Cited by 455Cancer-related Molecular PathwaysCell death mechanisms and regulationHeat shock proteins research

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Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

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Okamoto, K., Beach, D.·1994·The EMBO Journal

DOI 10.1002/j.1460-2075.1994.tb06807.xPMC PMC395420

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Abstract

Through a PCR-based differential screening method, cyclin G was identified as a novel transcriptional target of the p53 tumor suppressor gene product. In both a mouse p53 temperature-sensitive leukemic cell line and mouse embryonic fibroblasts (MEF) after gamma-irradiation, cyclin G mRNA was rapidly induced. MEF from a p53-deficient mouse expressed cyclin G at a level > 10-fold lower than that from a wild-type mouse. Using a DNA binding assay, a specific p53 binding site was identified upstream from the cyclin G gene, which functioned as a p53-dependent cis-acting element in a transient transfection assay. These results suggest that cyclin G might participate in a p53-mediated pathway to prevent tumorigenesis.

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Authors: Okamoto, K., & Beach, D.
Affiliations: Howard Hughes Medical Institute (US)
ORCID: Okamoto, K.
Venue: The EMBO Journal
Publisher: Springer Science and Business Media LLC
Published: 1994-10-01
Volume: 13
Issue: 20
Pages: 4816-4822
ISSN: 0261-4189 (ISSN-L)
1460-2075
DOI: 10.1002/j.1460-2075.1994.tb06807.x
PMC: PMC395420
OpenAlex: W1823168351
Cited by: 455
References: 40
Citations by year: 2026: 1 · 2025: 3 · 2024: 1 · 2023: 7 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 5 · 2017: 7 · 2016: 3 · 2015: 11 · 2014: 6 · 2013: 10 · 2012: 11
FWCI: 15.16
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: The EMBO Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
Institutional Repositories DataBase (IRDB) (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health
National Institute of General Medical Sciences (GM 396 20-06)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Keywords: cyclin G, p53, transcription factor target genes, tumor suppressor, p53 binding sites, cis-regulatory elements, gamma irradiation, carcinogenesis, mouse embryonic fibroblasts, leukemia cell lines
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Cells, Cultured, Molecular Sequence Data, Protein Binding, Transcription Factors, Tumor Cells, Cultured, Transcriptional Activation, Tumor Suppressor Protein p53, Cyclins, Mice, Cyclin G, Cyclin G1

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Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

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