Cited by 455Cancer-related Molecular PathwaysCell death mechanisms and regulationHeat shock proteins research

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Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

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Okamoto, K., Beach, D.·1994·The EMBO Journal

DOI 10.1002/j.1460-2075.1994.tb06807.xPMC PMC395420

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Abstract

Through a PCR-based differential screening method, cyclin G was identified as a novel transcriptional target of the p53 tumor suppressor gene product. In both a mouse p53 temperature-sensitive leukemic cell line and mouse embryonic fibroblasts (MEF) after gamma-irradiation, cyclin G mRNA was rapidly induced. MEF from a p53-deficient mouse expressed cyclin G at a level > 10-fold lower than that from a wild-type mouse. Using a DNA binding assay, a specific p53 binding site was identified upstream from the cyclin G gene, which functioned as a p53-dependent cis-acting element in a transient transfection assay. These results suggest that cyclin G might participate in a p53-mediated pathway to prevent tumorigenesis.

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El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
Wade Harper, J. (1993) · Cell · doi:10.1016/0092-8674(93)90499-g · Cited by 5,651
p53, guardian of the genome
Lane, D. P. (1992) · Nature · doi:10.1038/358015a0 · Cited by 5,138
Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction
Liang, P., & Pardee, A. B. (1992) · Science · doi:10.1126/science.1354393 · Cited by 4,964
The p53 tumour suppressor gene
Levine, A. J., Momand, J. A., & Finlay, C. A. (1991) · Nature · doi:10.1038/351453a0 · Cited by 3,785
Participation of p53 protein in the cellular response to DNA damage.
Kastan, M. B., Onyekwere, O. C., Sidransky, D., Vogelstein, B., & Craig, R. W. (1991) · PubMed · Cited by 3,761
p21 is a universal inhibitor of cyclin kinases
Xiong, Y., Hannon, G., Zhang, H., Casso, D., Kobayashi, R., & Beach, D. (1993) · Nature · doi:10.1038/366701a0 · Cited by 3,691
Self-citation
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
Lowe, S. W., Ruley, H. E., Jacks, T., & Housman, D. E. (1993) · Cell · doi:10.1016/0092-8674(93)90719-7 · Cited by 2,911
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
Yonish-Rouach, E., Resnftzky, D., Lotem, J., Sachs, L., Kimchi, A., & Oren, M. (1991) · Nature · doi:10.1038/352345a0 · Cited by 2,079

Show all 40 references

Research works printed but not linked: 1

Sambrook,J., Fritsch,E.F. and Maniatis,T. (1989) Molecular Cloning. A Laboratorv Manual. 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.

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Fotedar, R., Diederich, L., & Fotedar, A. (1996) · Springer eBooks · doi:10.1007/978-1-4615-5873-6_15 · Cited by 91
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Yang, J. J. (1998) · Carcinogenesis · doi:10.1093/carcin/19.6.1117 · Cited by 86
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Jeay, S., Gaulis, S., Ferretti, S., Bitter, H., Ito, M., Valat, T., Murakami, M., Ruetz, S., Guthy, D. A., Rynn, C., et al. (2015) · eLife · doi:10.7554/elife.06498 · Cited by 85
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Ohtsuka, T., Ryu, H., Minamishima, Y. A., Ryo, A., & Lee, S. W. (2003) · Oncogene · doi:10.1038/sj.onc.1206306 · Cited by 84
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Abarzúa, P., LoSardo, J. E., Gubler, M. L., & Neri, A. (1995) · PubMed · Cited by 83
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Göhler, T., Reimann, M., Cherny, D. I., Walter, K., Warnecke, G., Kim, E. L., & Deppert, W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202344200 · Cited by 82
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Madden, S. L., Galella, E. A., Riley, D., Bertelsen, A. H., & Beaudry, G. A. (1996) · PubMed · Cited by 80
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Mowat, M. R. A. (1998) · Advances in cancer research · doi:10.1016/s0065-230x(08)60764-2 · Cited by 78
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DeVeaux, S., Cohen‐Kaminsky, S., Shivdasani, R. A., Andrews, N. C., Filipe, A., Kuzniak, I., Orkin, S. H., Roméo, P., & Mignotte, V. (1997) · The EMBO Journal · doi:10.1093/emboj/16.18.5654 · Cited by 77
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Don, A. S. A., Dallapiazza, R. F., Bennin, D. A., Brake, T., Cowan, C. E., & Horne, M. C. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.09.023 · Cited by 77
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Farmer, G. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.21.4281 · Cited by 74
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Maiyar, A. C., Huang, A. J. Y., Phu, P. T., Cha, H. H., & Firestone, G. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.21.12414 · Cited by 74
Apoptotic response of spermatogenic cells to the germ cell mutagens etoposide, adriamycin, and diepoxybutane
Sjöblom, T., West, A., & Lähdetie, J. (1998) · Environmental and Molecular Mutagenesis · doi:10.1002/(sici)1098-2280(1998)31:2 · Cited by 74
Stable binding of the eukaryotic acidic phosphoproteins to the ribosome is not an absolute requirement for in vivo protein synthesis.
Remacha, M., Santos, C., Bermejo, B., Naranda, T., & Ballesta, J. P. G. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49806-2 · Cited by 73
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Steegenga, W. T., van Laar, T., Riteco, N., Mandarino, A., Shvarts, A., van der Eb, A. J., & Jochemsen, A. G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2101 · Cited by 73
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Thomas, A. E., & White, E. (1998) · Genes & Development · doi:10.1101/gad.12.13.1975 · Cited by 72
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Wang, X., & Ohnishi, T. (1997) · Journal of Radiation Research · doi:10.1269/jrr.38.179 · Cited by 70
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Cross, B. L., Chen, L., Cheng, Q., Li, B., Yuan, Z.-M., & Chen, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.228981 · Cited by 72
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Kim, Y., Shintani, S., Kohno, Y., Zhang, R., & Wong, D. T. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1926 · Cited by 68
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DeMichele‐Sweet, M. A. A., Weamer, E. A., Klei, L., Vrana, D. T., Hollingshead, D. J., Seltman, H. J., Sims, R., Foroud, T., Hernández, I., Moreno–Grau, S., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.81 · Cited by 69
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Yonish-Rouach, E. (1996) · Cellular and Molecular Life Sciences · doi:10.1007/bf01920109 · Cited by 68
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Tordjman, R., Ortéga, N., Coulombel, L., Plouët, J., Roméo, P., & Lemarchandel, V. (1999) · Blood · doi:10.1182/blood.v94.7.2301.419k24_2301_2309 · Cited by 67
Differential expression of human ferritin H chain gene in immortal human breast epithelial MCF-10F cells
Higgy, N. A., Salicioni, A. M., Russo, I. H., Zhang, P. L., & Russo, J. (1997) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199712)20:4 · Cited by 40
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Dillman, J. F., Phillips, C. S., Dorsch, L. M., Croxton, M. D., Hege, A. I., Sylvester, A. J., Moran, T. S., & Sciuto, A. M. (2004) · Chemical Research in Toxicology · doi:10.1021/tx049745z · Cited by 65
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Steiner, M. S., Zhang, X., Wang, Y., & Lu, Y. W. (2000) · PubMed · Cited by 65
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Nishi, H., Senoo, M., Nishi, K., Murphy, B., Rikiyama, T., Matsumura, Y., Habu, S., & Johnson, A. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101241200 · Cited by 65
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Froesch, B. A., Aimé, C., Leber, B. F., Andrews, D. W., & Reed, J. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6469 · Cited by 64
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Authors: Okamoto, K., & Beach, D.
Affiliations: Howard Hughes Medical Institute (US)
ORCID: Okamoto, K.
Venue: The EMBO Journal
Publisher: Springer Science and Business Media LLC
Published: 1994-10-01
Volume: 13
Issue: 20
Pages: 4816-4822
ISSN: 0261-4189 (ISSN-L)
1460-2075
DOI: 10.1002/j.1460-2075.1994.tb06807.x
PMC: PMC395420
OpenAlex: W1823168351
Cited by: 455
References: 40
Citations by year: 2026: 1 · 2025: 3 · 2024: 1 · 2023: 7 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 5 · 2017: 7 · 2016: 3 · 2015: 11 · 2014: 6 · 2013: 10 · 2012: 11
FWCI: 15.16
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: The EMBO Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
Institutional Repositories DataBase (IRDB) (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health
National Institute of General Medical Sciences (GM 396 20-06)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Keywords: cyclin G, p53, transcription factor target genes, tumor suppressor, p53 binding sites, cis-regulatory elements, gamma irradiation, carcinogenesis, mouse embryonic fibroblasts, leukemia cell lines
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Cells, Cultured, Molecular Sequence Data, Protein Binding, Transcription Factors, Tumor Cells, Cultured, Transcriptional Activation, Tumor Suppressor Protein p53, Cyclins, Mice, Cyclin G, Cyclin G1

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Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

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