, B.-X. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2005.05.013 · Cited by 45

CD45-induced Tumor Necrosis Factor α Production in Monocytes Is Phosphatidylinositol 3-Kinase-dependent and Nuclear Factor-κB-independent

Hayes, A. L., Smith, C., Foxwell, B. M. J., & Brennan, F. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.47.33455 · Cited by 44